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The stratum corneum barrier: impaired function in relation to associated lipids and proteins. 角质层屏障：功能受损与相关脂质和蛋白质有关。
IF 3.1
Tissue Barriers Pub Date : 2024-05-31 DOI: 10.1080/21688370.2024.2361197
Jie Chen, Changjie Liu, Yuan Yang, Xue Gong, Huan Qian
{"title":"The stratum corneum barrier: impaired function in relation to associated lipids and proteins.","authors":"Jie Chen, Changjie Liu, Yuan Yang, Xue Gong, Huan Qian","doi":"10.1080/21688370.2024.2361197","DOIUrl":"https://doi.org/10.1080/21688370.2024.2361197","url":null,"abstract":"<p><p>The skin is the largest organ of the human body and is widely considered to be the first-line defense of the body, providing essential protection against mechanical, physical, and chemical damage. Keratinocytes are the primary cells of the outer layer of the epidermis, which acts as a mechanical and permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. Here we report that some components of keratinocytes affect the formation and differentiation of the stratum corneum, which is the most specialized layer of the epidermis.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2361197"},"PeriodicalIF":3.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of reactive oxygen species in the regulation of the blood-brain barrier. 活性氧在调节血脑屏障中的作用。
IF 3.1
Tissue Barriers Pub Date : 2024-05-29 DOI: 10.1080/21688370.2024.2361202
Margarita Shuvalova, Anastasiia Dmitrieva, Vsevolod Belousov, Georgii Nosov
{"title":"The role of reactive oxygen species in the regulation of the blood-brain barrier.","authors":"Margarita Shuvalova, Anastasiia Dmitrieva, Vsevolod Belousov, Georgii Nosov","doi":"10.1080/21688370.2024.2361202","DOIUrl":"https://doi.org/10.1080/21688370.2024.2361202","url":null,"abstract":"<p><p>The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules, but they also serve as secondary messengers in intracellular signaling cascades during redox signaling. The impact of ROS on the BBB has been observed in multiple sclerosis, stroke, trauma, and other neurological disorders, making blocking ROS generation a promising therapeutic strategy for BBB dysfunction. However, it is important to consider ROS generation during normal BBB functioning for signaling purposes. This review summarizes data on proteins expressed by BBB cells that can be targets of redox signaling or oxidative stress. It also provides examples of signaling molecules whose impact may cause ROS generation in the BBB, as well as discusses the most common diseases associated with BBB dysfunction and excessive ROS generation, open questions that arise in the study of this problem, and possible ways to overcome them.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2361202"},"PeriodicalIF":3.1,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human in vitro blood barrier models: architectures and applications. 人体体外血液屏障模型：结构与应用。
IF 3.6
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-20 DOI: 10.1080/21688370.2023.2222628
Brittany E Watson, Julia A Miles, Melissa A Moss
{"title":"Human <i>in vitro</i> blood barrier models: architectures and applications.","authors":"Brittany E Watson, Julia A Miles, Melissa A Moss","doi":"10.1080/21688370.2023.2222628","DOIUrl":"10.1080/21688370.2023.2222628","url":null,"abstract":"<p><p>Blood barriers serve as key points of transport for essential molecules as well as lines of defense to protect against toxins. <i>In vitro</i> modeling of these barriers is common practice in the study of their physiology and related diseases. This review describes a common method of using an adaptable, low cost, semipermeable, suspended membrane to experimentally model three blood barriers in the human body: the blood-brain barrier (BBB), the gut-blood barrier (GBB), and the air-blood barrier (ABB). The GBB and ABB both protect from the outside environment, while the BBB protects the central nervous system from potential neurotoxic agents in the blood. These barriers share several commonalities, including the formation of tight junctions, polarized cellular monolayers, and circulatory system contact. Cell architectures used to mimic barrier anatomy as well as applications to study function, dysfunction, and response provide an overview of the versatility enabled by these cultural systems.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2222628"},"PeriodicalIF":3.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Models for barrier understanding in health and disease in lab-on-a-chips. 芯片实验室中了解健康和疾病障碍的模型。
IF 3.1
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-09 DOI: 10.1080/21688370.2023.2221632
J Ponmozhi, S Dhinakaran, Dorottya Kocsis, Kristóf Iván, Franciska Erdő
{"title":"Models for barrier understanding in health and disease in lab-on-a-chips.","authors":"J Ponmozhi, S Dhinakaran, Dorottya Kocsis, Kristóf Iván, Franciska Erdő","doi":"10.1080/21688370.2023.2221632","DOIUrl":"10.1080/21688370.2023.2221632","url":null,"abstract":"<p><p>The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exist to investigate barrier function in vivo and in vitro. To investigate barrier function in a highly reproducible manner, ethically, and high throughput, researchers have turned to non-animal techniques and micro-scale technologies. In this comprehensive review, the authors summarize the current applications of organ-on-a-chip microfluidic devices in the study of physiological barriers. The review covers the blood-brain barrier, ocular barriers, dermal barrier, respiratory barriers, intestinal, hepatobiliary, and renal/bladder barriers under both healthy and pathological conditions. The article then briefly presents placental/vaginal, and tumour/multi-organ barriers in organ-on-a-chip devices. Finally, the review discusses Computational Fluid Dynamics in microfluidic systems that integrate biological barriers. This article provides a concise yet informative overview of the current state-of-the-art in barrier studies using microfluidic devices.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2221632"},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells. 抑制折叠蛋白反应可增强 LPS 诱导的牛肺动脉内皮细胞屏障功能障碍和炎症。
IF 3.1
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-07-12 DOI: 10.1080/21688370.2023.2232245
Nektarios Barabutis, Mohammad S Akhter
{"title":"Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells.","authors":"Nektarios Barabutis, Mohammad S Akhter","doi":"10.1080/21688370.2023.2232245","DOIUrl":"10.1080/21688370.2023.2232245","url":null,"abstract":"<p><p>The development of novel strategies to counteract diseases related to barrier dysfunction is a priority, since sepsis and acute respiratory distress syndrome are still associated with high mortality rates. In the present study, we focus on the effects of the unfolded protein response suppressor (UPR) 4-Phenylbutyrate (4-PBA) in Lipopolysaccharides (LPS)-induced endothelial injury, to investigate the effects of that compound in the corresponding damage. 4-PBA suppressed binding immunoglobulin protein (BiP) - a UPR activation marker - and potentiated LPS - induced signal transducer and activator of transcription 3 (STAT3) and extracellular signal‑regulated protein kinase (ERK) 1/2 activation. In addition to those effects, 4-PBA enhanced paracellular hyperpermeability in inflamed bovine pulmonary endothelial cells, and did not affect cell viability in moderate concentrations. Our observations suggest that UPR suppression due to 4-PBA augments LPS-induced endothelial injury, as well as the corresponding barrier disruption.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2232245"},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers. 培养基和培养方式会改变猪结肠单层的细胞组成和屏障完整性。
IF 3.1
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-21 DOI: 10.1080/21688370.2023.2222632
Alicia M Barnett, Jane A Mullaney, Warren C McNabb, Nicole C Roy
{"title":"Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers.","authors":"Alicia M Barnett, Jane A Mullaney, Warren C McNabb, Nicole C Roy","doi":"10.1080/21688370.2023.2222632","DOIUrl":"10.1080/21688370.2023.2222632","url":null,"abstract":"<p><p>Intestinal organoid technology has revolutionized our approach to <i>in vitro</i> cell culture due in part to their three-dimensional structures being more like the native tissue from which they were derived with respect to cellular composition and architecture. For this reason, organoids are becoming the new gold standard for undertaking intestinal epithelial cell research. Unfortunately, their otherwise advantageous three-dimensional geometry prevents easy access to the apical epithelium, which is a major limitation when studying interactions between dietary or microbial components and host tissues. To overcome this problem, we developed porcine colonoid-derived monolayers cultured on both permeable Transwell inserts and tissue culture treated polystyrene plates. We found that seeding density and culture format altered the expression of genes encoding markers of specific cell types (stem cells, colonocytes, goblets, and enteroendocrine cells), and barrier maturation (tight junctions). Additionally, we found that changes to the formulation of the culture medium altered the cellular composition of colonoids and of monolayers derived from them, resulting in cultures with an increasingly differentiated phenotype that was similar to that of their tissue of origin.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2222632"},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
(Zebra)fishing for nephrogenesis genes. (斑马）寻找肾脏生成基因。
IF 3.6
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-05-31 DOI: 10.1080/21688370.2023.2219605
Brooke E Chambers, Nicole E Weaver, Caroline M Lara, Thanh Khoa Nguyen, Rebecca A Wingert
{"title":"(Zebra)fishing for nephrogenesis genes.","authors":"Brooke E Chambers, Nicole E Weaver, Caroline M Lara, Thanh Khoa Nguyen, Rebecca A Wingert","doi":"10.1080/21688370.2023.2219605","DOIUrl":"10.1080/21688370.2023.2219605","url":null,"abstract":"<p><p>Kidney disease is a devastating condition affecting millions of people worldwide, where over 100,000 patients in the United States alone remain waiting for a lifesaving organ transplant. Concomitant with a surge in personalized medicine, single-gene mutations, and polygenic risk alleles have been brought to the forefront as core causes of a spectrum of renal disorders. With the increasing prevalence of kidney disease, it is imperative to make substantial strides in the field of kidney genetics. Nephrons, the core functional units of the kidney, are epithelial tubules that act as gatekeepers of body homeostasis by absorbing and secreting ions, water, and small molecules to filter the blood. Each nephron contains a series of proximal and distal segments with explicit metabolic functions. The embryonic zebrafish provides an ideal platform to systematically dissect the genetic cues governing kidney development. Here, we review the use of zebrafish to discover nephrogenesis genes.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2219605"},"PeriodicalIF":3.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9540652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes: current knowledge and future perspectives. 外泌体：现有知识和未来展望。
IF 3.6
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-07-13 DOI: 10.1080/21688370.2023.2232248
Swati Singh, Deepraj Paul, Virendra Nath, Rohini A
{"title":"Exosomes: current knowledge and future perspectives.","authors":"Swati Singh, Deepraj Paul, Virendra Nath, Rohini A","doi":"10.1080/21688370.2023.2232248","DOIUrl":"10.1080/21688370.2023.2232248","url":null,"abstract":"<p><p>Exosomes are membrane-bound micro-vesicles that possess endless therapeutic potential for treatment of numerous pathologies including autoimmune, cardiovascular, ocular, and nervous disorders. Despite considerable knowledge about exosome biogenesis and secretion, still, there is a lack of information regarding exosome uptake by cell types and internal signaling pathways through which these exosomes process cellular response. Exosomes are key components of cell signaling and intercellular communication. In central nervous system (CNS), exosomes can penetrate BBB and maintain homeostasis by myelin sheath regulation and the waste products elimination. Therefore, the current review summarizes role of exosomes and their use as biomarkers in cardiovascular, nervous and ocular disorders. This aspect of exosomes provides positive hope to monitor disease development and enable early diagnosis and treatment optimization. In this review, we have summarized recent findings on physiological and therapeutic effects of exosomes and also attempt to provide insights about stress-preconditioned exosomes and stem cell-derived exosomes.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2232248"},"PeriodicalIF":3.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One small step for stool, one giant leap for IBD surveillance. 粪便的一小步，IBD 监测的一大步。
IF 3.1
Tissue Barriers Pub Date : 2024-02-07 DOI: 10.1080/21688370.2024.2314839
Dorrian G Cohen, Rebecca A Wingert
{"title":"One small step for stool, one giant leap for IBD surveillance.","authors":"Dorrian G Cohen, Rebecca A Wingert","doi":"10.1080/21688370.2024.2314839","DOIUrl":"https://doi.org/10.1080/21688370.2024.2314839","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs) are chronic conditions in which the digestive tract undergoes cycles of relapsing and remitting inflammatory episodes that cause patients to experience severe abdominal pain, bleeding, and diarrhea. Developing noninvasive and cost-effective surveillance methods that can detect an ensuing disease bout proffers an avenue to improve the quality of life for patients with IBD. Now, a recent report describes an ingenious, economical approach using a rationally designed <i>Escherichia coli</i> strain that can dynamically monitor inflammation inside the mammalian gastrointestinal tract. The ability of the engineered probiotic to specifically discern between dormant and activated inflammatory states of the digestive system demonstrates that living biosensors can be used to monitor health status, thus providing a powerful proof of concept that heralds the arrival of a new age of clinical diagnostics for people living with inflammatory diseases of the gut.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2314839"},"PeriodicalIF":3.1,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage. 红色羽毛：从鹦鹉到人和小鼠的感染揭示了新生隐球菌在哺乳动物体内传播过程中的遗传可塑性。
IF 3.1
Tissue Barriers Pub Date : 2024-01-28 DOI: 10.1080/21688370.2024.2309717
Dorrian G Cohen, Rebecca A Wingert
{"title":"Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of <i>Cryptococcus neoformans</i> during mammalian passage.","authors":"Dorrian G Cohen, Rebecca A Wingert","doi":"10.1080/21688370.2024.2309717","DOIUrl":"https://doi.org/10.1080/21688370.2024.2309717","url":null,"abstract":"<p><p>The fungus <i>Cryptococcus neoformans</i> is pervasive in our environment and causes the infectious disease cryptococcosis in humans, most commonly in immunocompromised patients. In addition to corroborating the avian origins of a case of cryptococcosis in an immunocompromised patient in 2000, a fascinating recent report has now characterized the genetic and phenotypic changes that occur in this <i>C. neoformans</i> during passage in mammalian hosts. Interestingly, mouse-passaged isolates showed differences in virulence factors ranging from capsule size, melanization, nonlytic macrophage exocytosis, and amoeba predation resistance as compared to the patient strain. Taken together, these results provide new insights about the relationship between mutations acquired during an infection and changes in virulence.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2309717"},"PeriodicalIF":3.1,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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