Tissue Barriers最新文献_第7页

Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage. 红色羽毛：从鹦鹉到人和小鼠的感染揭示了新生隐球菌在哺乳动物体内传播过程中的遗传可塑性。

IF 4

Tissue Barriers Pub Date : 2025-01-01 Epub Date: 2024-01-28 DOI: 10.1080/21688370.2024.2309717

Dorrian G Cohen, Rebecca A Wingert

引用次数: 0

RETRACTED ARTICLE: The protective effects of apelin-13 in HIV-1 tat- induced macrophage infiltration and BBB impairment. apelin-13对HIV-1 tat诱导的巨噬细胞浸润和BBB损伤的保护作用

IF 4

Tissue Barriers Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1080/21688370.2024.2392361

Qi Cao, Wei Zeng, Jingmin Nie, Yongjun Ye, Yanchao Chen

{"title":"RETRACTED ARTICLE: The protective effects of apelin-13 in HIV-1 tat- induced macrophage infiltration and BBB impairment.","authors":"Qi Cao, Wei Zeng, Jingmin Nie, Yongjun Ye, Yanchao Chen","doi":"10.1080/21688370.2024.2392361","DOIUrl":"10.1080/21688370.2024.2392361","url":null,"abstract":"Statement of RetractionWe, the Editors and Publisher of the journal Tissue Barriers, have retracted the following article:Cao, Q., Zeng, W., Nie, J., Ye, Y., & Chen, Y. (2024). The protective effects of apelin-13 in HIV-1 tat- induced macrophage infiltration and BBB impairment. Tissue Barriers. https://doi.org/10.1080/21688370.2024.2392361After publication, the corresponding author requested the withdrawal of the article because none of the listed authors had agreed to the publication of the article. When contacted for further information, only the corresponding author has responded. The corresponding author has provided proof of their affiliation and details of their current email address, which differs from the email address associated with the submission and publication of the article.As determining authorship is core to the integrity of published work, we are therefore retracting the article. The corresponding author listed in this publication has been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2392361"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs? 糖尿病对血液-组织屏障调节和血管并发症的影响：肺与其他器官是否不同？

IF 4

Tissue Barriers Pub Date : 2025-01-01 Epub Date: 2024-07-29 DOI: 10.1080/21688370.2024.2386183

Abdulaziz H Alanazi, Mohamed S Selim, Manyasreeprapti R Yendamuri, Duo Zhang, S Priya Narayanan, Payaningal R Somanath

{"title":"The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs?","authors":"Abdulaziz H Alanazi, Mohamed S Selim, Manyasreeprapti R Yendamuri, Duo Zhang, S Priya Narayanan, Payaningal R Somanath","doi":"10.1080/21688370.2024.2386183","DOIUrl":"10.1080/21688370.2024.2386183","url":null,"abstract":"Diabetes Mellitus presents a formidable challenge as one of the most prevalent and complex chronic diseases, exerting significant strain on both patients and the world economy. It is recognized as a common comorbidity among severely ill individuals, often leading to a myriad of micro- and macro-vascular complications. Despite extensive research dissecting the pathophysiology and molecular mechanisms underlying vascular complications of diabetes, relatively little attention has been paid to potential lung-related complications. This review aims to illuminate the impact of diabetes on prevalent respiratory diseases, including chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), tuberculosis (TB), pneumonia infections, and asthma, and compare the vascular complications with other vascular beds. Additionally, we explore the primary mechanistic pathways contributing to these complications, such as the expression modulation of blood-tissue-barrier proteins, resulting in increased paracellular and transcellular permeability, and compromised immune responses rendering diabetes patients more susceptible to infections. The activation of inflammatory pathways leading to cellular injury and hastening the onset of these respiratory complications is also discussed.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2386183"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic alterations of endothelial cells under transient and persistent hypoxia: study using a 3D microvessels-on-chip model. 内皮细胞在短暂和持续缺氧条件下的代谢变化：利用三维芯片微血管模型进行的研究。

IF 4

Tissue Barriers Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1080/21688370.2024.2431416

Kanchana Pandian, Anton Jan van Zonneveld, Amy Harms, Thomas Hankemeier

{"title":"Metabolic alterations of endothelial cells under transient and persistent hypoxia: study using a 3D microvessels-on-chip model.","authors":"Kanchana Pandian, Anton Jan van Zonneveld, Amy Harms, Thomas Hankemeier","doi":"10.1080/21688370.2024.2431416","DOIUrl":"10.1080/21688370.2024.2431416","url":null,"abstract":"Numerous signaling pathways are activated during hypoxia to facilitate angiogenesis, promoting interactions among endothelial cells and initiating downstream signaling cascades. Although the pivotal role of the nitric oxide (NO) response pathway is well-established, the involvement of arginine-specific metabolism and bioactive lipid mechanisms in 3D flow-activated in vitro models remains less understood. In this study, we explored the levels of arginine-specific metabolites and bioactive lipids in human coronary artery endothelial cells (HCAECs) under both transient and persistent hypoxia. We compared targeted metabolite levels between a 2D static culture model and a 3D microvessels-on-chip model. Notably, we observed robust regulation of NO metabolites in both transient and persistent hypoxic conditions. In the 2D model under transient hypoxia, metabolic readouts of bioactive lipids revealed increased oxidative stress markers, a phenomenon not observed in the 3D microvessels. Furthermore, we made a novel discovery that the responses of bioactive lipids were regulated by hypoxia inducible factor-1α (HIF-1α) in the 2D cell culture model and partially by HIF-1α and flow-induced shear stress in the 3D microvessels. Immunostaining confirmed the HIF-1α-induced regulation under both hypoxic conditions. Real-time oxygen measurements in the 3D microvessels using an oxygen probe validated that oxygen levels were maintained in the 3D model. Overall, our findings underscore the critical regulatory roles of HIF-1α and shear stress in NO metabolites and bioactive lipids in both 2D and 3D cell culture models.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2431416"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of reactive oxygen species in the regulation of the blood-brain barrier. 活性氧在调节血脑屏障中的作用。

IF 4

Tissue Barriers Pub Date : 2025-01-01 Epub Date: 2024-05-29 DOI: 10.1080/21688370.2024.2361202

Margarita Shuvalova, Anastasiia Dmitrieva, Vsevolod Belousov, Georgii Nosov

{"title":"The role of reactive oxygen species in the regulation of the blood-brain barrier.","authors":"Margarita Shuvalova, Anastasiia Dmitrieva, Vsevolod Belousov, Georgii Nosov","doi":"10.1080/21688370.2024.2361202","DOIUrl":"10.1080/21688370.2024.2361202","url":null,"abstract":"The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules, but they also serve as secondary messengers in intracellular signaling cascades during redox signaling. The impact of ROS on the BBB has been observed in multiple sclerosis, stroke, trauma, and other neurological disorders, making blocking ROS generation a promising therapeutic strategy for BBB dysfunction. However, it is important to consider ROS generation during normal BBB functioning for signaling purposes. This review summarizes data on proteins expressed by BBB cells that can be targets of redox signaling or oxidative stress. It also provides examples of signaling molecules whose impact may cause ROS generation in the BBB, as well as discusses the most common diseases associated with BBB dysfunction and excessive ROS generation, open questions that arise in the study of this problem, and possible ways to overcome them.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2361202"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Claudins in vulvar cancer - from epithelial barrier to potential tumor-agnostic cancer therapy. 外阴癌中的cladin -从上皮屏障到潜在的肿瘤不可知的癌症治疗。

IF 3.6

Tissue Barriers Pub Date : 2024-12-25 DOI: 10.1080/21688370.2024.2444724

Gilbert Georg Klamminger, Annick Bitterlich, Meletios P Nigdelis, Martin Ertz, Kim Yoo-Jin, Annette Hasenburg, Mathias Wagner

引用次数: 0

Correction. 修正。

IF 4

Tissue Barriers Pub Date : 2024-12-11 DOI: 10.1080/21688370.2024.2440987

引用次数: 0

The amazing axolotl: robust kidney regeneration following acute kidney injury. 神奇的斧头鱼：急性肾损伤后肾脏的强大再生能力。

IF 4

Tissue Barriers Pub Date : 2024-10-01 Epub Date: 2023-12-05 DOI: 10.1080/21688370.2023.2290946

Elysa Ng May May, Rebecca A Wingert

引用次数: 0

Effect of Bevacizumab on traumatic penumbra brain edema in rats at different time points. 贝伐单抗对不同时间点大鼠创伤性半影脑水肿的影响

IF 4

Tissue Barriers Pub Date : 2024-10-01 Epub Date: 2023-12-12 DOI: 10.1080/21688370.2023.2292463

Li Ai, Chen Xin, Muhammad Usman, Yu Zhu, Hong Lu

{"title":"Effect of Bevacizumab on traumatic penumbra brain edema in rats at different time points.","authors":"Li Ai, Chen Xin, Muhammad Usman, Yu Zhu, Hong Lu","doi":"10.1080/21688370.2023.2292463","DOIUrl":"10.1080/21688370.2023.2292463","url":null,"abstract":"Traumatic penumbra (TP) is a secondary injury area located around the core area of traumatic brain injury after brain trauma, and is an important factor affecting the outcome of traumatic brain injury (TBI). The main pathological change caused by TP is brain edema, including (cellular brain edema and vascular brain edema). The formation and development of brain edema in the TP area are closely related to the blood-brain barrier (BBB) and vascular endothelial growth factor (VEGF). VEGF is a vascular permeability factor that can promote angiogenesis and increase BBB permeability, and there is a debate on the pros and cons of its role in early TBI. Therefore, in the early stage of TBI, when using the VEGF inhibitor bevacizumab to treat TP area brain edema, the timing of bevacizumab administration is particularly important, and there are currently no relevant literature reports. This article explores the treatment time window and optimal treatment time point of bevacizumab in the treatment of cerebral edema in the TP area by administering the same dose of bevacizumab at different time points after brain injury in rats. The results showed that there was traumatic brain edema in TP area, BBB structure and function were damaged, VEGF expression and angiogenesis were increased. Compared with TBI + NS Group, after Bevacizumab treatment, brain edema in TP area was alleviated, BBB structure and function were improved, VEGF expression and angiogenesis were decreased in each treatment group, and the effect of TBI + Bevacizumab 1 h group was the most significant. Bevacizumab can be used as a targeted therapy for traumatic brain edema. The therapeutic time window of bevacizumab for traumatic brain edema is within 12 hours after TBI, and 1 h is the optimal therapeutic time point.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2292463"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases. 阿必鲁肽、度拉鲁肽、替唑帕肽和 DA5-CH 的脑摄取药代动力学，寻找阿尔茨海默氏症和帕金森氏症的新疗法。

IF 4

Tissue Barriers Pub Date : 2024-10-01 Epub Date: 2023-12-14 DOI: 10.1080/21688370.2023.2292461

Elizabeth M Rhea, Alice Babin, Peter Thomas, Mohamed Omer, Riley Weaver, Kim Hansen, William A Banks, Konrad Talbot

{"title":"Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases.","authors":"Elizabeth M Rhea, Alice Babin, Peter Thomas, Mohamed Omer, Riley Weaver, Kim Hansen, William A Banks, Konrad Talbot","doi":"10.1080/21688370.2023.2292461","DOIUrl":"10.1080/21688370.2023.2292461","url":null,"abstract":"Background: A number of peptide incretin receptor agonists (IRAs) show promise as therapeutics for Alzheimer's disease (AD) and Parkinson's disease (PD). Transport across the blood-brain barrier (BBB) is one way for IRAs to act directly within the brain. To determine which IRAs are high priority candidates for treating these disorders, we have studied their brain uptake pharmacokinetics.Methods: We quantitatively measure the ability of four IRAs to cross the BBB. We injected adult male CD-1 mice intravenously with 125I- or 14C-labeled albiglutide, dulaglutide, DA5-CH, or tirzepatide and used multiple-time regression analyses to measure brain kinetics up to 1 hour. For those IRAs failing to enter the brain 1 h after intravenous injection, we also investigated their ability to enter over a longer time frame (i.e., 6 h).Results: Albiglutide and dulaglutide had the fastest brain uptake rates within 1 hour. DA5-CH appears to enter the brain rapidly, reaching equilibrium quickly. Tirzepatide does not appear to cross the BBB within 1 h after iv injection but like albumin, did so slowly over 6 h, presumably via the extracellular pathways.Conclusions: We find that IRAs can cross the BBB by two separate processes; one that is fast and one that is slow. Three of the four IRAs investigated here have fast rates of transport and should be taken into consideration for testing as AD and PD therapeutics as they would have the ability to act quickly and directly on the brain as a whole.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2292461"},"PeriodicalIF":4.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138809805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0