Urolithiasis最新文献_第2页

Commentary on:'' ultrasound versus fluoroscopy-guided extracorporeal shockwave lithotripsy in renal calculi: a systematic review and meta-analysis''.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-25 DOI: 10.1007/s00240-025-01731-2

Yalong Zhang, Kangyu Wang, Li Yang

引用次数: 0

Understanding the clinical genetics of kidney stone disease using the Natera Renasight panel. 使用 Natera Renasight 面板了解肾结石病的临床遗传学。

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-24 DOI: 10.1007/s00240-025-01723-2

Andrewe L Baca, Rutul D Patel, Kevin Labagnara, Benjamin Green, Michael Zhu, Kavita Gupta, Beth Edelblute, Andrea A Asencio, Deep Sharma, Wei Chen, Dima Raskolnikov, Jillian Donnelly, Kara L Watts, Alexander C Small

{"title":"Understanding the clinical genetics of kidney stone disease using the Natera Renasight panel.","authors":"Andrewe L Baca, Rutul D Patel, Kevin Labagnara, Benjamin Green, Michael Zhu, Kavita Gupta, Beth Edelblute, Andrea A Asencio, Deep Sharma, Wei Chen, Dima Raskolnikov, Jillian Donnelly, Kara L Watts, Alexander C Small","doi":"10.1007/s00240-025-01723-2","DOIUrl":"10.1007/s00240-025-01723-2","url":null,"abstract":"We aimed to characterize the underlying genetics of kidney stone disease (KSD) in an urban and diverse population using the Natera Renasight genetic panel. This was a single-center prospective study of high-risk KSD patients, defined as recurrent stone formers or those with a family history with KSD. Buccal saliva DNA samples were collected with the commercially available Natera Renasight genetic panel and were analyzed using next-generation sequencing. The panel assesses 385 kidney disease related genes, including 45 linked to KSD. One hundred eleven high-risk KSD patients were enrolled. The majority were female (56%) with a median age of 50 (IQR 39.5-59.5), compromising a diverse ethnic background with 62% Hispanic, 23% White and 11% Black. Patients had median 3 (IQR 2-5) lifetime stone episodes, and 41% had family history of KSD. Genetic analysis was possible for 105 patients (95%). Eight (8%) had positive tests with only one patient found to have a pathogenic mutation associated with KSD (SLC7A9, cystinuria). The other 7 positive tests included amyloidosis (TTR, N = 3), Alport syndrome (COL4A3, N = 2), polycystic kidney disease (PKD1, N = 1), and susceptibility to ESRD (APOL1, N = 1). Patients with positive tests were more likely to have chronic kidney disease (38% vs 5%, p < 0.01), gout (13% vs 1%, p = 0.02) and carbonate apatite stones (38% vs 7%, p < 0.01). Our study sheds light on genetic factors of KSD in a diverse patient population. The results suggest that KSD is unlikely monogenetic in nature, but is more likely due to a complex interplay of polygenetic and environmental influences. Genetic testing may be most useful in KSD patients with chronic kidney disease.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"57"},"PeriodicalIF":2.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective evaluation of efficacy, safety, cumulative laser energy, and stone-free rates in the post-market SOLTIVE^™ SuperPulsed laser system registry: insights from team of worldwide endourological researchers' (T.O.W.E.R.) research consortium.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-23 DOI: 10.1007/s00240-025-01720-5

Ben H Chew, Victor K F Wong, Mitchell R Humphreys, Wilson Molina, Bodo Knudsen, Mantu Gupta, Duane D Baldwin, Peter Kronenberg, Palle Osther, Olivier Traxer

{"title":"Prospective evaluation of efficacy, safety, cumulative laser energy, and stone-free rates in the post-market SOLTIVE™ SuperPulsed laser system registry: insights from team of worldwide endourological researchers' (T.O.W.E.R.) research consortium.","authors":"Ben H Chew, Victor K F Wong, Mitchell R Humphreys, Wilson Molina, Bodo Knudsen, Mantu Gupta, Duane D Baldwin, Peter Kronenberg, Palle Osther, Olivier Traxer","doi":"10.1007/s00240-025-01720-5","DOIUrl":"10.1007/s00240-025-01720-5","url":null,"abstract":"The Thulium fiber laser (TFL) is a relatively new tool for endoscopic laser lithotripsy. The Endourological Society's T.O.W.E.R. registry sought to evaluate the stone-free rate (SFR) at 3 months following URS. A subset of the study sought to determine the association between cumulative TFL energy and SFRs. 423 patients with planned ureteroscopic lithotripsy using TFL (SOLTIVE™, Gyrus ACMI, Inc. d/b/a Olympus Surgical Technologies America) were prospectively enrolled between December 2020 and May 2023 at nine international sites. Baseline clinical characteristics and SFR data for kidney and ureteral stones were separately analyzed according to quartile cumulative TFL energy ranges. Median patient age was 58.0 (IQR: 44-67) years and maximal stone diameters were 9.9 (IQR: 7-12.9) mm and 7.4 (IQR 6.1-9.4) mm for kidney and ureteral stones, respectively. Overall SFR (no fragments) for renal and ureteral stones were 73.0% and 85.7% at 3-months. Cumulative energy levels were divided into quartiles and lower SFRs were observed with the highest quartile for kidney stones (p = 0.001), but not in ureteral stones. This correlated with kidney stone size as larger stones required more energy. The rate of adverse events related to the procedure was 1.9% (8/423). Higher stone burdens had lower stone free rates and required more cumulative laser energy. The TFL is effective in endoscopic lithotripsy. This post-marketing survey demonstrates that TFL is a safe and effective tool for endoscopic laser lithotripsy.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"56"},"PeriodicalIF":2.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of methylene blue-assisted tract visualization in ultrasound-guided percutaneous nephrolithotomy: a salvage technique for failed renal access.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-23 DOI: 10.1007/s00240-025-01728-x

Amir Hossein Hassani, Hooman Kamran, Abdolreza Haghpanah

{"title":"Efficacy of methylene blue-assisted tract visualization in ultrasound-guided percutaneous nephrolithotomy: a salvage technique for failed renal access.","authors":"Amir Hossein Hassani, Hooman Kamran, Abdolreza Haghpanah","doi":"10.1007/s00240-025-01728-x","DOIUrl":"https://doi.org/10.1007/s00240-025-01728-x","url":null,"abstract":"We propose using methylene blue with ultrasound-guided percutaneous nephrolithotomy (US-PCNL) as a salvage method when ultrasonography access is challenging, to prevent the necessity of creating a new tract or access failure. We retrospectively evaluated adult patients who underwent US-PCNL over two years by a single surgeon. Patients were divided into two groups based on methylene blue usage. In cases with challenging renal access, diluted methylene blue was injected via the ureteral catheter, and the nephroscope was used to locate the parenchymal defect by visualizing the blue area. Among 120 patients, 34 (28.3%) required methylene blue for renal access. Recurrent stones (70.6% vs. 47.7%; p-value: 0.023) and previous PCNL (41.2% vs. 18.6%; p-value: 0.010) were more common in these patients. All achieved successful access with a single tract. Although access time (median: 235 vs. 160 s; p-value: < 0.001) and operative duration (median: 90 vs. 85 min; p-value: 0.023) were statistically longer when methylene blue was used, the differences were not clinically significant. Analgesic use, hospital stay, hemoglobin drop, and creatinine rise were similar between groups. Stone-free rates after the first session were 50.0% with methylene blue and 57.0% without it (p-value: 0.489). Residual stone rates requiring ancillary procedures were higher when methylene blue was needed (20.6% vs. 9.4%), but the difference was not statistically significant (p-value: 0.126). Complication rates were similar between the groups. Methylene blue injection into the ureteral catheter is a safe and effective procedure for US-PCNL, reducing access failure and the need for new tracts.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"55"},"PeriodicalIF":2.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model. 香兰素在乙二醇诱导的高草酸大鼠模型中的抗尿石症活性

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-21 DOI: 10.1007/s00240-025-01733-0

Aslam Khan, Sara Salim, Syed Muzzammil Masaud, Ashfaq Ahmad, Muhammad Furqan Akhtar, Safur Rehman Mandukhail

{"title":"Antiurolithic activity of vanillin in ethylene glycol-induced hyperoxaluric rat model.","authors":"Aslam Khan, Sara Salim, Syed Muzzammil Masaud, Ashfaq Ahmad, Muhammad Furqan Akhtar, Safur Rehman Mandukhail","doi":"10.1007/s00240-025-01733-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01733-0","url":null,"abstract":"Vanillin, a natural compound derived from vanilla beans, exhibits antioxidant and anti-inflammatory properties, which may contribute to the prevention and treatment of renal stones. Therefore, this study is aimed to investigate the potential antiurolithic effect of vanillin in male hyperoxaluric Wistar rats. Computational molecular docking studies were used to investigate the interaction process and verify vanillin's role in the prevention of kidney stones containing calcium oxalate. Software tools were utilized to analyze the drug ligands' additional molecular characteristics, absorption, distribution, metabolism, and excretion (ADME), and toxicity. Urinary crystals were induced in rats by adding 0.75% ethylene glycol (EG) in drinking water for 3 weeks, along with 1% ammonium chloride (AC) during the initial three days. Molecular docking analysis revealed strong binding interactions of vanillin with Human CTP: Phosphoethanolamine Cytidylyltransferase (PDB ID: 3ELB) at the C5P binding site, with a binding affinity of -7.6 kcal/mol, suggesting a potential molecular basis for its antiurolithic activity. In vivo study showed that vanillin treatment dose dependently (30, 100 and 300 mg/kg body weight) reduced hyperoxaluria, hypercalciuria and crystal counts in kidneys of hyperoxaluric rats. The current results of our study suggest that vanillin possesses potential antiurolithic activity, showing enhanced therapeutic effects in urolithiasis, which could be a safe, effective and non-invasive option in modern medicine for the management of urinary stones.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"54"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence and relationship of dysbiosis in the urinary microbiota on patients with urolithiasis.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-19 DOI: 10.1007/s00240-025-01724-1

Hsiang-Ying Lee, Chung Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Sung Yong Cho, Deng-Chyang Wu

{"title":"The influence and relationship of dysbiosis in the urinary microbiota on patients with urolithiasis.","authors":"Hsiang-Ying Lee, Chung Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Sung Yong Cho, Deng-Chyang Wu","doi":"10.1007/s00240-025-01724-1","DOIUrl":"https://doi.org/10.1007/s00240-025-01724-1","url":null,"abstract":"Urolithiasis is a disease with high prevalence and recurrence rate. There are various risk factors impacting on stone formation including intestinal micorbiota. This study aims to investigate the relationship between urine microbiota with urolithiasis. We collected mid-stream voided urine samples from urolithiasis patients and control participants and stored them in a freezer at - 80 °C. All enrolled participants were requested to provide information about their clinical characteristics. The procedure included the extraction of the genomic DNA from the urine samples; the amplification by polymerase chain reaction (PCR); PCR product quantification, mixing, and purification; DNA library preparation; and sequencing was performed with quality control (QC) measures. Alpha diversity was indicative of the species complexity within individual urine samples, and beta diversity analysis was used to evaluate the differences among the samples in terms of species complexity. We enrolled 28 urolithiasis patients and 59 control participants who reported no recent antibiotic usage. In the beta diversity analysis, there was a significant difference between the microbiota in the samples of the urolithiasis and control groups according to ANOSIM statistical analysis. (P = 0.004). On comparing the groups, it showed Alcaligenes, Bacteroides, Blautia, Ruminococcaceae_UCG, Cutibacterium, Alistipes, Lachnoclostridium present more significant in control group than urolithiasis patients. In conclusion, our current study shows that dysbiosis of urine microbiota may be related to the development of urolithiasis. Further research targeting specific microbes to identify their role in the development of diseases is necessary and might provide novel diagnostic biomarkers and therapeutic options.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"53"},"PeriodicalIF":2.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Oxybutynin Chloride Extended-Release tablets on the double-J stent related symptoms following uncomplicated ureteroscopic lithotripsy.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-15 DOI: 10.1007/s00240-025-01725-0

Kuo-How Huang, Tsung-Yi Hsieh, Po-Ming Chow, Yuan-Ju Lee, Hsu-Che Huang, I-Ni Chiang, Teng-Kai Yang

{"title":"A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Oxybutynin Chloride Extended-Release tablets on the double-J stent related symptoms following uncomplicated ureteroscopic lithotripsy.","authors":"Kuo-How Huang, Tsung-Yi Hsieh, Po-Ming Chow, Yuan-Ju Lee, Hsu-Che Huang, I-Ni Chiang, Teng-Kai Yang","doi":"10.1007/s00240-025-01725-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01725-0","url":null,"abstract":"To evaluate the effects of Oxybutynin Chloride Extended-Release Tablets (Oxbu) on double-J stent-related symptoms following uncomplicated ureterosocpic lithotripsy (URSL). This is a double-blind, randomized, placebo-controlled study with a total of 120 subjects with ureteral calculi receiving double-J stent insertion following URSL. Subjects who meet the inclusion and exclusion criteria will be randomly assigned to Oxbu or placebo group. All patients completed a structured questionnaire assessing the stent-related symptoms one week after operation. The clinical data and stent characteristics were recorded as well. The severity of stent-related symptoms was compared between two groups. The mean age were 58.2 years both in Oxbu group and control group, and the demographic data were all comparable between the two groups. Oxbu group had significant improvement for stent related pain score (-0.47 points, P < 0.01) and quality of life score (-0.17 points, P < 0.01) compared to the control group. The male subgroup showed that Oxbu had less urgency item score (-0.59 points, P < 0.05). The subgroup analysis for female showed that Oxbu had more decrease in the intermittency item score (-0.89 points, P = 0.043) and aged < 50 showed Oxbu had more decrease in Overactive Bladder Symptoms Score total score and urgency item score (-0.8 and - 0.6 points, all P < 0.05). This study showed that Oxbu decreases the severity of double-J stent related pain and the quality of life score for patients received URSL. In the IPSS and OABSS item, the intermittency and urgency are improved in the Oxbu group. In conclusion, Oxbu treatment had beneficial effects to improve the severity of stent related symptoms.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"52"},"PeriodicalIF":2.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to Editor: Enhancing lithotripsy efficiency in retrograde intrarenal surgery via a flexible kidney-fixed position: findings from a prospective cohort study.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-12 DOI: 10.1007/s00240-025-01721-4

Sigen Huang, Jian Liu, Lizhong Fu, Zhengbin Zhu, Guoming Yuan, Jianbin Luo

引用次数: 0

Rutin ameliorates calcium oxalate crystal-induced kidney injury through anti-oxidative stress and modulation of intestinal flora.

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-10 DOI: 10.1007/s00240-025-01726-z

Haoyu Zhang, Huixuan Yang, Sha Du, Jiaxin Ren, Guofeng Qiao, Jie Ren

{"title":"Rutin ameliorates calcium oxalate crystal-induced kidney injury through anti-oxidative stress and modulation of intestinal flora.","authors":"Haoyu Zhang, Huixuan Yang, Sha Du, Jiaxin Ren, Guofeng Qiao, Jie Ren","doi":"10.1007/s00240-025-01726-z","DOIUrl":"https://doi.org/10.1007/s00240-025-01726-z","url":null,"abstract":"Kidney stones are a common urological disease. Although there are many ways to treat them, their high recurrence rate remains unresolved. Research has demonstrated that Lysimachia christinae Hance influences kidney stone development; however, the exact mechanism remains unclear. In this experiment, we investigated the protective effect of Lysimachia christinae Hance extract, rutin, on renal injury and its mechanism of action in a mouse model of glyoxalate-induced renal calculi. A kidney stone model was established in Balb/c mice by continuous intraperitoneal injection of glyoxalate (80 mg/kg) for 6 days. Simultaneous gavage of 30, and 60 mg/kg of rutin was administered for 6 days. Samples were collected for determination of index coefficients. Mouse kidney tissue was collected for RNA-seq, and segments of mouse colon were analyzed with 16 S RNA sequencing. We found that rutin significantly reduced renal calcium oxalate deposition and renal tissue injury in the glyoxylate-induced kidney stone model of mice. Rutin also significantly inhibited calcium oxalate deposition-induced apoptosis. In addition, rutin attenuates oxidative stress damage and inhibits the expression of signaling pathways associated with inflammation. 16 S RNA sequencing revealed that rutin regulated intestinal flora composition, significantly increasing the relative abundance of short-chain fatty acid-producing flora and promoting short-chain fatty acid production. In summary, rutin ameliorated renal tubular damage and apoptosis caused by renal stone deposition and reduced oxidative stress. It also regulates the intestinal flora, increases the enrichment of intestinal probiotics, and promotes the production of short-chain fatty acids, thereby inhibiting the formation of kidney stones.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"50"},"PeriodicalIF":2.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "ureteral access sheath or percutaneous nephrostomy during flexible ureteroscopy: which is better?"

IF 2 2区医学

Urolithiasis Pub Date : 2025-03-10 DOI: 10.1007/s00240-025-01722-3

Hao Xu, Shuangying Zhang, Yuxuan Song

引用次数: 0