Urolithiasis最新文献

Trace element signatures and regional differences in kidney stones: insights from a high-prevalence region. 微量元素特征和肾结石的地区差异：来自高患病率地区的见解。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-10-09 DOI: 10.1007/s00240-025-01868-0

Wenqian Sun, Guilin Han, Chaochun Fu, Di Wang, Siyu Wang, Ziyang Ding

{"title":"Trace element signatures and regional differences in kidney stones: insights from a high-prevalence region.","authors":"Wenqian Sun, Guilin Han, Chaochun Fu, Di Wang, Siyu Wang, Ziyang Ding","doi":"10.1007/s00240-025-01868-0","DOIUrl":"https://doi.org/10.1007/s00240-025-01868-0","url":null,"abstract":"The global rise in urolithiasis poses significant health risks. However, the formation mechanisms and environmental influences of kidney stones remain poorly understood. Investigating the elemental composition of kidney stones provides a critical approach to exploring these factors. This study analyzed kidney stones from Yunnan Province, a region with high nephrolithiasis prevalence, classifying them into three types: calcium oxalate (CO), uric acid (UA), and mixed CO and carbonate apatite (CA) stones. The long-term accumulation of calcium salts results in significantly higher concentrations of Ca, Zn, and Se in calcium stones compared to the crustal average. The concentrations of most elements in UA stones are generally lower than those in calcium stones. Mg, Zn, and Sr show significant correlations with multiple elements and inhibit stone crystallization, whereas Cu and Se appear to act only in apatite-containing stones. Additionally, the heavy metal characteristics of kidney stones exhibit notable regional differences. Kidney stones from Yunnan show significantly lower Zn and Sr levels than those from other regions, displaying unique geochemical features influenced by regional environmental and dietary factors. The heavy metal characteristics of kidney stones in Yunnan elucidate the mechanistic roles of individual elements and their associated environmental influences.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"190"},"PeriodicalIF":2.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of nephrostomy tube removal: intraoperative removal or postoperative day 1 removal. 取管时机：术中取管或术后第1天取管。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-10-09 DOI: 10.1007/s00240-025-01869-z

Huacai Zhu, Yuan Mai, Wei Wei, Zhanping Xu

引用次数: 0

Correction: Advancing the evidence base in extracorporeal shock wave lithotripsy: the need for consensus outcomes and standardized reporting. 更正：推进体外冲击波碎石的证据基础：需要共识结果和标准化报告。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-10-06 DOI: 10.1007/s00240-025-01846-6

Mohammed Ramadhan, Mohammad Alzaid, Tarek Benzouak, Arthur Braga, Fadl Hamouche, Ahmad Almarzouq

引用次数: 0

Retrograde intrarenal surgery for treatment of stones in congenital anomalous kidneys: a case-matched comparative study with extracorporeal shockwave lithotripsy. 逆行肾内手术治疗先天性异常肾结石：与体外冲击波碎石的病例对照研究。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-10-06 DOI: 10.1007/s00240-025-01860-8

Abul-Fotouh Ahmed, Mahmoud ElMesery, Mohamed Algammal, Abdullah Daoud, Ahmed Solyman, Ahmed Mosaad

引用次数: 0

Comment on "The association between frailty index and all-cause mortality in US individuals with kidney stones: mediation by systemic immune-inflammation (SII) index". 评论“美国肾结石患者虚弱指数与全因死亡率之间的关系：由全身免疫炎症（SII）指数介导”。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01864-4

Wenjian Li

引用次数: 0

Global, regional, and National lifetime risks of developing and dying from urolithiasis: a population-based systematic analysis from 1990 to 2021. 全球、地区和国家尿石症发生和死亡的终生风险：1990年至2021年基于人群的系统分析

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01858-2

Yongming Chen, Wenshuang Li, Yuhao Li, Huimin Hou, Lingfeng Li, Miao Wang, Shengfeng Wang, Ming Liu

{"title":"Global, regional, and National lifetime risks of developing and dying from urolithiasis: a population-based systematic analysis from 1990 to 2021.","authors":"Yongming Chen, Wenshuang Li, Yuhao Li, Huimin Hou, Lingfeng Li, Miao Wang, Shengfeng Wang, Ming Liu","doi":"10.1007/s00240-025-01858-2","DOIUrl":"https://doi.org/10.1007/s00240-025-01858-2","url":null,"abstract":"Urolithiasis is a common condition worldwide, marked by significant variations in lifetime risk across different regions, genders, and socioeconomic backgrounds. Understanding these disparities is crucial for developing effective public health strategies. This study aims to analyze these risks from 1990 to 2021 and project future trends in the incidence and mortality of urolithiasis. Data were obtained from the Global Burden of Disease (GBD) 2021 study, which provides comprehensive estimates on urolithiasis incidence, prevalence, and mortality across various demographics. Analyses were stratified by gender, age, Sociodemographic Index (SDI), and geographic regions, and included assessments of temporal trends and concentration indices (CIs). Additionally, AutoRegressive Integrated Moving Average (ARIMA) models were employed to project future trends regarding the lifetime risk of developing urolithiasis.The global lifetime risk of developing urolithiasis in 2021 was estimated at 62.95%, with the highest risks observed in Eastern Europe (89.20%), Southern Latin America (80.34%), and Central Asia (75.75%). Men exhibited a higher risk than women (70.40% vs. 50.34%). The global mortality risk from urolithiasis remained low at 0.03%, with the highest rates found in High-income Asia Pacific (0.07%) and Eastern Europe (0.06%). Notably, the lifetime risk of developing urolithiasis declined with advancing age, particularly after 40. ARIMA projections suggest a moderate increase in lifetime risk, potentially reaching nearly 70% by 2050, especially among females. Urolithiasis demonstrates significant global and regional disparities influenced by socioeconomic, environmental, and demographic factors. Comprehensive strategies that address these disparities will be essential for enhancing public health outcomes and reducing the incidence of urolithiasis worldwide.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"186"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: "Advancing decision-making in shock wave lithotripsy for upper ureteral stones: the role of radiological stone impaction markers". 致编辑的信：“推进输尿管上段结石冲击波碎石的决策：放射性结石嵌塞标记物的作用”。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01863-5

Ahmet Burak Yilmaz, Altug Tuncel

引用次数: 0

Commentary on "to investigate the effects of surgical position on intrarenal pressure and intrarenal temperature during retrograde intrarenal flexible ureteroscopic lithotripsy: an in vitro model". 关于“研究手术体位对逆行肾内输尿管镜碎石术中肾内压力和温度的影响：体外模型”的评论。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01832-y

Leela Kumaran, Sheifali Gupta

引用次数: 0

Variants of unknown significance are common in brushite stone formers undergoing genetic testing for nephrolithiasis. 不明意义的变异在进行肾结石基因检测的刷石结石患者中很常见。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01859-1

Tomas Paneque, Kyle Berst, Meenakshi Sambharia, Melissa Swee, Mycah Kimble, M Adela Mansilla, Margaret Freese, Christie P Thomas, Chad R Tracy, Ryan L Steinberg

{"title":"Variants of unknown significance are common in brushite stone formers undergoing genetic testing for nephrolithiasis.","authors":"Tomas Paneque, Kyle Berst, Meenakshi Sambharia, Melissa Swee, Mycah Kimble, M Adela Mansilla, Margaret Freese, Christie P Thomas, Chad R Tracy, Ryan L Steinberg","doi":"10.1007/s00240-025-01859-1","DOIUrl":"10.1007/s00240-025-01859-1","url":null,"abstract":"Up to 40% of all kidney stone disease may have an underlying genetic contribution. Brushite stone formers are known to have high rates of stone recurrence and urine chemistry abnormalities, suggesting a possible intrinsic kidney abnormality which may contribute to brushite stone formation. In this study, we sought to determine the burden of genetic variants amongst brushite stone formers. An IRB approved prospective study of brushite stone formers was conducted. Patients with any brushite on stone analysis were eligible for enrollment. Genetic testing was done on peripheral blood derived DNA and assessed using a clinically available nephrolithiasis gene panel. Primary analysis assessed rates of genetic variants amongst brushite stone formers. Secondary analysis assessed for distinct patterns in urine chemistries in different genotypes. 15 patients (8 males) with a median age of 32 years (range 22-69) underwent genetic testing. 12 patients (80%) were reported to have a genetic variant, with 6 (40%) having multiple variants. Two patients had a heterozygous pathogenic or likely pathogenic variant in a gene that causes autosomal recessive disease. 9 (60%) patients had a variant of unknown significance. 10 (67%) patients had genetic variants associated with hypophosphatemic rickets. Genetic variants of unknown significance are common in brushite stone formers. Further work is needed to assess the significance of these variants and their role in the lithogenic process.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"183"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the use of a ureteral access sheath improve perioperative outcomes in ureteroscopy? A real-world multi-institutional study. 输尿管导管鞘的使用是否能改善输尿管镜围手术期的预后？一个真实世界的多机构研究。

IF 2.2 2区医学

Urolithiasis Pub Date : 2025-09-29 DOI: 10.1007/s00240-025-01865-3

Abdel Bakayoko, Céline Mardelli, Hugo Dupuis, Louis Surlemont, Kevin Saout, Héloïse Ducousso, Hubert Bugel, Sofiane Seddik, Xavier Tillou, Karim Bensalah, Zine-Eddine Khene

{"title":"Does the use of a ureteral access sheath improve perioperative outcomes in ureteroscopy? A real-world multi-institutional study.","authors":"Abdel Bakayoko, Céline Mardelli, Hugo Dupuis, Louis Surlemont, Kevin Saout, Héloïse Ducousso, Hubert Bugel, Sofiane Seddik, Xavier Tillou, Karim Bensalah, Zine-Eddine Khene","doi":"10.1007/s00240-025-01865-3","DOIUrl":"10.1007/s00240-025-01865-3","url":null,"abstract":"Retrograde intrarenal surgery (RIRS) is commonly performed with a ureteral access sheath (UAS). Our objective was to evaluate the impact of UAS use in patients undergoing RIRS for renal stones. We conducted a retrospective, multicenter cohort study of all patients who underwent RIRS for kidney stones between January 2017 and December 2018 at six academic medical centers. Patients were stratified according to UAS use. To adjust for baseline differences, we applied inverse probability of treatment weighting (IPTW), a propensity score-based method that balances covariates between groups. A total of 1,177 patients were included: 740 (62.8%) underwent RIRS with a UAS and 437 (37.2%) without. After adjustment, adequate balance was achieved between groups. In IPTW analysis, the stone-free rate (SFR) at three months was comparable between groups (OR = 0.75; 95% CI [0.53-1.08]; p = 0.12). UAS use was associated with longer operative time (estimate = 3.71 min; 95% CI [1.08-7.32]; p = 0.04), lower probability of outpatient procedure (OR = 0.67; 95% CI [0.49-0.91]; p = 0.01), and higher likelihood of postoperative stenting (OR = 3.61; 95% CI [2.72-4.78]; p < 0.001). There were no significant differences in overall complications (OR = 1.16; 95% CI [0.68-1.99]; p = 0.57) or major complications (OR = 1.07; 95% CI [0.45-2.57]; p = 0.86). In this large multicenter retrospective study, UAS use during RIRS was associated with a similar stone-free rate but increased perioperative morbidity. These real-world findings suggest that routine UAS use may not always be necessary, although randomized controlled trials are required to define its role more definitively.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"182"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0