Urolithiasis最新文献

{"title":"Prediction of infectious complications after supine percutaneous nephrolithotomy: development and internal validation of a multivariable nomogram.","authors":"María Elena Martínez-Corral, Rocío Martínez-Corral, Daniel A Pérez-Fentes","doi":"10.1007/s00240-026-02000-6","DOIUrl":"https://doi.org/10.1007/s00240-026-02000-6","url":null,"abstract":"<p><p>To identify independent predictors of postoperative infectious complications following supine percutaneous nephrolithotomy (PCNL) and to develop and internally validate a predictive nomogram for individualized risk stratification. A prospective cohort study was performed including 906 renal units undergoing supine PCNL at a single tertiary referral center between October 2008 and December 2025. Patients were categorized into two groups according to postoperative infectious outcomes: those without infection (n = 804) and those with infection (n = 102), defined by the occurrence of postoperative fever or urosepsis. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of infectious complications. Based on these predictors, a nomogram was developed, and its performance was assessed in terms of discrimination using the area under the receiver operating characteristic curve (AUC) and calibration using calibration plots. Multivariable logistic regression analysis identified five independent predictors of postoperative infectious complications after PCNL: positive preoperative urine culture (OR 7.07; p < 0.001), multiple surgical steps (OR 1.82; p = 0.049), multiple percutaneous accesses (OR 4.25; p = 0.001), standard-caliber percutaneous tracts (OR 1.80; p = 0.019) and prolonged operative time (OR 1.01; p = 0.032). The resulting nomogram demonstrated good discriminatory performance (AUC = 0.805) and adequate calibration. Postoperative infectious complications after supine PCNL appear to result from the interplay between preoperative urinary infection and intraoperative procedural complexity, with positive urine culture emerging as the strongest predictor. The proposed nomogram enables individualized risk stratification and may support perioperative decision-making aimed at reducing infectious morbidity.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting thermal safety in comparative laser lithotripsy studies.","authors":"Zhihui Li, Lei Wang, Dongxiang Zheng","doi":"10.1007/s00240-026-02003-3","DOIUrl":"https://doi.org/10.1007/s00240-026-02003-3","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where does endogenous oxalate come from? - a systematic review of endogenous sources of urinary oxalate.","authors":"Brian Dick, Jorge Mena, Marshall Stoller","doi":"10.1007/s00240-026-01995-2","DOIUrl":"10.1007/s00240-026-01995-2","url":null,"abstract":"<p><p>Oxalate is a toxic waste product in humans, capable of complexing with calcium to form kidney stones. While some oxalate is consumed in the diet, there are endogenous sources in humans. This review compiles known endogenous sources of urinary oxalate. PubMed and Embase databases were searched, as well as backward citations, for relevant articles published in English. The search strategy relied on terms related to endogenous synthesis and metabolic tracing. Title/abstract review was performed, and articles were excluded from full review if they did not report data on human sources of endogenous oxalate. Risk of bias was assessed using a modified JBI checklist. Weighted averaging was used to combine results and predict endogenous oxalate production. Of 228 unique articles identified, 23 were eligible and included in this study. Total endogenous oxalate production was reported by 7 of the papers, representing 305 healthy subjects. Weighted mean of endogenous oxalate production was 23.8 mg/day (95% CI 23-24.6 mg/day) with a range of 17-34 mg/day. Daily turnover from the metabolic pool of ascorbic acid may account for up to 40% - 60% of total endogenous oxalate production. Other contributors include hydroxyproline (~ 15%), glycine (< 10%), and glycolate (~ 4%). Phenylalanine (< 0.7%), and fructose (negligible) contribute minimally. This review highlights that daily turnover from the metabolic pool of ascorbic acid is the primary source of endogenous oxalate. However, current estimates rely on highly variable data dating back nearly 70 years. Future research using modern metabolomics is required to re-characterize this pathway.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"A computational model for predicting shock in patients at risk of urosepsis after urolithiasis surgery\".","authors":"Lei Wang, Zhiui Li, Liang Zhong, Dongxiang Zheng","doi":"10.1007/s00240-026-01997-0","DOIUrl":"https://doi.org/10.1007/s00240-026-01997-0","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Development of a machine learning model for predicting urosepsis after ureteroscopic lithotripsy\".","authors":"Madhuri Tribhuvan, Shashikant N Phatke","doi":"10.1007/s00240-026-01996-1","DOIUrl":"https://doi.org/10.1007/s00240-026-01996-1","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance analysis and real-world adverse event profile (safety signals and product-related issues) of potassium citrate: a US FDA adverse event reporting system (FAERS) based analysis.","authors":"Rifat Burak Ergül, Ismail Taha Gürlek, Yasin Yitgin, Seyda Gül Ozcan, M Fırat Özervarlı, Serdar Turan, Samed Verep, Samet Şenel, Arda Atar, Muratcan Kiremit, Amelia Pietropaolo, M İlker Gökçe, Bhaskar Somani, Kemal Sarica, Tzevat Tefik","doi":"10.1007/s00240-026-01989-0","DOIUrl":"10.1007/s00240-026-01989-0","url":null,"abstract":"<p><p>Potassium citrate is widely used as oral alkali therapy for the prevention of recurrent nephrolithiasis. Despite its long-standing clinical use, systematically collected real-world safety data remain limited. We performed a pharmacovigilance analysis to characterize adverse event reports associated with potassium citrate using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). FAERS reports submitted between 2014 and 2025 listing potassium citrate as the primary suspect drug were analyzed. Duplicate records were removed, and adverse events were coded using the Medical Dictionary for Regulatory Activities (MedDRA) at both the system organ class and standardized event term levels (preferred terms, PTs). Disproportionality analyses were conducted using reporting odds ratio, proportional reporting ratio, bayesian confidence propagation neural network, and multi-item gamma poisson shrinker methods. A total of 408 unique reports were included. Most reports involved adults and were physician-reported from the United States. Disproportionality analysis identified potential safety issues (signals), defined as drug event associations reported more frequently than expected in FAERS and therefore warranting further evaluation, although not establishing causality. The strongest associations involved product-related issues, laboratory investigations, and gastrointestinal disorders. When these potential safety issues were described using standardized MedDRA event terms most reflected formulation- and administration-related problems, including tablet residue in stool, abnormal solubility, swallowing difficulty, throat irritation, and foreign body sensations. Reports of rash were infrequent. This first FAERS-based analysis of potassium citrate highlights that most reported adverse events are related to formulation and administration characteristics rather than drug toxicity. These findings support the overall tolerability of potassium citrate while underscoring the importance of adherence, patient education, and formulation-specific considerations in clinical practice. As a spontaneous reporting system, FAERS is valuable for hypothesis generation, label expansion, and post-marketing surveillance, but it is not suitable for estimating the incidence or absolute risk of adverse events.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO blood group distribution in patients with upper urinary tract stones: a case-control study.","authors":"Emrullah Durmus, Mehmet Sevim, Fesih Ok","doi":"10.1007/s00240-026-01998-z","DOIUrl":"https://doi.org/10.1007/s00240-026-01998-z","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the Role of Sampaio Pelvicalyceal Variants in Supine Mini-PCNL: Insights and Challenges.","authors":"Yaojun Zhou","doi":"10.1007/s00240-026-01992-5","DOIUrl":"https://doi.org/10.1007/s00240-026-01992-5","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining triage models in renal colic: methodological considerations.","authors":"Linjie Li, Zhijie Jiang, Shiqi Yang, Ge Wang, Jingsong Mou, Fei Gao","doi":"10.1007/s00240-026-01994-3","DOIUrl":"https://doi.org/10.1007/s00240-026-01994-3","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association between the C-reactive protein-to-albumin-to-lymphocyte (CALLY) index and kidney stones in US adults: a population-based study.","authors":"Jiaqing Yang, Jingliang Cao, Ai-Ping Nie, Qian Yuan, Qian Cheng, Kaihong Wang","doi":"10.1007/s00240-026-01991-6","DOIUrl":"https://doi.org/10.1007/s00240-026-01991-6","url":null,"abstract":"","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"54 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}