Turkish Journal of Hematology最新文献

A Case of VEXAS Syndrome Presenting with Unexplained Headache. 一个以不明原因头痛为表现的 VEXAS 综合征病例。

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-04-07 DOI: 10.4274/tjh.galenos.2025.2025.0080

Ünal Ataş, Fadime Nurcan Alhan, Dilek Beypınar, Sevinç Şahin, Şakir Özgür Keşkek

引用次数: 0

Successful Treatment of Childhood Hodgkin's Lymphoma and Secondary Myelofibrosis Resistant to Intensive Therapy, Including Allogeneic Transplantation. 成功治疗对强化治疗（包括同种异体移植）耐药的儿童霍奇金淋巴瘤和继发性骨髓纤维化。

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-04-07 DOI: 10.4274/tjh.galenos.2025.2025.0044

Deniz Koçak Göl, Veysel Gök, Alper Özcan, Ebru Yılmaz, Ekrem Ünal, Ümmühan Abdülrezzak, Özlem Canöz, Musa Karakükcü

引用次数: 0

Extranodal NK/T-cell Lymphoma, Nasal Type.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-27 DOI: 10.4274/tjh.galenos.2025.2025.0079

Ankur Jain

引用次数: 0

What Happened: Suddenly or Acute Abdomen? Difficult Case of ATRA Related Pneumatosis Cystoides Intestinalis.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-19 DOI: 10.4274/tjh.galenos.2025.2025.0020

Merve Ecem Erdoğan Yön, Ahmet Ceylan, Emel İşleyen Kaya, Esin Ölçücüoğlu, Funda Ceran, Simten Dağdaş, Gülsüm Özet

引用次数: 0

Peripheral T-cell Lymphoma, Not Otherwise Specified, Diagnosed From Prostate Tissue: A Rare Case.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-19 DOI: 10.4274/tjh.galenos.2025.2025.0037

Rafiye Çiftçiler, Hasan Önner, Cem Selim

引用次数: 0

Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-17 DOI: 10.4274/tjh.galenos.2025.2025.0034

Lokman H Tanrıverdi, Ahmet Sarıcı

{"title":"Efficacy, Safety, and Tolerability of Ferric Carboxymaltose and Iron Sucrose in Iron Deficiency Anemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Lokman H Tanrıverdi, Ahmet Sarıcı","doi":"10.4274/tjh.galenos.2025.2025.0034","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2025.2025.0034","url":null,"abstract":"Objective: To comprehensively compare the efficacy, safety, and tolerability of two commonly used intravenous iron preparations, ferric carboxymaltose (FCM) and iron sucrose (IS), in adult patients with iron-deficiency anemia (IDA).Methods: A systematic literature search was conducted across PubMed, Ovid Medline, Web of Science, Scopus, and the Cochrane Library up to Jan 1, 2024, to identify randomized controlled trials directly comparing FCM and IS treatments in adult patients with IDA. Primary outcome was change in hemoglobin levels during folllow-up. Meta-analyses were conducted with inverse variance random effects models.Results: Fourteen trials were included, with a total of 4757 patients. FCM resulted in a nonsignificant increase in hemoglobin levels (mean difference [MD] = 0.45 g/dL, 95% confidence interval [CI] = 0.08 to 0.83, p=0.02) and ferritin levels (MD = 37.32 ng/mL, 95% CI = 18.98 to 55.65, p<0.01) compared to IS. FCM was associated with a higher risk of hypersensitivity reactions compared to IS (RR: 2.97, 95% CI: 1.35-6.52, p<0.01) but showed no significant difference in severe adverse events (RR: 1.03, 95% CI: 0.88-1.21, p=0.70) and had a nonsignificant increased risk of hypophosphatemia (RR: 2.84, 95% CI: 0.89-9.06, p=0.08).Conclusions: Ten studies showed some concerns of risk of bias, and four studies had a high risk of bias for the change in hemoglobin levels during follow-up. Lack of standardized definitions for hypersensitivity reactions and variability in dosing protocols and follow-up durations across studies may affect the generalizability of our safety findings.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Myeloid Leukemia with NUP98::LNP1 Fusion Mimicking Chronic Myeloid Leukemia. 急性髓性白血病与 NUP98::LNP1 融合模拟慢性髓性白血病

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-17 DOI: 10.4274/tjh.galenos.2025.2024.0391

Haiyang Wang, Yu Peng, Zailin Yang

引用次数: 0

The Basophils in Acute Promyelocytic Leukemia: Clonality or Reactiveness?

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-17 DOI: 10.4274/tjh.galenos.2025.2024.0433

Xue Li, Qingqing Yang, Pengfei Qin, Baodan Yu

引用次数: 0

A Rare Case of Non-Hodgkin Lymphoma Presenting as a Mass Originating from the Corpus Cavernosum.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-10 DOI: 10.4274/tjh.galenos.2025.2024.0374

Ahmet Halil Sevinç, İlker Teke, Özge Hürdoğan, Ali Altay, Zeynep Cantürk, Murat Dursun, Ateş Kadıoğlu

引用次数: 0

Hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NFkB Signaling Pathway.

IF 1.5 4区医学

Turkish Journal of Hematology Pub Date : 2025-03-06 DOI: 10.4274/tjh.galenos.2025.2024.0160

Jian Wang, Binghui Du

{"title":"Hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NFkB Signaling Pathway.","authors":"Jian Wang, Binghui Du","doi":"10.4274/tjh.galenos.2025.2024.0160","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2025.2024.0160","url":null,"abstract":"Objective: Deep vein thrombosis (DVT) is a type of vascular disorder and the incidence is around 0.1%. Endothelial progenitor cells (EPCs) are precursor cells of endothelial cells and contribute to vascular repair and regeneration. CircRNAs become a new research hotspot as they are involved in various biological processes including the progression of DVT.Material and methods: The expression of hsa_circRNA_092488 was evaluated in venous blood samples obtained from DVT patients (n=42) and healthy controls (n=42). Gain- and loss-of-function studies of hsa_circRNA_092488 were carried out. Expression of related RNA and protein was examined by qRT-PCR, western blotting and immunofluorescence assays. The proliferation, migration, cell cycle and apoptosis of transfected cells were measured by CCK-8, Transwell assay as well as Flow cytometry. The association of hsa_circRNA_092488 and NLRP3 in EPCs was unrevealed using RNA pull-down analysis. Furthermore, stabilities of NLRP3 mRNA were examined in transfected EPCs.Results: In this study, up-regulation of hsa_circRNA_092488 was detected in DVT samples, which could suppress the proliferation and migration of EPCs, induce cell cycle arrest from S to G0/G1 phase and trigger cell apoptosis. Furthermore, NLRP3 was identified as the potential downstream molecule of hsa_circRNA_092488, and it could exert its regulatory functions through activating the NLRP3/NF-kB signaling. Overexpressed hsa_circRNA_092488 in the cell notably elevated the protein expression of caspase-1, IL-1b, P-NF-κB-p65/NF-κB-p65 and P-IκBa/IκBa; and vice versa, knockdown of hsa_circRNA_092488 significantly reduced the levels of these related proteins in EPCs.Conclusion: The hsa_circRNA_092488/NLRP3/NF-kB signaling could be novel therapeutic candidate for the treatment of DVT.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0