Veterinary Pathology最新文献

{"title":"Image Challenge in <i>Veterinary Pathology</i>.","authors":"","doi":"10.1177/03009858241281718","DOIUrl":"https://doi.org/10.1177/03009858241281718","url":null,"abstract":"","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":"62 1","pages":"7-8"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meningoencephalomyelitis and brachial plexitis in a dog infected with louping ill virus.","authors":"Sai Fingerhood, Karen L Mansfield, Arran J Folly, Ana Gomez Vitores, Mara Rocchi, Dominic Clarke, Cecilia Gola","doi":"10.1177/03009858241265035","DOIUrl":"10.1177/03009858241265035","url":null,"abstract":"<p><p>A foxhound from a hunting kennel in the United Kingdom was euthanized after being hospitalized with progressive neurologic signs, including tremors, seizures, and obtunded mentation. No abnormalities were appreciated on gross <i>postmortem</i> examination. Histologically, severe meningoencephalomyelitis and mild neuritis of the brachial plexus were present. Molecular analysis of brain tissue detected louping ill virus. In addition, louping ill virus-specific antigens were detected in neurons within the brainstem, the entire length of the spinal cord, as well as in rare cells in the brachial plexus using immunohistochemistry. The genetic sequence of the virus appears most closely related to a previously detected virus in a dog from a similar geographic location in 2015. This is the first characterization of the inflammatory lesions and viral distribution of louping ill virus in a naturally infected dog within the spinal cord and brachial plexus.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"87-91"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurology and comparative medicine influenced my career in neuropathology.","authors":"Brian A Summers","doi":"10.1177/03009858241303677","DOIUrl":"https://doi.org/10.1177/03009858241303677","url":null,"abstract":"","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241303677"},"PeriodicalIF":2.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infarctive encephalopathy in zoo-housed gibbons in North America.","authors":"Mei Aoki Schultz, Josephine B Rose, Katherine Olstad, Johnny R Cross, Kali A Holder, Katharine L Hope, Beth Richards, Andrew D Miller","doi":"10.1177/03009858241302844","DOIUrl":"https://doi.org/10.1177/03009858241302844","url":null,"abstract":"<p><p>Progressive neurologic signs without a known underlying etiology have been observed in managed gibbon populations housed at institutions in North America. In 2018, the Gibbon Species Survival Plan initiated a veterinary survey to evaluate clinical histories among gibbons displaying neurologic signs. The clinical results of this survey as well as the results of a centralized histologic review of brain samples from 5 species of managed gibbons displaying neurologic signs are outlined here. Reported neurologic deficits in gibbons surveyed included tremors (12/12, 100%), ataxia/incoordination (11/12, 92%), fine motor skill deficits (11/12, 92%), weakness (10/12, 83%), and mentation deficits (7/12, 58%). Gross lesions were not identified in the brain. However, in affected animals, histology revealed infarctive lesions in the cerebrocortical (14/15, 93% of animals) and cerebellar (10/15, 67% of animals) gray/white matter. Lesions were absent in the thalamus, mesencephalon, and brainstem. Lesions were typified by areas of parenchymal loss, perivascular foamy macrophage accumulation, and extensive gliosis dominated by gemistocytic astrocytes. In all affected animals, vessels located in the center of the lesions had increased tortuosity with loss of medial distinction, variable medial hyperplasia, and multifocal medial vacuolation that was accentuated by Masson's trichrome staining. Thrombotic lesions were not identified, and amyloid was not identified by Congo red staining. Ionized calcium-binding adaptor molecule 1 (IBA1) immunohistochemistry revealed extensive macrophage infiltration, even in areas in which lesions were not identified on histologic examination. This study reveals a pattern of small-vessel disease among gibbons displaying neurologic signs, and the resulting clinical syndrome is here termed \"gibbon infarctive encephalopathy.\"</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241302844"},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colocalization of hedgehog arterivirus 1 (HhAV-1) and histologic lesions in the European hedgehog (<i>Erinaceus europaeus</i>) with neurological disease.","authors":"Fabian Z X Lean, Mark F Stidworthy, Akbar Dastjerdi, Tim Partridge, Stephen Smith, Julie Gough, Alejandro Núñez, Becki Lawson, Katharina Seilern-Macpherson","doi":"10.1177/03009858241300553","DOIUrl":"https://doi.org/10.1177/03009858241300553","url":null,"abstract":"<p><p>The European hedgehog (<i>Erinaceus europaeus</i>) is a protected species of conservation concern in the UK. In recent years, there have been multiple incidents of fatal encephalitis in captive hedgehogs in wildlife rescue centers associated with the molecular detection of a hedgehog arterivirus (HhAV-1). However, it remains unclear whether the virus is the causative agent of the central nervous system (CNS) lesions. In a retrospective investigation using postmortem material from 7 captive hedgehogs with neurological disease, and a single hedgehog with previously identified meningoencephalitis, histologic examination was conducted in tandem with viral RNA <i>in situ</i> hybridization (ISH) to appraise tissue distribution of HhAV-1 and the colocalization with histologic lesions. ISH revealed multicellular tropism of HhAV-1 involving monocyte-macrophage and vascular endothelial cells, with viral RNA detected in multiple organs, likely due to endotheliotropism and viremia. In the CNS, encephalomyelitis was mild whilst viral RNA was abundant and widely distributed, particularly in the microglial population and localized to areas with glial nodules. Splenic lymphoid depletion was generally mild but was moderate to severe in 2 septicemic animals. Brain samples from 13 control hedgehogs, found dead in the wild due to predation/trauma, were also screened for HhAV-1, of which 8 tested positive by real-time reverse transcription polymerase chain reaction (RT-PCR) with a low viral load. No CNS lesions or ISH labeling was observed in 2 of these control hedgehogs that could be examined histologically. Combined, these findings indicate that HhAV-1 infections in captive hedgehogs in English wildlife rescue centers may be associated with histopathologic alterations and clinical neurological disease.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241300553"},"PeriodicalIF":2.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal cytoplasmic inclusion bodies in the brain of Lagotto Romagnolo dogs: A qualitative and quantitative histologic evaluation.","authors":"Sini Peura, Elina Kiiskinen, Tarja S Jokinen, Anna-Maija K Virtala, Pernilla Syrjä","doi":"10.1177/03009858241300555","DOIUrl":"https://doi.org/10.1177/03009858241300555","url":null,"abstract":"<p><p>Four neurologic diseases affect dogs of the Lagotto Romagnolo (LR) breed, namely benign familial juvenile epilepsy (BFJE), vacuolar storage disease, and 2 forms of cerebellar cortical degeneration. Intraneuronal inclusion bodies in cerebellar Purkinje cells were first described in the BFJE phenotype. Upon further characterization of these diseases, similar inclusions were also noted in the brain of LRs used as controls. This study investigated the clinical, histologic, and electron microscopic findings in 23 LRs to determine the nature of their neuronal inclusions and whether the presence, distribution, or number of inclusions is associated with neurologic signs. Electron microscopy of the inclusions revealed a cytoplasmic aggregate without a limiting membrane. The inclusions appeared proteinaceous on histochemical staining and positive on phosphotungstic-acid-hematoxylin (PTAH) stain for proteins rich in basic amino acids. Markers of commonly known proteinopathies of humans (ubiquitin, p62, LC3, α-synuclein, and β-amyloid) were not detected in the inclusions when assessed by immunohistochemistry. The overall presence of inclusion bodies was not significantly associated with the dog's neurologic status. The results show an association between inclusions in the cerebral cortex and an absence of clinical neurologic disease in LRs. There was no significant difference in the quantitative inclusion body burden when compared in LRs with or without neurologic signs. Although PTAH-positive proteinaceous neuronal inclusions are a common finding in LRs regardless of neurologic signs, these inclusions may be a protective response when present in the cerebral cortex.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241300555"},"PeriodicalIF":2.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary pontine and extrapontine brain malformations in Brazilian Tabapuã cattle.","authors":"Lucas da Costa Dutra, Sara Vilar Dantas Simões, Ricardo Barbosa de Lucena, Jefferson Filgueira Alcindo, Gildenor X Medeiros, Brian A Summers, Franklin Riet-Correa","doi":"10.1177/03009858241300552","DOIUrl":"https://doi.org/10.1177/03009858241300552","url":null,"abstract":"<p><p>A congenital neurologic disorder affected a herd of Tabapuã cattle. Of 98 newborn calves, 12 (12%) were affected; they were sired by 3 related bulls. This frequency suggested a genetic disorder caused by an autosomal recessive gene. Persisting recumbency, an altered sensorium, head tilt, nystagmus, episodic head and neck jerking, ventral strabismus, and opisthotonic posturing resulted in euthanasia by day 15. The postmortem findings were similar in 8 calves studied. The skull was smaller and flattened compared with unaffected calves. The cerebral hemispheres were slightly reduced in size with their gyral pattern simplified and showing occasional, focal macrogyria. The corpus callosum was partly aplastic. The pons held the most striking gross abnormality, namely, the absence of the pontine base and middle cerebellar peduncles while the trapezoid body in the medulla was reduced. There was severe hypoplasia of pontocerebellar fibers and a mildly reduced size of spinothalamic, corticospinal, and corticobulbar tracts. Histologically, numbers of neurons in the pontine basal, red, olivary, and cerebellar nuclei were reduced. Neurologic signs reflect these extensive pathologic changes, especially in the midbrain, brainstem, and caudal fossa. While olivopontocerebellar anomalies are known in domestic animals, selective pontine hypoplasia has not been reported. These Tabapuã calves share features of pontocerebellar hypoplasia (PCH), a human malformation, in which the pons and the cerebellum are most severely affected with impaired growth of other parts of the brain leading eventually to microcephaly. At least, 11 different forms of human PCH are related to mutations in several different genes.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241300552"},"PeriodicalIF":2.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piscichuvirus-associated meningoencephalomyelitis in a free-ranging American alligator (<i>Alligator mississippiensis</i>).","authors":"Peres R Badial, Weerapong Laovechprasit, Carley Laue, Brian A Stacy, James B Stanton, Kuttichantran Subramaniam, Robert J Ossiboff","doi":"10.1177/03009858241300559","DOIUrl":"https://doi.org/10.1177/03009858241300559","url":null,"abstract":"<p><p>The American alligator (<i>Alligator mississippiensis</i>) is a keystone species of the southeastern United States. In December of 2022, a free-ranging American alligator was found stuporous and tetraparetic. On postmortem evaluation, lesions were limited to the central nervous system, consisting of prominent perivascular cuffs of lymphocytes and histiocytes that extended into the surrounding neuroparenchyma along with gliosis. Next-generation sequencing of the affected brain identified the presence of a piscichuvirus closely related to the freshwater turtle neurovirus 1 (FTuNV-1) recently reported in an alligator snapping turtle with similar microscopic lesions. <i>In situ</i> hybridization using zz-probes that recognize FTuNV-1 identified widespread hybridization signal in neurons and glial cells in the alligator's brain and spinal cord. This case represents only the second association of piscichuviruses with vertebrate disease. Moreover, it highlights the potential for disease transmission between different orders (Crocodylia and Testudines) of free-ranging aquatic reptiles that share similar habitats in the United States.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241300559"},"PeriodicalIF":2.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological findings and differential diagnoses of lymph node diseases in slaughtered cattle in Brazil: A study of 2000 samples.","authors":"Carlos E B Lopes, Fabiana G Xavier, Rafael R Nicolino, Luana F M Cordeiro, Leandro C Rezende, Marcelo C Lopes, Dayse H L Silva, Antônio A Fonseca Júnior, Luciana R Ferreira, Marcelo F Camargos, Paulo M Soares Filho, Ivy C C Souza, Roselene Ecco","doi":"10.1177/03009858241257908","DOIUrl":"10.1177/03009858241257908","url":null,"abstract":"<p><p>Slaughterhouse inspections play a crucial role in the sanitary control of zoonoses and foodborne diseases. This study aimed to identify and analyze the frequencies of lymph node diseases in cattle slaughtered for human consumption, using the samples sent to the anatomic pathology service of the Federal Laboratory for Agricultural Defense (<i>Laboratório Federal de Defesa Agropecuária</i>), Minas Gerais, Brazil, from January 2015 to September 2022. In total, 2000 lymph node samples were analyzed, and additional information was individually retrieved. Lesions were most frequently identified in thoracic lymph nodes. Bacterial isolation and quantitative polymerase chain reaction (qPCR) were performed using samples suspected of tuberculosis. Tuberculosis cases accounted for 89.3% of the samples. Histopathology was more sensitive than other ancillary tests for diagnosing tuberculosis. Paraffin-embedded tissues from lymphoma cases were subjected to immunophenotyping using anti-CD3 and anti-CD79a immunohistochemistry. Frozen and/or paraffin-embedded tissues from lymphoma cases were used to identify the enzootic bovine leukosis (EBL) retrovirus through qPCR. Other diagnoses included primary (T- and B-cell lymphoma) and metastatic neoplasms (squamous cell carcinoma, pulmonary adenocarcinoma, undifferentiated carcinoma, undifferentiated adenocarcinoma, undifferentiated sarcoma, undifferentiated round cell tumor, mesothelioma, hepatic carcinoid, meningioma, and seminoma), actinogranulomas (pyogranulomatous lymphadenitis [actinobacillosis and actinomycosis]), idiopathic lymphadenitis (neutrophilic and/or histiocytic, granulomatous, and suppurative), and miscellaneous nonspecific lymphadenopathies (depletion/lymphoid atrophy, lymphangiectasia, erythrocyte drainage, parasitic eosinophilic lymphadenitis, follicular hyperplasia, and toxic granulomatous lymphadenitis). The combination of histopathology with complementary techniques is important for successful diagnosis, especially in complex cases of high epidemiological, economic, and zoosanitary importance, such as tuberculosis and EBL.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"952-964"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumed hemocytic neoplasms in scorpions.","authors":"Shawn Thomas, Christopher Gaudette, Simon Spiro, Daniel S Dombrowski, Elise E B LaDouceur","doi":"10.1177/03009858241257898","DOIUrl":"10.1177/03009858241257898","url":null,"abstract":"<p><p>Although neoplasia has been documented in invertebrates, it has not been reported in scorpions. This report describes presumed hemocytic neoplasia in 2 scorpions: a >3-year-old, female emperor scorpion (<i>Pandinus imperator)</i> and a >4-year-old, male, Asian forest scorpion (<i>Heterometrus</i> sp.). The emperor scorpion had a 1-month history of body wall swelling separating the exoskeleton of the caudal opisthosoma. At necropsy, this corresponded to a white mass in the caudal coelom. The forest scorpion was found dead and processed whole for histology, at which point multiple masses were identified in the coelom and invading skeletal muscle. Histologically, both masses were composed of sheets of hemocytes with round to oval nuclei; eosinophilic, periodic acid Schiff-positive, cytoplasmic granules; mild cellular atypia; and low mitotic rates. Features of inflammation (e.g., melanization and nodulation) were not observed. These masses were diagnosed as a hemocytoma (emperor scorpion) and a hemocytic sarcoma (forest scorpion), possibly of plasmatocyte origin.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"983-987"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}