Cutaneous mast cell tumors in California sea lions (Zalophus californianus).

IF 1.7 2区农林科学 Q2 PATHOLOGY

Veterinary Pathology Pub Date : 2025-09-20 DOI:10.1177/03009858251374690

Bryce M Miller, Nicole I Stacy, Marley Iredale, Judith Kovach-Zukin, Elise LaDouceur, Kathleen Colegrove, Brittany McHale, Grace White, Bethany Doescher, Carolina R Le-Bert, Robert J Ossiboff

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Abstract

Seven cutaneous mast cell tumors were identified in 6 geriatric California sea lions (Zalophus californianus). All tumors were within the dermis and grossly appeared as single, or in one case two, less than 1-cm-diameter, well-circumscribed, raised nodules. The majority (6/7) of the neoplasms occurred near mucocutaneous junctions (eyelid, lip, or anus). The mast cell tumors were composed of round cells arranged in sheets with poorly granulated cytoplasm or an absence of cytoplasmic granules in routine hematoxylin and eosin-stained sections. Cytology (n = 1) showed adequate staining of mast cell granules with Diff-Quik and Wright-Giemsa stains. Immunohistochemistry for cKIT revealed cytoplasmic to membranous immunoreactivity in all tumors. Giemsa staining for metachromatic granules was inconsistent. No local recurrence or metastasis has been observed in the 5 living individuals with follow-up periods ranging from 6 to 42 months. Given these findings, similar poorly granulated mast cell tumors in geriatric California sea lions are suspected to have biologically benign behavior.

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加利福尼亚海狮皮肤肥大细胞瘤。

在6只老年加利福尼亚海狮（Zalophus californianus）中发现7个皮肤肥大细胞瘤。所有肿瘤均位于真皮层内，大体表现为单个，或在一个病例中表现为两个，直径小于1厘米，边界清楚，凸起的结节。大多数（6/7）肿瘤发生在皮肤粘膜连接处（眼睑、嘴唇或肛门）附近。在常规苏木精染色和伊红染色切片上，肥大细胞肿瘤由排列成片状的圆形细胞组成，胞质颗粒化差或胞质颗粒缺失。细胞学（n = 1）显示diff - quick和Wright-Giemsa染色对肥大细胞颗粒进行了充分的染色。cKIT的免疫组化显示所有肿瘤的细胞质至膜性免疫反应。异色颗粒的吉姆萨染色不一致。5例患者随访6 ~ 42个月，未见局部复发或转移。鉴于这些发现，在老年加利福尼亚海狮中类似的颗粒状肥大细胞肿瘤被怀疑具有生物学上的良性行为。

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来源期刊

Veterinary Pathology 农林科学-病理学

CiteScore

4.70

自引率

8.30%

发文量

审稿时长

2 months

期刊介绍： Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.