Zijian Zhou, Zixuan Gong, Guoliang Lu, Baoxing Huang, Dawei Wang
{"title":"中国成人生物衰老加速与肾结石的关系：胰岛素抵抗的作用","authors":"Zijian Zhou, Zixuan Gong, Guoliang Lu, Baoxing Huang, Dawei Wang","doi":"10.1007/s00240-025-01857-3","DOIUrl":null,"url":null,"abstract":"<p><p>Advanced biological aging is linked to a higher risk of adverse health outcomes; however, its association with kidney stone (KS) remains unclear. This cross-sectional study investigated the relationship between biological aging acceleration (BAA) and KS, along with the potential mediating role of insulin resistance, in 18,868 Chinese adults aged 20-80 years undergoing health examinations at Ruijin Hospital between 2020 and 2024. Biological age was assessed using the Klemera-Doubal method biological age (KDM-BA) and Phenotypic age(PhenoAge) algorithms, with BAA calculated via residual analysis relative to the chronological age. Insulin resistance(IR) was evaluated using surrogate indices including the triglyceride glucose index (TyG), TyG-body mass index (TyG-BMI), and metabolic score for insulin resistance (METS-IR). The overall prevalence of KS was 5.25%. After full covariate adjustment, participants in the highest quintile of KDM-BA acceleration had a 1.34-fold higher risk of KS than those in the lowest quintile (95% confidence interval [CI]: 1.05-1.70). Similarly, those in the highest PhenoAge acceleration quintile exhibited a 1.39-fold increase in KS risk (95% CI: 1.10-1.76). KDM-BA and PhenoAge acceleration increased by 12% (odds ratio[OR]: 1.12, 95% CI: 1.04-1.20) and 9% (OR: 1.09, 95% CI: 1.03-1.16) per standard deviation, respectively, in correlation with higher KS risk. Restricted cubic spline analysis confirmed dose-response relationships for both KDM-BA (P-<sub>overall</sub>=0.002) and PhenoAge acceleration (P-<sub>overall</sub>=0.007) with KS. Mediation analysis indicated that IR accounted for 7-13% of these associations. These results imply that an increased risk of KS is linked to accelerated biological ageing, with IR playing a role in this association in Chinese adults. Metabolic and aging monitoring should be enhanced in patients with KS.</p>","PeriodicalId":23411,"journal":{"name":"Urolithiasis","volume":"53 1","pages":"178"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between biological aging acceleration and kidney stone in Chinese adults: exploring the role of insulin resistance.\",\"authors\":\"Zijian Zhou, Zixuan Gong, Guoliang Lu, Baoxing Huang, Dawei Wang\",\"doi\":\"10.1007/s00240-025-01857-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Advanced biological aging is linked to a higher risk of adverse health outcomes; however, its association with kidney stone (KS) remains unclear. This cross-sectional study investigated the relationship between biological aging acceleration (BAA) and KS, along with the potential mediating role of insulin resistance, in 18,868 Chinese adults aged 20-80 years undergoing health examinations at Ruijin Hospital between 2020 and 2024. Biological age was assessed using the Klemera-Doubal method biological age (KDM-BA) and Phenotypic age(PhenoAge) algorithms, with BAA calculated via residual analysis relative to the chronological age. Insulin resistance(IR) was evaluated using surrogate indices including the triglyceride glucose index (TyG), TyG-body mass index (TyG-BMI), and metabolic score for insulin resistance (METS-IR). The overall prevalence of KS was 5.25%. After full covariate adjustment, participants in the highest quintile of KDM-BA acceleration had a 1.34-fold higher risk of KS than those in the lowest quintile (95% confidence interval [CI]: 1.05-1.70). Similarly, those in the highest PhenoAge acceleration quintile exhibited a 1.39-fold increase in KS risk (95% CI: 1.10-1.76). KDM-BA and PhenoAge acceleration increased by 12% (odds ratio[OR]: 1.12, 95% CI: 1.04-1.20) and 9% (OR: 1.09, 95% CI: 1.03-1.16) per standard deviation, respectively, in correlation with higher KS risk. Restricted cubic spline analysis confirmed dose-response relationships for both KDM-BA (P-<sub>overall</sub>=0.002) and PhenoAge acceleration (P-<sub>overall</sub>=0.007) with KS. Mediation analysis indicated that IR accounted for 7-13% of these associations. These results imply that an increased risk of KS is linked to accelerated biological ageing, with IR playing a role in this association in Chinese adults. Metabolic and aging monitoring should be enhanced in patients with KS.</p>\",\"PeriodicalId\":23411,\"journal\":{\"name\":\"Urolithiasis\",\"volume\":\"53 1\",\"pages\":\"178\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urolithiasis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00240-025-01857-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urolithiasis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00240-025-01857-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Association between biological aging acceleration and kidney stone in Chinese adults: exploring the role of insulin resistance.
Advanced biological aging is linked to a higher risk of adverse health outcomes; however, its association with kidney stone (KS) remains unclear. This cross-sectional study investigated the relationship between biological aging acceleration (BAA) and KS, along with the potential mediating role of insulin resistance, in 18,868 Chinese adults aged 20-80 years undergoing health examinations at Ruijin Hospital between 2020 and 2024. Biological age was assessed using the Klemera-Doubal method biological age (KDM-BA) and Phenotypic age(PhenoAge) algorithms, with BAA calculated via residual analysis relative to the chronological age. Insulin resistance(IR) was evaluated using surrogate indices including the triglyceride glucose index (TyG), TyG-body mass index (TyG-BMI), and metabolic score for insulin resistance (METS-IR). The overall prevalence of KS was 5.25%. After full covariate adjustment, participants in the highest quintile of KDM-BA acceleration had a 1.34-fold higher risk of KS than those in the lowest quintile (95% confidence interval [CI]: 1.05-1.70). Similarly, those in the highest PhenoAge acceleration quintile exhibited a 1.39-fold increase in KS risk (95% CI: 1.10-1.76). KDM-BA and PhenoAge acceleration increased by 12% (odds ratio[OR]: 1.12, 95% CI: 1.04-1.20) and 9% (OR: 1.09, 95% CI: 1.03-1.16) per standard deviation, respectively, in correlation with higher KS risk. Restricted cubic spline analysis confirmed dose-response relationships for both KDM-BA (P-overall=0.002) and PhenoAge acceleration (P-overall=0.007) with KS. Mediation analysis indicated that IR accounted for 7-13% of these associations. These results imply that an increased risk of KS is linked to accelerated biological ageing, with IR playing a role in this association in Chinese adults. Metabolic and aging monitoring should be enhanced in patients with KS.
期刊介绍：
Official Journal of the International Urolithiasis Society
The journal aims to publish original articles in the fields of clinical and experimental investigation only within the sphere of urolithiasis and its related areas of research. The journal covers all aspects of urolithiasis research including the diagnosis, epidemiology, pathogenesis, genetics, clinical biochemistry, open and non-invasive surgical intervention, nephrological investigation, chemistry and prophylaxis of the disorder. The Editor welcomes contributions on topics of interest to urologists, nephrologists, radiologists, clinical biochemists, epidemiologists, nutritionists, basic scientists and nurses working in that field.
Contributions may be submitted as full-length articles or as rapid communications in the form of Letters to the Editor. Articles should be original and should contain important new findings from carefully conducted studies designed to produce statistically significant data. Please note that we no longer publish articles classified as Case Reports. Editorials and review articles may be published by invitation from the Editorial Board. All submissions are peer-reviewed. Through an electronic system for the submission and review of manuscripts, the Editor and Associate Editors aim to make publication accessible as quickly as possible to a large number of readers throughout the world.
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