{"title":"The Influence of Pre-operative Pain and Anxiety on Acute Postoperative Pain in Cardiac Surgery Patients Undergoing Enhanced Recovery after Surgery.","authors":"Aslıhan Aykut, Nevriye Salman, Zeliha Aslı Demir, Atakan Furkan Eser, Ayşegül Özgök, Serdar Günaydın","doi":"10.4274/TJAR.2023.231477","DOIUrl":"10.4274/TJAR.2023.231477","url":null,"abstract":"<p><strong>Objective: </strong>Perioperative multimodal analgesia is an important step in enhanced recovery after surgery (ERAS) care. Many factors, such as preoperative chronic pain and anxiety, may provide information about the expected postoperative pain. In this study, we evaluated preoperative pain and anxiety and investigate their effects on acute postoperative pain in patients undergoing elective cardiac surgery.</p><p><strong>Methods: </strong>After ethics committee approval, 67 consenting patients undergoing on-pump cardiac surgery under the ERAS program were included in our prospective observational study. Pre- and postoperative pain scores were obtained using a numeric rating scale (NRS) at rest and during movement. Preoperative anxiety was assessed on a 0-10 scale, and data were recorded. The relationships between pre-operative pain/anxiety and postoperative pain were evaluated using correlation analysis.</p><p><strong>Results: </strong>In preoperative pain assessment, the percentage of patients with a pain score above 4 with NRS was 1.5%, regardless of whether they were at rest or mobilize. In postoperative pain assessment, there were 20.9% and 34.3% patients with NRS >4 at rest and mobilization, respectively. 7.5% of patients had preoperative anxiety of grade 5 or higher. While preoperative pain was not correlated with postoperative pain, preoperative anxiety had a moderate positive correlation with postoperative pain (r=0.382, <i>P</i>=0.003).</p><p><strong>Conclusion: </strong>The prevalence of preoperative pain in patients who underwent cardiac surgery is quite low and is not associated with postoperative pain. There is also a significant relationship between the severity of preoperative anxiety and postoperative pain.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"491-495"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastric Ultrasound for Gastric Content Evaluation.","authors":"Shubha Srinivasareddy","doi":"10.4274/TJAR.2023.231479","DOIUrl":"10.4274/TJAR.2023.231479","url":null,"abstract":"<p><p>Gastric content aspiration occurs once every 2000-3000 general anaesthetics. It is associated with a 20% incidence of in-hospital mortality. The incidence of pulmonary aspiration in patients undergoing surgery is at least three times more, up to 1 in 895 general anaesthetics. Pulmonary aspiration indeed is associated with half of our airway-related mortality linked with anaesthesia. The pulmonary aspiration causes significant morbidity including respiratory failure, acute lung injury, and multi-organ failure in adults. This review study aims to compare the stomach volume and contents in patients following standard fasting guidelines by Point of care gastric ultrasound measurements. Perioperative gastric ultrasound is a developing diagnostic modality that is modest, easy, non-invasive and efficient. It is very helpful to determine gastric contents in adult, obese, paediatric, and obstetric patients. It is a dependable and replicable tool that can be used for effective anaesthetic management. Gastric ultrasound is an irreplaceable procedure to complement the use of fasting guidelines, particularly when these guidelines have not been followed, or may not be relevant. Further series of research with metanalysis is required to understand the influence of point-of-care gastric ultrasound assessment on perioperative outcomes.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"465-469"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yavuz Gürkan, İlayda Kalyoncu, Doğa Şimşek, Mete Manici
{"title":"Multiple Thoracic Wall Blocks for Awake Breast Surgery: A Case Report.","authors":"Yavuz Gürkan, İlayda Kalyoncu, Doğa Şimşek, Mete Manici","doi":"10.4274/TJAR.2023.231472","DOIUrl":"10.4274/TJAR.2023.231472","url":null,"abstract":"<p><p>Awake breast surgeries under nerve blocks have been a challenge for anaesthesiologists, and different block combinations have been used for surgery under sedation. Thoracic paravertebral block (TPVB) was thought to be sufficient alone for surgical anaesthesia of the breast. We performed a combination of TPVB, pectoralis nerve I block, and serratus anterior plane block for awake breast surgery in an elderly patient with serious comorbidities. Surgical anaesthesia was achieved, excluding skin incision. Any regional anaesthesia technique alone is not sufficient; rather, multiple thoracic wall blocks are needed for surgical anaesthesia of the breast.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"510-512"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sapna Ravindranath, Yatish S Ranganath, Kevin Backfish-White, John Wolfe, Sanjib Adhikary
{"title":"The Role of Regional Anaesthesia and Acute Pain Services in Value-Based Healthcare.","authors":"Sapna Ravindranath, Yatish S Ranganath, Kevin Backfish-White, John Wolfe, Sanjib Adhikary","doi":"10.4274/TJAR.2023.231478","DOIUrl":"10.4274/TJAR.2023.231478","url":null,"abstract":"<p><p>Value-based healthcare prioritizes patient outcomes and quality relative to costs, shifting focus from service volume to delivered value. This review explores the significant role of regional anaesthesia (RA) and acute pain services (APS) within the evolving value-based healthcare (VBHC) framework. At the heart of VBHC is the goal to enhance patient outcomes while simultaneously optimizing operational efficiency and reducing costs. The review underscores the need for VBHC and illustrates how integrating RA/APS with Enhanced Recovery Protocols can lead to improved outcomes, aligning directly with the goals of the Triple Aim. Several clinical studies show that RA improves patient outcomes, enhances operating room efficiency, and reduces costs. This is complemented by a discussion on the integration of RA and APS into the VBHC model, highlighting emerging value-based payment structures and strategies for their successful implementation. By merging specialized RA/APS protocols with standardized clinical practices, significant improvements in operating room efficiency and associated economic benefits are observed. Across the healthcare spectrum, from providers to payers, this synergy results in enhanced operational efficiency and communication, raising the standard of patient care. Additionally, the potential of RA and APS to address the opioid crisis, through alternative pain management methods, is emphasized. Globally, the shift towards VBHC requires international collaboration, sharing of best practices, and efficient resource allocation, with RA and APS playing a crucial role. In conclusion, as healthcare moves toward a value-driven model, RA and APS become increasingly essential, signaling a future of refined, patient-centered care.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"450-458"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The First Hundred Years of the Scientific Field of Anaesthesiology and Reanimation in the Republic of Turkey.","authors":"Hatice Türe, Haluk Gümüş","doi":"10.4274/TJAR.2023.231387","DOIUrl":"10.4274/TJAR.2023.231387","url":null,"abstract":"<p><p>As a scientific field, anaesthesiology and reanimation, with their significant place in the medical structure, have been practised since the beginning of surgical procedures. Today anaesthesiology and reanimation speciality cover more complex techniques and areas than alleviating patients' pain during surgery. In the first hundred years since the proclamation of the Turkish Republic, the path covered in our scientific field is to pave the way for the next hundred years.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"459-464"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melahat Yalçın Solak, Murat İzgi, Murat Tümer, Şennur Uzun
{"title":"Duties of Anaesthetists and Assessment of Awareness, Concerns, and Expectations on Anaesthesia Practices.","authors":"Melahat Yalçın Solak, Murat İzgi, Murat Tümer, Şennur Uzun","doi":"10.4274/TJAR.2023.231328","DOIUrl":"10.4274/TJAR.2023.231328","url":null,"abstract":"<p><strong>Objective: </strong>Numerous studies performed worldwide indicate that the public has limited knowledge of anaesthesia practices and anaesthetists' duties and responsibilities. This study aimed to identify the level of knowledge about anaesthetists and anaesthesia practices, and to assess the reasons for anxiety about anaesthesia of the population admitted to our hospital, which is tertiary in Turkey. The secondary aim was to analyze their differences according to sex, education level, and acquired anaesthesia experience.</p><p><strong>Methods: </strong>A survey comprising 23 questions was administered to 400 patients and/or their relatives, aged 18-85 years, who presented to our clinic for preoperative anaesthesia evaluation and for whom elective surgery was planned from March through October 2017.</p><p><strong>Results: </strong>Of the 400 participants, 213 were women and 187 were men. Of all participants in the survey, 51.2% were patients and 48.8% were patient relatives; 64.2% had anaesthesia experience and 35.8% had never had anaesthesia before. The survey group's level of knowledge about anaesthesia was generally low. According to education level, there was a statistically significant difference in the anaesthesia recognition level. However, the acquired anaesthesia experience did not affect the anaesthesia recognition level.</p><p><strong>Conclusion: </strong>To raise the level of knowledge about this topic, anaesthetists must provide patients with more detailed information during preoperative and postoperative visits, which would significantly reduce their anxiety levels. Further, we determined that increasing the use of methods such as media-based brochures, booklets, and videos to inform patients may increase knowledge levels and reduce anxiety levels.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 6","pages":"477-484"},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed A Mamoun, Alrefaey K Alrefaey, Maha Ahmed Abo-Zeid
{"title":"Continuous Serratus - Intercostal Plane Block for Perioperative Analgesia in Upper Abdominal Surgeries: A Prospective Randomized Controlled Study.","authors":"Mohamed A Mamoun, Alrefaey K Alrefaey, Maha Ahmed Abo-Zeid","doi":"10.4274/TJAR.2023.231260","DOIUrl":"10.4274/TJAR.2023.231260","url":null,"abstract":"<p><strong>Objective: </strong>Acute pain management after open abdominal surgeries is an essential goal in perioperative management.. Recently, serratus-intercostal plane block (SIPB) was suggested as an analgesic technique for upper abdominal surgeries.</p><p><strong>Methods: </strong>This prospective, randomized, controlled study included sixty adult patients scheduled for open upper abdominal surgeries. Patients were allocated into two equal groups: SIPB group (S group, n = 30) and control group (the C group, n = 30). In the S group, SIPB was performed in the midaxillary line at the eighth rib level followed by continuous infusion of local anaesthetic for the first postoperative day. In the C group, no block was done. The primary objective of the study was to control postoperative pain on the first postoperative day as assessed by the numerical rating scale (NRS). Secondary outcomes included perioperative hemodynamics, total postoperative analgesic consumption, number of analgesic requests, and incidence of postoperative nausea and vomiting.</p><p><strong>Results: </strong>The mean postoperative NRS reported in group S was statistically lower than that in group C (2.4±0.7, 3.9±0.31, <i>P</i> < 0.001). The postoperative morphine consumption was lower in the S group than in the C group [(0 (0-4), 3 (1-4), respectively, <i>P</i> < 0.001]. The incidence of PONV was significantly lower in the S group than in the C group (16.7% and 40%, <i>P</i> < 0.045).</p><p><strong>Conclusion: </strong>SIPB was associated with a better analgesic profile compared with the control group after upper abdominal surgeries. Further studies are recommended to determine block safety in special patient groups, including bariatric and laparoscopic surgeries.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 5","pages":"402-407"},"PeriodicalIF":0.5,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Preoperative Anxiety on Depth of Anaesthesia and In Vitro Fertilization Success.","authors":"Sevtap Hekimoğlu Şahin, Elif Çopuroğlu, Ece Yamak Altınpulluk, Necdet Süt, Beyhan Karamanlıoğlu, Koray Elter, Özge Yaman","doi":"10.4274/TJAR.2023.22829","DOIUrl":"10.4274/TJAR.2023.22829","url":null,"abstract":"<p><strong>Objective: </strong>Infertility anxiety may have a harmful effect on embryo quality and fertilization during in vitro fertilization (IVF). Monitoring brain function gives real-time information about the depth of anaesthesia of a patient. This study examined the effect of preoperative anxiety on the depth of anaesthesia and IVF success.</p><p><strong>Methods: </strong>One hundred thirty-one patients who had undergone oocyte retrieval were divided into two groups according to the Beck Anxiety Inventory (BAI): the low-anxious Group L (n = 71) and high-anxious Group H (n = 60). Hemodynamic stability, intraoperative total propofol and fentanyl consumption, good quality embryo (GQE) rate, and fertilization rate were recorded.</p><p><strong>Results: </strong>Fertilization and GQE rates were not significant between groups L and H. Total propofol consumption was significantly higher in group H than in group L. Heart rate (HR) preoperatively and postoperatively and systolic arterial pressure (SAP) preoperatively and diastolic arterial pressure (DAP) postoperatively were significantly increased in group H than in group L. The time for the modified Aldrete score to reach 9 (MAS 9) in group H was significantly higher than that in group L. The effect of variables that were found significantly in the univariate analysis (Propofol, HRpreop, HRpostop, SAPpreop, DAPpostop, and MAS 9) on BAI score.</p><p><strong>Conclusion: </strong>Total propofol consumption was higher in patients with high anxiety levels, but it did not have a negative effect on IVF success.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 5","pages":"414-419"},"PeriodicalIF":0.5,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Analgesic Efficacy of Ultrasound-Guided Quadratus Lumborum Block and Ilioinguinal-Iliohypogastric Nerve Block in Paediatric Patients After Inguinal Hernia Surgery: A Prospective Randomized Controlled Trial.","authors":"Mustafa Altınay, Hacer Şebnem Türk","doi":"10.4274/TJAR.2023.231289","DOIUrl":"10.4274/TJAR.2023.231289","url":null,"abstract":"<p><strong>Objective: </strong>To compare the postoperative analgesic efficacy of quadratus lumborum block (QLB) and ilioinguinal-iliohypogastric nerve block (IIIHB) in paediatric patients who have undergone unilateral inguinal hernia surgery.</p><p><strong>Methods: </strong>This prospective randomized controlled study was designed in a single center and included 60 paediatric patients aged 2-7 years who had undergone inguinal hernia repair surgery and received an American Society of Anesthesiologists score of 1-2. Patients were randomized into two groups: those receiving ultrasound-guided QLB and those receiving IIIHB. The primary outcomes of the study were patients' face, legs, activity, cry, and consolability (FLACC) scores at 1, 2, 6, 12, and 24 hours post-surgery.</p><p><strong>Results: </strong>The mean heart rate 15 and 30 minutes post-surgery in the QLB group was lower than that of the IIIHB group, and the difference at both times was statistically significant (<i>P</i> < 0.001). The mean FLACC score of the QLB group was lower than that of the IIIHB group at 6, 12, and 24 hours post-surgery, and the differences were statistically significant (<i>P</i>=0.004, <i>P</i>=0.006, and <i>P</i> < 0.001, respectively). Between the groups, there was no statistically significant difference in the number of patients who were administered rescue analgesics or oral ibuprofen, the time of first ibuprofen administration, or the frequency of complications (<i>P</i>=1.000, <i>P</i>=0.145, <i>P</i>=0.195, and <i>P</i>=1.000, respectively).</p><p><strong>Conclusion: </strong>Compared with IIIHB, QLB achieves superior postoperative analgesic effects in paediatric patients who have undergone inguinal hernia surgery, as evidenced by longer analgesic periods, lower pain scores, and lower analgesic consumption.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 5","pages":"443-449"},"PeriodicalIF":0.5,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kemal Tolga Saraçoğlu, Ayten Saraçoğlu, Mehmet Yıldırım, Cumaali Demirtaş, Metehan Akça, Ferda Serdoğan, İlyas Samet Ergün, Şermin Tetik, Sadrettin Pençe
{"title":"Effects of Different Crystalloid Fluids on Renal Tissue in an Experimental Model of Hemorrhagic Shock.","authors":"Kemal Tolga Saraçoğlu, Ayten Saraçoğlu, Mehmet Yıldırım, Cumaali Demirtaş, Metehan Akça, Ferda Serdoğan, İlyas Samet Ergün, Şermin Tetik, Sadrettin Pençe","doi":"10.4274/TJAR.2023.231262","DOIUrl":"10.4274/TJAR.2023.231262","url":null,"abstract":"<p><strong>Objective: </strong>The type of fluid that should be used in uncontrollable hemorrhages remains an area of research. This study was designed to compare the effects of resuscitation with Ringer's lactate (RL) solution versus a normal saline (NS) solution on hemodynamics, renal tissue histopathology, coagulation, and apoptosis in a rat model of hemorrhagic shock.</p><p><strong>Methods: </strong>The study employed groups designated as the control, hemorrhage, NS, and RL groups. Heart rate, mean arterial pressure, and respiratory rate were monitored. Annexin A5 values were assayed, rotational thromboelastometry analysis was performed, and excised kidney tissue samples were histopathologically analyzed.</p><p><strong>Results: </strong>Blood pressure levels were found to be significantly higher in the control group than those measured in the other groups. While the clotting time (CT) and clot formation time (CFT) in the hemorrhage group were significantly longer than those in the control and RL groups, the CT and CFT measured in the control group were significantly shorter compared to the RL group. The mean Annexin A5 level was in the hemorrhage group, which was significantly higher compared to the other groups. In the renal histopathological evaluation, the scores of proximal tubular injury, distal renal tubular injury, and interstitial renal tubular injury were found to be significantly lower in the control group compared to the other groups.</p><p><strong>Conclusion: </strong>This study demonstrated that NS or RL can be used safely to improve the hemodynamic symptoms resulting from hemorrhagic shock as a means to reduce apoptosis, and to decrease findings in favor of coagulopathy in bedside coagulation tests during the early stages of hemorrhagic shock until the time of starting a blood transfusion.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 5","pages":"380-387"},"PeriodicalIF":0.5,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}