Sudden death of a cynomolgus monkey due to transfusion-related acute lung injury (TRALI) after xeno-transfusion from a minipig.

IF 2.3 2区 农林科学 Q2 PATHOLOGY
Jinhyung Rho, Hyung-Seon Kim, Mi-Jin Yang, Jeong-Ho Hwang, Hwa-Young Son
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引用次数: 0

Abstract

Blood transfusion in veterinary science is vital but has not been thoroughly investigated due to the diversity and complexity between species. Here, we introduce the case of a cynomolgus monkey that exhibited loss of pupil reflex and died 1 hour after xeno-transfusion with triple-knockout red blood cells from a minipig. A full necropsy was performed to investigate the cause of death. Gross observations revealed foamy and bloody exudate in the mouth; however, no signs of injury were observed in the upper respiratory tract. The lung weight was nearly 5 times higher than that of similar-aged monkeys. The texture of the lung was sand-like, but red and dark red discoloration was observed throughout the lung. Histological examination revealed restricted hemorrhage in the perivascular region in the lungs and phagocytosis of red blood cells by neutrophils in the liver. Thus, the lesion corresponded to a transfusion-related acute lung injury.

一只食蟹猴在接受猪异种输血后,因输血相关急性肺损伤(TRALI)而猝死。
输血在兽医科学中是至关重要的,但由于物种之间的多样性和复杂性,尚未进行彻底的调查。在这里,我们介绍了一只食蟹猴的病例,它表现出瞳孔反射的丧失,并在异种输血后1小时死亡。进行了全面尸检以调查死因。肉眼观察发现口腔有泡沫和血性渗出物;然而,上呼吸道未见损伤迹象。其肺重量几乎是同龄猴子的5倍。肺质地呈沙样,但整个肺可见红色和暗红色变色。组织学检查显示肺血管周围局限性出血,肝脏中性粒细胞吞噬红细胞。因此,该病变对应于输血相关的急性肺损伤。
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来源期刊
Veterinary Pathology
Veterinary Pathology 农林科学-病理学
CiteScore
4.70
自引率
8.30%
发文量
99
审稿时长
2 months
期刊介绍: Veterinary Pathology (VET) is the premier international publication of basic and applied research involving domestic, laboratory, wildlife, marine and zoo animals, and poultry. Bridging the divide between natural and experimental diseases, the journal details the diagnostic investigations of diseases of animals; reports experimental studies on mechanisms of specific processes; provides unique insights into animal models of human disease; and presents studies on environmental and pharmaceutical hazards.
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