犬髓外浆细胞瘤的组织学谱：诊断挑战和皮肤组织细胞瘤的免疫组织化学分化。

IF 1.7 2区农林科学 Q2 PATHOLOGY

Veterinary Pathology Pub Date : 2025-08-28 DOI:10.1177/03009858251361141

Bartolomeu B N Santos, Paulo V Peixoto, Maria C Peleteiro, Daniel R Rissi, Sandra Carvalho, Ticiana N França

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引用次数: 0

摘要

本文研究了73例犬髓外浆细胞瘤（EMPs）的诊断特征及其与犬皮肤组织细胞瘤（CHs）的区别，采用组织学和免疫组织化学方法检测MUM1、CD3、CD79a、免疫球蛋白（Ig）轻链（λ和κ）和IBA1。大多数emp分为裂解型和成熟型。几乎92%的EMPs为MUM1阳性，77%的EMPs为CD79a阳性，74%的EMPs为Ig轻链λ和κ阳性。使用MUM1和Ig轻链导致诊断EMPs的灵敏度为100%，超过了MUM1和CD79a的组合（94%）。在8%的emp中，肿瘤细胞有假滤泡排列，而7%有淀粉样蛋白沉积，3%有矿化。CHs的IBA1阳性，但所有其他ihc阴性。

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Histologic spectrum of canine extramedullary plasmacytomas: Diagnostic challenges and immunohistochemical differentiation from cutaneous histiocytomas.

Here we assess the diagnostic features of 73 canine extramedullary plasmacytomas (EMPs) and their differentiation from canine cutaneous histiocytomas (CHs) using histology and immunohistochemistry for MUM1, CD3, CD79a, immunoglobulin (Ig) light chains (λ and κ), and IBA1. Most EMPs were classified as cleaved and mature subtypes. Almost 92% of EMPs were positive for MUM1, whereas 77% were positive for CD79a and 74% for Ig light chains λ and κ. The use of MUM1 and Ig light chains resulted in a sensitivity of 100% in diagnosing EMPs, surpassing the combination of MUM1 and CD79a (94%). In 8% of the EMPs, there was pseudofollicular arrangement of neoplastic cells, whereas 7% had amyloid deposition and 3% had mineralization. CHs were positive for IBA1 but negative for all other IHCs.

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来源期刊

Veterinary Pathology 农林科学-病理学

CiteScore

4.70

自引率

8.30%

发文量

审稿时长

2 months

期刊介绍： Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.