Urolithiasis最新文献

{"title":"Temporal trends and projections of urolithiasis in China and globally from 1990 to 2030: insights from the global burden of disease study 2021.","authors":"Jian Wu","doi":"10.1007/s00240-025-01790-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01790-5","url":null,"abstract":"<p><p>Urolithiasis is a prevalent urological condition that poses a significant public health challenge worldwide. This study investigates the impact of urolithiasis in China and globally between 1990 and 2021, with projections through 2030. Data on incidence and disability-adjusted life years (DALYs), along with age-standardized rates (ASR), were obtained from the Global Burden of Disease (GBD) 2021. Temporal trends were assessed by utilizing the Estimated Annual Percentage Change (EAPC) and Joinpoint regression analysis. Decomposition analyses were performed to assess the contributions of population growth, aging, and epidemiological changes. Future age-standardized incidence rates (ASIR) were forecast using the Auto-Regressive Integrated Moving Average (ARIMA) model. In 2021, the global number of urolithiasis cases reached 73.12 million, with China accounting for over 18 million. The condition primarily affects males and individuals aged 50-59 years. In both China and globally, the ASR of incidence and DALYs showed a downward trend from 1990 to 2021, with a more pronounced decline in China. However, the total number of incident cases continued to rise. Decomposition analysis revealed that population aging was a major contributor to the increase in cases in China, while global increases were largely driven by population growth. Projections from the ARIMA model indicate a slight further decrease in ASIRs by 2030 for both China and globally. These findings highlight the need for future efforts to focus on optimizing healthcare resources and strengthening primary prevention strategies to mitigate the public health impact of urolithiasis.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"118"},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in minimally invasive treatments for kidney stones: A bibliometric analysis (2015-2024).","authors":"Tunahan Ates, Ibrahim Halil Sukur, Fesih Ok, Mehmet Gurkan Arikan, Nebil Akdogan","doi":"10.1007/s00240-025-01785-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01785-2","url":null,"abstract":"<p><p>The prevalence of kidney stone disease has been increasing globally, resulting in a rise in minimally invasive treatment methods. Percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), extracorporeal shock wave lithotripsy (SWL), and endoscopic combined intrarenal surgery (ECIRS) have become standard procedures. This study aims to evaluate global publication trends in this field over the last decade. A bibliometric analysis was conducted using the Web of Science Core Collection database. A total of 3,693 articles published between 2015 and 2024 were analyzed. VOSviewer and Bibliometrix R package were used for data visualization, which included co-authorship networks, keyword co-occurrence analysis, and thematic evolution mapping. However, this analysis did not differentiate between various author roles, which may have influenced the perceived scientific impact of certain researchers, potentially favoring those with strong political or organizational affiliations. China, Turkey, and the USA were the top contributors to publications, with the USA ranking first in total citations. The number of studies has significantly increased over the past decade, indicating a growing trend. The most studied procedures were PCNL and related techniques, followed by RIRS, which has become more popular due to advancements in laser technology and flexible ureteroscopy. Thematic analysis identified trends in postoperative outcomes, complication management, and predictive models for treatment success. Thematic evolution mapping showed a decline in SWL studies, but an increase in interest in ECIRS and multimodal approaches. Minimally invasive kidney stone treatments have advanced significantly, with PCNL remaining the gold standard for large stones and RIRS emerging as a competitive alternative. Future research should focus on optimizing surgical outcomes, integrating AI-based decision support systems, and expanding international collaborations to enhance patient care.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"116"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"assessment of a novel bendable-tip ureteral access sheath with integrated suction: an in vitro study\".","authors":"Huacai Zhu, Jianhua Huang, Pengpeng Zhao, Zhanping Xu","doi":"10.1007/s00240-025-01787-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01787-0","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"115"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urologic training does not impact ability to accurately size kidney stone fragments.","authors":"Kelly Lehner, Jayson Kemble, Jamal Alamiri, Aaron Potretzke, Kevin Koo","doi":"10.1007/s00240-025-01780-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01780-7","url":null,"abstract":"<p><p>Accurate estimation of stone fragment size during ureteroscopy facilitates safe extraction. We aimed to determine whether training experience improves the accuracy of estimating fragment size. Six mock stones (range 1.2-7.4 mm) were placed in a renal model for simulated flexible ureteroscopy. Urology residents and high-volume ureteroscopy surgeons estimated fragment size and extractability through a 12/14-French sheath. Responses were compared among 3 training levels (PGY 1-2, PGY 3-5, and surgeons) and analyzed by objective measures of surgical experience and technical skill. Categorical and continuous variables were analyzed using ANOVA and Pearson correlation, respectively. 16 residents and 6 surgeons were included. Participants underestimated fragment size by 30% overall. As fragment size increased, the discrepancy between estimates and true size also increased. There was no statistical difference in accuracy among training groups and no association with experience or skill. Participants nearly always (98%) correctly identified < 4 mm fragments as extractable; in contrast, participants identified > 4 mm fragments as not extractable only 59% of the time. There was similarly no difference in predicting extraction by training level, experience, or skill. Both novice and experienced surgeons substantially underestimate fragment size during ureteroscopy, which may increase the risk of unsafe extraction. Technologies that enable real-time measurement may improve accuracy, regardless of surgeon experience.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"114"},"PeriodicalIF":2.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoroscopy- free modified RIRS in pediatric patients: evaluating safety, efficacy and methodological challenges.","authors":"Irem A Teke, K Serefhan Erten, O Serhat Gurocak, M Ozgur Tan","doi":"10.1007/s00240-025-01786-1","DOIUrl":"https://doi.org/10.1007/s00240-025-01786-1","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"113"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between clinical, biochemical, and nutritional factors in kidney stone formation and recurrence.","authors":"Kulsoom, Saleem Ahmad, Urwa, Irfan Ali Khan, Awais, Razvan Pricope, Bhavna Singla, Shivam Singla, Andreea Cazacu, Fatima Rahman, Valisher Sapayev Odilbek Uglu, Mukhayya Xusinovna Djumaniyazova, Zainab Saba, Wajahat Ali","doi":"10.1007/s00240-025-01784-3","DOIUrl":"https://doi.org/10.1007/s00240-025-01784-3","url":null,"abstract":"<p><p>This case-control study investigated the relationship between dietary habits and kidney stone development and recurrence at District Headquarters (DHQ) Hospital in Pakistan over a 12-month period. The study included 600 patients with a history of kidney stones and 50 healthy controls aged 18-65. Dietary patterns were evaluated using a 24-hour dietary recall and a semi-quantitative food frequency questionnaire (FFQ), with emphasis on oxalates, calcium, animal protein, fluid consumption, and other nutritional factors. Urinary and serum biomarkers-such as calcium, oxalate, citrate, sodium, potassium, pH, phosphate, magnesium, uric acid, and parathyroid hormone (PTH)-were also analyzed. Results indicated strong dietary links to kidney stone risk. Increased oxalate intake (*p* = 0.004), insufficient calcium consumption (*p* = 0.017), and high animal protein intake (*p* = 0.021) were significantly associated with stone formation. Elevated serum uric acid (> 6 mg/dL) was particularly linked to uric acid stones (*p* = 0.008). Urinary analysis revealed common abnormalities, including hyperoxaluria (80%), hypocitraturia (65%), and hypercalciuria (42%). Additionally, altered serum calcium and PTH levels in stone formers suggested secondary hyperparathyroidism as a potential contributing factor. Multivariate logistic regression identified several significant risk factors: high oxalate intake, low fluid consumption, hypocitraturia, and increased serum calcium and uric acid levels. These findings highlight the critical role of diet and metabolic factors in kidney stone formation and recurrence. Further studies are required to establish whether preventive strategies focusing on diet modification and biochemical management may help reduce the incidence and recurrence of kidney stones.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"112"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Mendelian randomization analysis and experimental investigation identifies the causal relationship between immunity and kidney stone disease.","authors":"Meng Gao, Minghui Liu, Liang Tang, Zewu Zhu, Hequn Chen, Tao Guo, Feng Zeng","doi":"10.1007/s00240-025-01782-5","DOIUrl":"https://doi.org/10.1007/s00240-025-01782-5","url":null,"abstract":"<p><p>This study investigated the causal relationship between immunity and kidney stone disease (KSD) by utilizing a Mendelian Randomization (MR) framework. We conducted a proteome-wide analysis to identify proteins associated with kidney stone disease risk using data from 4907 plasma proteins. Additionally, genetic instruments were employed to assess the impact of immune traits, including circulating inflammatory proteins, immune cell traits, immune-mediated diseases, and mRNA expression on kidney stone disease. Immunofluorescence staining was also performed to confirm gene expression patterns in kidney tissues affected by Randall's Plaque (RP). The results of the inverse variable weighting method showed that 174 plasma proteins were positively associated with KSD [ P < 0.05, odds ratio (OR) > 1]; 48 plasma proteins were negatively associated with KSD (P < 0.05, OR < 1). Subsequently, GO and KEGG analysis showed significant enrichment in immune pathways. Notably, elevated levels of inflammatory proteins such as CCL19 (OR per SD, 1.084; 95% CI = 1.006-1.167), OSM (OR per SD, 1.120; 95% CI = 1.023-1.227), and FGF5 (OR per SD, 1.077; 95% CI = 1.020-1.136) were associated with an increased risk of KSD. We also observed positive associations between 20 certain immune cell traits and KSD, while others 11 showed a negative correlation. Additionally, immune-mediated diseases, including psoriasis, Crohn's disease, and rheumatoid arthritis, were found to increase the risk of KSD (P < 0.05, OR > 1). Finally, summary-data-based MR analysis identified HLA-C, C4A and MICA as key immune system genes in blood and kidney eQTL data. Immunofluorescence staining verified the differential expression of HLA - C and C4A in clinical RP tissues.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"110"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of obesity, sarcopenia, and sarcopenic obesity with the risk of kidney stones in the U.S. Adult: results from NHANES 2011-2018.","authors":"Ruixiang He, Pei Li, Ye Lang, Bo Zhu, Xiaoyue Yang, Jiongming Li","doi":"10.1007/s00240-025-01783-4","DOIUrl":"https://doi.org/10.1007/s00240-025-01783-4","url":null,"abstract":"<p><p>Kidney stones (KS), a globally prevalent urological disorder, are linked to metabolic abnormalities and inflammation. Sarcopenia, characterized by progressive skeletal muscle loss and functional decline, frequently coexists with metabolic dysregulation. Sarcopenic obesity (SO), defined by reduced muscle mass and/or function combined with excessive adiposity, may synergistically exacerbate health risks beyond isolated sarcopenia or obesity. However, current studies investigating the relationship between obesity, sarcopenia, SO and KS are limited to single-factor analyses, with limited exploration of inflammatory mediation. This study aims to examine the associations of obesity, sarcopenia, and SO with KS, and for the first time, evaluate the mediating effects of inflammatory biomarkers within these relationships. A total of 10, 043 participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) were included. Obesity was defined by body mass index and sarcopenia was assessed using the appendicular muscle index (AMI). SO was defined as the coexistence of sarcopenia and obesity. KS was identified through responses to the \"Kidney Conditions-Urology\" questionnaire. Weighted multivariable-adjusted logistic regression was used to evaluate the correlation between obesity, sarcopenia, SO and the risk of KS. Mediation models were constructed to assess the mediating role of inflammatory biomarkers. In the U.S. adult population, the prevalence of obesity, sarcopenia, and SO were 35.68%, 7.19%, and 5.27%, respectively. Among the population included in this study, the incidence rates of KS among individuals with obesity, sarcopenia, and SO were 9.77%, 10.92%, and 11.95%, respectively. Multiple regression analysis demonstrated significant independent positive associations between all three body composition disorders and KS incidence after comprehensive adjustment for potential confounding variables. Mediation analyses revealed that neutrophil mediated 11.38% (P = 0.0100), 13.60% (P = 0.0200), and 15.55% (P = 0.0120) of the potential effects of obesity, sarcopenia, and SO on KS formation, respectively. Obesity, sarcopenia, and SO were all positively associated with KS risk in U.S. adults. Neutrophil plays a critical mediating role in the relationship between obesity, sarcopenia, SO and KS.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"111"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-arginine role for stone lower ureter: A randomized controlled trial.","authors":"Ahmed Mahmoud Mohammed Ahmed Elsherief, Ahmed Mahmoud Riyad, Emad Abdellah Ali, Amr Alam-Eldin Ahmed, Hassan Ali Gad, Ahmed Mamdouh Abd Elhameid","doi":"10.1007/s00240-025-01768-3","DOIUrl":"10.1007/s00240-025-01768-3","url":null,"abstract":"<p><p>This study aims to evaluate the effects of L-arginine 1000 mg once daily as a medical expulsive therapy (MET) for lower ureteral stones. This prospective, randomized controlled study was conducted on 162 patients with ureteral stones; 9 patients were excluded due to loss to follow-up, and the remaining 153 patients were divided into three groups. Group I (control) included 51 patients who received a placebo. Group II included 51 patients who received 1000 mg of L-arginine once daily. Group III included 51 patients who received tamsulosin 0.4 mg once daily. There was a highly statistically significant difference between the studied groups regarding ultrasound (U/S) and plain urinary tract (PUT) findings after 4 weeks. Spontaneous stone expulsion rates (SER) in the control, L-arginine, and tamsulosin groups were 6 (11.8%), 48 (94.1%), and 16 (31.4%), respectively (p < 0.001). The mean ± SD of stone expulsion time in the control, L-arginine, and tamsulosin groups was 19.6 ± 5.85, 19.02 ± 5, and 20.58 ± 5.78 days, respectively (p < 0.001). There was no statistically significant difference between the groups regarding the number of daily colic episodes and total analgesic dosage required. However, a statistically significant difference was noted regarding stone density and hydronephrosis. It is concluded that L-arginine is more effective than tamsulosin in increasing the SER and reducing stone expulsion time, with better pain control, making it a safe and effective MET for ureteral stones.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"109"},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative changes of blood routine in daytime transurethral ureteroscopic laser lithotripsy and construction of a risk prediction model for delayed discharge.","authors":"Huadi Yuan, Liyan Gao, Lina Chou, Zhazha Lin, Jiarong Sun, Hao Zhang, Wenjun Gao, Bohan Wang","doi":"10.1007/s00240-025-01770-9","DOIUrl":"10.1007/s00240-025-01770-9","url":null,"abstract":"<p><p>Day surgery is critical for efficient healthcare delivery, but delayed discharge remains a key quality metric. This study investigates perioperative blood index changes during transurethral ureteroscopic laser lithotripsy (TULL) and constructs a risk prediction model for delayed discharge. A retrospective analysis of 526 TULL day surgery patients (2017-2021) compared normal (n = 412) and delayed discharge groups (n = 114). Blood indicators (WBC, Hb, Lymph#, Mono#, Neut#, Eos#) and clinical variables were analyzed. Logistic regression and ROC curves evaluated predictive factors. Delayed discharge was linked to longer operation time (OR = 1.024) and higher urine WBC (OR = 1.001), while Mono# showed protective effects (OR = 0.127). The model achieved an AUC of 0.710 (95% CI: 0.637-0.787), with strong calibration. The model enables early identification of high-risk patients, guiding interventions to reduce delayed discharge and improve day surgery management.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"108"},"PeriodicalIF":2.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}