Turkish Journal of Ophthalmology最新文献

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The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder. 失明对生物节律的影响及昼夜节律紊乱的后果。
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.59296
Yavuz Selim Atan, Merve Subaşı, Pınar Güzel Özdemir, Muhammed Batur
{"title":"The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder.","authors":"Yavuz Selim Atan,&nbsp;Merve Subaşı,&nbsp;Pınar Güzel Özdemir,&nbsp;Muhammed Batur","doi":"10.4274/tjo.galenos.2022.59296","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.59296","url":null,"abstract":"<p><p>Various physiological systems and behaviors such as the sleep-wake cycle, vigilance, body temperature, and the secretion of certain hormones are governed by a 24-hour cycle called the circadian system. While there are many external stimuli involved the regulation of circadian rhythm, the most powerful environmental stimulus is the daily light-dark cycle. Blind individuals with no light perception develop circadian desynchrony. This leads to non-24-hour sleep-wake rhythm disorder, which is associated with sleep-wake disorders, as well as mood disorders and loss of appetite and gastrointestinal disturbances due to disrupted circadian hormone regulation. As the diagnosis is often delayed because of under-recognition in clinical practice, patients must cope with varying degrees of social and academic dysfunction. Most blind individuals report that non-24-hour sleep-wake rhythm disorder affects them more than blindness. In the treatment of totally blind patients suffering from non-24-hour sleep-wake rhythm disorder, the first-line management is behavioral approaches. Drug therapy includes melatonin and the melatonin agonist tasimelteon. Diagnosing blind individuals' sleep disorders is also relevant to treatment because they can be improved with the use of melatonin and its analogues or by phototherapy if they have residual vision. Therefore, assessing sleep problems and planning treatment accordingly for individuals presenting with blindness is an important issue for ophthalmologists to keep in mind.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/a8/TJO-53-111.PMC10127541.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Flap-Related Complications Following Temporal Inverted Internal Limiting Membrane Flap for Macular Hole Repair. 颞逆内限制膜瓣修复黄斑裂孔后皮瓣相关并发症。
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.04828
Gökçen Deniz Gülpınar İkiz, Ece Özdemir Zeydanlı, Şengül Özdek
{"title":"Flap-Related Complications Following Temporal Inverted Internal Limiting Membrane Flap for Macular Hole Repair.","authors":"Gökçen Deniz Gülpınar İkiz,&nbsp;Ece Özdemir Zeydanlı,&nbsp;Şengül Özdek","doi":"10.4274/tjo.galenos.2022.04828","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.04828","url":null,"abstract":"<p><p>Here we report three cases of flap-related complications following temporal inverted internal limiting membrane (ILM) flap technique for the repair of macular holes (MH). The first case showed a flap closure pattern in which the MH completely closed at 2 months spontaneously. The second case showed early anatomical and functional improvement provided by an immediate closure of the MH but developed flap contracture and nasally located epiretinal membrane (ERM) at postoperative 18 months. There was no functional deterioration, thus no further intervention was required. In the third case, early postoperative flap dislocation was observed and an additional surgery to reposition the flap was needed. The flap closure pattern observed with inverted ILM flap techniques may represent the ongoing healing process of large MHs and may be related to delayed spontaneous anatomical closure. ILM flap contracture and ERM formation may be a harmless long-term complication. Dislocation of the ILM flap is an unexpected early postoperative complication that may necessitate a second surgery for flap repositioning.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/e5/TJO-53-130.PMC10127537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Approach to Ocular Cicatricial Pemphigoid. 眼部瘢痕性类天疱疮的临床治疗。
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.34683
Mukaddes Damla Çiftçi, İlayda Korkmaz, Melis Palamar, Banu Yaman, Sait Eğrilmez, Ayşe Yağcı, Taner Akalın, Özlem Barut Selver
{"title":"Clinical Approach to Ocular Cicatricial Pemphigoid.","authors":"Mukaddes Damla Çiftçi,&nbsp;İlayda Korkmaz,&nbsp;Melis Palamar,&nbsp;Banu Yaman,&nbsp;Sait Eğrilmez,&nbsp;Ayşe Yağcı,&nbsp;Taner Akalın,&nbsp;Özlem Barut Selver","doi":"10.4274/tjo.galenos.2022.34683","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.34683","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the demographic data, ocular and systemic findings, clinical management, and outcomes of patients with ocular cicatricial pemphigoid (OCP).</p><p><strong>Materials and methods: </strong>The medical records of 11 patients diagnosed as having OCP in the ophthalmology department of Ege University between 2008 and 2021 were evaluated retrospectively.</p><p><strong>Results: </strong>The patients' mean follow-up time was 14±5.76 months. All eyes (100%) had conjunctival involvement and 18 (81.81%) had corneal involvement. According to the Tauber staging system, 7 (31.81%), 8 (36.36%), and 7 (31.81%) of the eyes were stage 2, 3, and 4, respectively. The diagnosis was confirmed in 6 (66.66%) of 9 patients who underwent biopsy. Amniotic membrane transplantation was performed in 7 eyes, entropion surgery in 2 eyes, and electrocauterization for trichiasis in 5 eyes. Systemic involvement was observed in 45.45% (5/11) of patients, most commonly oral mucosal involvement (18.18%). Review of medical records showed that alkylating agents, steroids, and dapsone were used in patients treated before 2020. Mycophenolate mofetil was preferred to be used in combination with corticosteroids. Although treatment responses before mycophenolate mofetil usage could not be evaluated well because of loss to follow-up, 4 (66.66%) of 6 patients who received steroid treatment combined with mycophenolate mofetil showed partial or complete clinical remission. No serious side effects and drug withdrawal were observed.</p><p><strong>Conclusion: </strong>OCP is a sight-threatening autoimmune disease that affects older adults. Although positive biopsy results are valuable for diagnosis, negative results do not exclude the diagnosis. The main treatment is systemic immunosuppressives. Disease activity can be suppressed, especially with early initiation of drug therapy. These patients require a multidisciplinary approach. Especially in the presence of isolated ocular findings, ophthalmologists should be able to make the decision to start immunosuppressive treatment, and systemic treatment should not be delayed.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/a4/TJO-53-79.PMC10127540.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Effect of Mask Use on the Ocular Surface During the COVID-19 Pandemic. COVID-19大流行期间口罩使用对眼表的影响
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.81948
Özlem Dikmetaş, Hilal Toprak Tellioğlu, İzlem Özturan, Sibel Kocabeyoğlu, Ali Bülent Çankaya, Murat İrkeç
{"title":"The Effect of Mask Use on the Ocular Surface During the COVID-19 Pandemic.","authors":"Özlem Dikmetaş,&nbsp;Hilal Toprak Tellioğlu,&nbsp;İzlem Özturan,&nbsp;Sibel Kocabeyoğlu,&nbsp;Ali Bülent Çankaya,&nbsp;Murat İrkeç","doi":"10.4274/tjo.galenos.2022.81948","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.81948","url":null,"abstract":"<p><strong>Objectives: </strong>The new coronavirus disease 2019 (COVID-19) pandemic emerged in Wuhan, China in October 2019 and spread rapidly all over the world, making extended mask use an inescapable rule of daily life. Literature data indicate that the use of face masks increases the symptoms of dry eye in addition to preventing the spread of COVID-19. The aim of our study was to evaluate the relationship between the clinical signs and symptoms of dry eye and the duration of mask use in healthy individuals using regular face masks.</p><p><strong>Materials and methods: </strong>Thirty-five patients aged 20-60 years with no additional ophthalmologic pathology were included in the study. Participants were stratified by duration of face mask use: ≤6 hours/day (group 1) and >6 hours/day (group 2). The patients were assessed with the Ocular Surface Disease Index (OSDI) questionnaire, fluorescein ocular surface staining, and tear break-up time (TBUT) to evaluate the effect of extended mask use on the ocular surface.</p><p><strong>Results: </strong>A total of 62 eyes of 35 patients, 20 women (57.1%) and 15 men (42.9%), were included in the study. The two mask use duration groups had similar OSDI values (p=0.736). When the ocular surface staining pattern was examined according to the Oxford scale, 50% (10/20) of the eyes in group 1 were assessed as stage 1 and the other 10 eyes as stage 0. In group 2, 47.6% (20/42) of the eyes were assessed as grade 1, 11.9% (5/42) as grade 2, and 4.7% (2/42) as grade 3.</p><p><strong>Conclusion: </strong>Prolonged face mask use was shown to cause decreased TBUT and increased ocular surface staining even in healthy individuals. Further studies are needed to investigate changes in the tear film after extended daily mask use.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/93/TJO-53-74.PMC10127546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An Association Between the Intestinal Permeability Biomarker Zonulin and the Development of Diabetic Retinopathy in Type II Diabetes Mellitus. 肠通透性生物标志物Zonulin与II型糖尿病视网膜病变的关系
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.70375
Burak Erdem, Yasemin Kaya, Tuğba Raika Kıran, Saadet Yılmaz
{"title":"An Association Between the Intestinal Permeability Biomarker Zonulin and the Development of Diabetic Retinopathy in Type II Diabetes Mellitus.","authors":"Burak Erdem,&nbsp;Yasemin Kaya,&nbsp;Tuğba Raika Kıran,&nbsp;Saadet Yılmaz","doi":"10.4274/tjo.galenos.2022.70375","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.70375","url":null,"abstract":"<p><strong>Objectives: </strong>Increased intestinal permeability (IP) and gut microbiota dysbiosis have been implicated in low-grade chronic inflammation, which is an important factor in the pathogenesis of diabetic retinopathy (DR). This study aims to demonstrate the relationship between the IP biomarker zonulin and DR in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Materials and methods: </strong>This study was conducted with a total of 89 T2DM patients, including 33 non-DR, 28 with non-proliferative DR (NPDR), and 28 with proliferative DR (PDR), and 32 healthy controls. Zonulin levels were determined from blood samples using an enzyme-linked immunosorbent assay kit.</p><p><strong>Results: </strong>There was no difference between the four groups in terms of age (p=0.236), gender (p=0.952), and body mass index (p=0.134) of the participants. Zonulin levels were significantly higher in the PDR group compared to the other three groups, as well as in the non-DR and NPDR groups compared to the control group. In multivariate logistic regression analysis, zonulin was found to be an independent predictor of DR (odds ratio: 1,781, 95% confidence interval: 1,122-2,829, p=0.014).</p><p><strong>Conclusion: </strong>Our study showed that elevated zonulin levels may play a significant role in the development of DR, particularly during the transition to the proliferative stage. This suggests that regulation of IP could be one of the targets of DR treatment. More studies are needed to determine whether a eubiotic gut microbiota and IP have a direct relationship with DR.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/8f/TJO-53-91.PMC10127545.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Different Cases, Different Manifestations of Post-COVID-19 Retinal Artery Occlusion: A Case Series. 不同病例,不同表现的covid -19后视网膜动脉闭塞:病例系列。
Turkish Journal of Ophthalmology Pub Date : 2023-04-20 DOI: 10.4274/tjo.galenos.2022.36930
Özgür Yalçınbayır, Gamze Uçan Gündüz, Funda Coşkun, Bahattin Hakyemez, Selim Doğanay
{"title":"Different Cases, Different Manifestations of Post-COVID-19 Retinal Artery Occlusion: A Case Series.","authors":"Özgür Yalçınbayır,&nbsp;Gamze Uçan Gündüz,&nbsp;Funda Coşkun,&nbsp;Bahattin Hakyemez,&nbsp;Selim Doğanay","doi":"10.4274/tjo.galenos.2022.36930","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.36930","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) is a procoagulant disease that increases the risk of clinically evident thrombotic complications. Herein we present 3 cases with different retinal artery occlusions that emerged soon after the diagnosis of COVID-19. The first patient had central retinal artery occlusion (CRAO) that resulted in visual loss in one eye. The second patient had inflammatory peripheral retinal artery occlusion, vasculitis, and uveitis which did not affect vision. The third patient presented with CRAO following the progression from orbital cellulitis to orbital apex syndrome. Interestingly, CRAO progressed to internal carotid artery occlusion in this case within days and resulted in monocular visual loss. Variations in the underlying pathophysiology and the characteristics of individual immune responses in patients with COVID-19 may be factors that determine differences in clinical manifestations. This article aims to describe different presentations of COVID-19-related retinal artery occlusions and discuss possible pathophysiological aspects.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/74/TJO-53-124.PMC10127544.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avascular Peripheral Retina in Infants. 婴儿视网膜周围无血管。
Turkish Journal of Ophthalmology Pub Date : 2023-02-24 DOI: 10.4274/tjo.galenos.2022.76436
Şengül Özdek, Ece Özdemir Zeydanlı, Caroline Baumal, Sandra Hoyek, Nimesh Patel, Audina Berrocal, Ashley Lopez-Cañizares, Hasenin Al-Khersan, Shunji Kusaka, Fukutaro Mano, Subhadra Jalali, Domenico Lepore, Solmaz Akar
{"title":"Avascular Peripheral Retina in Infants.","authors":"Şengül Özdek,&nbsp;Ece Özdemir Zeydanlı,&nbsp;Caroline Baumal,&nbsp;Sandra Hoyek,&nbsp;Nimesh Patel,&nbsp;Audina Berrocal,&nbsp;Ashley Lopez-Cañizares,&nbsp;Hasenin Al-Khersan,&nbsp;Shunji Kusaka,&nbsp;Fukutaro Mano,&nbsp;Subhadra Jalali,&nbsp;Domenico Lepore,&nbsp;Solmaz Akar","doi":"10.4274/tjo.galenos.2022.76436","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.76436","url":null,"abstract":"<p><p>Avascular peripheral retina in an infant is a common characteristic of numerous pediatric retinal vascular disorders and often presents a diagnostic challenge to the clinician. In this review, key features of each disease in the differential diagnosis, from retinopathy of prematurity, familial exudative vitreoretinopathy, Coats disease, incontinentia pigmenti, Norrie disease, and persistent fetal vasculature, to other rare hematologic conditions and telomere disorders, will be discussed by expert ophthalmologists in the field.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/40/TJO-53-44.PMC9973209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10848968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Behavioral Characteristics in Response to Visual Stimuli in Infants with Cerebral Visual Impairment. 脑性视觉障碍婴儿对视觉刺激反应的行为特征评价。
Turkish Journal of Ophthalmology Pub Date : 2023-02-24 DOI: 10.4274/tjo.galenos.2022.14296
Deniz Altınbay, İbrahim Taşkın
{"title":"Evaluation of Behavioral Characteristics in Response to Visual Stimuli in Infants with Cerebral Visual Impairment.","authors":"Deniz Altınbay,&nbsp;İbrahim Taşkın","doi":"10.4274/tjo.galenos.2022.14296","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.14296","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the behavioral characteristics of infants with cerebral visual impairment (CVI) in response to visual stimuli and the frequency of these features.</p><p><strong>Materials and methods: </strong>In this retrospective study, 32 infants aged 8-37 months who were referred to the low vision unit in 2019-2021 and diagnosed with CVI based on their demographic characteristics, systemic findings, and standard and functional visual examinations were evaluated. The frequency of ten behavioral characteristics exhibited by infants with CVI in response to visual stimuli as defined by Roman-Lantzy was examined in the patients.</p><p><strong>Results: </strong>The mean age was 23.46±11.45 months, the mean birth weight was 2,550±944 g, and the mean gestational age at birth was 35.39±4.68 weeks. There was hypoxic-ischemic encephalopathy in 22%, prematurity in 59%, periventricular leukomalacia in 16%, cerebral palsy in 25%, epilepsy in 50%, and strabismus in 68.7% of the patients. Color preference for fixation was observed in 40% and visual field preference was observed in 46% of the patients. The most preferred color was red (69%) and the most preferred visual field was right visual field (47%). Difficulty with distance viewing was observed in 84% of patients, visual latency in 72%, need for movement in 69%, absence of visually guided reach in 69%, difficulty with visual complexity in 66%, difficulty with visual novelty in 50%, light-gazing/nonpurposeful gaze in 50%, and atypical visual reflexes in 47%. There was no fixation in 25% of the patients.</p><p><strong>Conclusion: </strong>Behavioral characteristics in response to visual stimuli were observed in most infants with CVI. Knowing and recognizing these characteristic features by ophthalmologists will assist in early diagnosis, referral to visual habilitation, and planning habilitation techniques. These characteristic features are important in order to not miss this critical period in which the brain is still plastic and good responses to visual habilitation can be obtained.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/2a/TJO-53-1.PMC9973211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10846620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of Prostaglandin-Associated Periorbitopathy after Discontinuing Treatment. 停止治疗后前列腺素相关性眼周病的改善。
Turkish Journal of Ophthalmology Pub Date : 2023-02-24 DOI: 10.4274/tjo.galenos.2022.24365
Jose Manuel Abalo-Lojo, Pedro Vázquez Ferreiro, Maria Knight Asorey, Aida Estévez Colmenero, Francisco Gonzalez
{"title":"Improvement of Prostaglandin-Associated Periorbitopathy after Discontinuing Treatment.","authors":"Jose Manuel Abalo-Lojo,&nbsp;Pedro Vázquez Ferreiro,&nbsp;Maria Knight Asorey,&nbsp;Aida Estévez Colmenero,&nbsp;Francisco Gonzalez","doi":"10.4274/tjo.galenos.2022.24365","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.24365","url":null,"abstract":"<p><strong>Objectives: </strong>To report that the periorbital changes induced by prostaglandin analogue (PGA) eye drops are partially reversible after discontinuing treatment.</p><p><strong>Materials and methods: </strong>Nine patients with prostaglandin-associated periorbitopathy seen in a referral oculoplastic practice were included in this study, eight with unilateral glaucoma and one with bilateral open-angle glaucoma. All of them had been treated with topical PGA for at least one year, before the treatment was discontinued for cosmetic reasons.</p><p><strong>Results: </strong>In all cases, there were evident periocular differences between the treated eye and the fellow eye, consisting mainly of deepening of the upper eyelid sulcus and eyelid fat pad reduction. One year after discontinuing the PGA eye drops, improvement of these features was observed.</p><p><strong>Conclusion: </strong>Clinicians and patients should be aware of the side effects of topical PGA therapy on periorbital tissues, and that these side effects can partially regress after discontinuation of the medication.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/da/TJO-53-8.PMC9973213.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10846621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Optic Nerve Sheath Fenestration in Patients with Increased Intracranial Pressure. 视神经鞘开窗治疗颅内压增高的疗效。
Turkish Journal of Ophthalmology Pub Date : 2023-02-24 DOI: 10.4274/tjo.galenos.2022.45057
Sait Coşkun Özcan, Nedime Deveci, Deniz Özarslan Özcan, Feyza Önder
{"title":"Efficacy of Optic Nerve Sheath Fenestration in Patients with Increased Intracranial Pressure.","authors":"Sait Coşkun Özcan,&nbsp;Nedime Deveci,&nbsp;Deniz Özarslan Özcan,&nbsp;Feyza Önder","doi":"10.4274/tjo.galenos.2022.45057","DOIUrl":"https://doi.org/10.4274/tjo.galenos.2022.45057","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effectiveness of optic nerve sheath fenestration (ONSF) on visual functions in patients with increased intracranial pressure (İİP).</p><p><strong>Materials and methods: </strong>The medical records of 24 eyes of 17 patients who had İİP due to idiopathic intracranial hypertension, cerebral venous sinus thrombosis, or intracranial cyst and underwent ONSF surgery to prevent visual loss were evaluated. Pre- and postoperative visual acuity, optic disc images, and visual field findings were reviewed.</p><p><strong>Results: </strong>The mean age of the patients was 30.4±8.5 years, and 88.2% were female. The patients' mean body mass index was 28.67±6.1 kg/m<sup>2</sup>. The mean follow-up time was 24±12.1 months (range: 3-44). At postoperative 3 months, the mean best-corrected distance visual acuity had improved in 20 eyes (83.3%) and stabilized in 4 eyes (16.7%) compared to preoperative values. In visual field mean deviation, an improvement was observed in 10 eyes (90.9%), while 1 eye (9.1%) eye remained stable. Optic disc edema decreased in all patients.</p><p><strong>Conclusion: </strong>This study indicates that ONSF has beneficial effects on visual function in patients with rapidly progressive visual loss caused by increased intracranial pressure.</p>","PeriodicalId":23373,"journal":{"name":"Turkish Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/a9/TJO-53-13.PMC9973215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10846622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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