Veterinary Pathology最新文献_第3页

Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis. 2024 年动物淀粉样变性和蛋白质错误折叠疾病的分类：病理学和诊断综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-10-10 DOI: 10.1177/03009858241283750

Susumu Iwaide, Tomoaki Murakami, Niki Sedghi Masoud, Natsumi Kobayashi, Jessica S Fortin, Hiroki Miyahara, Keiichi Higuchi, James K Chambers

{"title":"Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis.","authors":"Susumu Iwaide, Tomoaki Murakami, Niki Sedghi Masoud, Natsumi Kobayashi, Jessica S Fortin, Hiroki Miyahara, Keiichi Higuchi, James K Chambers","doi":"10.1177/03009858241283750","DOIUrl":"https://doi.org/10.1177/03009858241283750","url":null,"abstract":"Amyloidosis is a group of diseases in which proteins become amyloid, an insoluble fibrillar aggregate, resulting in organ dysfunction. Amyloid deposition has been reported in various animal species. To diagnose and understand the pathogenesis of amyloidosis, it is important to identify the amyloid precursor protein involved in each disease. Although 42 amyloid precursor proteins have been reported in humans, little is known about amyloidosis in animals, except for a few well-described amyloid proteins, including amyloid A (AA), amyloid light chain (AL), amyloid β (Aβ), and islet amyloid polypeptide-derived amyloid. Recently, several types of novel amyloidosis have been identified in animals using immunohistochemistry and mass spectrometry-based proteomic analysis. Certain species are predisposed to specific types of amyloidosis, suggesting a genetic background for its pathogenesis. Age-related amyloidosis has also emerged due to the increased longevity of captive animals. In addition, experimental studies have shown that some amyloids may be transmissible. Accurate diagnosis and understanding of animal amyloidosis are necessary for appropriate therapeutic intervention and comparative pathological studies. This review provides an updated classification of animal amyloidosis, including associated protein misfolding disorders of the central nervous system, and the current understanding of their pathogenesis. Pathologic features are presented together with state-of-the-art diagnostic methods that can be applied for routine diagnosis and identification of novel amyloid proteins in animals.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241283750"},"PeriodicalIF":2.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gross, histologic, and ultrastructural features of iridophoromas in Siamese fighting fish (Betta splendens). 暹罗斗鱼（Betta splendens）虹膜瘤的大体、组织学和超微结构特征。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-10-09 DOI: 10.1177/03009858241281887

Samuel L P Diniz, Hodias S Oliveira Filho, Kin M O L Santos, José L C Duarte, Rafael L Oliveira, Felipe Pierezan, Aníbal G Armién, Jeann Leal de Araújo

{"title":"Gross, histologic, and ultrastructural features of iridophoromas in Siamese fighting fish (Betta splendens).","authors":"Samuel L P Diniz, Hodias S Oliveira Filho, Kin M O L Santos, José L C Duarte, Rafael L Oliveira, Felipe Pierezan, Aníbal G Armién, Jeann Leal de Araújo","doi":"10.1177/03009858241281887","DOIUrl":"https://doi.org/10.1177/03009858241281887","url":null,"abstract":"Pigment-containing and light-reflecting cell neoplasms, generically termed chromatophoromas, affect fish, reptiles, and amphibians. Chromatophoromas of light-reflecting cells are named iridophoromas. In this study, we aimed to describe the gross, histologic, and ultrastructural findings of 71 cases of iridophoromas in farmed Siamese fighting fish (Betta splendens). Macroscopically, iridophoromas appeared as whitish, gray, or black friable masses or plaques in the fin, trunk/tail, or head of the fish. Forty-five tumors (63%) were malignant and invaded the adjacent skeletal muscle and/or metastasized to other organs, whereas 26 (37%) tumors were restricted only to the skin, but due to the cytologic similarity to the malignant counterpart, we were not able to classify them as malignant or benign. Sixty-five (91%) tumors were classified as iridophoromas, whereas 6 (8%) were diagnosed as mixed chromatophoromas. Despite immunolabeling for PNL-2, melan A, or S-100 failing to demonstrate antigen expression, ultrastructural analysis identified light-reflecting neoplastic cells, unequivocally confirming iridophoromas as the predominant tumor. The high incidence of iridophoromas in Siamese fighting fish from the same breeding facility, coupled with a higher occurrence in royal blue and fancy copper color patterns and in young males, suggests a potential genetic/hereditary factor in the tumorigenesis of these neoplasms.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241281887"},"PeriodicalIF":2.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142393662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulinoma-associated protein 1 (INSM1) immunohistochemical expression in normal, hyperplastic, and neoplastic canine neuroendocrine tissues. 正常、增生和肿瘤性犬神经内分泌组织中胰岛素瘤相关蛋白 1 (INSM1) 的免疫组化表达。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-30 DOI: 10.1177/03009858241279127

Fu-Hua Yang, Ya-Pei Chang, Yen-Chen Chang, Hui-Wen Chang, Chian-Ren Jeng, Jia-Wei Jiang, Wen-Tien Tsao, I-Chi Luo, Wei-Hsiang Huang

{"title":"Insulinoma-associated protein 1 (INSM1) immunohistochemical expression in normal, hyperplastic, and neoplastic canine neuroendocrine tissues.","authors":"Fu-Hua Yang, Ya-Pei Chang, Yen-Chen Chang, Hui-Wen Chang, Chian-Ren Jeng, Jia-Wei Jiang, Wen-Tien Tsao, I-Chi Luo, Wei-Hsiang Huang","doi":"10.1177/03009858241279127","DOIUrl":"https://doi.org/10.1177/03009858241279127","url":null,"abstract":"Insulinoma-associated protein 1 (INSM1), a recently identified neuroendocrine marker, is a transcriptional regulator with highly conserved INSM1 homologues in various species. This study investigated the immunohistochemical reactivity of the INSM1 antibody in 20 normal canine neuroendocrine tissues from various anatomical locations, 87 hyperplastic or neoplastic tissues of neuroendocrine origin, and 62 non-neuroendocrine neoplasms and compared the results with those of chromogranin A and synaptophysin in neuroendocrine neoplasms. Western blot was performed on fresh canine pituitary glands and canine parathyroid glands to confirm the specificity of the anti-INSM1 antibody. The results showed that the anti-INSM1 antibody could detect nuclear expression in normal canine neuroendocrine tissues, except for the parathyroid glands. INSM1 was detectable in 79/87 (91%) of the hyperplastic and neoplastic neuroendocrine lesions, but all parathyroid carcinomas and parathyroid adenomas (three samples each) were negative for INSM1. In contrast, INSM1 was detected in only one of 62 (2%) non-neuroendocrine neoplasms. The overall percentage of neuroendocrine neoplasms that immunolabeled positively for all three markers was 89%. In addition, the nuclear expression of INSM1 was easier to interpret than that of chromogranin A or synaptophysin. These findings confirm that INSM1 is a useful immunohistochemical marker for diagnosing canine neuroendocrine neoplasms, except for parathyroid neoplasms, and should be considered as part of immunohistochemistry panels to improve diagnostic capability.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241279127"},"PeriodicalIF":2.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subacute and chronic toxic hepatopathy in cattle grazing pasture with Crotalaria spectabilis. 在牧场上放牧的牛出现亚急性和慢性中毒性肝病。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-26 DOI: 10.1177/03009858241281899

Marlon Ribeiro, Isadora N Bianchi, Wuglenya D M Silva, João Paulo S Cavasani, Ícaro G Santos, Luana Dias, Edson M Colodel, Fernando H Furlan

{"title":"Subacute and chronic toxic hepatopathy in cattle grazing pasture with Crotalaria spectabilis.","authors":"Marlon Ribeiro, Isadora N Bianchi, Wuglenya D M Silva, João Paulo S Cavasani, Ícaro G Santos, Luana Dias, Edson M Colodel, Fernando H Furlan","doi":"10.1177/03009858241281899","DOIUrl":"https://doi.org/10.1177/03009858241281899","url":null,"abstract":"This report describes subacute and chronic toxic hepatopathy in cattle due to Crotalaria spectabilis poisoning. A total of 200 male Nellore cattle were introduced into a paddock contaminated with C. spectabilis. After spending 20 days grazing in this area, 6 cattle became ill and died. The remaining 194 cattle were moved to non-contaminated pasture in a nearby farm and, 45 days after arrival, 15 cattle became ill and died. Three affected cattle were necropsied. The main clinical changes consisted of anorexia, isolation from the herd, weight loss, jaundice, recumbency, and death. The primary lesions were observed in the liver. Subacutely poisoned cattle had slightly firm livers with an accentuated lobular pattern. Histologically, hepatocyte loss with dilated sinusoids, hepatomegalocytosis, and fibrosis was observed. Cattle with chronic disease had small, pale, firm livers with an irregular hepatic capsular surface. Microscopic changes included hepatocyte loss, hepatomegalocytosis, bile duct proliferation, and fibrosis.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241281899"},"PeriodicalIF":2.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feline eosinophilic sclerosing fibroplasia associated with T-/natural killer-cell lymphoma. 猫嗜酸性硬化性纤维增生症伴有T细胞/自然杀伤细胞淋巴瘤。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-25 DOI: 10.1177/03009858241281911

Andrea Klang, Christof A Bertram, Taryn A Donovan, Linden E Craig, Ingrid Walter, Birgitt Wolfesberger, Brigitte Degasperi, Elisabeth Baszler, Barbara C Rütgen, Sabine E Hammer, Andrea Fuchs-Baumgartinger

引用次数: 0

Diagnostic challenge in veterinary pathology: Otitis in a humanized NOG-EXL mouse. 兽医病理学中的诊断难题：人源化 NOG-EXL 小鼠的耳炎。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-21 DOI: 10.1177/03009858241279141

Elinor Willis, Jillian Verrelle, Anthony Secreto, Stephen D Cole, George McClung, Kelley M Weinfurtner, Terence P F Gade, Enrico Radaelli

引用次数: 0

Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia 骨髓增生异常综合征和急性髓性白血病患犬的标准化骨髓评估、风险变量和存活率

IF 2.4 2区农林科学

Veterinary Pathology Pub Date : 2024-09-19 DOI: 10.1177/03009858241277982

Anna M. Meredith, Janet Beeler-Marfisi, Olaf Berke, Anthony J. Mutsaers, Dorothee Bienzle

{"title":"Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia","authors":"Anna M. Meredith, Janet Beeler-Marfisi, Olaf Berke, Anthony J. Mutsaers, Dorothee Bienzle","doi":"10.1177/03009858241277982","DOIUrl":"https://doi.org/10.1177/03009858241277982","url":null,"abstract":"Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are heterogeneous neoplasms of hematopoietic stem cells that are challenging to diagnose, differentiate, and prognosticate. Cytogenetic and mutational analyses are useful in humans but unavailable for dogs, where diagnosis and classification still rely largely on hematologic and morphologic assessment. The objectives of this study were to apply a classification scheme to myeloid neoplasms and to assess outcome in relation to predictor variables. Keyword search of a laboratory database, application of sequential exclusion criteria, and consensus from 3 reviewers yielded 70 cases of myeloid neoplasia with hematology results, and cytologic (11), histologic (14), or both (45) types of marrow specimens. Based on blast percentage and morphology, 42 cases were classified as MDS and 28 as AML. Dogs with MDS had significantly lower body weights, hemoglobin concentrations and blood blasts, and higher red blood cell size variability and platelet numbers than dogs with AML. Estimates of median survival using Kaplan-Meier curves for dogs with MDS and AML were 384 and 6 days, respectively ( P < .001). The instantaneous risk of death for dogs with MDS was approximately 5× lower than that of dogs with AML. Significant predictor variables of survival were body weight, white blood cell count, platelet count, and percent blood blasts ( P < .05). Hazard ratios (HRs) derived from best-fitting Cox regression models were 1.043, 0.998, and 1.061 for increased neutrophils, decreased platelets, and increased blood blasts, respectively. Findings from this study suggest that hematologic and morphologic variables are useful to predict outcomes in myeloid neoplasia.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":"32 1","pages":"3009858241277982"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal pathology in goats challenged with Clostridium perfringens type D strain CN1020 wild-type and its genetically modified derivatives 用 D 型产气荚膜梭菌 CN1020 野生型及其转基因衍生物对山羊进行肠道病理学研究

IF 2.4 2区农林科学

Veterinary Pathology Pub Date : 2024-09-18 DOI: 10.1177/03009858241273122

Eleonora L. Morrell, Mauricio A. Navarro, Jorge P. Garcia, Juliann Beingesser, Francisco A. Uzal

{"title":"Intestinal pathology in goats challenged with Clostridium perfringens type D strain CN1020 wild-type and its genetically modified derivatives","authors":"Eleonora L. Morrell, Mauricio A. Navarro, Jorge P. Garcia, Juliann Beingesser, Francisco A. Uzal","doi":"10.1177/03009858241273122","DOIUrl":"https://doi.org/10.1177/03009858241273122","url":null,"abstract":"Clostridium perfringens type D is the causative agent of enterotoxemia in sheep, goats, and cattle. Although in sheep and cattle, the disease is mainly characterized by neurological clinical signs and lesions, goats with type D enterotoxemia frequently have alterations of the alimentary system. Epsilon toxin (ETX) is the main virulence factor of C. perfringens type D, although the role of ETX in intestinal lesions in goats with type D enterotoxemia has not been fully characterized. We evaluated the contribution of ETX to C. perfringens type D enteric pathogenicity using an intraduodenal challenge model in young goats, with the virulent C. perfringens type D wild-type strain CN1020; its isogenic etx null mutant; an etx-complemented strain; and sterile, non-toxic culture medium. The intestinal tract of each animal was evaluated grossly, microscopically, and immunohistochemically for activated caspase-3. Both ETX-producing strains induced extensive enterocolitis characterized by severe mucosal necrosis, apoptosis, and diffuse suppurative infiltrates. No significant gross or microscopic lesions were observed in goats inoculated with the non–ETX-containing inocula. These results confirm that ETX is essential for the production of intestinal lesions in goats with type D disease. Also, our results suggest that the intestinal pathology of type D enterotoxemia in goats is, at least in part, associated with apoptosis.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":"106 1","pages":"3009858241273122"},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokeratin expression by sarcomas does not indicate synovial origin in dogs. 在狗身上，肉瘤中细胞角蛋白的表达并不表明源自滑膜。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-16 DOI: 10.1177/03009858241279135

Annalisa C Wager, Cary Springer, Rebecca Bergee, Linden E Craig

{"title":"Cytokeratin expression by sarcomas does not indicate synovial origin in dogs.","authors":"Annalisa C Wager, Cary Springer, Rebecca Bergee, Linden E Craig","doi":"10.1177/03009858241279135","DOIUrl":"https://doi.org/10.1177/03009858241279135","url":null,"abstract":"Sarcoma samples from 33 dogs, 25 subcutaneous and 8 articular, were submitted for cytokeratin immunohistochemistry. Eight of the 25 subcutaneous sarcomas (32%) expressed cytokeratin in 1% to 50% of the neoplastic cells. Of the 7 articular sarcomas evaluated, 1 (14%) expressed cytokeratin in 10% of neoplastic cells. The Kaplan-Meier survival analysis showed that the mean overall survival of dogs with subcutaneous sarcomas (28.1 months [confidence interval [CI]:17.8, 38.4]) did not significantly differ from those with articular sarcomas (24.8 months [CI = 0.5, 29.0]). Overall survival of dogs with sarcomas (both locations combined) immunoreactive for cytokeratin (31.2 months [CI = 17.8, 44.6]) did not differ from those not immunoreactive for cytokeratin (22.0 months [CI = 8.4, 35.6]). Therefore, cytokeratin expression does not indicate synovial origin (P = .64) and neither sarcoma location (P = .76) nor cytokeratin expression (P = .53) affects patient overall survival in this small study. The use of cytokeratin immunohistochemistry is not helpful to determine synovial origin of sarcomas in dogs.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"3009858241279135"},"PeriodicalIF":2.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors. 有丝分裂活动：关于猫科动物肿瘤评估方法和预后价值的系统性文献综述。

IF 2.3 2区农林科学

Veterinary Pathology Pub Date : 2024-09-01 Epub Date: 2024-03-27 DOI: 10.1177/03009858241239566

Christof A Bertram, Taryn A Donovan, Alexander Bartel

{"title":"Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors.","authors":"Christof A Bertram, Taryn A Donovan, Alexander Bartel","doi":"10.1177/03009858241239566","DOIUrl":"10.1177/03009858241239566","url":null,"abstract":"Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to provide an overview of the assessment methods and prognostic value. A systematic literature search in PubMed and Scopus and a nonsystematic search in Google Scholar were conducted. All articles on feline tumors that correlated mitotic activity with patient outcome were identified. Data analysis revealed that of the 42 eligible articles, mitotic count (MC, mitotic figures/tumor area) was evaluated in 39 studies, and mitotic index (MI, mitotic figures/tumor cells) in 3 studies. The risk of bias was considered high for most studies (26/42, 62%) based on small study populations, insufficient details of the MC/MI methods, and lack of statistical measures for diagnostic accuracy or effect on outcome. The MC/MI methods varied between studies. A significant association of MC with survival was determined in 20 of 28 (71%) studies (10 studies evaluated other outcome metrics or provided individual patient data), while 1 study found an inverse effect. Three tumor types had at least 4 studies, and a prognostic association with survival was found in 5 of 6 studies on mast cell tumors, 5 of 5 on mammary tumors, and 3 of 4 on soft-tissue sarcomas. MI was shown to correlate with survival for mammary tumors by 2 research groups; however, comparisons to MC were not conducted. Further studies with standardized mitotic activity methods and appropriate statistical analysis for discriminant ability of patient outcome are needed to infer the prognostic value of MC and MI.","PeriodicalId":23513,"journal":{"name":"Veterinary Pathology","volume":" ","pages":"743-751"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0