1990 年至 2021 年全球、地区和国家青壮年尿路结石负担:2021 年全球疾病负担研究数据分析。

IF 2 2区 医学 Q2 UROLOGY & NEPHROLOGY
Dingguo Zhang, Jinjun Tian, Guoliang Lu, Zijian Zhou, Dawei Wang
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引用次数: 0

摘要

尿石症的全球负担引起了越来越多的关注,但仍然缺乏关于年轻人尿石症的趋势和地区差异的数据。本研究利用全球疾病负担(GBD) 2021结果工具的数据,分析了204个国家和21个地区15-49岁年轻人的年发病率和残疾调整生命年(DALYs)率。计算年龄标准化率(ASRs)以方便直接比较,并使用Joinpoint Regression Program评估时间趋势以确定平均年百分比变化(AAPC)。通过Spearman和Pearson相关分析评估尿石症负担与社会人口统计指数(SDI)的关系。在全球范围内,发病率从1990年的3460万例上升到2021年的5070万例,而发病率的ASR下降(AAPC: - 0.35%, 95%置信区间[CI]: - 0.38%至- 0.29%)。同样,DALYs的ASR下降(AAPC: -0.71%, 95% CI: -0.80%至- 0.62%)。男性的asr始终高于女性,尽管两性都有下降趋势。高SDI地区的负担减少,而一些低SDI和中低SDI地区的asr增加。2021年,东欧的asr发病率和DALYs最高,而南亚报告的病例绝对数量最高。SDI与ASR发病率呈显著正相关。这些发现强调了全球年轻人尿石症负担的变化,在过去的30年里,发病率和DALYs普遍下降。然而,某些低SDI区域的增长趋势突出表明,需要采取有针对性的公共卫生干预措施,以解决区域差距问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global, regional, and nation burden of urolithiasis in young adults from 1990 to 2021: analysis of data from the global burden of disease study 2021.

The global burden of urolithiasis has attracted increasing attention, but there is still a lack of data on the trends and regional disparities of urolithiasis among young adults. Utilizing data from the Global Burden of Disease (GBD) 2021 Results Tool, this study analyzed annual incidence and disability-adjusted life years (DALYs) rates across 204 countries and 21 regions among young adults aged 15-49 years. Age-standardized rates (ASRs) were calculated to facilitate direct comparisons, and temporal trends were assessed using the Joinpoint Regression Program to determine average annual percentage changes (AAPC). The relationship between urolithiasis burden and the sociodemographic index (SDI) was evaluated through Spearman and Pearson correlation analyses. Globally, the number of incident cases rose from 34.6 million in 1990 to 50.7 million in 2021, while the ASR of incidence declined (AAPC: - 0.35%, 95% confidence interval[CI]: - 0.38% to - 0.29%). Similarly, the ASR of DALYs decreased (AAPC: -0.71%, 95% CI: -0.80% to - 0.62%). Males consistently exhibited higher ASRs than females, though both sexes showed declining trends. Regions with higher SDI values experienced decreasing burdens, while some low- and low-middle SDI regions saw increasing ASRs. In 2021, Eastern Europe recorded the highest ASRs of incidence and DALYs, whereas South Asia reported the highest absolute number of cases. A significant positive correlation was observed between SDI and ASR of incidence. These findings underscore the shifting global burden of urolithiasis among young adults, with a general decline in incidence and DALYs over the past three decades. However, the increasing trends in certain low SDI regions highlight the need for targeted public health interventions to address regional disparities.

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来源期刊
Urolithiasis
Urolithiasis UROLOGY & NEPHROLOGY-
CiteScore
4.50
自引率
6.50%
发文量
74
期刊介绍: Official Journal of the International Urolithiasis Society The journal aims to publish original articles in the fields of clinical and experimental investigation only within the sphere of urolithiasis and its related areas of research. The journal covers all aspects of urolithiasis research including the diagnosis, epidemiology, pathogenesis, genetics, clinical biochemistry, open and non-invasive surgical intervention, nephrological investigation, chemistry and prophylaxis of the disorder. The Editor welcomes contributions on topics of interest to urologists, nephrologists, radiologists, clinical biochemists, epidemiologists, nutritionists, basic scientists and nurses working in that field. Contributions may be submitted as full-length articles or as rapid communications in the form of Letters to the Editor. Articles should be original and should contain important new findings from carefully conducted studies designed to produce statistically significant data. Please note that we no longer publish articles classified as Case Reports. Editorials and review articles may be published by invitation from the Editorial Board. All submissions are peer-reviewed. Through an electronic system for the submission and review of manuscripts, the Editor and Associate Editors aim to make publication accessible as quickly as possible to a large number of readers throughout the world.
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