Turkish Journal of Medical Sciences最新文献

{"title":"Non-pulmonary arterial involvement in Behçet's disease: a multicenter retrospective case series.","authors":"Özge Karakök, Duygu Kerim, Şerife Çoşkun Sağirkaya, Gamze Akkuzu, Burcu Ceren Uludoğan, Gezmiş Kimyon, Hasan Kocaayan, Senar Şan, Özkan Urak, Gökçe Kenar, Ayşe Cefle, Servet Akar, Nazife Şule Yaşar Bilge, Cemal Bes, Şükran Erten, Ahmet Omma, Gökhan Keser, Kenan Aksu, Tulin Ergun, Rafi Haner Direskeneli, Fatma Alibaz Öner","doi":"10.55730/1300-0144.6206","DOIUrl":"10.55730/1300-0144.6206","url":null,"abstract":"<p><strong>Background/aim: </strong>In Behçet's disease (BD), arterial involvement represents a significant clinical challenge associated with serious complications. The present study evaluates the characteristic features, affected vessels, lesion types, treatments, and outcomes in BD patients with nonpulmonary arterial involvement.</p><p><strong>Materials and methods: </strong>Included in this retrospective study were 65 BD patients whose interventions and clinical courses were accessed from medical records. The treatments administered included immunosuppressive (IS) therapies and surgical/endovascular procedures. Fisher's exact and t-test/Mann-Whitney U test were used for statistical analysis.</p><p><strong>Results: </strong>Fifty-nine of the patients (90.8%) were male. The median (Q1-Q3) follow-up was 4 (2-12.8) years. The most commonly affected vessels were the aorta (n = 21, 32.3%) and the femoral artery (n = 19, 29.2%). Aneurysm (n = 50, 63.2%) and thrombosis (n = 18, 22.7%) were the predominant lesions; 14 (21.5%) patients experienced arterial involvement while receiving IS therapy; and 11 (16.9%) had cardiac involvement. Cyclophosphamide and azathioprine were the most commonly used IS agents. Among the 39 (60%) patients who underwent surgical and/or interventional procedures, 32 (82%) had successful outcomes. A second arterial event was experienced by 15.3% of the sample during follow-up, and a third by 3%. Active disease was noted in nine (13.8%) patients at the time of their last visit, and of the six (9.2%) that died, most had both arterial and cardiac involvement.</p><p><strong>Conclusion: </strong>Arterial involvement in BD mostly presents with aneurysms, especially in men. Surgical interventions in addition to IS therapies are required in approximately 50% of cases. As can be understood from the 15.3% relapse rate in the present study, arterial events are not uncommon, underlining the need for long-term monitoring and sustained IS treatment. Of the 9.2% of cases who died, most had both arterial and cardiac involvement.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"730-739"},"PeriodicalIF":1.4,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of lamellar crescentic wedge resection on corneal astigmatism and optical aberrations in patients with advanced pellucid marginal degeneration.","authors":"Ayşe Burcu, Hande Hüsniye Telek, Hakan Mert, Yaprak Arzu Özdemir, Züleyha Yalnız Akkaya, Evin Şingar, Selma Özbek Uzman","doi":"10.55730/1300-0144.6199","DOIUrl":"10.55730/1300-0144.6199","url":null,"abstract":"<p><strong>Background/aim: </strong>The present study investigates the long-term changes in corneal astigmatism and aberrations following lamellar wedge resection in cases with advanced pellucid marginal degeneration (PMD).</p><p><strong>Materials and methods: </strong>Patients with advanced PMD whose visual acuity did not improve with glasses or contact lenses underwent lamellar crescentic wedge resection. Pre- and postoperative assessments at 3, 6, 12, and 24 months using Pentacam HR were conducted to identify changes in corrected visual acuity, corneal astigmatism, and higher-order aberrations (HOAs) following the procedure, and compared with a control group.</p><p><strong>Results: </strong>Statistically significant postoperative improvements in corrected visual acuity were observed at 6 and 12 months compared to preoperative values. At postoperative 3, 6, 12, and 24 months, significant improvements from preoperative values were noted in logMAR, astigmatism, and Kmax parameters (p < 0.05). A comparison of the patients with PMD and a control group revealed significant postoperative reductions in anterior and posterior coma, trefoil, spherical, and tetrafoil aberrations at 4 mm and 6 mm (p < 0.05). Most parameters remained statistically different from the healthy controls, indicating improvement without complete normalization. Although no significant difference was noted in the 6 mm anterior root mean square (RMS) value, a statistically significant reduction was observed in the 6 mm posterior RMS value at postoperative 3 and 6 months (p < 0.05).</p><p><strong>Conclusion: </strong>Lamellar crescentic wedge resection may be considered an appropriate and relatively safe surgical option for selected patients with advanced PMD, avoiding the risks associated with open-eye surgery, graft rejection, and secondary glaucoma. Long-term improvements in visual acuity, corneal astigmatism, and selected HOAs were noted following the procedure. Given the limited sample size and exploratory study design, these findings should be interpreted with caution and considered hypothesis-generating rather than definitive.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"654-666"},"PeriodicalIF":1.4,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Turkish version of the Barthel Index-dyspnea in patients with pulmonary hypertension.","authors":"Pınar Merç, Rengin Demir, Melih Zeren, Habibe Durdu, Ümit Yaşar Sinan, Mehmet Serdar Küçükoğlu","doi":"10.55730/1300-0144.6213","DOIUrl":"10.55730/1300-0144.6213","url":null,"abstract":"<p><strong>Background/aim: </strong>The Barthel Index-dyspnea (BI-d) is a respiratory disease-specific tool developed on the basis of the Barthel Index (BI), which provides a simple and quick way to measure the degree of dyspnea in activities of daily living (ADL). Dyspnea is one of the most common symptoms of pulmonary hypertension (PH). The objective of this study was to explore the reliability and validity of the Turkish version of the BI-d in patients with PH.</p><p><strong>Materials and methods: </strong>A total of 73 PH patients were included in the study. Criterion validity was explored using the modified Medical Research Council (mMRC) dyspnea scale, 6-min walk test (6MWT), and London Chest Activities of Daily Living (LCADL) scale, while divergent validity was examined through correlations between the BI-d and BI.</p><p><strong>Results: </strong>The BI-d demonstrated strong correlations with the LCADL (r = 0.801) and mMRC (r = 0.775), and a moderately negative correlation with the 6MWD (r = -0.510), supporting criterion-related validity. A weak negative correlation with the BI (r = -0.289) supported divergent validity. The BI-d scores differed significantly across the mMRC grades and PH functional classes, confirming known-group validity. Reliability analyses showed good internal consistency (Cronbach's α = 0.85) and excellent test-retest reliability (intraclass correlation coefficient = 0.94).</p><p><strong>Conclusion: </strong>The Turkish version of the BI-d demonstrates high reliability and validity in PH. As a tool that integrates respiratory burden with activity-related functional performance, it provides a practical assessment of dyspnea-related impairment during ADL.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"794-800"},"PeriodicalIF":1.4,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common femoral vein wall thickness as a supportive imaging marker in the differential diagnosis of Behçet's uveitis.","authors":"Seda Kutluğ Ağaçkiran, Esra Kardeş, Abdulbaki Ağaçkiran, Haner Direskeneli, Fatma Alibaz Öner","doi":"10.55730/1300-0144.6209","DOIUrl":"10.55730/1300-0144.6209","url":null,"abstract":"<p><strong>Background/aim: </strong>Ocular involvement is a major cause of morbidity in Behçet's disease (BD), and its diagnosis may be challenging, particularly for patients with isolated ocular manifestations or incomplete fulfillment of diagnostic criteria. Increased common femoral vein (CFV) wall thickness measured by Doppler ultrasonography (US) has previously been shown to be a sensitive and specific marker for systemic BD. This study aimed to evaluate whether CFV wall thickness measurement may serve as a supportive tool in distinguishing Behçet's uveitis (BU) from other forms of inflammatory uveitis.</p><p><strong>Materials and methods: </strong>This retrospective study included 45 patients with BU fulfilling the International Study Group criteria for BD and 72 patients with non-BD uveitis of infectious and noninfectious etiologies. Bilateral CFV wall thickness was measured using color Doppler US by a radiologist blinded to the clinical data. Group comparisons were performed and multivariate linear regression analyses were used to assess whether BU was independently associated with increased CFV wall thickness after adjustment for potential confounders. Exploratory analyses additionally evaluated the effects of disease duration and systemic treatment status.</p><p><strong>Results: </strong>Mean CFV wall thickness was significantly higher in the BU group than in the non-BU group in both extremities (p < 0.001). BU remained an independent predictor of increased CFV wall thickness after adjustment for sex and venous Doppler findings. Additional exploratory analyses adjusting for disease duration and current systemic treatment status did not change this association.</p><p><strong>Conclusion: </strong>CFV wall thickness measured by Doppler US was significantly increased in patients with BU compared to other forms of inflammatory uveitis. These findings suggest that CFV wall thickness may serve as a supportive or adjunctive imaging marker in selected cases to assist in the differential diagnosis of ocular BD.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"761-768"},"PeriodicalIF":1.4,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of transforaminal epidural steroid injection on pain, disability, and kinesiophobia in lumbar disc herniation with radicular pain.","authors":"Hande Ece Öz, Rumeysa Çetinkaya Bulutoğlu, Furkan Çetin, Ezgi Can, Alp Eren Çelenlioğlu, Ender Sir","doi":"10.55730/1300-0144.6203","DOIUrl":"10.55730/1300-0144.6203","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim was to evaluate the effect of single-level transforaminal epidural steroid injection (TFESI) on kinesiophobia (KP) in patients with lumbar radicular pain (RP) caused by single-root, single-level lumbar disc herniation (LDH).</p><p><strong>Materials and methods: </strong>A total of 63 patients diagnosed with unilateral single-level radicular pain due to LDH and treated with single-level TFESI were included. The Numeric Rating Scale (NRS), modified Oswestry Disability Index (MODI), Tampa Scale of Kinesiophobia (TSK), and Neuropathic pain (NP)-Douleur Neuropathique 4 Questionnaire (DN4) were used before the procedure and at 3 weeks and 3 months postoperatively.</p><p><strong>Results: </strong>At baseline, 76.19% (n = 48) of the patients exhibited KP. Significant improvements were observed in the NRS, TSK, MODI, and DN4 scores at both 3 weeks and 3 months (p < 0.001). Clinical outcomes were similar between the patients with and without KP, except for DN4 scores, which remained significantly higher in the KP group. A ≥50% reduction in the TSK score at the 3-month follow-up was positively correlated with ≥50% improvements in the NRS, MODI, and DN4 scores. Additionally, a longer symptom duration was negatively associated with the degree of improvement in the TSK.</p><p><strong>Conclusion: </strong>Our findings suggest that TFESI is an effective and safe method for alleviating pain and kinesiophobia in patients with chronic radicular pain due to LDH. Clinicians should be aware that a prolonged duration of symptoms is a risk factor that negatively influences the effectiveness of TFESI in cases of KP.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"698-707"},"PeriodicalIF":1.4,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uniportal VATS wedge pulmonary resection.","authors":"Kubilay Inan, Özgür Ömer Yildiz","doi":"10.55730/1300-0144.6346","DOIUrl":"10.55730/1300-0144.6346","url":null,"abstract":"<p><strong>Background/aim: </strong>Video-assisted thoracic surgery (VATS) has emerged as a common approach in surgical procedures involving the lung, mediastinum, thoracic wall, and diaphragm. Recent studies have described the performance of diagnostic and therapeutic VATS procedures via a single port, and the technique has become the preferred diagnostic modality for various intrathoracic pathologies and for patients deemed unsuitable for fine-needle biopsy.</p><p><strong>Materials and methods: </strong>The records of 57 patients who underwent diagnostic and therapeutic uniportal VATS for wedge pulmonary resection between January 2024 and January 2025 were reviewed retrospectively, and details regarding the surgical method, length of hospital stay, complications, and diagnostic accuracy were recorded. The procedures were performed for the diagnosis of interstitial lung disease and for the treatment of undiagnosed pulmonary nodules and primary spontaneous pneumothorax.</p><p><strong>Results: </strong>Of the total sample, 15.8% (n = 9) were female and 84.2% (n = 48) were male, and the mean age was 39.9 years (range 16-77 years). All 57 patients underwent uniportal thoracoscopic pulmonary wedge resection, with 35 treated for pneumothorax and 22 for other conditions. Those treated for pneumothorax were predominantly younger, with a mean age of 26.6 years ( range 16-77 years), while the mean age of the nonpneumothorax patients was 56 years (28-77 years).</p><p><strong>Conclusion: </strong>Thoracoscopic surgery is now the preferred method for both patients and surgeons, and the role of VATS in diagnosis and treatment is growing and gaining value. As a minimally invasive procedure, VATS is associated with a comfortable postoperative period for both the patient and surgeon, which supports its role as a safe and feasible approach to wedge pulmonary resections for certain indications.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 4","pages":"1023-1030"},"PeriodicalIF":1.4,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13528744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of repetitive peripheral magnetic stimulation and transcutaneous electrical nerve stimulation in upper trapezius myofascial pain syndrome.","authors":"Shahriyar Kalbiyev, Şehim Kutlay, Atilla Halil Elhan, Yeşim Kurtaiş Aytür, Aysun Genç","doi":"10.55730/1300-0144.6178","DOIUrl":"10.55730/1300-0144.6178","url":null,"abstract":"<p><strong>Background/aim: </strong>In this prospective, randomized, single-blind study, the effects of repetitive peripheral magnetic stimulation (rPMS) and transcutaneous electrical nerve stimulation (TENS) on pain intensity, functional status, and tissue elasticity were evaluated in patients with upper trapezius myofascial pain syndrome (MPS).</p><p><strong>Materials and methods: </strong>A total of 75 female patients were randomly allocated to three groups: rPMS, TENS, and sham rPMS. All participants were provided with an exercise program consisting of cervical range-of-motion (ROM), stretching, and strengthening exercises. Outcome measures included pain intensity assessed using the visual analog scale, pressure pain threshold (PPT), the Neck Disability Index, cervical ROM, SF-36 subscale scores, and ultrasound shear-wave elastography. All data were collected and compared before treatment, immediately after treatment, and 1 month after treatment.</p><p><strong>Results: </strong>Both rPMS and TENS significantly reduced pain intensity, increased PPT, and improved functional outcomes compared with the sham rPMS group. However, rPMS was associated with a greater increase in PPT compared with TENS (p = 0.013). A significant improvement in ROM was observed across all three groups for all neck positions, except for extension in the sham rPMS group. The rPMS group showed significant improvements in four SF-36 subscales compared with the sham rPMS group, whereas the TENS group showed no significant differences. Furthermore, improvements in physical functioning (p = 0.011) and mental health (p = 0.007) scores were significantly greater in the rPMS group than in the TENS group. A significant increase in muscle elasticity was observed only in the TENS group; no significant change was observed in the rPMS or sham rPMS groups.</p><p><strong>Conclusion: </strong>The findings may suggest that rPMS may be a promising noninvasive modality for the management of MPS. It may be used to reduce pain and improve functional outcomes in patients with MPS. Elastography findings may indicate that neurophysiological mechanisms contribute substantially to pain and dysfunction; however, mechanical stiffness cannot be excluded as a contributing factor. Longer follow-up studies are needed to determine the effectiveness of rPMS treatment protocols.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"439-453"},"PeriodicalIF":1.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma data in Türkiye between 2016 and 2022: a nationwide descriptive and observational study covering the entire adult population.","authors":"Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Naim Ata, Mustafa Hamidullah Türkkani, Mustafa Mahir Ülgü, Şuayip Birinci, Funda Aksu","doi":"10.55730/1300-0144.6185","DOIUrl":"10.55730/1300-0144.6185","url":null,"abstract":"<p><strong>Background/aim: </strong>Determining the current burden of asthma in countries is important in the diagnosis and follow-up of asthma patients and for the development of national health policies. Our study aimed to clarify the epidemiological and clinical data regarding asthmatic adults in Türkiye.</p><p><strong>Materials and methods: </strong>The study was designed as a nationwide descriptive, observational cross-sectional study. Data on adult patients who were followed with the diagnosis of asthma in all public, private, and university hospitals in Türkiye between January 2016 and December 2022 were obtained from the e-Nabız database of the Ministry of Health and analyzed.</p><p><strong>Results: </strong>The number of patients followed with a diagnosis of asthma in Türkiye between 2016 and 2022 was 2,700,183. The mean age of these patients was 45.70 years (standard deviation: 15.87) and 74.5% of them were female. Of the patients, 92.3% were prescribed dry powder inhalers, 98.41% metered dose inhalers, and 80.38% montelukast. The short-acting beta-2 agonist (SABA) prescription rate was 65.74% and SABA was prescribed as the sole medication for 0.10% of patients. The percentage of patients prescribed nebulized treatment was found to be 69.83%. Among asthmatic adults, the rate of at least one emergency room visit was 12.4%, the rate of hospitalization in the ward was 5.6%, and the rate of intensive care unit admission was 0.1%.</p><p><strong>Conclusion: </strong>Asthma is a major health burden in Türkiye, as is the case around the world. National planning for the diagnosis and follow-up of patients needs to be improved and continued.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 2","pages":"509-517"},"PeriodicalIF":1.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum angiopoietin-1 and angiopoietin-2 levels in Turkish patients with Behçet's disease: associations with clinical manifestations and inflammatory markers.","authors":"Sercan Gücenmez, Hakan Emmungil, Figen Yargucu Zihni, Gökhan Keser, Kenan Aksu","doi":"10.55730/1300-0144.6200","DOIUrl":"10.55730/1300-0144.6200","url":null,"abstract":"<p><strong>Background/aim: </strong>Emerging evidence suggests that dysregulated angiogenesis may contribute to the pathogenesis of Behçet's disease (BD). This study primarily aimed to investigate serum angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) levels in Turkish patients with BD and compare them with healthy controls. The secondary aims were to compare angiopoietin levels based on clinical manifestations, disease activity, and medication use and to investigate their correlations with age, disease duration, and inflammatory markers.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 56 consecutive patients with BD, diagnosed according to International Study Group criteria, and 56 age- and sex-matched healthy controls. Physical characteristics, clinical manifestations, time since symptom onset, time since diagnosis, medications, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were recorded. Serum Ang-1 and Ang-2 levels were measured by enzyme-linked immunosorbent assay. Comparisons between the two groups were analyzed using the Student t-test or Mann-Whitney U test, and correlations were assessed using Pearson or Spearman correlation coefficients, depending on the data distribution.</p><p><strong>Results: </strong>Serum Ang-1 and Ang-2 levels were significantly higher in patients with BD compared to healthy controls (p < 0.001 and p = 0.031, respectively). Patients with genital ulcers had significantly lower serum Ang-1 levels compared to those without (p = 0.029). Additionally, Ang-2 levels showed moderate positive correlations with CRP (r = 0.518, p < 0.001) and ESR (r = 0.459, p < 0.001).</p><p><strong>Conclusion: </strong>The elevated expression of Ang-1 and Ang-2 in Turkish patients with BD supports the growing evidence of their possible roles in BD pathogenesis.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 3","pages":"667-673"},"PeriodicalIF":1.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation as a harbinger of death: a retrospective cohort study of preoperative biomarker risk stratification in orthopedic trauma.","authors":"Serkan Aydin, Burhan Kurtuluş","doi":"10.55730/1300-0144.6141","DOIUrl":"10.55730/1300-0144.6141","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to evaluate the prognostic significance of preoperative inflammatory markers including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), and procalcitonin in predicting 30-day and 1-year mortality in patients undergoing femur fracture surgery.</p><p><strong>Materials and methods: </strong>This retrospective, multicenter cohort study included patients who underwent surgical treatment for femur fractures between January 2018 and December 2024. Patients were stratified into survivor and nonsurvivor groups based on 30-day and 1-year outcomes. Demographic characteristics, comorbidities, laboratory parameters, and inflammatory indices were recorded and analyzed. Linear and multivariate logistic regression analyses were performed to identify independent predictors of mortality. Receiver operating characteristic (ROC) curve analysis was used to assess the predictive performance of the inflammatory markers.</p><p><strong>Results: </strong>A total of 430 patients were included, 310 (72.1%) of whom survived while 120 (27.9%) died during the 1-year follow-up. The 30-day mortality rate was 15% (n = 65) and the 1-year mortality rate was 38% (n = 163). Nonsurvivors were significantly older (81.3 ± 9.6 vs. 75.2 ± 10.1 years, p < 0.001) and had higher rates of diabetes mellitus (45% vs. 30%, p = 0.003), hypertension (80% vs. 40%, p < 0.001), and chronic kidney disease (55% vs. 16%, p < 0.001). Laboratory analysis showed elevated white blood cell count, red cell distribution width, neutrophils, CRP, procalcitonin, NLR, PLR, and MLR, while albumin was lower in nonsurvivors (all p < 0.05). Multivariate analysis identified age, chronic kidney disease, low albumin, elevated creatinine, CRP, the MLR, and hospital stay as independent mortality predictors. The MLR showed the strongest association (OR = 4.12 for 30-day mortality; OR = 3.85 for 1-year). ROC analysis revealed CRP (AUC = 0.811 and 0.783) and the MLR (AUC = 0.765 and 0.751) as the most accurate predictors, followed by the NLR and hospital stay.</p><p><strong>Conclusion: </strong>Preoperative inflammatory markers, particularly the MLR and CRP, were strongly associated with short- and long-term mortality in femur fracture surgery. Their integration into preoperative assessment may enhance risk stratification and guide clinical decision-making.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"56 1","pages":"90-98"},"PeriodicalIF":1.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}