Veterinary Pathology最新文献_第2页

Prognostic significance of pSTAT3 expression in feline mammary carcinomas. pSTAT3表达在猫乳腺癌中的预后意义。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-20 DOI: 10.1177/03009858251338851

Keishi Owaki, Mami Murakami, Kentaro Okamoto, Akihiro Hirata, Hiroki Sakai

{"title":"Prognostic significance of pSTAT3 expression in feline mammary carcinomas.","authors":"Keishi Owaki, Mami Murakami, Kentaro Okamoto, Akihiro Hirata, Hiroki Sakai","doi":"10.1177/03009858251338851","DOIUrl":"https://doi.org/10.1177/03009858251338851","url":null,"abstract":"Feline mammary carcinomas (FMCs) have a highly malignant and metastatic behavior and are associated with a poor prognosis. There is a need to identify new effective therapies for FMC. Signal transducer and activator of transcription 3 (STAT3) is activated in various human and animal tumors. It has been proposed as a potential prognostic marker and therapeutic target in human breast cancer (HBC). Given the similarities between HBC and FMCs, we hypothesized STAT3 expression in FMCs may be prognostically significant. In this study, 60 FMC samples were immunohistochemically evaluated for the expression of total STAT3 (tSTAT3), phosphorylated STAT3 (pSTAT3), and Ki-67. The pSTAT3 and Ki-67 indexes were calculated, and their associations with clinicopathological features, as well as tumor-specific survival (TSS), were investigated. Receiver operating characteristic curves were generated to determine the cutoff values for pSTAT3 and Ki-67 using Youden's index as the criterion. All FMCs positively immunolabeled for tSTAT3 and pSTAT3. Significant associations were observed between the pSTAT3 index and the WHO clinical stage, lymph node metastasis, and lymphovascular invasion. However, no significant associations were established with any other factors. Using the cutoff value to classify the pSTAT3 index, the higher pSTAT3 index (>25.2%) was significantly associated with decreased TSS (P = .00570). No significant associations were established between the Ki-67 index and any of the factors. Also, a significant positive association was observed between the pSTAT3 and Ki-67 indexes (P = .0001). This significant association with TSS underscores the potential role of pSTAT3 as a prognostic marker in FMC.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251338851"},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute inhalation toxicity in nine white ibis (Eudocimus albus) exposed to theatrical fog containing triethylene glycol and propylene glycol. 暴露于含有三甘醇和丙二醇的戏剧雾中的9只白朱鹭的急性吸入毒性。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-16 DOI: 10.1177/03009858251338853

Jayne S Ellis, Richard M Fulton, Andreas F Lehner, John P Buchweitz

{"title":"Acute inhalation toxicity in nine white ibis (Eudocimus albus) exposed to theatrical fog containing triethylene glycol and propylene glycol.","authors":"Jayne S Ellis, Richard M Fulton, Andreas F Lehner, John P Buchweitz","doi":"10.1177/03009858251338853","DOIUrl":"https://doi.org/10.1177/03009858251338853","url":null,"abstract":"Nine wild American white ibis (Eudocimus albus) were found deceased or were moribund and subsequently euthanized within 24 hours after exposure to theatrical fog containing propylene glycol and triethylene glycol at a Halloween event at a zoological institution. Gross examinations revealed that all birds had congestion, edema, and hemorrhage throughout the lungs. Histologically, all birds had pathologic changes within the trachea and lungs indicative of acute respiratory insult. Microscopic changes in the trachea included segmental to diffuse epithelial attenuation with loss of cilia, alternating with regions of goblet cells filled with abundant mucus. In the lungs, all birds had perivascular edema and degenerative changes to the epithelium lining primary and secondary bronchi including hypereosinophilia and apical cytoplasmic blebbing of bronchial epithelial cells. In addition, in the lungs of 4 birds with longer intervals between exposure and death, there was granulomatous pneumonia, heterophilic perivascular cuffing, and multifocal bronchial epithelial necrosis. Propylene glycol and triethylene glycol were detected in lung and kidney tissues by gas chromatography-tandem mass spectrometry (GC-MS/MS). Traces of oxalic acid were found, along with presence of glycolic acid. While exposure to aerosolized glycols has been shown to cause irritation and minor degenerative changes to the respiratory epithelium in laboratory animals and humans, this study represents a unique investigation into the first reported incidence of acute inhalation toxicity and death following exposure to aerosolized glycol-containing theatrical fog in birds.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858251338853"},"PeriodicalIF":2.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sudden death of a cynomolgus monkey due to transfusion-related acute lung injury (TRALI) after xeno-transfusion from a minipig. 一只食蟹猴在接受猪异种输血后，因输血相关急性肺损伤（TRALI）而猝死。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-16 DOI: 10.1177/03009858251338850

Jinhyung Rho, Hyung-Seon Kim, Mi-Jin Yang, Jeong-Ho Hwang, Hwa-Young Son

引用次数: 0

Image challenge in Veterinary Pathology. 兽医病理学中的图像挑战。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2025-05-05 DOI: 10.1177/03009858241312641

引用次数: 0

Canine synovial lipomatosis: Clinicopathologic findings and HGMA2 immunohistochemistry in 4 cases. 犬滑膜脂肪瘤病4例临床病理及HGMA2免疫组化分析

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2025-01-02 DOI: 10.1177/03009858241306404

Keiichi Kuroki, Katelin Dark, Jimmy C Lattimer, Gayle C Johnson

引用次数: 0

Immunohistochemical expression of TLR1, TLR2, TLR4, and TLR9 in the different types of lesions associated with bovine paratuberculosis. TLR1、TLR2、TLR4和TLR9在牛副结核相关不同类型病变中的免疫组织化学表达

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2024-12-25 DOI: 10.1177/03009858241302850

David Zapico, José Espinosa, Miguel Criado, Daniel Gutiérrez, María Del Carmen Ferreras, Julio Benavides, Valentín Pérez, Miguel Fernández

{"title":"Immunohistochemical expression of TLR1, TLR2, TLR4, and TLR9 in the different types of lesions associated with bovine paratuberculosis.","authors":"David Zapico, José Espinosa, Miguel Criado, Daniel Gutiérrez, María Del Carmen Ferreras, Julio Benavides, Valentín Pérez, Miguel Fernández","doi":"10.1177/03009858241302850","DOIUrl":"10.1177/03009858241302850","url":null,"abstract":"The factors that determine the appearance of the different pathologic forms associated with bovine paratuberculosis are not fully understood, but new research suggests a critical role of innate immunity. Toll-like receptors (TLRs) trigger the recognition of invading pathogens by innate immune cells and the onset of specific immune responses. The aim of this work was to assess, immunohistochemically, the expression of TLR1, TLR2, TLR4, and TLR9 in intestinal samples of 20 cows showing different types of paratuberculous lesions: uninfected controls, focal lesions, paucibacillary, and multibacillary diffuse forms. The majority of labeled cells were morphologically consistent with macrophages. A differential cell count was performed in the intestinal lamina propria, gut-associated lymphoid tissue, and mesenteric lymph node. TLR9 immunolabeling between the different types of lesions was compared using a complete H-score. Focal and diffuse paucibacillary forms contained significantly increased TLR2-expressing macrophages outside of the lesions compared with the controls and diffuse multibacillary forms, and moderate TLR9 immunolabeling within granulomas. In the multibacillary granulomatous lesions, the expression of TLR1 and TLR4 was observed as well as increased TLR9 expression compared with the rest of the groups. Differences in the predominance of one type or another of TLR allows us to elucidate the importance of the innate immune response and its possible role in the development of the different types of paratuberculosis lesions.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"305-318"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feline dermoid cyst: Retrospective case series and literature review. 猫皮样囊肿：回顾性病例系列和文献复习。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1177/03009858251317457

Daniel Felipe Barrantes Murillo, Daniel R Rissi, Dominique J Wiener, Tatiane Terumi Negrão Watanabe

{"title":"Feline dermoid cyst: Retrospective case series and literature review.","authors":"Daniel Felipe Barrantes Murillo, Daniel R Rissi, Dominique J Wiener, Tatiane Terumi Negrão Watanabe","doi":"10.1177/03009858251317457","DOIUrl":"10.1177/03009858251317457","url":null,"abstract":"Dermoid cysts are developmental abnormalities usually located at the dorsal body midline. Histologically, these lesions reduplicate the skin, with associated collagen bundles, adnexal structures, and are filled by keratin and hairs. While these cysts have well-recognized breed and anatomical predispositions in dogs, the information in feline patients is restricted to scattered case reports and anecdotal data. Through a multi-institutional retrospective case series, we aim to describe the clinical and demographic features of this condition in cats. We retrieved a total of 220 cases. The average age at the time of diagnosis was 5.5 years, with 59.5% (131/220) being males. Domestic short hairs were the most represented breed, accounting for 56.4% (124/220) of the cases. The average cyst diameter was 1.4 cm, and 99.5% (219/220) of the cases the cysts were cutaneous and subcutaneous with the most common anatomical location being the neck (55.9%; 123/220). One dermoid cyst was in the mesentery. In most cases, no associated inflammatory lesions were reported (66.4%; 146/220). The anatomical location of the dermoid cyst did not differ significantly among sexes (Chi-square test, P = .840), breeds (Chi-square test, P = .999), ages (Chi-square test, P = .627), or other histological findings related to the cyst (Chi-square test, P = .363).","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"293-299"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenge in veterinary pathology: Does negative Ziehl-Neelsen staining rule out mycobacteriosis? 兽医病理学的诊断挑战：ziehl - nielsen染色阴性是否可以排除分枝杆菌病？

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1177/03009858251331342

Anna Huupponen, Sini Ulmanen, Thomas Grönthal, Taru Lienemann, Sanna Viitanen, Pernilla Syrjä

引用次数: 0

Tumor-infiltrating lymphocytes vary in different canine soft tissue sarcoma histological types. 不同犬软组织肉瘤组织学类型的肿瘤浸润淋巴细胞不同。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2024-12-09 DOI: 10.1177/03009858241300556

Giancarlo Avallone, Elena Brigandì, Chiara Tugnoli, Antonella Rigillo, Barbara Bacci, Paola Roccabianca

{"title":"Tumor-infiltrating lymphocytes vary in different canine soft tissue sarcoma histological types.","authors":"Giancarlo Avallone, Elena Brigandì, Chiara Tugnoli, Antonella Rigillo, Barbara Bacci, Paola Roccabianca","doi":"10.1177/03009858241300556","DOIUrl":"10.1177/03009858241300556","url":null,"abstract":"Soft tissue sarcomas (STSs) are conventionally viewed as poorly immunogenic tumors; however, some human STSs have recently been reported to elicit an immune response, thus representing potential candidates for immunotherapy. Data regarding immune cell infiltrates in canine STSs are limited and reported without tumor-type stratification. The aim of this study was to retrospectively assess tumor-infiltrating lymphocytes (TILs) in canine STSs of 5 different histotypes. Eighty-seven canine STSs were collected: 22 perivascular wall tumors (PWTs), 19 liposarcomas, 17 fibrosarcomas, 16 myxosarcomas, and 13 leiomyosarcomas. The tumors were graded and immunolabeled for CD3, CD20, and FoxP3, and slides were scanned. T-cell, B-cell, Treg, and total TIL densities were quantified with QuPath software and expressed as cells/mm2. The B/T-cells ratio and Treg/T-cell proportions were calculated. Total TIL densities were higher in PWTs and myxosarcomas (median = 225 and 303, respectively). PWTs had higher T-cell density but lower Treg proportion (median = 152 and 7.6% respectively). Myxosarcomas had higher Treg densities and B/T-cell ratios (median = 24.4 and 1.57, respectively). No association with grade was found among STSs as a group. In myxosarcomas, higher grade was significantly associated with higher total TILs, and CD20+ and FoxP3+ cell densities (p < .05). The results suggest that PWTs and myxosarcomas may represent the most immunogenic STS types. Myxosarcomas elicit a B-cell and Treg-rich immune response; PWTs stimulate a T-cell-rich and Treg-poor reaction. The immune system response may contribute to the more aggressive behavior of myxosarcomas and the more indolent course of PWTs.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"276-283"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathogenesis of West Nile virus-associated lymphohistiocytic proliferative cutaneous lesions of American alligators (Alligator mississippiensis). 西尼罗河病毒相关的美洲短吻鳄淋巴组织细胞增生性皮肤病变的发病机制。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1177/03009858251317481

Ilaria M Piras, Javier G Nevarez, Lynn Stevenson, Frazer Bell, Georgios Ilia, Susan Peters, Deirdre Slawski, Pamela A Kelly

{"title":"The pathogenesis of West Nile virus-associated lymphohistiocytic proliferative cutaneous lesions of American alligators (Alligator mississippiensis).","authors":"Ilaria M Piras, Javier G Nevarez, Lynn Stevenson, Frazer Bell, Georgios Ilia, Susan Peters, Deirdre Slawski, Pamela A Kelly","doi":"10.1177/03009858251317481","DOIUrl":"10.1177/03009858251317481","url":null,"abstract":"\"Pix\" is one of the most common skin defects that reduce the quality of crocodilian leather. The name is derived from their resemblance to pit marks made by an ice pick. Histologically, each \"pix\" is associated with a focal dermal accumulation of immune cells, specifically lymphocytes and histiocytes. Consequently, these defects have been termed lymphohistiocytic proliferative cutaneous lesions (LPCLs). In farmed American alligators (Alligator mississippiensis), LPCLs have been associated with seropositivity against West Nile virus (WNV) and the presence of viral genome in the skin. Despite this association, the nature and pathogenesis of LPCLs remain unclear. Using immunohistochemistry and in situ hybridization, we unravel the microanatomy of LPCLs of alligators and localize WNV genome within the lesions. Our results show that LPCL lesions consist of de novo follicular aggregates of lymphocytes segregated into B- and T-cell zones, like tertiary lymphatic follicles of mammals and birds. Furthermore, the presence of WNV genome was highlighted by in situ hybridization in the macrophages of LPCLs, gut-associated lymphoid tissues, and the spleen. Our results suggest that LPCLs may form in American alligators' skin as part of a generalized lymphofollicular proliferation, likely as an immune response against WNV infection.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"343-354"},"PeriodicalIF":2.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0