Tissue Barriers最新文献_第6页

The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs? 糖尿病对血液-组织屏障调节和血管并发症的影响：肺与其他器官是否不同？

IF 3.6

Tissue Barriers Pub Date : 2024-07-29 DOI: 10.1080/21688370.2024.2386183

Abdulaziz H Alanazi, Mohamed S Selim, Manyasreeprapti R Yendamuri, Duo Zhang, S Priya Narayanan, Payaningal R Somanath

{"title":"The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs?","authors":"Abdulaziz H Alanazi, Mohamed S Selim, Manyasreeprapti R Yendamuri, Duo Zhang, S Priya Narayanan, Payaningal R Somanath","doi":"10.1080/21688370.2024.2386183","DOIUrl":"https://doi.org/10.1080/21688370.2024.2386183","url":null,"abstract":"Diabetes Mellitus presents a formidable challenge as one of the most prevalent and complex chronic diseases, exerting significant strain on both patients and the world economy. It is recognized as a common comorbidity among severely ill individuals, often leading to a myriad of micro- and macro-vascular complications. Despite extensive research dissecting the pathophysiology and molecular mechanisms underlying vascular complications of diabetes, relatively little attention has been paid to potential lung-related complications. This review aims to illuminate the impact of diabetes on prevalent respiratory diseases, including chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), tuberculosis (TB), pneumonia infections, and asthma, and compare the vascular complications with other vascular beds. Additionally, we explore the primary mechanistic pathways contributing to these complications, such as the expression modulation of blood-tissue-barrier proteins, resulting in increased paracellular and transcellular permeability, and compromised immune responses rendering diabetes patients more susceptible to infections. The activation of inflammatory pathways leading to cellular injury and hastening the onset of these respiratory complications is also discussed.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2386183"},"PeriodicalIF":3.6,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canadine inhibits epithelial mesenchymal transformation of HPV-negative cervical cancer. Canadine抑制HPV-阴性宫颈癌症的上皮-间质转化。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-10-11 DOI: 10.1080/21688370.2023.2256641

Yan Ma, Qian-Qian Yang, Dong-Mei Gu, Xiao Yuan, Yu-Hong Wang, Ling-Chuan Guo

{"title":"Canadine inhibits epithelial mesenchymal transformation of HPV-negative cervical cancer.","authors":"Yan Ma, Qian-Qian Yang, Dong-Mei Gu, Xiao Yuan, Yu-Hong Wang, Ling-Chuan Guo","doi":"10.1080/21688370.2023.2256641","DOIUrl":"10.1080/21688370.2023.2256641","url":null,"abstract":"Although the majority of the population will be protected due to the advent and widespread use of the HPV vaccine, the treatment of cervical cancer for all causes, including HPV-negative cervical cancer, is still worthy of further research. The focal point of this study was Canadine's inhibition of epithelial-mesenchymal transformation (EMT) in cervical cancer. Immunoblotting, wound healing and tumor invasion experiments showed that low concentration of Canadine could inhibit the EMT process, proliferation and migration of HT-3 cells (HPV-negative cell line). Combined with GEO database, it was found that the expression levels of several genes highly expressed in cervical tumor tissues could be inhibited by Canadine, especially MAGEA3. Further experiments confirmed that the inhibition of Canadine on MAGEA3 protein increased with time. The small interference and overexpression plasmid of MAGEA3 were designed and verified. In HT-3 cells, when MAGEA3 levels were directly decreased, mesenchymal phenotypic markers were decreased and epithelial phenotypic markers were increased. The opposite result was obtained by overexpression of MAGEA3. In addition, the inhibition of EMT due to the reduction of endogenous MAGEA3 by Canadine was also offset by the overexpression of exogenous MAGEA3. The study concludes that Canadine inhibits EMT of cervical cancer by inhibiting MAGEA3.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2256641"},"PeriodicalIF":3.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41214120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD). 天然 PPARγ 激动剂对非酒精性脂肪肝（NAFLD）的治疗作用。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-12-05 DOI: 10.1080/21688370.2023.2289830

Swati Singh, Anit Kumar, Suruchi Gupta, Rohini Agrawal

引用次数: 0

You shall not pass: how complement C5 mediated antifungal immunity blocks systemic candidiasis and preserves renal tissue barriers. 你不应该通过：补体C5介导的抗真菌免疫如何阻断系统性念珠菌感染并保护肾组织屏障。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-10-04 DOI: 10.1080/21688370.2023.2257110

Dorrian G Cohen, Rebecca A Wingert

引用次数: 0

Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis. 泛素化组蛋白 H2A：表皮中的分子杰基尔与海德。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-17 DOI: 10.1080/21688370.2023.2236007

Lina Dagnino

引用次数: 0

Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier. Sertoli 细胞对补体的调节可能有助于在血液-睾丸屏障内形成免疫保护环境。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-13 DOI: 10.1080/21688370.2023.2233385

Rachel L Washburn, Jannette M Dufour

引用次数: 0

Gene expression profiles of neonatal porcine Sertoli cells at baseline and after incubation in normal human serum as determined by RNA sequencing. 通过 RNA 测序确定的基线和在正常人血清中培养后新生猪 Sertoli 细胞的基因表达谱。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-07-30 DOI: 10.1080/21688370.2023.2242060

Rachel L Washburn, Jannette M Dufour

引用次数: 0

Forever young by Alpha(diversity)ville: restricting intestinal microbiome maturation stunts immune system development and increases susceptibility to infection. 阿尔法(多样性)村永远年轻:限制肠道微生物群成熟阻碍免疫系统发育并增加对感染的易感性。

IF 3.6

Tissue Barriers Pub Date : 2024-07-02 Epub Date: 2023-11-18 DOI: 10.1080/21688370.2023.2281209

Dorrian G Cohen, Rebecca A Wingert

引用次数: 0

Potential of nutraceuticals in celiac disease. 营养保健品在乳糜泻中的潜力。

IF 3.6

Tissue Barriers Pub Date : 2024-06-30 DOI: 10.1080/21688370.2024.2374628

Mahtab Jahdkaran, Nastaran Asri, Hadi Esmaily, Mohammad Rostami-Nejad

{"title":"Potential of nutraceuticals in celiac disease.","authors":"Mahtab Jahdkaran, Nastaran Asri, Hadi Esmaily, Mohammad Rostami-Nejad","doi":"10.1080/21688370.2024.2374628","DOIUrl":"https://doi.org/10.1080/21688370.2024.2374628","url":null,"abstract":"Celiac Disease (CD) is the most common hereditarily-based food intolerance worldwide and a chronic inflammatory condition. The current standard treatment for CD involves strict observance and compliance with a gluten-free diet (GFD). However, maintaining a complete GFD poses challenges, necessitating the exploration of alternative therapeutic approaches. Nutraceuticals, bioactive products bridging nutrition and pharmaceuticals, have emerged as potential candidates to regulate pathways associated with CD and offer therapeutic benefits. Despite extensive research on nutraceuticals in various diseases, their role in CD has been relatively overlooked. This review proposes comprehensively assessing the potential of different nutraceuticals, including phytochemicals, fatty acids, vitamins, minerals, plant-based enzymes, and dietary amino acids, in managing CD. Nutraceuticals exhibit the ability to modulate crucial CD pathways, such as regulating gluten fragment accessibility and digestion, intestinal barrier function, downregulation of tissue transglutaminase (TG2), intestinal epithelial morphology, regulating innate and adaptive immune responses, inflammation, oxidative stress, and gut microbiota composition. However, further investigation is necessary to fully elucidate the underlying cellular and molecular mechanisms behind the therapeutic and prophylactic effects of nutraceuticals for CD. Emphasizing such research would contribute to future developments in CD therapies and interventions.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2374628"},"PeriodicalIF":3.6,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The roles of tight junction protein cingulin in human endometrioid endometrial cancer. 紧密连接蛋白cingulin在人类子宫内膜样内膜癌中的作用。

IF 3.1

Tissue Barriers Pub Date : 2024-06-02 DOI: 10.1080/21688370.2024.2361976

Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima

{"title":"The roles of tight junction protein cingulin in human endometrioid endometrial cancer.","authors":"Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, Takashi Kojima","doi":"10.1080/21688370.2024.2361976","DOIUrl":"https://doi.org/10.1080/21688370.2024.2361976","url":null,"abstract":"The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC). CGN as well as LSR decreased during the malignancy of endometrioid endometrial cancer (EEC). Although tTJ protein LSR is involved in the malignancy of some cancers, including EEC, the role of CGN is unknown. In this study, we investigated the roles of CGN with tTJ proteins in human EEC cells by using the CGN-overexpressing EEC cell line Sawano. In 2D cultures, CGN was colocalized with LSR and TRIC at tTJ or at γ-tubulin-positive centrosomes. In immunoprecipitation with CGN antibodies, CGN directly bound to LSR, TRIC, and β-tubulin. Knockdown of CGN by the siRNA decreased the epithelial barrier and enhanced cell proliferation, migration and invasion, as well as knockdown of LSR. In the Sawano cells cocultured with normal human endometrial stromal cells, knockdown of CGN decreased expression of LSR and TRIC via MAPK and AMPK pathways. In 2.5D cultures, knockdown of CGN induced the formation of abnormal cysts and increased the permeability of FD-4 to the lumen. In 2D and 2.5D cultures, treatment with β-estradiol with or without EGF or TGF-β decreased CGN expression and the epithelial permeability barrier and enhanced cell migration, and pretreatment with EW7197+AG1478, U0126 or an anti-IL-6 antibody prevented this. In conclusion, CGN, with tTJ proteins might suppress the malignancy of human EEC and its complex proteins are sensitive to estrogen and growth factors derived from stromal cells.","PeriodicalId":23469,"journal":{"name":"Tissue Barriers","volume":" ","pages":"2361976"},"PeriodicalIF":3.1,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0