Turkish Journal of Medical Sciences最新文献

{"title":"Acute effects of virtual reality-based relaxation and exergaming on primary dysmenorrhea symptoms.","authors":"Muhammed Şeref Yildirim, Merve Çoğ, Büşra Mehder Akbaş, Sinem Salar, Hilal Keklicek","doi":"10.55730/1300-0144.5981","DOIUrl":"10.55730/1300-0144.5981","url":null,"abstract":"<p><strong>Background/aim: </strong>Primary dysmenorrhea (PD) is a menstrual disorder with significant physical and psychological impacts. Physical activity and relaxation techniques are proven methods for managing PD. Advances in virtual reality (VR) suggest that immersive relaxation and exergaming could provide new avenues for symptom relief. This study aimed to investigate the acute effects of VR-based interventions on PD symptoms and compare them with a control group receiving Jacobson's Relaxation.</p><p><strong>Materials and methods: </strong>A randomized, controlled, single-blind trial was conducted with 43 female participants aged 18-30 years with regular menstrual cycles and PD. Participants were allocated to three groups: (I) immersive VR relaxation, (II) nonimmersive VR exergaming, or (III) Jacobson's relaxation (control group). Each participant completed a single 20-min session of their assigned intervention. Primary outcomes included abdomino-pelvic pain intensity, menstrual symptom severity, sleep quality, and perceived intervention effectiveness.</p><p><strong>Results: </strong>All interventions reduced pain (r = 0.78-0.85) and symptom severity (r = 0.73-0.88) (p < 0.05), with no sleep quality changes. Between-group comparisons showed the control group to be more effective than nonimmersive VR exergaming in reducing menstrual symptom severity (p = 0.021, η² = 0.144) and yielded higher perceived effectiveness (p = 0.010, η² = 0.182).</p><p><strong>Conclusion: </strong>Both VR-based interventions and the control group effectively alleviated PD symptoms, with the control group providing the most consistent symptom relief. Despite promising results for VR-based methods, traditional relaxation may be more accessible and better tolerated.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"377-385"},"PeriodicalIF":1.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative vasorelaxant effects of atorvastatin and rosuvastatin in rat aorta: investigating the role of perivascular adipose tissue.","authors":"Deniz Kaleli Durman, Meryem Aras, G Ruveyda Aktaş, B Sönmez Uydeş Doğan","doi":"10.55730/1300-0144.5996","DOIUrl":"https://doi.org/10.55730/1300-0144.5996","url":null,"abstract":"<p><strong>Background/aim: </strong>Statins are known to display pleiotropic effects on the vascular system, beyond their lipid-lowering properties. Studies on isolated vascular preparations have demonstrated their acute relaxant effects on vascular tone. Considering the increased evidence in regard to the contribution of perivascular adipose tissue (PVAT) in the regulation of vascular homeostasis, we aimed to investigate the possible modulatory role of PVAT in the vascular effects of atorvastatin and rosuvastatin in isolated rat aorta.</p><p><strong>Materials and methods: </strong>Thoracic aortas isolated from young male Wistar rats were divided into two groups: rings with intact PVAT (+) and rings without PVAT (-), and then mounted in an isolated organ bath system. Rat aortic rings were standardized with potassium chloride (KCl, 40 mM), and then endothelium-dependent relaxation responses were checked by acetylcholine (Ach, 10^-7-10^-4 M). The concentration-dependent (10^-7-10^-4 M) effects of atorvastatin and rosuvastatin were studied on rat aortic rings precontracted submaximally with phenylephrine (Phe, 10^-6-3 × 10^-5 M). In addition, endothelium-independent relaxation responses were evaluated by sodium nitroprusside (SNP, 10^-6 M) at the end of each experiment.</p><p><strong>Results: </strong>Rat aortic rings with intact PVAT (+) and without PVAT (-) displayed similar endothelium-dependent and -independent relaxations to Ach and SNP, respectively. Increasing concentrations (10^-7-10^-4 M) of atorvastatin and rosuvastatin directly relaxed the aortic rings with and without PVAT. The maximum relaxant effects of rosuvastatin was found significantly greater than atorvastatin.</p><p><strong>Conclusion: </strong>The current study demonstrated that atorvastatin and rosuvastatin displayed prominent relaxations in rat aortic rings with intact PVAT (+) and without PVAT (-). Notably, rosuvastatin produced a greater vasorelaxant effect compared to atorvastatin in rat aortic rings with and without PVAT. Current study provides a novel evidence that PVAT does not significantly influence statin-mediated vasorelaxation under physiological conditions.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"518-524"},"PeriodicalIF":1.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of different scoring systems and biochemical markers in determining the severity and complications of acute pancreatitis.","authors":"Ahmet Ali Aktaş, Pınar Taşar, Deniz Siğirli, Sadık Ayhan Kiliçturgay","doi":"10.55730/1300-0144.5989","DOIUrl":"https://doi.org/10.55730/1300-0144.5989","url":null,"abstract":"<p><strong>Background and study aim: </strong>The aim of the study is to demonstrate the effectiveness of different scoring systems and inflammatory markers in predicting the severity, local complications, pancreatic necrosis, and mortality of acute pancreatitis (AP).</p><p><strong>Materials and methods: </strong>The data of 357 patients whom the severity of pancreatitis was classified according to the Revised Atlanta Classification System diagnosed with AP were retrospectively examined. Also The APACHE II, BISAP, mCTSI, and Ranson scores of all patients were calculated. After determining the cut-off values for scoring systems and inflammatory markers with ROC analysis, comparison for AP severity, local complication, necrosis, and mortality.</p><p><strong>Results: </strong>In the study, 2.8% of patients had severe pancreatitis. It was found that the risk of developing local complications increased 2.82 times in cases with an 48^th-h CRP value >192 mg/L compared to those below this threshold, and 48.96 times in cases with an mCTSI score >2 compared to ≤ 2 cases. It was found that having a Ranson score >4 increased the risk of mortality by 9.07 times compared to having a score of ≤4 (p = 0.038). It was observed that having a BISAP >2 increased the risk of severe AP by 11.79 times compared to ≤2. In cases where the 48^th-h NLR value was >13.33, the risk of severe AP was found to have increased by 5.85 times.</p><p><strong>Conclusion: </strong>Although the superiority of scoring systems could not be demonstrated in our study, CRP and MCTSI for local complications, BISAP for severity and Ranson score for mortality were the determining variables.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"451-460"},"PeriodicalIF":1.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzyl alcohol improves Ang II-induced vascular and renal injury.","authors":"Zhenyu Gu, Qi Hua","doi":"10.55730/1300-0144.5995","DOIUrl":"https://doi.org/10.55730/1300-0144.5995","url":null,"abstract":"<p><strong>Background/aim: </strong>The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalities playing a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA), identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renal injury in murine models.</p><p><strong>Materials and methods: </strong>Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusion using a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid artery diastolic, and systolic pressures in mice were determined with a blood pressure monitor. Vascular structure changes were assessed with HE and Masson staining, while kidney pathology was examined using HE. Serum urea nitrogen, creatinine, and cystatin C levels were measured with ELISA kit.</p><p><strong>Results: </strong>Metabolomics analysis identified metabolite BA as a potential target for hypertension management. Compared to the Ang II group, BA reduced systolic blood pressure by 11.58% and diastolic blood pressure by 14.62% in the fourth week. After sodium nitroprusside treatment, the Ang II group showed reduced vasodilation reactivity versus the control. BA significantly restored this reactivity, unlike acetylcholine. Furthermore, BA was observed to attenuate Ang II-induced vascular mediator thickening, the mediator-to-lumen ratio, and collagen deposition. Ang II administration resulted in renal structural damage and increased concentrations of urea nitrogen, creatinine, and serum cystatin C, which was reversed by BA treatment.</p><p><strong>Conclusion: </strong>BA exhibits potential in enhancing the vasodilatory response, vascular remodeling, and renal injury associated with Ang II.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"509-517"},"PeriodicalIF":1.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can mac-2 binding protein glycosylation isomer serve as a biomarker for predicting pulmonary arterial pressure and pulmonary hypertension in systemic sclerosis?","authors":"Rıdvan Mercan, Dilara Bulut Gökten, Sonat Pınar Kara, Neslihan Melik Üzüm, Savaş Güzel","doi":"10.55730/1300-0144.5984","DOIUrl":"https://doi.org/10.55730/1300-0144.5984","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to explore the role of Mac-2 binding protein glycosylation isomer (M2BPGi) serum levels as a biomarker that could contribute to understanding organ involvement and the overall disease process in systemic sclerosis (SSc).</p><p><strong>Materials and methods: </strong>The cross-sectional study examined 108 patients with SSc. Seventy-two people were included in the control group. Demographic and clinical characteristics of the patients, laboratory and radiological findings, pulmonary function tests and echocardiography results, and presence of pulmonary hypertension (PHT) based on echocardiographic evaluation were recorded. Venous blood samples of 5 mL were collected from individuals. Human M2BPGi levels in the samples were measured using a specific kit.</p><p><strong>Results: </strong>There was no significant difference between the M2BPGi levels in the patient (median = 4749.69 pg/mL, mean = 5351.75 ± 2483.97) and the control group (median = 4638.07, mean = 4611.86 ± 1333.15) (p = 0.071). Considering pulmonary arterial pressure (PAP) status, the average M2BPGi level in the normal PAP group was 5898.15 ± 2555.61 pg/mL, while it was 4258.96 ± 1973.08 pg/mL in the increased PAP group. The difference between these groups was statistically significant (p: 0.021). Examining PHT status, the average M2BPGi level was 5942.01 ± 2579.14 pg/mL in the group without PHT, decreasing to 4264.44 ± 1917.63 pg/mL in the group with PHT. There is a significant relationship regarding PHT (p: 0.016).</p><p><strong>Conclusion: </strong>This study explores the relationship between M2BPGi and systemic involvements in SSc. It demonstrates a significant relationship between M2BPGi and PAP and PHT, suggesting that M2BPGi might serve as a noninvasive biomarker for predicting both PAP and PHT.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"404-412"},"PeriodicalIF":1.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of metabolic uptake in gynecological organs using FDG-PET in women diagnosed with nongynecological malignancies.","authors":"Funda Atalay, Uğurcan Zorlu, Koray Aslan, Fatma Batak, Tuba Zengin Aksel, Gülin Uçmak","doi":"10.55730/1300-0144.6037","DOIUrl":"10.55730/1300-0144.6037","url":null,"abstract":"<p><strong>Background/aim: </strong>Gynecological malignancies, including those affecting the uterus, cervix, vagina, vulva, and adnexa, pose significant physical and psychosocial burdens. Early detection and effective management of these malignancies are critical for improving outcomes. This study aims to evaluate metabolic uptake patterns in gynecological organs using fluorodeoxyglucose positron emission tomography (FDG-PET) and to analyze their malignancy potential in women with nongynecological cancers.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 221 women with nongynecological malignancies who exhibited pathological FDG uptake in gynecological organs on FDG-PET/CT imaging. Lesions were evaluated based on the standardized uptake value maximum (SUVmax), morphological characteristics on contrast-enhanced CT, and further gynecological assessment using ultrasonography, biopsy, and endometrial sampling. Statistical analyses, including the receiver operating characteristics curve and descriptive statistics, were performed using SPSS software, with significance set at p < 0.05.</p><p><strong>Results: </strong>Pathological FDG uptake was observed in the uterus (60.6%), adnexa (30.3%), cervix (14.02%), vulva (4%), and vagina (2.2%). The mean SUVmax of lesions varied across sites, with uterine lesions showing a mean SUVmax of 6.96 ± 3.55. An SUVmax cutoff of >10.11 predicted malignancy in uterine lesions with 86% sensitivity and 82% specificity. Among patients with uterine involvement, malignancy was confirmed in 10 cases, all of whom were on tamoxifen therapy. Endometrial thickness was significantly higher in malignancy cases (10.6 mm vs. 5.8 mm, p = 0.014). Ultrasonography and biopsy findings largely confirmed the benign nature of other lesions, highlighting the role of multimodal diagnostic approaches.</p><p><strong>Conclusion: </strong>FDG-PET imaging is a valuable tool for identifying metabolic activity in gynecological organs and for differentiating malignant lesions from benign ones. High SUVmax values and endometrial thickness are significant indicators of malignancy, particularly in patients undergoing hormonal therapy. This study underscores the importance of integrating metabolic imaging with clinical and morphological assessments for the early detection and management of gynecological malignancies.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 4","pages":"855-859"},"PeriodicalIF":1.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadratus lumborum block for total abdominal hysterectomy: a double-blind, randomized, controlled trial.","authors":"Nada Pejcic, Marija Kutlesic, Ivan Velickovic, Vladimir Milic, Slavisa Kovacevic, Radmilo J Jankovic, Dejan Mitic, Radomir Mitic, Nenad Zornic","doi":"10.55730/1300-0144.5978","DOIUrl":"10.55730/1300-0144.5978","url":null,"abstract":"<p><strong>Background/aim: </strong>The Quadratus lumborum block (QLB) is an interfascial block recommended for multimodal pain therapy after cesarean section in patients who cannot receive intrathecal morphine. We wanted to investigate whether QLB contributes to better analgesia after total abdominal hysterectomy (TAH). The study was registered on the website ClinicalTrials.gov (registration number NCT05765318).</p><p><strong>Materials and methods: </strong>Patients scheduled for TAH were randomized into two groups of 30 members each. The treatment group received QLB, while the control group did not undergo any block. The primary outcome was the amount of morphine during the first 12 postoperative h. Secondary outcomes included the total amount of morphine for 24 h, time to the first request for additional analgesia, pain intensity at rest and during activity, frequency of nausea and vomiting, and the degree of sedation at 2, 6, 12, and 24 h postoperatively.</p><p><strong>Results: </strong>Patients in the QLB group received significantly less morphine (4.13 mg) compared to the control group (9.73 mg) during the first 12 postoperative h (p < 0.001) and also during the first 24 h. The patients in the QLB group had longer time interval to the first breakthrough pain (7.87 h) compared to the control group (2.63 h) (p < 0.001), lower NRS scores at rest and during activity after 2, 12, and 24 h, and better satisfaction with provided pain relief during the first 24 h postoperatively.</p><p><strong>Conclusion: </strong>QLB reduces postoperative morphine use and postoperative pain intensity on the NRS scale, both at rest and during activity, as part of multimodal pain therapy for TAH.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"349-359"},"PeriodicalIF":1.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical features and treatment modality of pediatric patients with Steven Johnson syndrome/toxic epidermal necrolysis: a single-center experience.","authors":"Funda Aytekin Güvenir, Vildan Selin Çayhan, Selman Kürşat Balci, Ragıp Dere, Hatice Irmak Çelik, Serhat Emeksiz, Ahmet Selmanoğlu, Zeynep Şengül Emeksiz, Emrah Şenel, Emine Dibek Misirlioğlu","doi":"10.55730/1300-0144.5990","DOIUrl":"10.55730/1300-0144.5990","url":null,"abstract":"<p><strong>Background/aim: </strong>Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening severe cutaneous drug hypersensitivity reactions. The aim of our study was to evaluate the clinical features of pediatric patients diagnosed with SJS, TEN or SJS/TEN overlap and to examine treatment modalities.</p><p><strong>Materials and methods: </strong>Patients aged 0-18 years who were followed up with SJS, TEN or SJS/TEN overlap at Ankara Bilkent City Hospital between August 2019 and January 2024 were retrospectively analyzed.</p><p><strong>Results: </strong>Twelve patients who met the inclusion criteria were included in the study. Five of the patients had SJS, four had SJS/TEN overlap, and three had TEN. Eight of the patients were female, and the median age at presentation was 10.5 (IQR:6-16) years. Ten of the patients had a history of drug use. Eight patients had antibiotics, two had proton pump inhibitors, two had allopurinol, and two had antiepileptic (lamotrigine and valproic acid) use. All 12 patients received IVIG and systemic steroid therapy. Three TEN and four SJS/TEN overlap patients received cyclosporine. Two TEN patients underwent plasmapheresis. The most common long-term sequelae were dermatological sequelae.</p><p><strong>Conclusion: </strong>SJS/TEN patients should be monitored with a multidisciplinary approach, and if necessary, in the burn intensive care unit. Primary treatment is supportive care. Early initiation of cyclosporine may have a positive effect on the prognosis in patients with SJS/TEN overlap and TEN.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 2","pages":"461-469"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the home environment in children with developmental delays: insights from a cross-sectional study in Türkiye.","authors":"Emel Ömercioğlu, Ebru Cihan Çam, Ömer Nazım Gülçek, Elif N Özmert","doi":"10.55730/1300-0144.5956","DOIUrl":"10.55730/1300-0144.5956","url":null,"abstract":"<p><strong>Background/aim: </strong>A stimulating home environment in early childhood plays a crucial role in fostering child development. This study aimed to evaluate the home environment of children with developmental delays and who had not received special education support in any developmental domain.</p><p><strong>Materials and methods: </strong>The study comprised of 50 preschool children with developmental delay monitored at Hacettepe University Division of Developmental Pediatrics and 70 typically developing preschool children from Ankara 29 Mayıs State Hospital, General Pediatrics Department. Physicians and experienced child development professionals employed the Ages and Stages Questionnaire (ASQ) to perform developmental assessments on each child. The characteristics of the home environment for all participants were evaluated using the Home Environment Questionnaire (HEQ), and their sociodemographic details were recorded.</p><p><strong>Results: </strong>The home stimulation scores for children with developmental delay were significantly lower compared to those for their typically developing peers (p < 0.001). Physical violence against children was reported by 34% of parents of children with developmental delays (p < 0.001). The presence of developmental delay (p < 0.001, CI 12.629-7.927), the family socioeconomic status (p = 0.002, CI 3.813-1.486), and the number of family members (p = 0.001, Cl 2.595-0.708) were significantly associated with home stimulation scores.</p><p><strong>Conclusion: </strong>Initial assessment of children with developmental delays suggest that the stimuli in their home environment are of lower quality relative to those of typically developing peers, and these children are subjected to markedly higher levels of physical violence. These results underscore the need for early childhood caretakers, public health practitioners, and other professionals to design and implement targeted interventions, particularly prioritizing low-income families living in disadvantaged environments.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"184-192"},"PeriodicalIF":1.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison study of sensory processing in older adults with and without dementia.","authors":"Medine Nur Özata Değerli, Didem Karaduman, Burcu Balam Doğu, Onur Altuntaş","doi":"10.55730/1300-0144.5948","DOIUrl":"10.55730/1300-0144.5948","url":null,"abstract":"<p><strong>Background/aim: </strong>Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.</p><p><strong>Materials and methods: </strong>This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.</p><p><strong>Results: </strong>The study included 120 older adults (60 with dementia and 60 without dementia) aged 75.35 ± 7.86 years. Older adults with dementia showed an above-norm low registration (<i>x</i> ² = 27.62) and sensory sensitive (<i>x</i> ² = 14.96) compared to without dementia. However, no significant differences were observed between the groups in sensation seeking and sensation avoiding (p > 0.05). There was a difference between the two groups in taste/smell, movement, visual, touch, and auditory modulation (p < 0.05).</p><p><strong>Conclusion: </strong>These findings highlight significant differences in sensory processing and modulation associated with dementia. Understanding these differences may offer valuable insights for developing individualized approaches to dementia management.</p>","PeriodicalId":23361,"journal":{"name":"Turkish Journal of Medical Sciences","volume":"55 1","pages":"103-111"},"PeriodicalIF":1.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}