Veterinary Pathology最新文献

Cutaneous silica-associated (cat litter) granulomas in the paws of 13 domestic cats. 13只家猫爪子皮肤二氧化硅相关（猫砂）肉芽肿。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-13 DOI: 10.1177/03009858251352588

Alea Agrawal, Wilson Garuba, Natalie Dunn, Daniel R Rissi, Sarah Morar Schneider, Bhavya Sharma, Denae LoBato

{"title":"Cutaneous silica-associated (cat litter) granulomas in the paws of 13 domestic cats.","authors":"Alea Agrawal, Wilson Garuba, Natalie Dunn, Daniel R Rissi, Sarah Morar Schneider, Bhavya Sharma, Denae LoBato","doi":"10.1177/03009858251352588","DOIUrl":"https://doi.org/10.1177/03009858251352588","url":null,"abstract":"Silica is a well-known stimulus of granulomatous inflammation in the lungs of humans and other animals. However, it has been poorly studied as a cause of cutaneous inflammation in domestic animals, despite the predominance of silica in traditional (clay-based) cat litter substrates. Here we characterize the clinical and pathologic findings of 13 surgical biopsies from the paws or paw pads of domestic cats submitted to 2 veterinary institutions between 2005 and 2023. Gross lesions often included chronic or intermittent paw pad swelling, ulceration and bleeding, or draining tracts, particularly in the front paws. All biopsies consisted of granulomatous to pyogranulomatous inflammation with birefringent, amorphous to granular, blue-gray, intrahistiocytic material consistent with silica. Raman spectra were collected from 3 biopsy samples at 45 different locations. Using multivariate analysis, the foreign material in the biopsies had similar Raman spectra to multiple brands of silica-based cat litter. Ten of 13 biopsies also contained evidence of plasma cell pododermatitis, suggesting that underlying paw pad disease may predispose some cats to cutaneous cat litter implantation. In these cats, subsequent granulomatous inflammation may obscure the underlying condition and exacerbate clinical disease. Routine polarization of feline paw or paw pad biopsies is recommended to aid in recognition of cat litter granulomas. Careful examination for a predisposing condition is also warranted when cat litter granulomas are identified. Recurrence is common following surgery; affected cats, and predisposed cats with paw pad disease, may benefit from the use of alternate litter substrates to prevent this lesion or its recurrence.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251352588"},"PeriodicalIF":2.3,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical characterization of cells of the mononuclear phagocyte system in the mouse. 小鼠单核吞噬细胞系统细胞的免疫组织化学表征。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-12 DOI: 10.1177/03009858251352581

Luca Bertola, Andrea G Valenti, Andrea Cappelleri, Simone Canesi, Eugenio Scanziani, Camilla Recordati, Lucia Minoli

{"title":"Immunohistochemical characterization of cells of the mononuclear phagocyte system in the mouse.","authors":"Luca Bertola, Andrea G Valenti, Andrea Cappelleri, Simone Canesi, Eugenio Scanziani, Camilla Recordati, Lucia Minoli","doi":"10.1177/03009858251352581","DOIUrl":"https://doi.org/10.1177/03009858251352581","url":null,"abstract":"The mononuclear phagocyte system (MPS) is an ensemble of heterogeneous cells comprising circulating monocytes, macrophages, and dendritic cells. Immunohistochemistry is a valuable technique to detect, quantify, and localize MPS cells in tissues, but a comprehensive characterization of MPS cells in normal tissues of mice is lacking to date. The aim of this study was to immunohistochemically characterize MPS cells in a set of murine healthy tissues and in a subset of representative disease states. Sections of healthy tissues obtained from 21 C57BL/6J and C57BL/6N mice and sections of inflammatory (necrosuppurative hepatitis and Pneumocystis murina-associated pneumonia) and experimentally induced neoplastic conditions (human fibrosarcoma xenograft and mammary carcinoma syngraft) were immunolabeled with a panel of MPS markers, including IBA1, F4/80, macrophage receptor with collagenous structure (MARCO), CD206, arginase 1, Ym1, induced nitric oxide synthase, heme-oxygenase 1 (HO-1), and class II major histocompatibility complex (MHC-II). For each tissue, the amount, morphology, location, and immunolabeling intensity of positive cells were evaluated using semi-quantitative scores. Results highlighted the morphological and immunophenotypic heterogeneity of murine MPS cells. The panel of antibodies used allowed for discrimination of different cell populations across the examined tissues based on immunophenotype, microanatomical location, and morphology, providing useful morphological and functional clues on MPS cells in both physiological and diseased conditions. The results of this study provide a valuable reference regarding the amount, morphology, microanatomical location, and immunophenotype of MPS subsets in healthy murine tissues. In addition, it highlights the plasticity of these cells in inflammatory and neoplastic settings, underscoring the importance of a comprehensive characterization of MPS cells in physiological and disease states.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251352581"},"PeriodicalIF":2.3,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144620749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenge in veterinary pathology: Generalized alopecia in a Holstein dairy cow. 兽医病理学诊断挑战：荷斯坦奶牛全身性脱发。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-07 DOI: 10.1177/03009858251347531

Mirjam Hildebrand, Laura Schäfer, Isabelle Kübler, Manfred Henrich, Monika Welle, Keith E Linder, Peter L Venjakob

引用次数: 0

Feline oral in situ carcinoma associated with papillomavirus infection: A case series of 7 cats. 猫口腔原位癌伴乳头瘤病毒感染：7只猫的病例系列。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-03 DOI: 10.1177/03009858251352594

John S Munday, Cynthia M Bell, Emma L Gulliver

{"title":"Feline oral in situ carcinoma associated with papillomavirus infection: A case series of 7 cats.","authors":"John S Munday, Cynthia M Bell, Emma L Gulliver","doi":"10.1177/03009858251352594","DOIUrl":"https://doi.org/10.1177/03009858251352594","url":null,"abstract":"Cutaneous lesions due to papillomavirus (PV) infection are well described in cats. However, there are few reports of similar lesions in the oral cavity. In this case series, 7 cats with in situ carcinomas of the oral mucosa are reported. Lesions appeared histologically like cutaneous Bowenoid in situ carcinomas, and PV-induced cell changes were visible within lesions from 6 cats. A PV etiology was further supported by intense p16CDKN2A protein immunolabeling within all lesions. Five lesions contained Felis catus papillomavirus (FcaPV) type 3 DNA, while 2 contained FcaPV1 DNA. Cats had clinical signs of drooling and oral pain for over 6 months prior to diagnosis, and the dorsal surface of the tongue was most often affected. Four cats had multiple oral lesions, and 2 cats had oral and skin lesions. Of the 6 cats for which clinical outcome was known, 3 are still alive at least 6 months after diagnosis, 2 died of unrelated causes 7 and 14 months after diagnosis, and 1 cat was euthanatized due to oral pain 18 months after diagnosis. Results suggest PV-associated oral in situ carcinoma is a specific disease entity of cats. Lesions are slowly progressive with pain management allowing long survival times. No cases were known to progress to invasive squamous cell carcinoma, and feline oral squamous cell carcinomas appear to infrequently develop as a progression from these lesions. Due to the marked difference in biological behavior, diagnosticians should differentiate PV-associated oral in situ carcinomas and oral squamous cell carcinomas in cats.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251352594"},"PeriodicalIF":2.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special focus on veterinary neuropathology. 特别关注兽医神经病理学。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1177/03009858251344319

Andrew D Miller, Jey W Koehler, Anna Oevermann, Daniel R Rissi

引用次数: 0

Image challenge in Veterinary Pathology, answers: Neuropathology. 兽医病理学中的图像挑战，答案：神经病理学。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1177/03009858251331764

引用次数: 0

Image challenge in Veterinary Pathology. 兽医病理学中的图像挑战。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1177/03009858251331763

引用次数: 0

Histologic comparison of hepatic iron overload in managed care and free-ranging Egyptian rousette bats (Rousettus aegyptiacus). 管理护理和自由放养的埃及红塞蝙蝠肝铁超载的组织学比较。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-07-01 DOI: 10.1177/03009858251352580

Jessica A Elbert, Brittany McHale, Nicole L Gottdenker, Caitlin E Burrell, Rita McManamon, Shannon G M Kirejczyk, Brian R Amman, Tara K Sealy, Patrick Atimnedi, Jonathan S Towner, Elizabeth W Howerth

{"title":"Histologic comparison of hepatic iron overload in managed care and free-ranging Egyptian rousette bats (Rousettus aegyptiacus).","authors":"Jessica A Elbert, Brittany McHale, Nicole L Gottdenker, Caitlin E Burrell, Rita McManamon, Shannon G M Kirejczyk, Brian R Amman, Tara K Sealy, Patrick Atimnedi, Jonathan S Towner, Elizabeth W Howerth","doi":"10.1177/03009858251352580","DOIUrl":"https://doi.org/10.1177/03009858251352580","url":null,"abstract":"Iron overload is a leading cause of morbidity and mortality in Egyptian rousette bats (ERBs; Rousettus aegyptiacus) within managed care settings. We compared hepatic iron accumulation and tissue damage in samples collected from managed care bats in a zoo setting, a research colony, and a free-ranging population with the goal of determining if iron overload was a potential cause of morbidity for free-ranging ERBs. Livers from 20 zoo bats, 8 research colony bats, and 69 free-ranging bats were histologically evaluated for fibrosis, necrosis, and iron accumulation in hepatocytes and Kupffer cells. Hemochromatosis was identified only in the zoo population, with hemosiderosis identified in all research colony bats and many free-ranging bats. There were statistically significant associations between age classification, population, and diagnosis and between Marburg virus infection status and histologic liver iron scores. In addition, there were positive associations with statistical significance between age class (juvenile, adult) and histologic iron scores and between population type (zoo bats > research colony bats > free-ranging bats) and histologic iron scores. Excessive hepatic iron storage does not appear to be a source of morbidity within free-ranging ERB populations.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251352580"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural language processing in veterinary pathology: A review. 自然语言处理在兽医病理学中的应用综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-06-30 DOI: 10.1177/03009858251347529

Lev Stimmer, Raoul V Kuiper, Laura Polledo, Lorenzo Ressel, Josep M Monné Rodriguez, Inês B Veiga, Jonathan Williams, Vanessa Herder

{"title":"Natural language processing in veterinary pathology: A review.","authors":"Lev Stimmer, Raoul V Kuiper, Laura Polledo, Lorenzo Ressel, Josep M Monné Rodriguez, Inês B Veiga, Jonathan Williams, Vanessa Herder","doi":"10.1177/03009858251347529","DOIUrl":"https://doi.org/10.1177/03009858251347529","url":null,"abstract":"Natural language processing (NLP), a branch of artificial intelligence that focuses on the interaction between computers and human language, has potential in advancing veterinary pathology through its ability to source knowledge efficiently from vast data sets, generate high-quality text rapidly, and enhance data searchability. This review explores the applications of NLP in veterinary pathology, emphasizing its potential role in diagnostics, training pathologists, and research. NLP might offer many advantages, such as accuracy, speed, and cost reduction, especially for routine tasks including text summarization and report generation. These benefits make NLP a promising technology for achieving precision, adding value, and driving innovation in health care. However, caution is warranted, as NLP models may introduce biases and errors due to the quality of the data they are trained on, have limitations in interpreting nuanced or context-specific information, and lead to private data leakage. Furthermore, the multifaceted nature of veterinary pathology data may require specifically trained and expert-validated algorithms for accurate interpretation. To ensure the credibility and validity of research findings, pathologists must critically evaluate and complement obtained outputs with human expertise and judgment. This article highlights the transformative potential of NLP in veterinary pathology, underscores the importance of integrating this technology into the field for enhanced diagnostic accuracy and research advancements, and gives real-life examples from pathologists for pathologists, which illustrate how NLP can be applied in veterinary pathology.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251347529"},"PeriodicalIF":2.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gross, histologic, and molecular findings in fatal infections by Trachemys herpesvirus 1 in black-bellied sliders (Trachemys dorbigni). 黑腹滑鼠（多氏滑鼠）中致死性感染的大体、组织学和分子研究结果

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-06-28 DOI: 10.1177/03009858251352582

Gabriela Hartmann, Milena Carolina Paz, Gabriela Espíndola Birlem, Liana Thayse Ribeiro, Francisca Maria Sousa Barbosa, Carolina Buss Brunner, Cassiane Elisabete Lopes, Mariana Bandeira Casagrande, Ana Carolina Contri Natal, Paola Antunes, Livia Eichenberg Surita, Marcelo Meller Alievi, Cláudio Wageck Canal, Matheus Nunes Weber, Saulo Petinatti Pavarini

{"title":"Gross, histologic, and molecular findings in fatal infections by Trachemys herpesvirus 1 in black-bellied sliders (Trachemys dorbigni).","authors":"Gabriela Hartmann, Milena Carolina Paz, Gabriela Espíndola Birlem, Liana Thayse Ribeiro, Francisca Maria Sousa Barbosa, Carolina Buss Brunner, Cassiane Elisabete Lopes, Mariana Bandeira Casagrande, Ana Carolina Contri Natal, Paola Antunes, Livia Eichenberg Surita, Marcelo Meller Alievi, Cláudio Wageck Canal, Matheus Nunes Weber, Saulo Petinatti Pavarini","doi":"10.1177/03009858251352582","DOIUrl":"https://doi.org/10.1177/03009858251352582","url":null,"abstract":"Herpesviruses are among the most significant viral pathogens that affect captive and free-ranging testudines. Moreover, herpesviruses are known to establish latent infections. In this report, we describe 2 cases of Trachemys herpesvirus infection in captive adult black-bellied sliders (Trachemys dorbigni) submitted for necropsy after a 2-week history of respiratory signs and oral lesions. Gross examination revealed severe diphtheric stomatitis, rhinitis, tracheitis, esophagitis, gastritis, and reddened lungs. Histologically, there were multifocal areas of necrosis with syncytial cells and fibrin deposition. Intranuclear amphophilic to eosinophilic inclusions were frequent in epithelial and syncytial cells, especially in the respiratory tract. Oral cavity and esophageal swabs were collected during necropsy and subjected to a multiplex nested PCR assay targeting herpesvirus DNA. The amplified DNA was sequenced and analyzed phylogenetically, confirming the virus as Trachemys herpesvirus. This is the first detailed description of clinical disease and associated lesions caused by Trachemys herpesvirus infection.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251352582"},"PeriodicalIF":2.3,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0