Turkish Journal of Ophthalmology最新文献

{"title":"Real-World Comparison of the Effectiveness of Defocus Incorporated Multiple Segments and Myopi-X Spectacle Lenses for Myopia Control in Turkish Children: A Retrospective Study.","authors":"Nilay Akagün, Uğur Emrah Altıparmak","doi":"10.4274/tjo.galenos.2026.23529","DOIUrl":"10.4274/tjo.galenos.2026.23529","url":null,"abstract":"<p><strong>Objectives: </strong>This study compared the 12-month real-world effectiveness of defocus incorporated multiple segments (DIMS) spectacle lenses, Myopi-X progressive addition lenses, and single-vision (SV) lenses in slowing myopia progression in children.</p><p><strong>Materials and methods: </strong>This retrospective observational study included 385 eyes using one of the three spectacle types. Baseline age, spherical equivalent refraction (SER), and axial length (AL) were recorded. Twelve-month changes in SER and AL were analyzed using the Kruskal-Wallis test with Bonferroni-adjusted pairwise comparisons. Generalized estimating equations (GEE) were used to assess the effects of treatment group, age group, sex, and baseline AL group on SER and AL changes.</p><p><strong>Results: </strong>The study population consisted of 118 Myopi-X eyes (32.4%), 107 SV eyes (29.4%), and 139 DIMS eyes (38.2%). Baseline demographic and ocular characteristics (including age, sex, SER, AL, age group, and baseline AL group) were comparable among the groups (all p>0.05). After 12 months, mean SER progression was -0.35±0.34 diopters (D) in the Myopi-X group, -0.46±0.37 D in the SV group, and -0.24±0.33 D in the DIMS group (p<0.001). Mean AL elongation was 0.21±0.12 mm, 0.24±0.17 mm, and 0.17±0.16 mm, respectively (p=0.004). GEE analyses demonstrated a significant treatment effect for both SER and AL change (p<0.001 for both). The least progression occurred in the DIMS group, followed by Myopi-X, while the SV group showed the highest progression. Baseline AL group was the only significant predictor of AL elongation (β=0.210, 95% confidence interval: 0.189-0.231, p<0.001), with greater elongation in eyes with high baseline AL. Age group and sex did not significantly influence SER or AL outcomes.</p><p><strong>Conclusion: </strong>DIMS spectacle lenses were more effective than Myopi-X and SV lenses in reducing both refractive progression and axial elongation over 12 months. Baseline AL was a key determinant of axial growth, supporting the use of individualized risk assessment in pediatric myopia management.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: \"Preferred Retinal Locus in Juvenile Macular Dystrophy\".","authors":"Erum Habib","doi":"10.4274/tjo.galenos.2026.89021","DOIUrl":"10.4274/tjo.galenos.2026.89021","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Graft Detachment During Gonioscopy-Assisted Transluminal Trabeculotomy in a Patient Who Underwent Descemet Membrane Endothelial Keratoplasty.","authors":"Raziye Dönmez Gün, Burak Tanyıldız, Erdi Karadağ, Mustafa Talan","doi":"10.4274/tjo.galenos.2025.67672","DOIUrl":"10.4274/tjo.galenos.2025.67672","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"61-64"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Advanced Surface Moisturizing Technologies on Contact Lens Comfort in Digital Platform Users.","authors":"Mehtap Arslantürk Eren, Tuna Çelik Büyüktepe, Ömür Ö Uçakhan-Gündüz","doi":"10.4274/tjo.galenos.2025.68984","DOIUrl":"10.4274/tjo.galenos.2025.68984","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate and compare the on-eye performance and comfort of two lotrafilcon B contact lenses, each manufactured using different surface moisturizing technologies, in individuals who use digital platforms for more than 3 hours daily.</p><p><strong>Materials and methods: </strong>Twenty-nine asymptomatic habitual contact lens wearers participated in a randomized, double-masked crossover study. Each subject wore either Air Optix Aqua or Air Optix Plus HydraGlyde contact lenses for a month before switching to the other lens type for another month. Contact Lens Dry Eye Questionnaire 8 (CLDEQ-8) scores, biomicroscopic examination, tear function tests, and blink rates were recorded at baseline and at the end of each month. The patients were asked to complete a Likert-type questionnaire evaluating vision and comfort, along with first-impression ratings for visual clarity, comfort, and dryness with each lens.</p><p><strong>Results: </strong>The mean age of patients was 25.5±7.2 years. Tarsal papillary grade was significantly lower, and tear-film break up time was higher with Air Optix Plus HydraGlyde lenses compared to Air Optix Aqua lenses (p<0.05). There were no significant differences between the two lenses in terms of slit-lamp findings, Schirmer's test, blink rate, or CLDEQ-8 scores (p>0.05). Air Optix Plus HydraGlyde lenses provided significantly better end-of-day comfort and less blurred vision, dryness, and eye tiredness (p<0.05).</p><p><strong>Conclusion: </strong>Air Optix Plus HydraGlyde lenses with advanced surface moisturizing technology were superior in terms of end-of-day comfort, end-of-month comfort, and visual clarity. Technological advances in silicone hydrogel lens surface treatments seem to be helpful in improving contact lens comfort in lens wearers with moderate daily exposure to digital devices.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Corneal Scenario: Concurrent Diagnosis of Epithelial Basement Membrane Dystrophy and Crocodile Shagreen.","authors":"Serap Ünal, Ayşe Bozkurt Oflaz, Şaban Gönül, Banu Bozkurt","doi":"10.4274/tjo.galenos.2025.61254","DOIUrl":"10.4274/tjo.galenos.2025.61254","url":null,"abstract":"","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"65-68"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravitreal Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema in Türkiye: 48-Month Data, BOSPHORUS-DME Study Group Report No. 1.","authors":"Ece Özal, Abdullah Özkaya, Murat Arıcı, Anıl Korkmaz, Serhat Ermiş, Şerife Çiloğlu Hayat, Murat Karapapak, Sadık Altan Özal, Akın Çakır, Gamze Karataş, Dilan Yıldız, Mehmet Erdoğan, İbrahim Koçak, Nihat Sayın, Veysel Levent Karabaş, Ecem Önder Tokuç, Semra Tiryaki Demir, Mehmet Egemen Karataş, Turgay Uçak, Mine Öztürk, Bengi Demirayak, İsmail Umut Onur, Mustafa Hepokur","doi":"10.4274/tjo.galenos.2026.67863","DOIUrl":"10.4274/tjo.galenos.2026.67863","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the 48-month visual and anatomical outcomes, as well as the number of clinic visits and intravitreal injections, in patients treated with three consecutive loading doses of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME) under real-world conditions in Türkiye.</p><p><strong>Materials and methods: </strong>In this retrospective, multicenter study conducted by the BOSPHORUS-DME Study Group, the medical records of 2,424 eyes of 1,696 patients who experienced vision loss due to DME and were treated with intravitreal anti-VEGF injections between January 2019 and January 2023 were reviewed. The study was carried out across eight tertiary referral hospitals located on the European side of İstanbul and in the province of Kocaeli. Seven cohort groups were created based on follow-up at baseline and months 3, 6, 12, 18, 24, 36, and 48. Best-corrected visual acuity (BCVA), central macular thickness (CMT), the number of clinic visits and injections, and the rates of anti-VEGF or dexamethasone switching were analyzed.</p><p><strong>Results: </strong>The study included a total of 2,424 eyes of 1,696 patients (mean age: 60.6±10.0 years; 46.4% female). The mean baseline BCVA and CMT were 0.34±0.24 (decimal) and 400±134 μm, respectively. At month 48, these values improved to 0.49±0.29 (p<0.0001) and 324±115 μm (p<0.0001). The mean cumulative number of injections at years 1, 2, 3, and 4 were 6.5, 9.6, 12.2, and 15.7, respectively. A switch in anti-VEGF therapy occurred between month 3 and 6 in 43.5% of eyes, mostly due to mandatory transition to on-label agents.</p><p><strong>Conclusion: </strong>This is the largest and longest real-world study on DME treatment conducted in Türkiye. It demonstrates that visual and anatomical gains can be sustained over a 48-month period. While the overall trend aligns with previous real-world studies, the higher injection frequency in our cohort appears to have contributed to more favorable outcomes. These findings underscore the importance of early intensive therapy and sustained treatment adherence in the real-world management of DME.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Intravitreal Dexamethasone Implant Monotherapy in Naïve Patients with Diabetic Macular Edema.","authors":"Gamze Karataş, Akın Çakır, Öznur Aday, Tahsin Uzundede, Furkan Kırık, Ahmet Melih Özoğuz, Hakan Özdemir, Mustafa Nuri Elçioğlu","doi":"10.4274/tjo.galenos.2025.77246","DOIUrl":"10.4274/tjo.galenos.2025.77246","url":null,"abstract":"<p><strong>Objectives: </strong>To demonstrate the efficacy and safety of repeated dexamethasone (DEX) implants in eyes with naïve diabetic macular edema (DME) using real-life data over a minimum of 36 months follow-up.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included treatment-naïve DME patients treated with intravitreal DEX monotherapy and followed for at least 36 months. Main outcomes were best corrected visual acuity (BCVA) and central macular thickness (CMT) change. Secondary outcomes were optical coherence tomography findings, including serous macular detachment, hard exudate, hyperreflective foci, cystoid degeneration, pearl necklace sign, epiretinal membrane (ERM), disorganization of the retinal inner layers (DRIL), ellipsoid zone and external limiting membrane (EZ-ELM) integrity, and intra-cystic hyperreflective material, as well as intraocular pressures and lens status.</p><p><strong>Results: </strong>The study included 74 eyes of 52 patients. The mean follow-up period and number of injections were 49.24±13.51 months and 6.83±2.76, respectively. Both BCVA and CMT improved significantly throughout follow-up (p=0.009; p<0.001). The mean BCVA increased by 7.9±2.1 letters, and 38 patients (51.3%) gained ≥10 letters. Hyperreflective foci (p<0.001), pearl necklace sign (p=0.012), and intra-cystic hyperreflective material (p=0.042) decreased significantly, while ERM (p=0.006), DRIL (p<0.001), and EZ-ELM defects (p<0.001) increased significantly.</p><p><strong>Conclusion: </strong>Intravitreal DEX monotherapy is a safe and effective treatment option for treatment-naïve DME patients in long-term follow-up.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"24-30"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Ophthalmology Applications: From the Perspective of Strabismus and Pediatric Ophthalmology.","authors":"Zeynep Akgün, Elif Demirkılınç Biler, Melis Palamar","doi":"10.4274/tjo.galenos.2025.55562","DOIUrl":"10.4274/tjo.galenos.2025.55562","url":null,"abstract":"<p><p>Ophthalmology significantly contributes to the healthcare sector's carbon footprint. Despite recent increases in sustainability research in ophthalmology, there remains limited information on initiatives specific to pediatric ophthalmology and strabismus. This review aims to examine the existing literature and provide insights into sustainability and reducing carbon footprints in these areas. Although there has been no specific assessment of carbon emissions associated with congenital and developmental cataracts, measures related to cataract surgery and operating room practices remain relevant. Strabismus surgeries can be considered environmentally friendly, affordable, and energy-efficient procedures. Involving non-ophthalmologist personnel, expanding telemedicine applications, and restructuring outpatient services could reduce clinic congestion, lower costs, and improve sustainability. Some amblyopia examinations requiring long-term follow-up could be performed at local healthcare centers. While compliance and effectiveness are primary concerns in patching treatment, it is crucial to acknowledge that the patches generate significant waste and carbon footprints. Therefore, exploring alternative solutions is essential. Anesthesia poses an additional challenge for pediatric examinations, and various strategies have been suggested to reduce carbon dioxide emissions. Additionally, artificial intelligence is promising and its integration into pediatric ophthalmic examinations could further enhance sustainability. In brief, although pediatric ophthalmology and strabismus are considered environmentally friendly subspecialties of ophthalmology, especially in the operating room, there are many steps that can be taken for \"sustainable ophthalmology,\" from anesthesia to amblyopia treatment and outpatient clinic services.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior Segmental Optic Nerve Hypoplasia: A Rare Mimicker of Normal-Tension Glaucoma-A Case Series from Türkiye.","authors":"Cansu Yüksel Elgin, İlayda Kaner Savcı, Özcan Ocakoğlu","doi":"10.4274/tjo.galenos.2025.89699","DOIUrl":"10.4274/tjo.galenos.2025.89699","url":null,"abstract":"<p><p>This retrospective case series presents the characteristic features of superior segmental optic nerve hypoplasia (SSONH) in four patients who were initially misdiagnosed with normal-tension glaucoma (NTG), aiming to raise awareness of this rare condition in Türkiye. Four patients (two females and two males) with a mean age of 38 years were included. All were initially diagnosed with NTG and treated with brimonidine drops for three years. Comprehensive ophthalmological examinations were performed, including optic disc photography, optical coherence tomography retinal nerve fiber layer (RNFL) analysis, and visual field testing, with follow-up evaluations conducted over at least one year. Bilateral involvement was observed in two cases, and unilateral involvement in the other two. History of maternal diabetes was noted in 50% of the patients. During medication-free follow-up, all patients demonstrated stable structural and functional parameters, supporting the diagnosis of SSONH. These findings suggest that SSONH should be considered in young patients presenting with superior RNFL thinning and corresponding inferior visual field defects. The non-progressive nature of the condition helps differentiate it from glaucomatous optic neuropathy. Recognizing unilateral cases is essential for avoiding misdiagnosis.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"56 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12917343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Results and Complications of Lensectomy in Simple Extreme Microphthalmos Cases.","authors":"Gülşah Gümüş Akgün, Neşe Alagöz, Ece Doğruel, Nilay Kandemir Beşek, Ahmet Kırgız, Erdem Erdoğdu, İhsan Çakır, Çiğdem Altan, Tekin Yaşar","doi":"10.4274/tjo.galenos.2025.61354","DOIUrl":"10.4274/tjo.galenos.2025.61354","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the refractive outcomes, changes in intraocular pressure (IOP) and anterior chamber depth (ACD), and postoperative complications following lensectomy for angle-closure in cases of simple extreme microphthalmos.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed eyes with simple extreme microphthalmos (axial length <18 mm) that underwent lensectomy between January 2015 and July 2024. Data collection included demographic details, preoperative and postoperative best corrected visual acuity (BCVA), IOP, number of antiglaucoma medications, ACD, the diopter (D) of the implanted intraocular lens (IOL) according to the Hoffer-Q formula, postoperative refractive error, and surgical complications.</p><p><strong>Results: </strong>A total of 20 eyes from 12 patients were analyzed, with a mean patient age of 55.4±8.7 years and an average axial length of 16.48±0.8 mm. The average power of the implanted IOL was 53.32±6.2 D, ranging from 44 to 64 D. The mean preoperative spherical refractive equivalent (SE) was +12.4±2.8 D, while the mean postoperative SE was -6.67±5.2 D (p<0.05). Postoperative spherical refractive error exceeding -1.00 D was detected in 15 eyes (75%). Postoperatively, significant decreases were observed in IOP and the need for antiglaucoma medication (p=0.02 for both). The mean ACD increased significantly after surgery compared to the preoperative ACD (p=0.01). The difference between the intended refractive outcome and the postoperative spherical refractive error was statistically significant (p<0.05). Postoperatively, 8 eyes (40%) had a BCVA of ≤0.7 logarithm of the minimum angle of resolution (logMAR), 10 (50%) had a BCVA between >0.7 and <1.4 logMAR and 2 eyes (10%) had a BCVA of ≥1.4 logMAR.</p><p><strong>Conclusion: </strong>Lensectomy in cases of extreme microphthalmos effectively reduces IOP and reliance on antiglaucoma medications and increases the ACD. However, a notable incidence of postoperative myopic refractive error remains a concern.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":"55 6","pages":"336-340"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}