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Retrospective Evaluation of Clinical and Follow-Up Outcomes in Primary Cutaneous CD30+ Lymphoproliferative Disorders 原发性皮肤CD30+淋巴细胞增生性疾病的临床和随访结果的回顾性评价。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-03-06 DOI: 10.4274/tjh.galenos.2025.2025.0045
Hatice Şanlı, Ahmet Taha Aydemir, İncilay Kalay Yıldızhan, Aylin Heper, Işınsu Kuzu, Ayça Kırmızı, Ayşenur Botsalı, Bengü Nisa Akay
{"title":"Retrospective Evaluation of Clinical and Follow-Up Outcomes in Primary Cutaneous CD30<sup>+</sup> Lymphoproliferative Disorders","authors":"Hatice Şanlı, Ahmet Taha Aydemir, İncilay Kalay Yıldızhan, Aylin Heper, Işınsu Kuzu, Ayça Kırmızı, Ayşenur Botsalı, Bengü Nisa Akay","doi":"10.4274/tjh.galenos.2025.2025.0045","DOIUrl":"10.4274/tjh.galenos.2025.2025.0045","url":null,"abstract":"<p><p>This study evaluated the demographic data, clinical characteristics, treatment approaches, and treatment responses of 43 patients with primary cutaneous CD30<sup>+</sup> lymphoproliferative disorders. Lymphomatoid papulosis (LyP) was characterized by predominantly papular (94.1%) and generalized (70.6%) lesions, while primary cutaneous anaplastic large-cell lymphoma (pcALCL) presented with tumoral (77.8%) and solitary (77.8%) lesions (p<0.001). Common treatments for LyP included methotrexate (response rate: 78.5%), topical corticosteroids (response rate: 83.3%), and phototherapy (response rate: 85.8%), but relapse rates were high. In pcALCL, complete remission was achieved with all treatments, with no relapses after brentuximab vedotin (BV). Secondary malignancies were noted in 20.6% of LyP cases. Both LyP and pcALCL had a 100% 5-year disease-specific survival rate, although two LyP patients (5.9%) died of secondary malignancies. In conclusion, LyP and pcALCL are both indolent lymphomas, with LyP being more prone to relapse. BV is effective for resistant pcALCL. LyP patients need long-term monitoring due to the risk of secondary malignancies.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"136-141"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The IRF2-INPP4B Pathway Aggravates Acute Myeloid Leukemia IRF2-INPP4B通路在CD4+ T细胞中被激活，并通过抑制细胞凋亡而加重急性髓系白血病的发展。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-02-17 DOI: 10.4274/tjh.galenos.2024.2025.0292
Xiangqin Xing, Mei Zhang, Shengfen Tan, Junfeng Zhu, Jiajia Li, Pingping Zhang, Yuan Yuan, Meng Wang, Feng Zhang
{"title":"The IRF2-INPP4B Pathway Aggravates Acute Myeloid Leukemia","authors":"Xiangqin Xing, Mei Zhang, Shengfen Tan, Junfeng Zhu, Jiajia Li, Pingping Zhang, Yuan Yuan, Meng Wang, Feng Zhang","doi":"10.4274/tjh.galenos.2024.2025.0292","DOIUrl":"10.4274/tjh.galenos.2024.2025.0292","url":null,"abstract":"<p><strong>Objective: </strong>Interferon-regulatory factor 2 (IRF2) and inositol polyphosphate 4-phosphatase B (INPP4B) are indispensable for differentiating immune T-cells, but the regulatory principle of the IRF2-INPP4B signaling channel in the apoptosis of acute myeloid leukemia (AML) cells remains unclear. This work investigates the function and regulatory principle of IRF2-INPP4B signaling in the progression of AML.</p><p><strong>Materials and methods: </strong>CD4<sup>+</sup> T-cells were extracted from peripheral blood and characterized via flow cytometry. Flow cytometry was used to estimate apoptosis in the HL60 AML cell line and determine the Th1/Th2 cell ratio. Quantitative real-time polymerase chain reaction was used to measure <i>IRF2</i> mRNA. Western blotting was performed to evaluate the protein levels of IRF2, INPP4B, JAK2, p-JAK2, STAT3, p-STAT3, and caspase 3. Interleukin-4 and interferon gamma concentrations were determined using enzyme-linked immunoadsorption assay kits.</p><p><strong>Results: </strong>We discovered that levels of IRF2 and INPP4B were high in AML-derived CD4<sup>+</sup> T-cells. Furthermore, CD4<sup>+</sup> T-cells encouraged HL60 cell apoptosis. Downregulation of IRF2 encouraged HL60 cell apoptosis via alterations in the Th1/Th2 ratio while the overexpression of IRF2 stimulated the JAK2-STAT3 signaling channel and downregulated caspase 3.</p><p><strong>Conclusion: </strong>We revealed that IRF2-INPP4B signaling in CD4<sup>+</sup> T-cells stimulated the JAK2-STAT3 signaling channel and downregulated caspase 3, reducing AML cell apoptosis and aggravating AML progression. This work highlights an important regulatory principle concerning AML progression, as the IRF2-INPP4B pathway might impact the JAK2-STAT3 signaling channel. The findings contribute to our knowledge of the complicated interplay of these pathways in AML.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"82-91"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty Precipitation in Donor Bone Marrow Caused by Overnight Cold Preservation in a Refrigerator 供体骨髓在冰箱冷藏过夜后脂肪沉淀。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-04-10 DOI: 10.4274/tjh.galenos.2025.2025.0087
Osamu Imataki, Tomohiro Kaji, Makiko Uemura
{"title":"Fatty Precipitation in Donor Bone Marrow Caused by Overnight Cold Preservation in a Refrigerator","authors":"Osamu Imataki, Tomohiro Kaji, Makiko Uemura","doi":"10.4274/tjh.galenos.2025.2025.0087","DOIUrl":"10.4274/tjh.galenos.2025.2025.0087","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"161-162"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric Manifestations in Polycythemia Vera: A Case of Refractory Delirium and Psychosis Responding to Hematological Treatment 真性红细胞增多症的精神病学表现：一例难治性谵妄和精神病对血液治疗的反应。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-04-29 DOI: 10.4274/tjh.galenos.2025.2025.0060
Yusuf Ezel Yıldırım, Hatice Irmak Erözeren, Emine Gültürk, Nuran Çağlar Tanrıverdi, Özlem Devrim Balaban
{"title":"Psychiatric Manifestations in Polycythemia Vera: A Case of Refractory Delirium and Psychosis Responding to Hematological Treatment","authors":"Yusuf Ezel Yıldırım, Hatice Irmak Erözeren, Emine Gültürk, Nuran Çağlar Tanrıverdi, Özlem Devrim Balaban","doi":"10.4274/tjh.galenos.2025.2025.0060","DOIUrl":"10.4274/tjh.galenos.2025.2025.0060","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"167-169"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-379-5p Inhibited the Proliferation of Acute Myeloid Leukemia Cells Through Negative Regulation of YBX1 MiR-379-5p通过负调控YBX1抑制急性髓系白血病细胞增殖。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-02-24 DOI: 10.4274/tjh.galenos.2025.2024.0424
Huichao Wu, Lin Zhao, Huanyu Guo, Yingjie Xie, Jianhua Hu, Xinxia Tan
{"title":"miR-379-5p Inhibited the Proliferation of Acute Myeloid Leukemia Cells Through Negative Regulation of <i>YBX1</i>","authors":"Huichao Wu, Lin Zhao, Huanyu Guo, Yingjie Xie, Jianhua Hu, Xinxia Tan","doi":"10.4274/tjh.galenos.2025.2024.0424","DOIUrl":"10.4274/tjh.galenos.2025.2024.0424","url":null,"abstract":"<p><strong>Objective: </strong>Acute myeloid leukemia (AML) highly lethal hematological malignancy that is difficult to treat. This study aimed to clarify the molecular mechanisms of miR-379-5p in AML progression.</p><p><strong>Materials and methods: </strong>Quantitative real-time polymerase chain reaction was utilized to evaluate miR-379-5p expression levels in AML patients and a control group. A receiver operating characteristic curve was created to assess the clinical predictive value of miR-379-5p in AML, while cell experiments used the CCK-8 assay, flow cytometry, and transwell chambers. Potential target genes of miR-379-5p were predicted by employing online bioinformatics tools, followed by validation using a dual luciferase reporter assay.</p><p><strong>Results: </strong>miR-379-5p expression was significantly decreased in AML patients and had clinical predictive value for the disease. In AML cell lines, miR-379-5p was downregulated; conversely, the upregulation of miR-379-5p inhibited proliferation, migration, and invasion while promoting apoptosis. Notably, <i>YBX1</i> was a potential target gene of miR-379-5p and its upregulation reduced the effects of miR-379-5p on AML cell behavior.</p><p><strong>Conclusion: </strong>miR-379-5p has potential as a biomarker for AML by regulating cell proliferation and apoptosis through the targeting of <i>YBX1</i>.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"92-99"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral T-Cell Lymphoma, Not Otherwise Specified, Diagnosed from Prostate Tissue: A Rare Case 前列腺组织外周性t细胞淋巴瘤，未明确诊断：一例罕见病例。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-22 Epub Date: 2025-03-19 DOI: 10.4274/tjh.galenos.2025.2025.0037
Rafiye Çiftçiler, Hasan Önner, Cem Selim
{"title":"Peripheral T-Cell Lymphoma, Not Otherwise Specified, Diagnosed from Prostate Tissue: A Rare Case","authors":"Rafiye Çiftçiler, Hasan Önner, Cem Selim","doi":"10.4274/tjh.galenos.2025.2025.0037","DOIUrl":"10.4274/tjh.galenos.2025.2025.0037","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"156-157"},"PeriodicalIF":1.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cabot Ring at Different Stages of Erythropoiesis in the Bone Marrow of a Leukemic Patient 白血病患者骨髓红细胞生成不同阶段的卡伯特环。
IF 1.3 4区 医学
Turkish Journal of Hematology Pub Date : 2025-05-06 DOI: 10.4274/tjh.galenos.2025.2025.0086
Atakan Turgutkaya, Ayşe Hilal Eroğlu Küçükdiler, İrfan Yavaşoğlu
{"title":"The Cabot Ring at Different Stages of Erythropoiesis in the Bone Marrow of a Leukemic Patient","authors":"Atakan Turgutkaya, Ayşe Hilal Eroğlu Küçükdiler, İrfan Yavaşoğlu","doi":"10.4274/tjh.galenos.2025.2025.0086","DOIUrl":"10.4274/tjh.galenos.2025.2025.0086","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sitosterolemia with Compound Heterozygous Variants in the ABCG5 Gene: A Rare Cause of Non-Immune Hemolysis and Macrothrombocytopenia 伴有ABCG5基因复合杂合变异体的谷固醇血症：非免疫性溶血和巨血小板减少症的罕见病因。
IF 1.3 4区 医学
Turkish Journal of Hematology Pub Date : 2025-04-29 DOI: 10.4274/tjh.galenos.2025.2025.0093
Başak Bostankolu Değirmenci, Hamza Polat
{"title":"Sitosterolemia with Compound Heterozygous Variants in the <i>ABCG5</i> Gene: A Rare Cause of Non-Immune Hemolysis and Macrothrombocytopenia","authors":"Başak Bostankolu Değirmenci, Hamza Polat","doi":"10.4274/tjh.galenos.2025.2025.0093","DOIUrl":"10.4274/tjh.galenos.2025.2025.0093","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of VEXAS Syndrome Presenting with Unexplained Headache. 一个以不明原因头痛为表现的 VEXAS 综合征病例。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-04-07 DOI: 10.4274/tjh.galenos.2025.2025.0080
Ünal Ataş, Fadime Nurcan Alhan, Dilek Beypınar, Sevinç Şahin, Şakir Özgür Keşkek
{"title":"A Case of VEXAS Syndrome Presenting with Unexplained Headache.","authors":"Ünal Ataş, Fadime Nurcan Alhan, Dilek Beypınar, Sevinç Şahin, Şakir Özgür Keşkek","doi":"10.4274/tjh.galenos.2025.2025.0080","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2025.2025.0080","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Images of Temporomandibular Joint Arthropathy in Patient with Severe Hemophilia B with Inhibitor and Patient with Type III von Willebrand Disease with Inhibitor 一名严重血友病 B 型患者（含抑制剂）和一名 III 型 Von Willebrand 患者（含抑制剂）的颞下颌关节关节病图像。
IF 1.5 4区 医学
Turkish Journal of Hematology Pub Date : 2025-02-28 Epub Date: 2024-09-25 DOI: 10.4274/tjh.galenos.2024.2024.0342
Selda Yenel, Dilek Aynur Çankal, Zühre Akarslan, Merve Yazol, Zühre Kaya
{"title":"Images of Temporomandibular Joint Arthropathy in Patient with Severe Hemophilia B with Inhibitor and Patient with Type III von Willebrand Disease with Inhibitor","authors":"Selda Yenel, Dilek Aynur Çankal, Zühre Akarslan, Merve Yazol, Zühre Kaya","doi":"10.4274/tjh.galenos.2024.2024.0342","DOIUrl":"10.4274/tjh.galenos.2024.2024.0342","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"59-60"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142354705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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