Veterinary Pathology最新文献_第2页

Response to "Letters or not, here we come! A communal perspective on credentials needed for a productive career in veterinary pathology". 对 "不管有没有文凭，我们都来了！兽医病理学领域富有成效的职业生涯所需证书的共同视角"。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1177/03009858241306413

Grant Maxie

引用次数: 0

Insulinoma-associated protein 1 (INSM1) immunohistochemical expression in normal, hyperplastic, and neoplastic canine neuroendocrine tissues. 正常、增生和肿瘤性犬神经内分泌组织中胰岛素瘤相关蛋白 1 (INSM1) 的免疫组化表达。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-09-30 DOI: 10.1177/03009858241279127

Fu-Hua Yang, Ya-Pei Chang, Yen-Chen Chang, Hui-Wen Chang, Chian-Ren Jeng, Jia-Wei Jiang, Wen-Tien Tsao, I-Chi Luo, Wei-Hsiang Huang

{"title":"Insulinoma-associated protein 1 (INSM1) immunohistochemical expression in normal, hyperplastic, and neoplastic canine neuroendocrine tissues.","authors":"Fu-Hua Yang, Ya-Pei Chang, Yen-Chen Chang, Hui-Wen Chang, Chian-Ren Jeng, Jia-Wei Jiang, Wen-Tien Tsao, I-Chi Luo, Wei-Hsiang Huang","doi":"10.1177/03009858241279127","DOIUrl":"10.1177/03009858241279127","url":null,"abstract":"Insulinoma-associated protein 1 (INSM1), a recently identified neuroendocrine marker, is a transcriptional regulator with highly conserved INSM1 homologues in various species. This study investigated the immunohistochemical reactivity of the INSM1 antibody in 20 normal canine neuroendocrine tissues from various anatomical locations, 87 hyperplastic or neoplastic tissues of neuroendocrine origin, and 62 non-neuroendocrine neoplasms and compared the results with those of chromogranin A and synaptophysin in neuroendocrine neoplasms. Western blot was performed on fresh canine pituitary glands and canine parathyroid glands to confirm the specificity of the anti-INSM1 antibody. The results showed that the anti-INSM1 antibody could detect nuclear expression in normal canine neuroendocrine tissues, except for the parathyroid glands. INSM1 was detectable in 79/87 (91%) of the hyperplastic and neoplastic neuroendocrine lesions, but all parathyroid carcinomas and parathyroid adenomas (three samples each) were negative for INSM1. In contrast, INSM1 was detected in only one of 62 (2%) non-neuroendocrine neoplasms. The overall percentage of neuroendocrine neoplasms that immunolabeled positively for all three markers was 89%. In addition, the nuclear expression of INSM1 was easier to interpret than that of chromogranin A or synaptophysin. These findings confirm that INSM1 is a useful immunohistochemical marker for diagnosing canine neuroendocrine neoplasms, except for parathyroid neoplasms, and should be considered as part of immunohistochemistry panels to improve diagnostic capability.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"178-186"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute myeloid leukemia with peripheral lymph node involvement in dogs: A retrospective study of 23 cases. 犬急性髓性白血病伴外周淋巴结受累：23 例病例的回顾性研究。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-14 DOI: 10.1177/03009858241295397

Jaspreet Kaur, Gabriella Diamantino, Katherine Morrison, Kristina Meichner, Nora L Springer, Martha Hoffman, Dorothee Bienzle, Tracy Stokol

{"title":"Acute myeloid leukemia with peripheral lymph node involvement in dogs: A retrospective study of 23 cases.","authors":"Jaspreet Kaur, Gabriella Diamantino, Katherine Morrison, Kristina Meichner, Nora L Springer, Martha Hoffman, Dorothee Bienzle, Tracy Stokol","doi":"10.1177/03009858241295397","DOIUrl":"10.1177/03009858241295397","url":null,"abstract":"Acute myeloid leukemia (AML) can infiltrate extramedullary tissues, such as the liver, spleen, and lymph nodes and can be difficult to differentiate from lymphoma in cytologic and histologic specimens. Our goal was to identify cytologic features that would support a diagnosis of AML in peripheral lymph node aspirates, for which we used the term extramedullary AML (eAML). Medical records of 23 dogs with a diagnosis of AML and archived lymph node aspirate smears from 2016 to 2024 were reviewed across 4 institutions. Inclusion criteria included ≥50% myeloid blasts plus differentiating myeloid cells in lymph node smears, confirmation of myeloid lineage by flow cytometric analysis, and complete medical records. Peripheral lymphadenopathy was the reason for presentation (9/23, 39%) or was found incidentally on physical examination (14/23, 61%). Most dogs were bi- or pancytopenic (18/23, 78%), with blasts identified in blood smears of 18 dogs (78%). Initial lymph node aspirate interpretations included hematopoietic neoplasia (8/21, 38%), AML (6/21, 29%), lymphoma (5/21, 24%), lymphoid hyperplasia (1/21, 5%), and granulocytic precursor infiltrates (1/21, 5%). On lymph node smear review, cytologic features supporting an eAML were differentiating granulocytes, blasts with myeloid features or promonocytes, dysplastic changes in myeloid cells, and retention of residual lymphocytes. The median survival was 22 days (range = 1-360 days), and 69% of 16 dogs given chemotherapy or glucocorticoids lived for 30 days or more. Our study highlights the importance of hemogram results and lymph node aspirate smear examination for morphologic features of myeloid differentiation to help diagnose eAML in lymph node smears.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"195-205"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image challenge in Veterinary Pathology, answers: Alimentary diseases.

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 DOI: 10.1177/03009858241300558

引用次数: 0

Feline eosinophilic sclerosing fibroplasia associated with T-/natural killer-cell lymphoma. 猫嗜酸性硬化性纤维增生症伴有T细胞/自然杀伤细胞淋巴瘤。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-09-25 DOI: 10.1177/03009858241281911

Andrea Klang, Christof A Bertram, Taryn A Donovan, Linden E Craig, Ingrid Walter, Birgitt Wolfesberger, Brigitte Degasperi, Elisabeth Baszler, Barbara C Rütgen, Sabine E Hammer, Andrea Fuchs-Baumgartinger

引用次数: 0

Head tilt in 6 Ankole-Watusi cattle (Bos taurus ankole) with chronic exudative cornual sinusitis. 6 头患有慢性渗出性粟状窦炎的安科莱-瓦图西牛（Bos taurus ankole）的头部倾斜。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1177/03009858241295396

Latasha Ludwig, Emily Rätsep, Deidre Fontenot, Kenneth J Conley, Carlos E Rodriguez, Cédric B Larouche

引用次数: 0

Response to: Certifying "day one ready" pathologists: are we accomplishing our goals? 回应：认证 "第一天就绪 "的病理学家：我们的目标实现了吗？

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-12-16 DOI: 10.1177/03009858241303204

Lauri Diehl, Jerry Ritchey, Rachel Reams, Amy Durham, Tony Alves, Kevin Esch, Nicky Parry, Paige Carmichael, Tara Arndt, Alicia Olivier, Ryan Jennings, Shelley Burton

引用次数: 0

Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies. 基于人工智能的猫科动物小肠活检中淋巴细胞的定量分析。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-10-14 DOI: 10.1177/03009858241286828

Judit M Wulcan, Paula R Giaretta, Sai Fingerhood, Simone de Brot, Esther E V Crouch, Tatiana Wolf, Maria Isabel Casanova, Pedro R Ruivo, Pompei Bolfa, Nicolás Streitenberger, Christof A Bertram, Taryn A Donovan, Michael Kevin Keel, Peter F Moore, Stefan M Keller

{"title":"Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies.","authors":"Judit M Wulcan, Paula R Giaretta, Sai Fingerhood, Simone de Brot, Esther E V Crouch, Tatiana Wolf, Maria Isabel Casanova, Pedro R Ruivo, Pompei Bolfa, Nicolás Streitenberger, Christof A Bertram, Taryn A Donovan, Michael Kevin Keel, Peter F Moore, Stefan M Keller","doi":"10.1177/03009858241286828","DOIUrl":"10.1177/03009858241286828","url":null,"abstract":"Feline chronic enteropathy is a poorly defined condition of older cats that encompasses chronic enteritis to low-grade intestinal lymphoma. The histological evaluation of lymphocyte numbers and distribution in small intestinal biopsies is crucial for classification and grading. However, conventional histological methods for lymphocyte quantification have low interobserver agreement, resulting in low diagnostic reliability. This study aimed to develop and validate an artificial intelligence (AI) model to detect intraepithelial and lamina propria lymphocytes in hematoxylin and eosin-stained small intestinal biopsies from cats. The median sensitivity, positive predictive value, and F1 score of the AI model compared with the majority opinion of 11 veterinary anatomic pathologists, were 100% (interquartile range [IQR] 67%-100%), 57% (IQR 38%-83%), and 67% (IQR 43%-80%) for intraepithelial lymphocytes, and 89% (IQR 71%-100%), 67% (IQR 50%-82%), and 70% (IQR 43%-80%) for lamina propria lymphocytes, respectively. Errors included false negatives in whole-slide images with faded stain and false positives in misidentifying enterocyte nuclei. Semiquantitative grading at the whole-slide level showed low interobserver agreement among pathologists, underscoring the need for a reproducible quantitative approach. While semiquantitative grade and AI-derived lymphocyte counts correlated positively, the AI-derived lymphocyte counts overlapped between different grades. Our AI model, when supervised by a pathologist, offers a reproducible, objective, and quantitative assessment of feline intestinal lymphocytes at the whole-slide level, and has the potential to enhance diagnostic accuracy and consistency for feline chronic enteropathy.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"139-151"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobrucellosis (Brucella ceti) in striped dolphins (Stenella coeruleoalba): Immunohistochemical studies on immune response and neuroinflammation. 条纹海豚（Stenella coeruleoalba）的神经布鲁氏菌病（布鲁氏菌 ceti）：免疫反应和神经炎症的免疫组化研究。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-05-17 DOI: 10.1177/03009858241250336

Agustín Rebollada-Merino, Federica Giorda, Martí Pumarola, Laura Martino, Alberto Gomez-Buendia, Umberto Romani-Cremaschi, Cristina Casalone, Virginia Mattioda, Fabio Di Nocera, Giuseppe Lucifora, Antonio Petrella, Lucas Domínguez, Mariano Domingo, Carla Grattarola, Antonio Rodríguez-Bertos

{"title":"Neurobrucellosis (Brucella ceti) in striped dolphins (Stenella coeruleoalba): Immunohistochemical studies on immune response and neuroinflammation.","authors":"Agustín Rebollada-Merino, Federica Giorda, Martí Pumarola, Laura Martino, Alberto Gomez-Buendia, Umberto Romani-Cremaschi, Cristina Casalone, Virginia Mattioda, Fabio Di Nocera, Giuseppe Lucifora, Antonio Petrella, Lucas Domínguez, Mariano Domingo, Carla Grattarola, Antonio Rodríguez-Bertos","doi":"10.1177/03009858241250336","DOIUrl":"10.1177/03009858241250336","url":null,"abstract":"Neurobrucellosis is a shared condition of cetaceans and humans. However, the pathogenesis and immune response in cetacean neurobrucellosis has not been extensively studied. In this multicentric investigation, 21 striped dolphin (Stenella coeruleoalba) neurobrucellosis (Brucella ceti) cases diagnosed over a 10-year period (2012-2022) were retrospectively evaluated. For each case, morphological changes were assessed by evaluating 21 histological parameters. Furthermore, the immunohistochemical expression of Brucella antigen, glial fibrillary acid protein (GFAP), and a selection of inflammatory cell (IBA-1, CD3, and CD20) and cytokine (tumor necrosis factor-alpha [TNF-α], interferon-gamma [IFN-γ], interleukin [IL]-1β, IL-2, and IL-6) markers were investigated. Inflammation of the leptomeninges, ependyma, and/or choroid plexus was lymphohistiocytic, containing macrophages/microglia (IBA-1+), T-cells (CD3+), and B-cells (CD20+) in equal proportion. B-cells occasionally formed tertiary follicles. GFAP expression showed astrocytosis in most cases. Expression of TNF-α, IFN-γ, and IL-2 indicated an intense proinflammatory response, stimulating both macrophages and T-cells. Our results showed that the inflammation and neuroinflammation in neurobrucellosis of striped dolphins mimic human neurobrucellosis and in vitro and in vivo studies in laboratory animals. Cetacean disease surveillance can be exploited to expand the knowledge of the pathogenesis and immunology of infectious diseases, particularly brucellosis, under a One Health approach.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"226-236"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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High mortality associated with avian reoviral hepatitis in young quail (Colinus virginianus). 幼鹌鹑（Colinus virginianus）与禽呼肠孤病毒肝炎相关的高死亡率。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-03-01 Epub Date: 2024-12-12 DOI: 10.1177/03009858241302842

Panchan Sitthicharoenchai, Jianqiang Zhang, Liying Tian, Judith Stasko, Amro Hashish, Cheng-Shun Hsueh, Yuko Sato, Benjamin Hause, Mohamed El-Gazzar

引用次数: 0