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Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD). 天然 PPARγ 激动剂对非酒精性脂肪肝（NAFLD）的治疗作用。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-12-05 DOI: 10.1080/21688370.2023.2289830
Swati Singh, Anit Kumar, Suruchi Gupta, Rohini Agrawal
{"title":"Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD).","authors":"Swati Singh, Anit Kumar, Suruchi Gupta, Rohini Agrawal","doi":"10.1080/21688370.2023.2289830","DOIUrl":"10.1080/21688370.2023.2289830","url":null,"abstract":"<p><p>NAFLD is a condition that develops when the liver accumulates excess fat without alcohol consumption. This chronic liver ailment progresses along with insulin resistant and is typically not diagnosed until the patients have cirrhosis. Nuclear hormone receptor superfamily PPARs are essential for metabolism of fatty acids and glucose. In liver, lipid metabolism is regulated by nuclear receptors and PPARα, and PPARβ/δ encourages fatty acid β-oxidation. PPAR-γ, an energy-balanced receptor is a crucial regulator in NAFLD. The partial activation of PPAR-γ could lead to increased level of adiponectin and insulin sensitivity, thus improved NAFLD. Because of less side effects, natural compounds are emerged as potential therapeutic agents for NAFLD by PPARγ agonists. Although the results from preclinical studies are promising, further research is needed to determine the potential dosing and efficacy of mentioned compounds in human subjects. In this review, we summarize the effect of natural PPARγ agonist in the NAFLD.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2289830"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis. 泛素化组蛋白 H2A：表皮中的分子杰基尔与海德。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-17 DOI: 10.1080/21688370.2023.2236007
Lina Dagnino
{"title":"Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis.","authors":"Lina Dagnino","doi":"10.1080/21688370.2023.2236007","DOIUrl":"10.1080/21688370.2023.2236007","url":null,"abstract":"<p><p>The epidermis of the skin provides a barrier between the organism and the external environment. It is constantly subjected to physical and chemical insults, and thus susceptible to wounding and to neoplastic transformation. Long-lasting epigenetic modifications in epidermal stem cells are now shown to link responses to skin injuries with cell priming for carcinoma development, through regulation of histone H2A ubiquitylation.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2236007"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10203480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier. Sertoli 细胞对补体的调节可能有助于在血液-睾丸屏障内形成免疫保护环境。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-13 DOI: 10.1080/21688370.2023.2233385
Rachel L Washburn, Jannette M Dufour
{"title":"Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier.","authors":"Rachel L Washburn, Jannette M Dufour","doi":"10.1080/21688370.2023.2233385","DOIUrl":"10.1080/21688370.2023.2233385","url":null,"abstract":"<p><p>Sertoli cells are a crucial component of the blood-testis barrier (BTB), which isolates the adluminal compartment of the seminiferous tubules from the rest of the testis thus forming an environment to immunely protect the developing germ cells. The mechanisms of regulating immune responses within this environment are currently under investigation. Here, we focused on Sertoli cell regulation of the complement system.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2233385"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
You shall not pass: how complement C5 mediated antifungal immunity blocks systemic candidiasis and preserves renal tissue barriers. 你不应该通过：补体C5介导的抗真菌免疫如何阻断系统性念珠菌感染并保护肾组织屏障。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-10-04 DOI: 10.1080/21688370.2023.2257110
Dorrian G Cohen, Rebecca A Wingert
{"title":"You shall not pass: how complement C5 mediated antifungal immunity blocks systemic candidiasis and preserves renal tissue barriers.","authors":"Dorrian G Cohen, Rebecca A Wingert","doi":"10.1080/21688370.2023.2257110","DOIUrl":"10.1080/21688370.2023.2257110","url":null,"abstract":"<p><p>The rising prevalence of fungal infections is a significant and growing public health threat, and this risk is further underscored by our incomplete understanding of why organs like the kidney are so susceptible to systemic candidiasis. To combat the high mortality of such infections, we urgently need to advance our understanding of fungal pathogenesis and how it articulates with human immune response. Now, a recent landmark study has illuminated a crucial role of the complement system in the response to candidiasis and determined the stepwise local response of phagocytes within the kidney during infection. These fundamental discoveries provide crucial insights that can be leveraged to improve the care and outcome for patients with fungal infections.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2257110"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene expression profiles of neonatal porcine Sertoli cells at baseline and after incubation in normal human serum as determined by RNA sequencing. 通过 RNA 测序确定的基线和在正常人血清中培养后新生猪 Sertoli 细胞的基因表达谱。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-30 DOI: 10.1080/21688370.2023.2242060
Rachel L Washburn, Jannette M Dufour
{"title":"Gene expression profiles of neonatal porcine Sertoli cells at baseline and after incubation in normal human serum as determined by RNA sequencing.","authors":"Rachel L Washburn, Jannette M Dufour","doi":"10.1080/21688370.2023.2242060","DOIUrl":"10.1080/21688370.2023.2242060","url":null,"abstract":"<p><p>Sertoli cells are unique cells that contribute to the formation of the blood-testis barrier, which is important in sustaining the environment to promote spermatogenesis and to protect immunogenic germ cells from autoimmune destruction. This is achieved through tight junctions and production of regulatory immune factors. These Sertoli cell attributes make them a relevant model for various studies involving male reproduction, autoimmune protection, and even transplantation. RNA sequencing analyses were performed on baseline neonatal porcine Sertoli cells (NPSC) and NPSC after incubation in normal human serum for 90 minutes. We previously analyzed this data for immune-related factors, such as complement components, and for differentially expressed genes related to immune function. Still, these data sets provide insight into understanding how Sertoli cells create an immunoregulatory environment, which has applications in reproduction, transplantation, and autoimmunity.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2242060"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forever young by Alpha(diversity)ville: restricting intestinal microbiome maturation stunts immune system development and increases susceptibility to infection. 阿尔法(多样性)村永远年轻:限制肠道微生物群成熟阻碍免疫系统发育并增加对感染的易感性。
IF 4
Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-11-18 DOI: 10.1080/21688370.2023.2281209
Dorrian G Cohen, Rebecca A Wingert
{"title":"Forever young by Alpha(diversity)ville: restricting intestinal microbiome maturation stunts immune system development and increases susceptibility to infection.","authors":"Dorrian G Cohen, Rebecca A Wingert","doi":"10.1080/21688370.2023.2281209","DOIUrl":"10.1080/21688370.2023.2281209","url":null,"abstract":"<p><p>The microbiome is a keystone of adult gastrointestinal (GI) tract health, where it facilitates digestion, wards off pathogen colonization, and exerts a powerful influence on the physiological health of organs ranging from the brain to the kidneys. From its establishment at birth and through the initial years of childhood, the human microbiome is particularly dynamic, shifting in its composition and alpha (species) diversity to an adult profile as dietary sustenance transitions from milk-based sources to others such as solid food. An innovative study has now demonstrated how microbiome maturation is requisite both for the progression of immune system development and for long-term gut barrier function. These insights have significant ramifications for designing pediatric approaches to cultivate immune cell ontogeny in the formative stages of human infancy.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2281209"},"PeriodicalIF":4.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human in vitro blood barrier models: architectures and applications. 人体体外血液屏障模型：结构与应用。
IF 4
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-20 DOI: 10.1080/21688370.2023.2222628
Brittany E Watson, Julia A Miles, Melissa A Moss
{"title":"Human <i>in vitro</i> blood barrier models: architectures and applications.","authors":"Brittany E Watson, Julia A Miles, Melissa A Moss","doi":"10.1080/21688370.2023.2222628","DOIUrl":"10.1080/21688370.2023.2222628","url":null,"abstract":"<p><p>Blood barriers serve as key points of transport for essential molecules as well as lines of defense to protect against toxins. <i>In vitro</i> modeling of these barriers is common practice in the study of their physiology and related diseases. This review describes a common method of using an adaptable, low cost, semipermeable, suspended membrane to experimentally model three blood barriers in the human body: the blood-brain barrier (BBB), the gut-blood barrier (GBB), and the air-blood barrier (ABB). The GBB and ABB both protect from the outside environment, while the BBB protects the central nervous system from potential neurotoxic agents in the blood. These barriers share several commonalities, including the formation of tight junctions, polarized cellular monolayers, and circulatory system contact. Cell architectures used to mimic barrier anatomy as well as applications to study function, dysfunction, and response provide an overview of the versatility enabled by these cultural systems.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2222628"},"PeriodicalIF":4.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Models for barrier understanding in health and disease in lab-on-a-chips. 芯片实验室中了解健康和疾病障碍的模型。
IF 4
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-09 DOI: 10.1080/21688370.2023.2221632
J Ponmozhi, S Dhinakaran, Dorottya Kocsis, Kristóf Iván, Franciska Erdő
{"title":"Models for barrier understanding in health and disease in lab-on-a-chips.","authors":"J Ponmozhi, S Dhinakaran, Dorottya Kocsis, Kristóf Iván, Franciska Erdő","doi":"10.1080/21688370.2023.2221632","DOIUrl":"10.1080/21688370.2023.2221632","url":null,"abstract":"<p><p>The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exist to investigate barrier function in vivo and in vitro. To investigate barrier function in a highly reproducible manner, ethically, and high throughput, researchers have turned to non-animal techniques and micro-scale technologies. In this comprehensive review, the authors summarize the current applications of organ-on-a-chip microfluidic devices in the study of physiological barriers. The review covers the blood-brain barrier, ocular barriers, dermal barrier, respiratory barriers, intestinal, hepatobiliary, and renal/bladder barriers under both healthy and pathological conditions. The article then briefly presents placental/vaginal, and tumour/multi-organ barriers in organ-on-a-chip devices. Finally, the review discusses Computational Fluid Dynamics in microfluidic systems that integrate biological barriers. This article provides a concise yet informative overview of the current state-of-the-art in barrier studies using microfluidic devices.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2221632"},"PeriodicalIF":4.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells. 抑制折叠蛋白反应可增强 LPS 诱导的牛肺动脉内皮细胞屏障功能障碍和炎症。
IF 4
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-07-12 DOI: 10.1080/21688370.2023.2232245
Nektarios Barabutis, Mohammad S Akhter
{"title":"Unfolded protein response suppression potentiates LPS-induced barrier dysfunction and inflammation in bovine pulmonary artery endothelial cells.","authors":"Nektarios Barabutis, Mohammad S Akhter","doi":"10.1080/21688370.2023.2232245","DOIUrl":"10.1080/21688370.2023.2232245","url":null,"abstract":"<p><p>The development of novel strategies to counteract diseases related to barrier dysfunction is a priority, since sepsis and acute respiratory distress syndrome are still associated with high mortality rates. In the present study, we focus on the effects of the unfolded protein response suppressor (UPR) 4-Phenylbutyrate (4-PBA) in Lipopolysaccharides (LPS)-induced endothelial injury, to investigate the effects of that compound in the corresponding damage. 4-PBA suppressed binding immunoglobulin protein (BiP) - a UPR activation marker - and potentiated LPS - induced signal transducer and activator of transcription 3 (STAT3) and extracellular signal‑regulated protein kinase (ERK) 1/2 activation. In addition to those effects, 4-PBA enhanced paracellular hyperpermeability in inflamed bovine pulmonary endothelial cells, and did not affect cell viability in moderate concentrations. Our observations suggest that UPR suppression due to 4-PBA augments LPS-induced endothelial injury, as well as the corresponding barrier disruption.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2232245"},"PeriodicalIF":4.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers. 培养基和培养方式会改变猪结肠单层的细胞组成和屏障完整性。
IF 4
Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-21 DOI: 10.1080/21688370.2023.2222632
Alicia M Barnett, Jane A Mullaney, Warren C McNabb, Nicole C Roy
{"title":"Culture media and format alter cellular composition and barrier integrity of porcine colonoid-derived monolayers.","authors":"Alicia M Barnett, Jane A Mullaney, Warren C McNabb, Nicole C Roy","doi":"10.1080/21688370.2023.2222632","DOIUrl":"10.1080/21688370.2023.2222632","url":null,"abstract":"<p><p>Intestinal organoid technology has revolutionized our approach to <i>in vitro</i> cell culture due in part to their three-dimensional structures being more like the native tissue from which they were derived with respect to cellular composition and architecture. For this reason, organoids are becoming the new gold standard for undertaking intestinal epithelial cell research. Unfortunately, their otherwise advantageous three-dimensional geometry prevents easy access to the apical epithelium, which is a major limitation when studying interactions between dietary or microbial components and host tissues. To overcome this problem, we developed porcine colonoid-derived monolayers cultured on both permeable Transwell inserts and tissue culture treated polystyrene plates. We found that seeding density and culture format altered the expression of genes encoding markers of specific cell types (stem cells, colonocytes, goblets, and enteroendocrine cells), and barrier maturation (tight junctions). Additionally, we found that changes to the formulation of the culture medium altered the cellular composition of colonoids and of monolayers derived from them, resulting in cultures with an increasingly differentiated phenotype that was similar to that of their tissue of origin.</p>","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2222632"},"PeriodicalIF":4.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11042055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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