Turkish Journal of Hematology最新文献

{"title":"Exploration of Leucine-Rich Alpha-2 Glycoprotein 1 (LRG1) and Its Association with Proangiogenic Mediators in Sickle Cell Disease: A Potential Player in the Pathogenesis of the Disease","authors":"Oğuzhan Özcan, Murat Kaçmaz, Fatma Hazal Erdoğan, Lütfiye Seçil Deniz Balyen, Hamdi Oğuzman, Hasan Kaya, Abdullah Arpacı","doi":"10.4274/tjh.galenos.2025.2025.0441","DOIUrl":"10.4274/tjh.galenos.2025.2025.0441","url":null,"abstract":"<p><strong>Objective: </strong>Leucine-rich alpha-2-glycoprotein 1 (LRG1) is a novel mediator involved in abnormal angiogenesis. We aimed to investigate circulating LRG1 levels and their relationship with proangiogenic mediators in sickle cell disease (SCD).</p><p><strong>Materials and methods: </strong>A total of 50 patients with SCD, with 25 in steady-state condition (SCD-SS) and 25 in periods of painful vaso-occlusive crisis (SCD-VOC), and 25 healthy controls were included in the study. Demographical and clinical data were collected from hospital records. Serum LRG1, vascular endothelial growth factor A (VEGFA), and hypoxia-inducible factor 1-alpha (HIF1A) levels were measured by enzyme-linked immunosorbent assay (ELISA), and C-reactive protein (CRP) was measured by the nephelometric method. Routine biochemical parameters were assessed using an autoanalyzer. Multinomial logistic regression was used to analyze ELISA parameters, and receiver operating characteristic (ROC) curves were constructed to determine the optimal cut-off point for HIF1A to predict VOCs in SCD patients.</p><p><strong>Results: </strong>LRG1 and VEGFA levels were significantly higher in SCD patients than controls (p<0.001), with no difference between the SCD-SS and SCD-VOC groups. HIF1A, CRP, and lactate dehydrogenase levels differed significantly across all groups, being highest in the SCD-VOC group (p<0.001). After adjusting for age and sex, LRG1, HIF1A, and VEGFA remained elevated in the SCD groups. HIF1A correlated with CRP (r=0.351, p=0.024), but LRG1 showed no correlation with proangiogenic mediators in the SCD-VOC group. The area under the ROC curve was calculated as 0.694 (95% confidence interval: 0.542-0.845, p=0.021) and the optimal cut-off point was 494.5 pg/mL for HIF1A in predicting vaso-occlusive crises in patients with SCD.</p><p><strong>Conclusion: </strong>Circulating LRG1 levels may reflect neutrophil activation and contribute to the cross-talk between proangiogenic mediators released in SCD.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"100-107"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basophils in Acute Promyelocytic Leukemia: Clonality or Reactiveness?","authors":"Xue Li, Qingqing Yang, Pengfei Qin, Baodan Yu","doi":"10.4274/tjh.galenos.2025.2024.0433","DOIUrl":"10.4274/tjh.galenos.2025.2024.0433","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"148-149"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Re-Pigmentation After Nilotinib","authors":"Öznur Aydın, Mehmet Turgut","doi":"10.4274/tjh.galenos.2025.2025.0102","DOIUrl":"10.4274/tjh.galenos.2025.2025.0102","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"163-164"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Evaluation of Clinical and Follow-Up Outcomes in Primary Cutaneous CD30⁺ Lymphoproliferative Disorders","authors":"Hatice Şanlı, Ahmet Taha Aydemir, İncilay Kalay Yıldızhan, Aylin Heper, Işınsu Kuzu, Ayça Kırmızı, Ayşenur Botsalı, Bengü Nisa Akay","doi":"10.4274/tjh.galenos.2025.2025.0045","DOIUrl":"10.4274/tjh.galenos.2025.2025.0045","url":null,"abstract":"<p><p>This study evaluated the demographic data, clinical characteristics, treatment approaches, and treatment responses of 43 patients with primary cutaneous CD30⁺ lymphoproliferative disorders. Lymphomatoid papulosis (LyP) was characterized by predominantly papular (94.1%) and generalized (70.6%) lesions, while primary cutaneous anaplastic large-cell lymphoma (pcALCL) presented with tumoral (77.8%) and solitary (77.8%) lesions (p<0.001). Common treatments for LyP included methotrexate (response rate: 78.5%), topical corticosteroids (response rate: 83.3%), and phototherapy (response rate: 85.8%), but relapse rates were high. In pcALCL, complete remission was achieved with all treatments, with no relapses after brentuximab vedotin (BV). Secondary malignancies were noted in 20.6% of LyP cases. Both LyP and pcALCL had a 100% 5-year disease-specific survival rate, although two LyP patients (5.9%) died of secondary malignancies. In conclusion, LyP and pcALCL are both indolent lymphomas, with LyP being more prone to relapse. BV is effective for resistant pcALCL. LyP patients need long-term monitoring due to the risk of secondary malignancies.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"136-141"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The IRF2-INPP4B Pathway Aggravates Acute Myeloid Leukemia","authors":"Xiangqin Xing, Mei Zhang, Shengfen Tan, Junfeng Zhu, Jiajia Li, Pingping Zhang, Yuan Yuan, Meng Wang, Feng Zhang","doi":"10.4274/tjh.galenos.2024.2025.0292","DOIUrl":"10.4274/tjh.galenos.2024.2025.0292","url":null,"abstract":"<p><strong>Objective: </strong>Interferon-regulatory factor 2 (IRF2) and inositol polyphosphate 4-phosphatase B (INPP4B) are indispensable for differentiating immune T-cells, but the regulatory principle of the IRF2-INPP4B signaling channel in the apoptosis of acute myeloid leukemia (AML) cells remains unclear. This work investigates the function and regulatory principle of IRF2-INPP4B signaling in the progression of AML.</p><p><strong>Materials and methods: </strong>CD4⁺ T-cells were extracted from peripheral blood and characterized via flow cytometry. Flow cytometry was used to estimate apoptosis in the HL60 AML cell line and determine the Th1/Th2 cell ratio. Quantitative real-time polymerase chain reaction was used to measure <i>IRF2</i> mRNA. Western blotting was performed to evaluate the protein levels of IRF2, INPP4B, JAK2, p-JAK2, STAT3, p-STAT3, and caspase 3. Interleukin-4 and interferon gamma concentrations were determined using enzyme-linked immunoadsorption assay kits.</p><p><strong>Results: </strong>We discovered that levels of IRF2 and INPP4B were high in AML-derived CD4⁺ T-cells. Furthermore, CD4⁺ T-cells encouraged HL60 cell apoptosis. Downregulation of IRF2 encouraged HL60 cell apoptosis via alterations in the Th1/Th2 ratio while the overexpression of IRF2 stimulated the JAK2-STAT3 signaling channel and downregulated caspase 3.</p><p><strong>Conclusion: </strong>We revealed that IRF2-INPP4B signaling in CD4⁺ T-cells stimulated the JAK2-STAT3 signaling channel and downregulated caspase 3, reducing AML cell apoptosis and aggravating AML progression. This work highlights an important regulatory principle concerning AML progression, as the IRF2-INPP4B pathway might impact the JAK2-STAT3 signaling channel. The findings contribute to our knowledge of the complicated interplay of these pathways in AML.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"82-91"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Precipitation in Donor Bone Marrow Caused by Overnight Cold Preservation in a Refrigerator","authors":"Osamu Imataki, Tomohiro Kaji, Makiko Uemura","doi":"10.4274/tjh.galenos.2025.2025.0087","DOIUrl":"10.4274/tjh.galenos.2025.2025.0087","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"161-162"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric Manifestations in Polycythemia Vera: A Case of Refractory Delirium and Psychosis Responding to Hematological Treatment","authors":"Yusuf Ezel Yıldırım, Hatice Irmak Erözeren, Emine Gültürk, Nuran Çağlar Tanrıverdi, Özlem Devrim Balaban","doi":"10.4274/tjh.galenos.2025.2025.0060","DOIUrl":"10.4274/tjh.galenos.2025.2025.0060","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"167-169"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-379-5p Inhibited the Proliferation of Acute Myeloid Leukemia Cells Through Negative Regulation of <i>YBX1</i>","authors":"Huichao Wu, Lin Zhao, Huanyu Guo, Yingjie Xie, Jianhua Hu, Xinxia Tan","doi":"10.4274/tjh.galenos.2025.2024.0424","DOIUrl":"10.4274/tjh.galenos.2025.2024.0424","url":null,"abstract":"<p><strong>Objective: </strong>Acute myeloid leukemia (AML) highly lethal hematological malignancy that is difficult to treat. This study aimed to clarify the molecular mechanisms of miR-379-5p in AML progression.</p><p><strong>Materials and methods: </strong>Quantitative real-time polymerase chain reaction was utilized to evaluate miR-379-5p expression levels in AML patients and a control group. A receiver operating characteristic curve was created to assess the clinical predictive value of miR-379-5p in AML, while cell experiments used the CCK-8 assay, flow cytometry, and transwell chambers. Potential target genes of miR-379-5p were predicted by employing online bioinformatics tools, followed by validation using a dual luciferase reporter assay.</p><p><strong>Results: </strong>miR-379-5p expression was significantly decreased in AML patients and had clinical predictive value for the disease. In AML cell lines, miR-379-5p was downregulated; conversely, the upregulation of miR-379-5p inhibited proliferation, migration, and invasion while promoting apoptosis. Notably, <i>YBX1</i> was a potential target gene of miR-379-5p and its upregulation reduced the effects of miR-379-5p on AML cell behavior.</p><p><strong>Conclusion: </strong>miR-379-5p has potential as a biomarker for AML by regulating cell proliferation and apoptosis through the targeting of <i>YBX1</i>.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"92-99"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral T-Cell Lymphoma, Not Otherwise Specified, Diagnosed from Prostate Tissue: A Rare Case","authors":"Rafiye Çiftçiler, Hasan Önner, Cem Selim","doi":"10.4274/tjh.galenos.2025.2025.0037","DOIUrl":"10.4274/tjh.galenos.2025.2025.0037","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"156-157"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Contribution of Turkish Hematology to Global Literature - A Comparative Analysis.","authors":"Ömür Gökmen Sevindik, Yaşa Gül Mutlu, Fatih Demirkan","doi":"10.4274/tjh.galenos.2025.2025.0029","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2025.2025.0029","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}