The role of reactive oxygen species in the regulation of the blood-brain barrier.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Margarita Shuvalova, Anastasiia Dmitrieva, Vsevolod Belousov, Georgii Nosov
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引用次数: 0

Abstract

The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the blood and brain, and maintains central nervous system homeostasis. Various factors affect BBB barrier functions, including reactive oxygen species (ROS). ROS can act as stressors, damaging biological molecules, but they also serve as secondary messengers in intracellular signaling cascades during redox signaling. The impact of ROS on the BBB has been observed in multiple sclerosis, stroke, trauma, and other neurological disorders, making blocking ROS generation a promising therapeutic strategy for BBB dysfunction. However, it is important to consider ROS generation during normal BBB functioning for signaling purposes. This review summarizes data on proteins expressed by BBB cells that can be targets of redox signaling or oxidative stress. It also provides examples of signaling molecules whose impact may cause ROS generation in the BBB, as well as discusses the most common diseases associated with BBB dysfunction and excessive ROS generation, open questions that arise in the study of this problem, and possible ways to overcome them.

活性氧在调节血脑屏障中的作用。
血脑屏障(BBB)调节血液和大脑之间代谢物和细胞的交换,维持中枢神经系统的平衡。影响血脑屏障功能的因素有很多,其中包括活性氧(ROS)。ROS 可充当应激源,破坏生物分子,但也可在氧化还原信号传导过程中充当细胞内信号级联的次级信使。在多发性硬化症、中风、创伤和其他神经系统疾病中都观察到了 ROS 对 BBB 的影响,因此阻断 ROS 的产生是治疗 BBB 功能障碍的一种很有前景的治疗策略。然而,考虑到 ROS 在 BBB 正常运作过程中产生信号的目的也很重要。本综述总结了有关 BBB 细胞表达的可作为氧化还原信号或氧化应激靶标的蛋白质的数据。它还举例说明了其影响可能导致 BBB 中产生 ROS 的信号分子,并讨论了与 BBB 功能障碍和过量 ROS 生成相关的最常见疾病、研究这一问题时出现的开放性问题以及克服这些问题的可能方法。
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来源期刊
Tissue Barriers
Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.60
自引率
6.50%
发文量
25
期刊介绍: Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.
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