Tissue Barriers最新文献_第9页

Metformin-dependent variation of microglia phenotype dictates pericytes maturation under oxygen-glucose deprivation. 二甲双胍依赖性小胶质细胞表型的变化决定了氧-葡萄糖剥夺下周细胞的成熟。

IF 3.1

Tissue Barriers Pub Date : 2022-10-02 DOI: 10.1080/21688370.2021.2018928

Mohammad Hossein Geranmayeh, Reza Rahbarghazi, Nazli Saeedi, Mehdi Farhoudi

{"title":"Metformin-dependent variation of microglia phenotype dictates pericytes maturation under oxygen-glucose deprivation.","authors":"Mohammad Hossein Geranmayeh, Reza Rahbarghazi, Nazli Saeedi, Mehdi Farhoudi","doi":"10.1080/21688370.2021.2018928","DOIUrl":"https://doi.org/10.1080/21688370.2021.2018928","url":null,"abstract":"Blood-brain barrier resident cells are in the frontline of vascular diseases. To maintain brain tissue homeostasis, a series of cells are integrated regularly to form the neurovascular unit. It is thought that microglia can switch between M1/M2 phenotypes after the initiation of different pathologies. The existence of transition between maturity and stemness features in pericytes could maintain blood-brain barrier functionality against different pathologies. In the current study, the effect of metformin on the balance of the M1/M2 microglial phenotype under oxygen-glucose deprivation conditions and the impact of microglial phenotype changes on pericyte maturation have been explored. Both microglia and pericytes were isolated from the rat brain. Data showed that microglia treatment with metformin under glucose- and oxygen-free conditions suppressed microglia shifting into the M2 phenotype (CD206+ cells) compared to the control (p < .01) and metformin-treated groups (p < .05). Incubation of pericytes with microglia-conditioned media pretreated with metformin under glucose- and oxygen-free conditions or normal conditions increased pericyte maturity. These changes coincided with the reduction of the Sox2/NG2 ratio compared to the control pericytes (p < .05). Data revealed the close microglial-pericytic interplay under the ischemic and hypoxic conditions and the importance of microglial phenotype acquisition on pericyte maturation.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 4","pages":"2018928"},"PeriodicalIF":3.1,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9620990/pdf/KTIB_10_2018928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Biotherapeutic effect of cell-penetrating peptides against microbial agents: a review. 细胞穿透肽对微生物的生物治疗作用研究进展。

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-10-25 DOI: 10.1080/21688370.2021.1995285

Idris Zubairu Sadiq, Aliyu Muhammad, Sanusi Bello Mada, Bashiru Ibrahim, Umar Aliyu Umar

{"title":"Biotherapeutic effect of cell-penetrating peptides against microbial agents: a review.","authors":"Idris Zubairu Sadiq, Aliyu Muhammad, Sanusi Bello Mada, Bashiru Ibrahim, Umar Aliyu Umar","doi":"10.1080/21688370.2021.1995285","DOIUrl":"https://doi.org/10.1080/21688370.2021.1995285","url":null,"abstract":"Selective permeability of biological membranes represents a significant barrier to the delivery of therapeutic substances into both microorganisms and mammalian cells, restricting the access of drugs into intracellular pathogens. Cell-penetrating peptides usually 5-30 amino acids with the characteristic ability to penetrate biological membranes have emerged as promising antimicrobial agents for treating infections as well as an effective delivery modality for biological conjugates such as nucleic acids, drugs, vaccines, nanoparticles, and therapeutic antibodies. However, several factors such as antimicrobial resistance and poor drug delivery of the existing medications justify the urgent need for developing a new class of antimicrobials. Herein, we review cell-penetrating peptides (CPPs) used to treat microbial infections. Although these peptides are biologically active for infections, effective transduction into membranes and cargo transport, serum stability, and half-life must be improved for optimum functions and development of next-generation antimicrobial agents.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"1995285"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359368/pdf/KTIB_10_1995285.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions. 上皮完整性、连接复合物和与肠道功能相关的生物标志物。

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-10-30 DOI: 10.1080/21688370.2021.1996830

Arash Alizadeh, Peyman Akbari, Johan Garssen, Johanna Fink-Gremmels, Saskia Braber

{"title":"Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions.","authors":"Arash Alizadeh, Peyman Akbari, Johan Garssen, Johanna Fink-Gremmels, Saskia Braber","doi":"10.1080/21688370.2021.1996830","DOIUrl":"https://doi.org/10.1080/21688370.2021.1996830","url":null,"abstract":"An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the immune system and may result in chronic inflammation. The epithelial cells of the intestinal barrier are connected by tight junctions, which form an anastomosing network sealing adjacent epithelial cells. Tight junctions are composed of transmembrane and cytoplasmic scaffolding proteins. Transmembrane tight junction proteins at the apical-lateral membrane of the cell consist of occludin, claudins, junctional adhesion molecules, and tricellulin. Cytoplasmic scaffolding proteins, including zonula occludens, cingulin and afadin, provide a direct link between transmembrane tight junction proteins and the intracellular cytoskeleton. Each individual component of the tight junction network closely interacts with each other to form an efficient intestinal barrier. This review aims to describe the molecular structure of intestinal epithelial tight junction proteins and to characterize their organization and interaction. Moreover, clinically important biomarkers associated with impairment of gastrointestinal integrity are discussed.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"1996830"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/1a/KTIB_10_1996830.PMC9359365.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39844192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Bioinformatics analyses reveal cell-barrier junction modulations in lung epithelial cells on SARS-CoV-2 infection. 生物信息学分析揭示了SARS-CoV-2感染时肺上皮细胞的细胞屏障连接调节。

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-11-05 DOI: 10.1080/21688370.2021.2000300

Mir S Adil, Daulat Khulood, S Priya Narayanan, Payaningal R Somanath

{"title":"Bioinformatics analyses reveal cell-barrier junction modulations in lung epithelial cells on SARS-CoV-2 infection.","authors":"Mir S Adil, Daulat Khulood, S Priya Narayanan, Payaningal R Somanath","doi":"10.1080/21688370.2021.2000300","DOIUrl":"https://doi.org/10.1080/21688370.2021.2000300","url":null,"abstract":"Cell junctions maintain the blood-tissue barriers to preserve vascular and tissue integrity. Viral infections reportedly modulate cell-cell junctions to facilitate their invasion. However, information on the effect of COVID-19 infection on the gene expression of cell junction and cytoskeletal proteins is limited. Using the Gene Expression Omnibus and Reactome databases, we analyzed the data on human lung A549, NHBE, and Calu-3 cells for the expression changes in cell junction and cytoskeletal proteins by SARS-CoV-2 (CoV-2) infection. The analysis revealed changes in 3,660 genes in A549, 100 genes in NHBE, and 592 genes in Calu-3 cells with CoV-2 infection. Interestingly, EGOT (9.8-, 3- and 8.3-fold; p < .05) and CSF3 (4.3-, 33- and 56.3-fold; p < .05) were the only two genes significantly elevated in all three cell lines (A549, NHBE and Calu-3, respectively). On the other hand, 39 genes related to cell junctions and cytoskeleton were modulated in lung cells, with DLL1 demonstrating alterations in all cells. Alterations were also seen in several miRNAs associated with the cell junction and cytoskeleton genes modulated in the analysis. Further, matrix metalloproteinases involved in disease pathologies, including MMP-3, -9, and -12 demonstrated elevated expression on CoV-2 infection (p < .05). The study findings emphasize the integral role of cell junction and cytoskeletal genes in COVID-19, suggesting their therapeutic potential. Our analysis also identified a distinct EGOT gene that has not been previously implicated in COVID-19. Further studies on these newly identified genes and miRNAs could lead to advances in the pathogenesis and therapeutics of COVID-19.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"2000300"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359367/pdf/KTIB_10_2000300.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota. zonulin转基因小鼠表现出通过消耗肠道微生物群而改善的行为改变。

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-11-14 DOI: 10.1080/21688370.2021.2000299

Alba Miranda-Ribera, Gloria Serena, Jundi Liu, Alessio Fasano, Marcy A Kingsbury, Maria R Fiorentino

{"title":"The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota.","authors":"Alba Miranda-Ribera, Gloria Serena, Jundi Liu, Alessio Fasano, Marcy A Kingsbury, Maria R Fiorentino","doi":"10.1080/21688370.2021.2000299","DOIUrl":"https://doi.org/10.1080/21688370.2021.2000299","url":null,"abstract":"The gut-brain axis hypothesis suggests that interactions in the intestinal milieu are critically involved in regulating brain function. Several studies point to a gut-microbiota-brain connection linking an impaired intestinal barrier and altered gut microbiota composition to neurological disorders involving neuroinflammation. Increased gut permeability allows luminal antigens to cross the gut epithelium, and via the blood stream and an impaired blood-brain barrier (BBB) enters the brain impacting its function. Pre-haptoglobin 2 (pHP2), the precursor protein to mature HP2, is the first characterized member of the zonulin family of structurally related proteins. pHP 2 has been identified in humans as the thus far only endogenous regulator of epithelial and endothelial tight junctions (TJs). We have leveraged the Zonulin-transgenic mouse (Ztm) that expresses a murine pHP2 (zonulin) to determine the role of increased gut permeability and its synergy with a dysbiotic intestinal microbiota on brain function and behavior. Here we show that Ztm mice display sex-dependent behavioral abnormalities accompanied by altered gene expression of BBB TJs and increased expression of brain inflammatory genes. Antibiotic depletion of the gut microbiota in Ztm mice downregulated brain inflammatory markers ameliorating some anxiety-like behavior. Overall, we show that zonulin-dependent alterations in gut permeability and dysbiosis of the gut microbiota are associated with an altered BBB integrity, neuroinflammation, and behavioral changes that are partially ameliorated by microbiota depletion. Our results suggest the Ztm model as a tool for the study of the cross-talk between the microbiome/gut and the brain in the context of neurobehavioral/neuroinflammatory disorders.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"2000299"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359372/pdf/KTIB_10_2000299.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39875258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial. 金盏菊治疗手部急性伤口的随机试验。

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-10-21 DOI: 10.1080/21688370.2021.1994822

Giana Silveira Giostri, Eduardo Murilo Novak, Marcelo Buzzi, Luiz Cesar Guarita-Souza

{"title":"Treatment of acute wounds in hand with Calendula officinalis L.: A randomized trial.","authors":"Giana Silveira Giostri, Eduardo Murilo Novak, Marcelo Buzzi, Luiz Cesar Guarita-Souza","doi":"10.1080/21688370.2021.1994822","DOIUrl":"https://doi.org/10.1080/21688370.2021.1994822","url":null,"abstract":"Most injuries in the hand and fingers, especially on the digital pulps, are suited for healing by secondary intention. Nevertheless, delay in epithelization seems to unfavorably restrict this technique. The purpose of this controlled randomized clinical trial is to analyze by means of photo planimetry the progression of the healing process by secondary intention in acute wounds of the hand using the standardized extract of Calendula officinalis L. (SEC). The cohort of eligible participants included two groups of 20 patients with skin loss in the hand and fingers treated by secondary intention. Control group (CG) used mineral oil and intervention group (IG) received SEC. Wound pictures were captured at each outpatient assessment until epithelization was achieved and measured with ImageJ. Intervention group (IG) and control group (CG) with 19 wounds each, primarily formed by men in their 40's with wounds in their index and ring fingers on the left side, showed homogeneous variables and similar initial wound areas. Epithelization time was shorter and healing speed was faster in IG (IG = 8.6 ± 4.7 days and 9.5 ± 5.8%day versus CG = 13.2 ± 7.4 days and 6.2 ± 2.9%day, ƿ < 0.05), leading to the conclusion that healing by secondary intention in acute wounds of the hand and fingers with SEC led to a faster epithelization.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"1994822"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359387/pdf/KTIB_10_1994822.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39537598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Urinary IgG, serum CX3CL1 and miRNA-152-3p: as predictors of nephropathy in Egyptian type 2 diabetic patients. 尿IgG、血清CX3CL1和miRNA-152-3p:作为埃及2型糖尿病患者肾病的预测因子

IF 3.1

Tissue Barriers Pub Date : 2022-07-03 Epub Date: 2021-10-23 DOI: 10.1080/21688370.2021.1994823

Aml E Abdou, Haneya A A Anani, Hanan F Ibrahim, Eman Elshohat Ebrahem, Nora Seliem, Eman M I Youssef, Niveen M Ghoraba, Asmaa S Hassan, Marwa A A Ramadan, Eman Mahmoud, Shorouk Issa, Hend M Maghraby, Eman K Abdelrahman, Hala Ali Mohammed Hassan

{"title":"Urinary IgG, serum CX3CL1 and miRNA-152-3p: as predictors of nephropathy in Egyptian type 2 diabetic patients.","authors":"Aml E Abdou, Haneya A A Anani, Hanan F Ibrahim, Eman Elshohat Ebrahem, Nora Seliem, Eman M I Youssef, Niveen M Ghoraba, Asmaa S Hassan, Marwa A A Ramadan, Eman Mahmoud, Shorouk Issa, Hend M Maghraby, Eman K Abdelrahman, Hala Ali Mohammed Hassan","doi":"10.1080/21688370.2021.1994823","DOIUrl":"https://doi.org/10.1080/21688370.2021.1994823","url":null,"abstract":"The purpose of this study was to assess the role of urinary IgG, serum CX3CL1 and miRNA 152-3p levels as predictors of nephropathy in type 2 Egyptian diabetic patients. Sixty type 2 diabetic patients and twenty healthy controls were enrolled in a cross-sectional study. Then they were grouped into: three groups based upon urine albumin excretion (UAE). The expression of miRNA 152-3p in serum was measured using quantitative polymerase chain reaction (RTq-PCR). Serum CX3CL1 and urinary IgG concentrations were measured by ELISA. RTq-PCR revealed that serum miRNA-152-3p levels in patients were significantly higher than in controls. There was significant differences between group with normoalbuminuria and groups with diabetic nephropathy DN as regard to age, duration of nephropathy, Albumin/Creatinine ratio (A/C ratio), creatinine, urine IgG, CX3CL1 and HbA1c. In diabetic patients, there was a significant positive correlation between miRNA-152-3p levels and disease duration only as well as significant positive correlations between urinary IgG levels and age, disease duration, serum creatinine, A/C ratio, and urea. Positive correlation between serum fractalkine CX3CL1 level and age, duration of disease, urea, creatinine, A/C ratio, HbA1C and IgG in patient with DN. Serum CX3CL1 level, urinary IgG were significantly increased with the progress of nephropathy so these integrated biomarkers could be used as good predictors for early identification of nephropathy. But miRNA- 152-3p has inadequate prognostic indicator for ESRD progression.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 3","pages":"1994823"},"PeriodicalIF":3.1,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359404/pdf/KTIB_10_1994823.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39553925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model. MMP9在瘘管性CD患者肠瘘及人异种移植小鼠模型肠瘘中的表达。

IF 3.1

Tissue Barriers Pub Date : 2022-04-03 DOI: 10.1080/21688370.2021.1994350

Céline Mamie, Ramona S Bruckner, Silvia Lang, Nahum Y Shpigel, Matthias Turina, Andreas Rickenbacher, Daniela Cabalzar-Wondberg, Yolanda Chvatchko, Gerhard Rogler, Michael Scharl

{"title":"MMP9 expression in intestinal fistula from patients with fistulizing CD and from human xenograft mouse model.","authors":"Céline Mamie, Ramona S Bruckner, Silvia Lang, Nahum Y Shpigel, Matthias Turina, Andreas Rickenbacher, Daniela Cabalzar-Wondberg, Yolanda Chvatchko, Gerhard Rogler, Michael Scharl","doi":"10.1080/21688370.2021.1994350","DOIUrl":"https://doi.org/10.1080/21688370.2021.1994350","url":null,"abstract":"Fistula treatment represents a major unmet medical need in the therapy of Crohn's disease (CD). Current medical therapies, such as anti-TNF antibody treatments, are often insufficient and do not achieve permanent fistula closure. Previously published data point toward a critical role for metalloproteinase-9 (MMP-9)/gelatinase B in fistula pathogenesis. The aim of this project was to investigate in detail MMP-9 expression in different fistula types and to confirm that MMP-9 is a potential target for fistula therapy in CD patients.Immunohistochemistry for total and active MMP-9, Cytokeratin 8 (CK-8) and co-staining of active MMP-9/CK-8 was performed in specimen derived from perianal fistulas, entero-enteric fistulas and fistulas from patients not responding to anti-TNF therapy. In addition, fistulas from the xenograft mouse model (anti-TNF treated or untreated) were analyzed.Total and active MMP-9 protein was detectable in cells lining the tracts of perianal and entero-enteric fistulas. Of note, total and active MMP-9 was also expressed in fistulas of CD patients non-responding to anti-TNF treatment. Interestingly, we detected considerable co-staining of active MMP-9 and CK-8 in particular in cells lining the fistula tract and in transitional cells around the fistulas. Furthermore, total and active MMP-9 are detectable in both anti-TNF treated and untreated xenograft fistulas.Taken together, our data suggest that MMP-9 is involved in fistula pathogenesis in CD patients, in fistulas of different origins and particularly in patients non-responding to anti-TNF therapy. Our xenograft fistula model is suitable for in vivo studies investigating a possible therapeutic role for MMP-9 targeting as fistula therapy.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 2","pages":"1994350"},"PeriodicalIF":3.1,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067458/pdf/KTIB_10_1994350.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of connexins in breast cancer: from misregulated cell communication to aberrant intracellular signaling. 附件蛋白在乳腺癌中的作用：从失调的细胞通讯到异常的细胞内信号传导。

IF 3.6

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-08-06 DOI: 10.1080/21688370.2021.1962698

Yagmur Ceren Unal, Busra Yavuz, Engin Ozcivici, Gulistan Mese

{"title":"The role of connexins in breast cancer: from misregulated cell communication to aberrant intracellular signaling.","authors":"Yagmur Ceren Unal, Busra Yavuz, Engin Ozcivici, Gulistan Mese","doi":"10.1080/21688370.2021.1962698","DOIUrl":"10.1080/21688370.2021.1962698","url":null,"abstract":"In spite of clinical advancements and improved diagnostic techniques, breast cancers are the leading cause of cancer-associated deaths in women worldwide. Although 70% of early breast cancers can be cured, there are no efficient therapies against metastatic breast cancers. Several factors including connexins and gap junctions play roles in breast tumorigenesis. Connexins are critical for cellular processes as a linkage between connexin mutations and hereditary disorders demonstrated their importance for tissue homeostasis. Further, alterations in their expression, localization and channel activities were observed in many cancers including breast cancer. Both channel-dependent and independent functions of connexins were reported in initiation and progression of cancers. Unlike initial reports suggesting tumor suppressor functions, connexins and gap junctions have stage, context and isoform dependent effects in breast cancers similar to other cancers. In this review, we tried to describe the current understanding of connexins in tumorigenesis specifically in breast cancers.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 1","pages":"1962698"},"PeriodicalIF":3.6,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794248/pdf/KTIB_10_1962698.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39280983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials. 作为癌症治疗靶点的 Claudin-18.2：基础研究和临床试验的累积发现。

IF 3.1

Tissue Barriers Pub Date : 2022-01-02 Epub Date: 2021-09-05 DOI: 10.1080/21688370.2021.1967080

Daisuke Kyuno, Akira Takasawa, Kumi Takasawa, Yusuke Ono, Tomoyuki Aoyama, Kazufumi Magara, Yuna Nakamori, Ichiro Takemasa, Makoto Osanai

{"title":"Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials.","authors":"Daisuke Kyuno, Akira Takasawa, Kumi Takasawa, Yusuke Ono, Tomoyuki Aoyama, Kazufumi Magara, Yuna Nakamori, Ichiro Takemasa, Makoto Osanai","doi":"10.1080/21688370.2021.1967080","DOIUrl":"10.1080/21688370.2021.1967080","url":null,"abstract":"Claudins are major components of tight junctions that maintain cell polarity and intercellular adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic target. During carcinogenesis, claudin expression is generally downregulated; however, overexpression of claudin-18.2 has been observed in several types of cancers. Upregulated and mislocalized claudin-18.2 expression in cancer cells has been suggested as a therapeutic target. Research on claudin-18.2 has revealed its involvement in carcinogenesis. Clinical trials using zolbetuximab, a monoclonal antibody targeting claudin-18.2, for patients with advanced cancer yielded positive results with few high-grade adverse events; thus, it is expected to be a novel and effective therapeutic. Here, we review current insights into the role that claudin-18.2 plays in basic cancer research and clinical applications. A better understanding of these roles will facilitate the development of new treatment strategies for cancer patients with poor prognoses.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":"10 1","pages":"1967080"},"PeriodicalIF":3.1,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794250/pdf/KTIB_10_1967080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39387694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0