Urolithiasis最新文献_第10页

Comment on "predictors and associations of complications in ureteroscopy for stone disease using AI: outcomes from the FLEXOR registry". 对“人工智能用于结石疾病输尿管镜检查并发症的预测因素和关联：来自FLEXOR登记的结果”的评论。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-30 DOI: 10.1007/s00240-025-01777-2

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Disruptions in Tiopronin therapy: impacts on clinical outcomes of pediatric cystinuria patients during the COVID-19 pandemic. 硫普罗宁治疗中断：对COVID-19大流行期间儿童胱氨酸尿病患者临床结局的影响

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-30 DOI: 10.1007/s00240-025-01767-4

Hülya Gözde Önal, Hülya Nalçacioğlu, Demet Tekcan Karali, Meltem Necibe Ceyhan Bilgici, Ozlem Aydog, Ozan Özkaya, Ender Özdem, Saban Sarikaya

{"title":"Disruptions in Tiopronin therapy: impacts on clinical outcomes of pediatric cystinuria patients during the COVID-19 pandemic.","authors":"Hülya Gözde Önal, Hülya Nalçacioğlu, Demet Tekcan Karali, Meltem Necibe Ceyhan Bilgici, Ozlem Aydog, Ozan Özkaya, Ender Özdem, Saban Sarikaya","doi":"10.1007/s00240-025-01767-4","DOIUrl":"10.1007/s00240-025-01767-4","url":null,"abstract":"Cystinuria, characterized by defective renal absorption of cystine causing recurrent nephrolithiasis, demands ongoing management. This study examines the effects of COVID-19-related disruptions in tiopronin availability on the clinical outcomes of pediatric cystinuria patients. This retrospective cohort study analyzed medical records of 11 pediatric patients with cystinuria, followed from 2001 to 2023. Patients were diagnosed using urine microscopy/biochemistry and stone composition analysis. Clinical outcomes, including renal function and stone status, were assessed using serial ultrasonographic evaluations and 24-hour urinary cystine measurements. At diagnosis, the median age was 13 months, and 63.6% were female. Acute kidney injury was observed in 36.4% of patients, with 27.3% requiring emergency dialysis. The interruption of tiopronin treatment led to significant renal function deterioration and increased stone burden, as evidenced by an increase in the median number of kidney stones from 2 (IQR: 1-3) to 4 (IQR: 2-5, p = 0.045) and a rise in 24-hour urinary cystine levels from 286 mg/1.73 m² (IQR: 82-552.5) to 434 mg/1.73 m² (IQR: 198-854, p = 0.043). Data prior to the interruption showed a median glomerular filtration rate (GFR) of 80.4 mL/min/1.73 m² and creatinine levels of 2.47 mg/dL. After resuming tiopronin, there was a notable improvement to a median GFR of 161 mL/min/1.73 m² and creatinine levels of 0.48 mg/dL. Managing cystinuria during the pandemic underscored the critical role of continuous access to medications like tiopronin in preventing renal deterioration. Developing strategies to ensure an uninterrupted drug supply during global health emergencies is crucial for managing chronic conditions such as cystinuria.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"103"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Origin of monosodium urate Randall's plaques. 尿酸钠兰德尔斑块的起源。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-27 DOI: 10.1007/s00240-025-01743-y

Els Van de Perre, Elise Maréchal, Karl Martin Wissing, Jean-Philippe Haymann, Michel Daudon, Emmanuel Letavernier

{"title":"Origin of monosodium urate Randall's plaques.","authors":"Els Van de Perre, Elise Maréchal, Karl Martin Wissing, Jean-Philippe Haymann, Michel Daudon, Emmanuel Letavernier","doi":"10.1007/s00240-025-01743-y","DOIUrl":"https://doi.org/10.1007/s00240-025-01743-y","url":null,"abstract":"In 3.4% of Randall's plaques, monosodium urate can be detected. The formation mechanism of these Randall's plaques is unrevealed and the clinical and biochemical characteristics of affected patients are unknown. In this single centre study, we retrospectively analysed the clinical and biochemical characteristics of patients with kidney stone formation related to monosodium urate-containing Randall's plaques (NaUr pos RP) and those with stone formation related to \"classical\" Randall's plaques (NaUr neg RP). There was a significantly higher urinary calcium and magnesium excretion in the NaUr neg RP group (6.09 vs. 4.61 mmol/24 h, p = 0.03 and 4.78 vs. 3.55 mmol/24 h, p = 0.02). There was no significant difference in urinary uric acid excretion or urinary pH between both groups. The NaUr pos RP group tended to have more frequent hyperuricemia (71.4 vs. 44.8%, p = 0.08) and to be more frequently male (92.9 vs. 70.1%, p = 0.10) and had higher median age (53.5 vs. 27.5, p < 0.001) and serum creatinine (96.4 vs. 77.0 µmol/L, p < 0.001). Additionally, there was a signal of higher prevalences of hypertension, dyslipidemia, cardiovascular disease and gout in the NaUr pos RP group. Different formation mechanisms seem implicated in the formation of NaUr pos RP and NaUr neg RP - associated kidney stones. We hypothesize a mechanism of interstitial monosodium urate precipitation at the renal papilla driven by high systemic uric acid serum concentration to be involved in NaUr pos RP formation. Treatment with xanthine oxidase inhibitors may reduce the risk of recurrent stone formation on this specific Randall's plaque.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"99"},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UreteroPyeloVisClear catheter: a new frontier in ureteroscopic lithotripsy for ureteral stones. 输尿管静脉透明导尿管：输尿管镜碎石治疗输尿管结石的新前沿。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-24 DOI: 10.1007/s00240-025-01769-2

Chen Yang, Huang Haiwen, Zeng Xue, Ding Tianfu, Lin Shen, Xiao Bo, Li Jianxing

{"title":"UreteroPyeloVisClear catheter: a new frontier in ureteroscopic lithotripsy for ureteral stones.","authors":"Chen Yang, Huang Haiwen, Zeng Xue, Ding Tianfu, Lin Shen, Xiao Bo, Li Jianxing","doi":"10.1007/s00240-025-01769-2","DOIUrl":"10.1007/s00240-025-01769-2","url":null,"abstract":"Conventional semirigid ureteroscopy for ureteral stones faces challenges such as stone retropulsion, poor intraoperative vision, and elevated intrarenal pressure. This study evaluates the safety and efficacy of a novel multi-channel negative pressure suction catheter (UreteroPyeloVisClear Catheter, VCC) in ureteroscopic lithotripsy. To compare the performance of VCC with conventional rigid ureteroscopy, this study evaluated operative time, stone clearance rates, and complication incidence between VCC and traditional semirigid ureteroscopy. A prospective cohort study included 42 patients with ureteral stones (diameter ≤ 2.0 cm), randomized into VCC (n = 21) and traditional (n = 21) groups. The VCC group utilized an integrated negative pressure suction and active water circulation system, while the traditional group used standard semirigid ureteroscopy. The primary outcome was operative time, with secondary outcomes including stone clearance rates, retropulsion incidence, basket utilization, and complication rates. The VCC group demonstrated significantly shorter operative time (39.95 ± 10.24 vs. 53.00 ± 26.95 min, p = 0.001) and reduced basket utilization (5% vs. 57%, p < 0.001). Stone retropulsion rates were lower in the VCC group (5% vs. 14%, p = 0.294), though not statistically significant. Both groups achieved 100% stone-free rates at 1 month. Postoperative pain scores (VCC: 0.90 ± 1.36 vs. traditional: 1.24 ± 1.49) and complication rates (0% vs. 5%) showed no significant differences. The VCC significantly reduces operative time and reliance on auxiliary instruments while maintaining safety and stone-free outcomes. Its innovative design addresses key limitations of traditional ureteroscopy, offering a promising advancement for ureteral stone management.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"97"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser lithotripsy of a brushite crystalline aggregate stone model: fragment distribution vs. BegoStone and human stones. 电刷石晶体骨料模型的激光碎石：碎片分布vs. BegoStone和人石。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-24 DOI: 10.1007/s00240-025-01771-8

Leilane Glienke, John W Robinson, Timothy L Hall, Khurshid R Ghani, Adam J Matzger, William W Roberts

{"title":"Laser lithotripsy of a brushite crystalline aggregate stone model: fragment distribution vs. BegoStone and human stones.","authors":"Leilane Glienke, John W Robinson, Timothy L Hall, Khurshid R Ghani, Adam J Matzger, William W Roberts","doi":"10.1007/s00240-025-01771-8","DOIUrl":"10.1007/s00240-025-01771-8","url":null,"abstract":"Laser research is hampered by a lack of accurate stone models that replicate fragmentation during laser lithotripsy. We sought to assess the distribution of stone fragments from laser ablation of new brushite crystalline powder and brushite crystalline aggregate stone models and compare with human stones and BegoStone. Samples of 15:3 and 15:5 BegoStone, powder, and aggregate model stones were tested alongside human CHPD and COM stone samples. All samples were secured and hydrated before Ho: YAG laser energy was delivered (Lumenis P120H) using a 200-micron D/F/L fiber. Lithotripsy was performed by repeatedly translating the fiber automatically through a predetermined grid of points (MATLAB program) until > 50% of each sample was ablated. Fragments were separated by sieving. For each stone type, 70.2-96.9% of the mass of fragments consisted of particles smaller than 0.25 mm. The percentage by mass of fragments greater than 1 mm in trials with 0.8 J x 10 Hz settings was 0.5%, 0.0%, 1.1% and 5.1% for BegoStone 15:3, BegoStone 15:5, powder model, and aggregate model respectively, compared to 5.5% for CHPD and 16.2% for COM. Only the aggregate model, CHPD and COM samples produced fragments > 2 mm. The new aggregate model stone better replicates the fragment distribution of human stones after laser lithotripsy. The method of producing the aggregate model stone - incorporating crystal and chemical components found in urinary stones - holds promise for developing better stone models needed to address a range of important lithotripsy research questions.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"98"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive performance of Triple-D, Quadruple-D, and Mayo adhesive probability scores in ESWL for renal stones: a retrospective cohort study. 肾结石ESWL中3d、4d和Mayo粘连概率评分的预测性能：一项回顾性队列研究。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-22 DOI: 10.1007/s00240-025-01765-6

Osman Murat Ipek, Erdinc Dincer, Ahmet Halil Sevinc, Burcu Hanci Sevinc, Cengiz Canakci, Orkunt Ozkaptan

{"title":"Predictive performance of Triple-D, Quadruple-D, and Mayo adhesive probability scores in ESWL for renal stones: a retrospective cohort study.","authors":"Osman Murat Ipek, Erdinc Dincer, Ahmet Halil Sevinc, Burcu Hanci Sevinc, Cengiz Canakci, Orkunt Ozkaptan","doi":"10.1007/s00240-025-01765-6","DOIUrl":"10.1007/s00240-025-01765-6","url":null,"abstract":"This study aimed to compare the predictive performance of Triple-D, Quadruple-D, and Mayo Adhesive Probability (MAP) scoring systems in estimating stone-free (SF) status following extracorporeal shock wave lithotripsy (ESWL) in patients with renal stones. This retrospective cohort study was conducted on patients who underwent ESWL between January 2020 and January 2024. Pre-treatment non-contrast computed tomography was used to assess stone characteristics and calculate Triple-D, Quadruple-D, and MAP scores. Patients were categorized into stone-free (SF) and residual stone (RS) groups based on imaging performed three months after treatment. Residual fragments of < 4 mm were defined as SF. The study included 198 patients (60.6% male; mean age 45.5 ± 13.1 years). According to logistic regression analysis, a low MAP score (< 2.5) was the strongest independent predictor of SF status (OR: 15.5; 95% CI: 5.1-47.1; p < 0.001), followed by a high Quadruple-D score (> 1.5) (OR: 7.4; 95% CI: 2.2-24.1; p = 0.001) and low stone density (< 600 HU) (OR: 4.9; 95% CI: 1.1-21.8; p = 0.037). Conversely, a higher number of shockwaves and the need for additional procedures were associated with RS (both p < 0.001). Among the scoring systems, MAP score demonstrated the highest predictive accuracy with an AUC of 0.817, outperforming Quadruple-D (AUC: 0.722) and Triple-D (AUC: 0.639). MAP score was the most powerful and accurate independent predictor of SF status after ESWL, offering superior clinical utility compared to Triple-D and Quadruple-D scores in pre-treatment evaluation.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"96"},"PeriodicalIF":2.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of Silodosin as medical expulsive therapy after shock wave lithotripsy in paediatric patients ‍‍with renal stones. 西洛多辛作为儿科肾结石患者冲击波碎石后医学排出治疗的安全性和有效性‍‍。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-20 DOI: 10.1007/s00240-025-01760-x

Mohammed Lotfi Amer, Mohamed Essam Elkholefy, Heba Dawoud, Mohamed Gaber, Osama Mostafa El-Gamal, Tarek Gameel

{"title":"Safety and efficacy of Silodosin as medical expulsive therapy after shock wave lithotripsy in paediatric patients ‍‍with renal stones.","authors":"Mohammed Lotfi Amer, Mohamed Essam Elkholefy, Heba Dawoud, Mohamed Gaber, Osama Mostafa El-Gamal, Tarek Gameel","doi":"10.1007/s00240-025-01760-x","DOIUrl":"10.1007/s00240-025-01760-x","url":null,"abstract":"This study was designed to assess the safety and efficacy of Silodosin as a medical expulsive therapy following shockwave lithotripsy (SWL) in paediatric patients with renal stones. In this prospective randomized controlled study conducted at Tanta University Hospital from January 2022 to March 2024, thirty children with a single de novo radiopaque renal pelvic stone less than 2 cm scheduled for SWL were randomized into two equal groups. Group A (n = 15) received Silodosin 4 mg once daily after the first SWL session, and Group B (n = 15) received a matching placebo. The first dose was administered on the night of the initial SWL session and continued until stone-free status was confirmed, for a maximum of 4 weeks. The stone expulsion time was set as a primary outcome, while the secondary outcomes were one-session stone-free rate (SFR), postoperative pain scores, and Silodosin related adverse events. The results showed that the mean stone expulsion time in group A (11.4 ± 1.8 days) was significantly shorter compared to group B (16.4 ± 1.6 days; P < 0.0001). One-session SFR was 86.6% in Silodosin group compared to 73.3% in Placebo group (P = 0.6). Pain visual analogue scores were significantly lower in group A (2.31 ± 1.75) than in group B (5.08 ± 2.43; P = 0.003). No severe drug-related adverse effects were reported in either group. In conclusion, Silodosin appears to be a safe and effective adjunct to SWL in paediatric patients, significantly reducing stone expulsion time and postoperative pain. Larger studies are needed to confirm these findings.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"95"},"PeriodicalIF":2.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor regarding the article "RIRS with FV-UAS vs. MPCNL for 2-3-cm upper urinary tract stones: a prospective study". 关于“RIRS联合FV-UAS与MPCNL治疗2-3-cm上尿路结石：一项前瞻性研究”一文的致编辑信。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-17 DOI: 10.1007/s00240-025-01766-5

Recep Burak Degirmentepe

引用次数: 0

Size matters: an in vitro evaluation of flexible vacuum-assisted ureteral access sheaths. 尺寸问题：柔性真空辅助输尿管通路鞘的体外评价。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-17 DOI: 10.1007/s00240-025-01710-7

Aideen Madden, Carlos Altez, Jordi Peña Lueza, Johan Cabrera, Alberto Quarà, Stefano Moretto, Răzvan-Ionut Popescu, Mariela Corrales, Olivier Traxer

{"title":"Size matters: an in vitro evaluation of flexible vacuum-assisted ureteral access sheaths.","authors":"Aideen Madden, Carlos Altez, Jordi Peña Lueza, Johan Cabrera, Alberto Quarà, Stefano Moretto, Răzvan-Ionut Popescu, Mariela Corrales, Olivier Traxer","doi":"10.1007/s00240-025-01710-7","DOIUrl":"https://doi.org/10.1007/s00240-025-01710-7","url":null,"abstract":"Suction in retrograde-intrarenal surgery (RIRS) has been the focus of ongoing innovation. Expanding ranges of flexible vacuum-assisted ureteric access sheaths (FV-UAS) combined with single-use digital flexible ureteroscopes (SU-DFU) produce many potential combinations. This study aims to evaluate the efficacy of these combinations in clearing stone fragments. Three different models of flexible vacuum-assisted ureteric access sheaths were tested: Clear Petra™ (8.5/9.5Fr, 10-12Fr, 12-14Fr), YiGao™ (10-12Fr, 12-14Fr) and Innovex™ (10-12Fr, 12-14Fr). A total of 6 ratio of endoscope-to-sheath diameters (RESDs) (0.53, 0.63, 0.74, 0.79, 0.88 and 0.95) were assessed by using three different single-use digital flexible ureteroscopes (6.3Fr Hugemed™, 7.5Fr Pusen™, 9.5Fr Lithovue™). Two techniques, continuous in-scope suction and pull-out with suction were tested across 5 dust size ranges (63-125, 125-250, 250-500 µm and 0.5-1 mm, 1-2 mm). A combination resulting in a ratio of endoscope-to-sheath diameter of 0.53 offered the best range, with up to 2 mm fragments aspirated with equal success by either method. Maximal stone clearance rates at 10.2 g/min were achieved with the combination of a 7.5Fr Pusen™ with 12-14F flexible vacuum-assisted ureteric access sheath, with a ratio of endoscope-to-sheath diameter of 0.63 using continuous in-scope suction for fragments 125-250 µm. Continuous in-scope suction emerges as the dominant technique for smaller stone fragments and pull-out with suction as dominant or equivalent for greater fragment sizes. The ratio of endoscope-to-sheath diameter is not the only factor critical to improving stone-free rates. Technique should be adapted according to estimated stone fragment size.","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"94"},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to editor: In-vitro and in-vivo evaluation for anti-urolithiasis potential of ficus racemosa L. bark extract in ethylene glycol induced rat model. 致编者信：总状无花果树皮提取物在乙二醇诱导大鼠模型中抗尿石症潜力的体外和体内评价。

IF 2 2区医学

Urolithiasis Pub Date : 2025-05-15 DOI: 10.1007/s00240-025-01764-7

Qi Xu

引用次数: 0