探索脂肪酸在乳糜泻中的作用：潜在的治疗途径。

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Tissue Barriers Pub Date : 2024-12-03 DOI:10.1080/21688370.2024.2435552

Sajjad Bakhtiari, Nastaran Asri, Abdolrahim Nikzamir, Shokoufeh Ahmadipour, Mohammad Rostami-Nejad, Carolina Ciacci

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引用次数: 0

摘要

背景：脂肪酸（FAs）在乳糜泻（CD）炎症通路调节中起关键作用。本研究探讨了成人和儿童CD患者血清FAs水平与促炎性和抗炎性细胞因子表达的关系。方法：采用气相色谱法分析20例CD治疗患者（11例儿童，9例成人）和20例健康对照（10例儿童，10例成人）血清FA水平。实时荧光定量PCR检测细胞因子（IL-6、TNF-α、IL-10、IL-12、tgf - β、NF-κB）基因表达。结果：患有CD的儿童肉豆蔻烯酸水平下降（p = 0.03），而成人升高（p = 0.04）。IL-6 mRNA的表达在儿童组（p = 0.01）和成人组（p = 0.04）均有升高。TNF-α在成人中表达明显升高（p = 0.01）。在儿童中，IL-10 mRNA水平与棕榈酸呈正相关（p = 0.01, r = 0.73）， TGF-β与肉豆蔻烯酸呈正相关（p = 0.03, r = 0.63）。在成人中，IL-10与二同型γ -亚麻酸呈正相关（p = 0.04, r = 0.68），与亚油酸呈负相关（p = 0.02, r = -0.72）。这些与年龄相关的差异可能反映了疾病持续时间、代谢和发育因素、饮食摄入和肠道微生物群组成的变化。结论：这些发现提示FAs可能是改善不同年龄组CD管理的治疗靶点。

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Exploring fatty acid effects in celiac disease: potential therapeutic avenues.

Background: Fatty acids (FAs) play pivotal roles in modulating inflammatory pathways in celiac disease (CD). The present study explored the relationship between serum FAs levels and the expression of both pro- and anti-inflammatory cytokines in adult and pediatric patients with CD.

Methods: Serum FA levels in 20 treated CD patients (11 children, 9 adults) and 20 healthy controls (10 children, 10 adults) were analyzed using gas chromatography. Cytokine gene expression (IL-6, TNF-α, IL-10, IL-12, TGFβ, NF-κB) was assessed through quantitative real-time PCR.

Results: Myristoleic acid levels decreased in children with CD (p = 0.03) but increased in adults (p = 0.04). Elevated IL-6 mRNA expression was found in both pediatric (p = 0.01) and adult (p = 0.04) groups. TNF-α expression was significantly higher in adults (p = 0.01). In children, IL-10 mRNA levels positively correlated with palmitic acid (p = 0.01, r = 0.73), and TGF-β correlated with myristoleic acid (p = 0.03, r = 0.63). In adults, IL-10 positively correlated with dihomo-gamma-linolenic acid (p = 0.04, r = 0.68) and negatively with linoleic acid (p = 0.02, r = -0.72). These age-related differences may reflect variations in disease duration, metabolic and developmental factors, dietary intake, and gut microbiota composition.

Conclusion: These findings suggest that FAs could be therapeutic targets for improving CD management across different age groups.

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.