Veterinary Pathology最新文献_第10页

Diagnostic challenge in veterinary pathology: Tri-cavitary effusion in a cat with systemic pyogranulomatous inflammation. 兽医病理学诊断难题：一只患有全身化脓性炎症的猫的三腔积液。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-01-21 DOI: 10.1177/03009858241226648

Sai Fingerhood, Pradeep Neupane, Edward B Breitschwerdt, Eunju April Choi

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Image challenge in Veterinary Pathology, answers: Pulmonary diseases. 兽医病理学中的图像挑战，答案：肺部疾病。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 DOI: 10.1177/03009858241257926

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Image challenge in Veterinary Pathology. 兽医病理学中的图像挑战。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 DOI: 10.1177/03009858241257895

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Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins. 评估 437 种不同胚胎起源的犬肿瘤中 SOX10 的表达。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-02-17 DOI: 10.1177/03009858241231562

Sophie Nelissen, Andrew D Miller

{"title":"Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins.","authors":"Sophie Nelissen, Andrew D Miller","doi":"10.1177/03009858241231562","DOIUrl":"10.1177/03009858241231562","url":null,"abstract":"Several members of the SRY-related HMG-box (SOX) protein family are implicated in tumorigenesis, metastasis, and regulation of the tumor microenvironment. SOX10, which is involved in neural crest cell migration and differentiation, has long been recognized a sensitive and specific immunohistochemical (IHC) marker in the diagnosis of melanoma in humans. However, expression of SOX10 in other tumor types has infrequently been evaluated in humans until recently and has not been thoroughly investigated in the dog. Our aim was to characterize the expression of SOX10 in canine neoplasms to objectively assess its value as a diagnostic IHC marker. Immunohistochemistry for SOX10 was performed on 437 archived, formalin-fixed paraffin-embedded tissues from representative canine neoplasms of ectodermal (15 tumor types), mesodermal (13 tumor types), endodermal (8 tumor types), and mixed/unknown (7 tumor types) embryologic origin. Oral and cutaneous tumors of melanocytic origin were used as positive controls. Intense SOX10 immunolabeling was observed in most tumors of ectodermal origin, including consistent expression in mammary carcinomas, and gliomas. Embryonal and hair follicle neoplasms inconsistently exhibited strong nuclear immunolabeling. Oral fibrosarcomas and undifferentiated oral sarcomas both inconsistently exhibited moderate to strong nuclear immunolabeling. Neoplasms of mesodermal and endodermal origin lacked immunolabeling. Salivary carcinomas, representing an unknown/mixed embryologic origin, were strongly labeled. SOX10 expression is not limited to melanomas, but is expressed by canine tumors of diverse tissues and embryologic derivation. Importantly, expression of SOX10 by a subset of oral sarcomas impairs its value as a marker for spindle cell oral melanomas.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"704-711"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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From cutting-edge liquid biopsy to the evolving landscape of antibody drug conjugates and emerging trends in digital and computational pathology: Award-winning presentations await you at the 2024 ACVP/ASVCP annual meeting. 从前沿的液体活检到不断发展的抗体药物共轭物，以及数字和计算病理学的新兴趋势：2024 年 ACVP/ASVCP 年会将为您奉上屡获殊荣的精彩演讲。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.1177/03009858241266946

Sanjeev Gumber

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Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors. 有丝分裂活动：关于犬肿瘤评估方法和预后价值的系统性文献综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-27 DOI: 10.1177/03009858241239565

Christof A Bertram, Taryn A Donovan, Alexander Bartel

{"title":"Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors.","authors":"Christof A Bertram, Taryn A Donovan, Alexander Bartel","doi":"10.1177/03009858241239565","DOIUrl":"10.1177/03009858241239565","url":null,"abstract":"One of the most relevant prognostic indices for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review was to analyze the methods and prognostic relevance of histologically measuring mitotic activity that have been reported for canine tumors in the literature. A total of 137 articles that correlated the mitotic activity in canine tumors with patient outcome were identified through a systematic (PubMed and Scopus) and nonsystematic (Google Scholar) literature search and eligibility screening process. Mitotic activity methods encompassed the mitotic count (MC, number of mitotic figures per tumor area) in 126 studies, presumably the MC (method not specified) in 6 studies, and the mitotic index (MI, number of mitotic figures per number of tumor cells) in 5 studies. A particularly high risk of bias was identified based on the available details of the MC methods and statistical analyses, which often did not quantify the prognostic discriminative ability of the MC and only reported P values. A significant association of the MC with survival was found in 72 of 109 (66%) studies. However, survival was evaluated by at least 3 studies in only 7 tumor types/groups, of which a prognostic relevance is apparent for mast cell tumors of the skin, cutaneous melanoma, and soft tissue tumor of the skin and subcutis. None of the studies using the MI found a prognostic relevance. This review highlights the need for more studies with standardized methods and appropriate analysis of the discriminative ability to prove the prognostic value of the MC and MI in various tumor types. Future studies are needed to evaluate the influence of the performance of individual pathologists on the appropriateness of prognostic thresholds and investigate methods to improve interobserver reproducibility.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"752-764"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Response to "Eponyms in science: A proposal to minimize their use". 对 "科学中的外来语地名：关于尽量减少使用外来语地名的建议

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1177/03009858241262494

Grant Maxie

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Eponyms in science: A proposal to minimize their use. 科学中的外来语地名：关于尽量减少使用外来语地名的建议。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-05-09 DOI: 10.1177/03009858241252408

F Yvonne Schulman, Daniel R Rissi

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Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species. 一种新型奈瑟菌诱发家猫栓塞性坏死性肺炎。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-05 DOI: 10.1177/03009858241235392

Christopher R Bolt, Vikash K Singh, Arno Wünschmann, Hallie C Richards, Kelly L Gehlhaus, Sunil K Mor

{"title":"Embolic necrosuppurative pneumonia in domestic cats induced by a novel Neisseria species.","authors":"Christopher R Bolt, Vikash K Singh, Arno Wünschmann, Hallie C Richards, Kelly L Gehlhaus, Sunil K Mor","doi":"10.1177/03009858241235392","DOIUrl":"10.1177/03009858241235392","url":null,"abstract":"Three cats, aged 2 to 11 years, presented to the University of Minnesota Veterinary Diagnostic Laboratory over a 3-year period following euthanasia or death due to respiratory distress. Thoracic radiographs revealed nodular, soft tissue opacities throughout the lung fields in all cases. On postmortem examination, approximately 60% to 80% of the lung parenchyma were expanded by multifocal to coalescing, well-demarcated, beige, semi-firm nodules. Histologically, large numbers of neutrophils, fewer macrophages, fibrin, and cellular and karyorrhectic debris effaced the pulmonary parenchyma. The inflammatory foci contained aggregates of gram-negative cocci. 16s rRNA Sanger sequencing and whole-genome sequencing identified the bacteria isolated from the lung of all cats under aerobic conditions as a novel Neisseria spp. Based on whole-genome sequence analysis, all 3 sequences shared 92.71% and 92.67% average nucleotide identity with closely related Neisseria animaloris NZ LR134440T and Neisseria animaloris GCA 002108605T, respectively. The in silico DNA-DNA hybridization identity compared to our isolates was 46.6% and 33.8% with strain DSM Neisseria zoodegmatis 21642 and strain DSM 21643, respectively. All 3 sequences have less than 95% average nucleotide identity and less than 70% DNA-DNA hybridization identity, suggesting that the 3 isolates are a novel species of the genus Neisseria. Infection with Neisseria spp. induces an embolic pneumonia in cats that radiographically and pathologically resembles a metastatic neoplastic process and should be considered among the etiologic differential diagnoses in cases of infectious pulmonary disease with a disseminated, nodular lung pattern.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"783-791"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi). 蒙特塞拉特黄鹂（Icterus oberi）小脑中多葡聚糖体的发生率和特征。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-08-15 DOI: 10.1177/03009858241270000

Simon Spiro, Marta Pereira, Kieran A Bates, Zane Jaunmuktane, David J Everest, Mark F Stidworthy, Daniela Denk, Alejandro Núñez, Ethan Wrigglesworth, Andrew Theodoulou, Alberto Barbon, Emma Nye, Yan Liu, Adrian L Smith, Steven Fiddaman

{"title":"Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (Icterus oberi).","authors":"Simon Spiro, Marta Pereira, Kieran A Bates, Zane Jaunmuktane, David J Everest, Mark F Stidworthy, Daniela Denk, Alejandro Núñez, Ethan Wrigglesworth, Andrew Theodoulou, Alberto Barbon, Emma Nye, Yan Liu, Adrian L Smith, Steven Fiddaman","doi":"10.1177/03009858241270000","DOIUrl":"https://doi.org/10.1177/03009858241270000","url":null,"abstract":"Polyglucosan bodies are accumulations of insoluble glucose polymers and proteins that form intracytoplasmic inclusions in the brain, large numbers of which can be indicative of neurodegenerative diseases such as Lafora disease. Montserrat orioles (Icterus oberi) are an icterid passerine endemic to Montserrat with conservation populations maintained in captivity abroad. We demonstrate that polyglucosan bodies are unusually abundant in the cerebellar molecular and Purkinje cell layers and cerebellar peduncles of captive-bred and wild-caught Montserrat orioles. The bodies are periodic acid-Schiff positive and diastase resistant and label with concanavalin A and for ubiquitin, consistent with those seen in humans. We found no association of the polyglucosan bodies with concurrent neurological lesions or clinical signs, nor with EPM2A and EPM2B gene mutations associated with Lafora disease. We conclude that an abundance of cerebellar polyglucosan bodies may be a normal finding in aged Montserrat orioles and not a threat to the captive breeding population.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241270000"},"PeriodicalIF":2.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0