{"title":"Aberrant alpha-smooth muscle actin expression in the lateral ventricle of <i>Ccdc85C</i> knockout rats.","authors":"Nure Jannat, Md Mehedi Hasan, Hisaki Tokuno, Miyuu Tanaka, Takeshi Izawa, Jyoji Yamate, Mitsuru Kuwamura","doi":"10.1177/03009858241312611","DOIUrl":null,"url":null,"abstract":"<p><p><i>Coiled-coil domain containing 85c</i> (<i>Ccdc85c</i>) is a causative gene for genetic hydrocephalus found in hemorrhagic hydrocephalus (<i>hhy</i>) mice. The <i>Ccdc85c</i> knockout (KO) rat has subcortical heterotopia with frequent brain hemorrhage as seen in <i>hhy</i> mice. In this study, we report aberrant alpha-smooth muscle actin (α-SMA) expression in the wall of lateral ventricle of the <i>Ccdc85c</i> KO rats. The α-SMA-positive cells were distributed at the dorsal, medial, and lateral regions of the lateral ventricle of KO rats. The expression of α-SMA was first observed on postnatal day 20 (P20) and became noticeably stronger at P26 when hydrocephalus was prominent. Double immunofluorescence showed co-expression of α-SMA with nestin, vimentin, and glial fibrillary acidic protein in the ventricular lining of KO rats. Therefore, we conclude that α-SMA-positive cells may represent an immature subpopulation of cells at adult age around the lateral ventricle of <i>Ccdc85c</i> KO rats.</p>","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241312611"},"PeriodicalIF":2.3000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Pathology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1177/03009858241312611","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for genetic hydrocephalus found in hemorrhagic hydrocephalus (hhy) mice. The Ccdc85c knockout (KO) rat has subcortical heterotopia with frequent brain hemorrhage as seen in hhy mice. In this study, we report aberrant alpha-smooth muscle actin (α-SMA) expression in the wall of lateral ventricle of the Ccdc85c KO rats. The α-SMA-positive cells were distributed at the dorsal, medial, and lateral regions of the lateral ventricle of KO rats. The expression of α-SMA was first observed on postnatal day 20 (P20) and became noticeably stronger at P26 when hydrocephalus was prominent. Double immunofluorescence showed co-expression of α-SMA with nestin, vimentin, and glial fibrillary acidic protein in the ventricular lining of KO rats. Therefore, we conclude that α-SMA-positive cells may represent an immature subpopulation of cells at adult age around the lateral ventricle of Ccdc85c KO rats.
期刊介绍：
Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
