Tissue Barriers最新文献_第10页

Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs. 细胞穿透肽可改善抗癌药物的药代动力学和药效学。

IF 3.6

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-08-17 DOI: 10.1080/21688370.2021.1965418

Izabela Rusiecka, Iwona Gągało, Ivan Kocić

引用次数: 0

GAP junctions: multifaceted regulators of neuronal differentiation. GAP连接:神经元分化的多方面调节。

IF 3.1

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-10-15 DOI: 10.1080/21688370.2021.1982349

Sarmistha Talukdar, Luni Emdad, Swadesh K Das, Paul B Fisher

{"title":"GAP junctions: multifaceted regulators of neuronal differentiation.","authors":"Sarmistha Talukdar, Luni Emdad, Swadesh K Das, Paul B Fisher","doi":"10.1080/21688370.2021.1982349","DOIUrl":"https://doi.org/10.1080/21688370.2021.1982349","url":null,"abstract":"Gap junctions are intercellular membrane channels consisting of connexin proteins, which contribute to direct cytoplasmic exchange of small molecules, substrates and metabolites between adjacent cells. These channels play important roles in neuronal differentiation, maintenance, survival and function. Gap junctions regulate differentiation of neurons from embryonic, neural and induced pluripotent stem cells. In addition, they control transdifferentiation of neurons from mesenchymal stem cells. The expression and levels of several connexins correlate with cell cycle changes and different stages of neurogenesis. Connexins such as Cx36, Cx45, and Cx26, play a crucial role in neuronal function. Several connexin knockout mice display lethal or severely impaired phenotypes. Aberrations in connexin expression is frequently associated with various neurodegenerative disorders. Gap junctions also act as promising therapeutic targets for neuronal regenerative medicine, because of their role in neural stem cell integration, injury and remyelination.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 1","pages":"1982349"},"PeriodicalIF":3.1,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794256/pdf/KTIB_10_1982349.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39521380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

DCE-MRI of Brain Fluid Barriers: In Vivo Water Cycling at the Human Choroid Plexus. 脑液屏障的DCE-MRI:人脉络膜丛体内水循环。

IF 3.1

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-09-18 DOI: 10.1080/21688370.2021.1963143

Valerie C Anderson, Ian J Tagge, Aaron Doud, Xin Li, Charles S Springer, Joseph F Quinn, Jeffrey A Kaye, Katherine V Wild, William D Rooney

{"title":"DCE-MRI of Brain Fluid Barriers: In Vivo Water Cycling at the Human Choroid Plexus.","authors":"Valerie C Anderson, Ian J Tagge, Aaron Doud, Xin Li, Charles S Springer, Joseph F Quinn, Jeffrey A Kaye, Katherine V Wild, William D Rooney","doi":"10.1080/21688370.2021.1963143","DOIUrl":"https://doi.org/10.1080/21688370.2021.1963143","url":null,"abstract":"Metabolic deficits at brain-fluid barriers are an increasingly recognized feature of cognitive decline in older adults. At the blood-cerebrospinal fluid barrier, water is transported across the choroid plexus (CP) epithelium against large osmotic gradients via processes tightly coupled to activity of the sodium/potassium pump. Here, we quantify CP homeostatic water exchange using dynamic contrast-enhanced MRI and investigate the association of the water efflux rate constant (kco) with cognitive dysfunction in older individuals. Temporal changes in the longitudinal relaxation rate constant (R1) after contrast agent bolus injection were measured in a CP region of interest in 11 participants with mild cognitive dysfunction [CI; 73 ± 6 years] and 28 healthy controls [CN; 72 ± 7 years]. kco was determined from a modified two-site pharmacokinetic exchange analysis of the R1 time-course. Ktrans, a measure of contrast agent extravasation to the interstitial space was also determined. Cognitive function was assessed by neuropsychological test performance. kco averages 5.8 ± 2.7 s-1 in CN individuals and is reduced by 2.4 s-1 [ca. 40%] in CI subjects. Significant associations of kco with global cognition and multiple cognitive domains are observed. Ktrans averages 0.13 ± 0.07 min-1 and declines with age [-0.006 ± 0.002 min-1 yr-1], but shows no difference between CI and CN individuals or association with cognitive performance. Our findings suggest that the CP water efflux rate constant is associated with cognitive dysfunction and shows an age-related decline in later life, consistent with the metabolic disturbances that characterize brain aging.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 1","pages":"1963143"},"PeriodicalIF":3.1,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794257/pdf/KTIB_10_1963143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39433161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease. E-cadherin 激活抗体可限制小鼠炎症性肠病的屏障功能障碍和炎症。

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-08-17 DOI: 10.1080/21688370.2021.1940741

Chirosree Bandyopadhyay, Leslayann Schecterson, Barry M Gumbiner

{"title":"E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease.","authors":"Chirosree Bandyopadhyay, Leslayann Schecterson, Barry M Gumbiner","doi":"10.1080/21688370.2021.1940741","DOIUrl":"10.1080/21688370.2021.1940741","url":null,"abstract":"Deficits in gastrointestinal (GI) paracellular permeability has been implicated in etiology of Inflammatory Bowel Disease (IBD), and E-cadherin, a key component of the epithelial junctional complex, has been implicated in both barrier function and IBD. We have previously described antibodies against E-cadherin that activate cell adhesion, and in this study, we show that they increase transepithelial electrical resistance in epithelial cell monolayers in vitro. We therefore tested the hypothesis that adhesion activating E-cadherin mAbs will enhance epithelial barrier function in vivo and limit progression of inflammation in IBD. Activating mAbs to mouse E-cadherin were tested in different mouse models of IBD including the IL10-/- and adoptive T cell transfer models of colitis. Previously established histological and biomarker measures of inflammation were evaluated to monitor disease progression. Mouse E-cadherin activating mAb treatment reduced total colitis score, individual histological measures of inflammation, and other hallmarks of inflammation compared to control treatment. Activating mAbs also reduced the fecal accumulation lipocalin2 and albumin content, consistent with enhanced barrier function. Therefore, E-cadherin activation could be a potential strategy for limiting inflammation in UC.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"9 4","pages":"1940741"},"PeriodicalIF":3.1,"publicationDate":"2021-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/5b/KTIB_9_1940741.PMC8794503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39319214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connexins in the development and physiology of stem cells. 干细胞发育和生理中的连接蛋白。

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-07-06 DOI: 10.1080/21688370.2021.1949242

Anaclet Ngezahayo, Frederike A Ruhe

引用次数: 4

Effect of Adipose derived mesenchymal stem cells on multiple Organ Injuries in diet-induced obese mice. 脂肪源性间充质干细胞对饮食诱导肥胖小鼠多器官损伤的影响。

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-07-25 DOI: 10.1080/21688370.2021.1952150

Fatima A Saleh, Hala Jaber, Ali Eid

{"title":"Effect of Adipose derived mesenchymal stem cells on multiple Organ Injuries in diet-induced obese mice.","authors":"Fatima A Saleh, Hala Jaber, Ali Eid","doi":"10.1080/21688370.2021.1952150","DOIUrl":"10.1080/21688370.2021.1952150","url":null,"abstract":"Background: Obesity is a complex disease involving the accumulation of body fat that can inflict a substantial risk to health due to the potent role it plays in the development of a series of chronic diseases including cardiovascular diseases (CVD), nonalcoholic fatty liver diseases (NAFLD), kidney diseases, diabetes, and some cancers. Despite all efforts made, no therapy has succeeded in reversing the obesity pandemic and its associated diseases. Herein, the aim was to study the effect of adipose-derived mesenchymal stem cells on obesity-induced multi-organ injuries in a diet-induced obese mouse model. Male C57BL/6 mice were fed with regular chow diet or high fat diet (HFD) to induce obesity for 15 weeks after which the mice were administered two doses of adipose-derived mesenchymal stem cells (ASC-treated groups) or media as control (media-treated groups). Animals were sacrificed and adipose, hepatic, renal, and cardiac tissues were obtained for histopathological evaluation. Mice on HFD showed excessive pathological alterations such as epididymal adipose tissue expansion, hepatic fat accumulation, glomerular swelling, and cardiomyocyte hypertrophy. However, treatment with ASCs significantly reversed the significant histopathological abnormalities induced by obesity. In conclusion, this study demonstrated the therapeutic effects of adipose-derived mesenchymal stem cells on obesity-associated complications such as NAFLD, CVD, and kidney disorders in a diet-induced obese animal model, which were partly due to the attenuation of inflammatory cytokines such as TNF-α and IL-6.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"9 4","pages":"1952150"},"PeriodicalIF":3.1,"publicationDate":"2021-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21688370.2021.1952150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39223238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread. 病毒相关的粘膜上皮紧密连接的破坏及其在病毒传播和扩散中的作用。

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-07-09 DOI: 10.1080/21688370.2021.1943274

Sharof Tugizov

引用次数: 11

Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis. 盲肠结扎及脓毒症穿刺模型小鼠肺内NEK家族激酶的诱导

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-06-20 DOI: 10.1080/21688370.2021.1929787

Mohammad A Uddin, Mohammad S Akhter, Khadeja-Tul Kubra, Nektarios Barabutis

引用次数: 7

Barrier maintenance by S1P during inflammation and sepsis. S1P在炎症和败血症中的屏障维持作用。

IF 3.1

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-06-21 DOI: 10.1080/21688370.2021.1940069

Anke C Ziegler, Markus H Gräler

引用次数: 3

Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium. 利伐沙班可保护血管内皮免受氧杂环醇引起的损伤和炎症激活。

IF 3.6

Tissue Barriers Pub Date : 2021-10-02 Epub Date: 2021-07-29 DOI: 10.1080/21688370.2021.1956284

Paulina Gorzelak-Pabis, Marlena Broncel, Katarzyna Wojdan, Adrian Gajewski, Maciej Chalubinski, Mateusz Gawrysiak, Ewelina Wozniak

{"title":"Rivaroxaban protects from the oxysterol-induced damage and inflammatory activation of the vascular endothelium.","authors":"Paulina Gorzelak-Pabis, Marlena Broncel, Katarzyna Wojdan, Adrian Gajewski, Maciej Chalubinski, Mateusz Gawrysiak, Ewelina Wozniak","doi":"10.1080/21688370.2021.1956284","DOIUrl":"10.1080/21688370.2021.1956284","url":null,"abstract":"Background: Rivaroxaban is one of the direct factor Xa inhibitors. Its function in the inactivated coagulation cascade is unclear. The aim of the study was to assess the effect of rivaroxaban on the endothelial integrity and inflammatory properties of endothelial cells stimulated by 25-hydroxycholesterol (25-OHC).Methods: HUVECs were stimulated with 25-OHC, rivaroxaban and 25-OHC+ rivaroxaban. HUVEC integrity and permeability were measured using the xCELLigence system and paracellular flux assay. The mRNA expression of tissue factor, ICAM-1, VEGF, IL-33, MCP-1, TNF-α was analyzed in the real-time PCR. Apoptosis and viability were measured by flow cytometry. The VEGF protein concentration was assessed by ELISA. The confocal microscope was used to evaluate the expression of VE-cadherin in endothelial cells.Results: 25-OHC decreased endothelial cell integrity and increased the mRNA expression of IL-33, tissue factor, ICAM-1, MCP-1, VEGF, TNF-α as compared to unstimulated controls. Following the stimulation with rivaroxaban, HUVEC restored integrity disrupted by 25-OHC (p < .01). In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-α, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01). Rivaroxaban 100 mg/ml+25-OHC increased the VE-cadherin expression in endothelium as compared to 25-OHC (p < .05).Conclusion: Our finding suggests that rivaroxaban may restore the endothelial barrier and inhibit the inflammatory activation caused by oxysterol in vitro.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"9 4","pages":"1956284"},"PeriodicalIF":3.6,"publicationDate":"2021-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794498/pdf/KTIB_9_1956284.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39262485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0