Transplant International最新文献_第3页

Lapdoctor: Multicentre Validation of a Scoring System for Preoperative Evaluation of Difficulty of Laparoscopic Donor Nephrectomy. 腹腔镜供肾切除术难度评估评分系统的多中心验证。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14100

Jacopo Romagnoli, Gionata Spagnoletti, Francesco Emilio Rossini, Roberto Iezzi, Alessandro Posa, Maria Paola Salerno, Patrizia Silvestri, Aldo Eugenio Rossini, Cristina Silvestre, Barbara Franchin, Alessandro Giacomoni, Leonardo Centonze, Marco Spada, Maurizio Iaria, Carmelo Puliatti, Lucrezia Furian

{"title":"Lapdoctor: Multicentre Validation of a Scoring System for Preoperative Evaluation of Difficulty of Laparoscopic Donor Nephrectomy.","authors":"Jacopo Romagnoli, Gionata Spagnoletti, Francesco Emilio Rossini, Roberto Iezzi, Alessandro Posa, Maria Paola Salerno, Patrizia Silvestri, Aldo Eugenio Rossini, Cristina Silvestre, Barbara Franchin, Alessandro Giacomoni, Leonardo Centonze, Marco Spada, Maurizio Iaria, Carmelo Puliatti, Lucrezia Furian","doi":"10.3389/ti.2025.14100","DOIUrl":"10.3389/ti.2025.14100","url":null,"abstract":"We previously developed and validated LAPDOCTOR (LAParoscopic-Donor-nephreCTomy-scORe), a novel scoring system for the preoperative assessment of the difficulty of living donor nephrectomy (LDN). To prove its significance, we extended our investigation to a prospective, multicenter, national study. Difficulty was assessed by the operating surgeon using a scale from 1 to 3 (1-standard, 2-moderately difficult, 3-very difficult) based on eight parameters: availability of laparoscopic space, mobilization of the colon, kidney, gonadal, adrenal and renal vein, renal artery, and ureter. Donor CT-scans were blindly reviewed by a radiologist, and the LAPDOCTOR scores were compared with the difficulty levels assigned by the surgeon to investigate the match rates. One hundred eighty-five donors were enrolled, with a mean age of 54 years (range 24-77), BMI 25 kg/m2 (range 17-35), and male/female 59/126. LDN was blindly scored as standard in 45% of the cases, moderately-difficult in 52%, and very-difficult in 3%. The agreement between the LAPDOCTOR and expert donor surgeons' rate in categorizing LDN into risk groups had a QWK of 0.711 (95% CI 0.577-0.844) with p < 0.001. The LAPDOCTOR enables precise preoperative determination of the difficulty of LDN, particularly in very difficult cases, and assessment of surgical risk in living kidney donors.Clinical trial notation: https://ClinicalTrials.gov, Identifier NCT05769686.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14100"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Path Forward: A Review on Enhanced Recovery After Cardiothoracic Transplantation. 前进的道路：心肺移植后增强康复的综述。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14163

Irene Bello, Laurens J Ceulemans, Cristiano Amarelli

引用次数: 0

Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs. 大鼠脑死亡增加供体器官中性粒细胞胞外陷阱形成。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14223

Maryna Van Zyl, Roberto Armstrong Junior, Petra Ottens, Harry Van Goor, Mia-Jeanne Van Rooy, Ton Lisman, Henri G D Leuvenink, Jan-Luuk Hillebrands

{"title":"Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs.","authors":"Maryna Van Zyl, Roberto Armstrong Junior, Petra Ottens, Harry Van Goor, Mia-Jeanne Van Rooy, Ton Lisman, Henri G D Leuvenink, Jan-Luuk Hillebrands","doi":"10.3389/ti.2025.14223","DOIUrl":"https://doi.org/10.3389/ti.2025.14223","url":null,"abstract":"During brain-death, increased numbers of neutrophils are recruited to organs as part of the inflammatory response. In the organ microenvironment, the recruited neutrophils may release neutrophil extracellular traps (NETs) through interaction with various pro-inflammatory stimuli, contributing to brain-death-induced endothelial activation, microthrombus formation and ultimately a decline in organ quality. To investigate whether NETs form in organs from brain-dead donors; kidneys, hearts, livers, and plasma samples were collected from brain-dead or sham-operated rats. The presence of NET-specific components, neutrophils and macrophages were analyzed through immunofluorescent microscopy. Endothelial activation and platelet infiltration were analyzed through immunohistochemistry and qRT-PCR analysis. Plasma free thiol levels were used to evaluate systemic oxidative stress. Increased neutrophils, NETs and NET/neutrophil ratios were observed in kidneys, hearts and livers of brain-dead rats compared to sham-operated rats. Numbers of NETs positively correlated with the extent of endothelial cell activation. Brain-dead animals also had increased kidney and liver macrophages, increased infiltrated platelets in the liver, and elevated systemic oxidative stress, compared to sham-operated animals. Our findings established the presence of NETs in organs from a brain-dead donor model and suggest that NETs, alongside increased inflammation and a redox imbalance, might prime organs for microvascular endothelial dysfunction and increased injury during brain-death.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14223"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of Europeans to Xenotransplantation Research: 2. Pig Islet and Cell Xenotransplantation. 欧洲人对异种器官移植研究的贡献：猪胰岛与细胞异种移植。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14143

Rita Bottino, Krish Vasudev, Zuzanna Iwanczyk, Emanuele Cozzi, David K C Cooper

{"title":"Contributions of Europeans to Xenotransplantation Research: 2. Pig Islet and Cell Xenotransplantation.","authors":"Rita Bottino, Krish Vasudev, Zuzanna Iwanczyk, Emanuele Cozzi, David K C Cooper","doi":"10.3389/ti.2025.14143","DOIUrl":"https://doi.org/10.3389/ti.2025.14143","url":null,"abstract":"Pig islet xenotransplantation in nonhuman primates (NHPs) has made considerable progress during the past 30 years, and European scientists in both Europe and the USA have contributed to this progress. At times, there have been, or are, active research programs in Sweden, Germany, Belgium, and the USA. The first clinical experiments of wild-type (i.e., genetically-unmodified) pig islet xenotransplantation were carried out by Groth and his colleagues in Stockholm in 1994, but without significant success. Hering's group in Minneapolis was the first to report prolonged survival of wild-type pig islets in NHPs in 2006, and the first report of insulin-independence for >12 months was by a \"European\" research team at the University of Pittsburgh in 2009. Recent progress has been slow, in part through a lack of funding, but recent advances in pig organ xenotransplantation suggest that pig islet xenotransplantation is poised for clinical experiments in the near future. In addition, there have been encouraging experimental studies of pig neural cell injections into the brains of monkeys with a pharmacologically-induced Parkinson's disease.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14143"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal Rejection Assessment: New Strategies for Early Detection. 热排斥评估：早期检测的新策略。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14108

Irina Filz von Reiterdank, Rohil Jain, Eloi de Clermont-Tonnerre, Alexandra Tchir, Curtis L Cetrulo, Alexandre G Lellouch, J Henk Coert, Aebele B Mink van der Molen, Shannon N Tessier, Korkut Uygun

{"title":"Thermal Rejection Assessment: New Strategies for Early Detection.","authors":"Irina Filz von Reiterdank, Rohil Jain, Eloi de Clermont-Tonnerre, Alexandra Tchir, Curtis L Cetrulo, Alexandre G Lellouch, J Henk Coert, Aebele B Mink van der Molen, Shannon N Tessier, Korkut Uygun","doi":"10.3389/ti.2025.14108","DOIUrl":"https://doi.org/10.3389/ti.2025.14108","url":null,"abstract":"Skin pigmentation can pose challenges for physicians to diagnose pathologies. In Vascularized Composite Allotransplantation (VCA), this increases the difficulty of diagnosing rejection by clinical observation, which could be improved by noninvasive monitoring, thereby completely avoiding or aiding in guiding location for invasive diagnostics. In this study, pigmented and non-pigmented allogeneic and non-pigmented syngeneic control transplant recipients underwent daily thermal assessment using infrared (IR) gun and forward-looking IR (FLIR) imaging of VCAs using a rodent partial hindlimb transplant model. Daily clinical assessment was performed, and biopsies were taken on postoperative day (POD) 1, 3, and 7. Clinical and histological assessments indicated signs of rejection on POD 3. In contrast, thermal assessment using the IR gun detected significant differences as early as POD 1, notably a decrease in temperature, when comp ared to syngeneic control transplants. This demonstrates the capability of thermal assessments to identify early signs of rejection before clinical symptoms become apparent. The findings suggest that thermal assessments can serve as a non-contact, objective adjunct tool for early detection of graft rejection, with consideration of skin pigmentation. This approach may reduce the need for invasive biopsies, thereby improving patient comfort and reducing potential complications associated with current diagnostic methods.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14108"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14654

Simon R Knight, John Fallon

引用次数: 0

The Feasibility of a Beating-Heart Transplant From Brain-Dead Donors. 从脑死亡捐赠者身上移植跳动心脏的可行性。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.13921

Igor Vendramin, Sandro Sponga, Alessandro Di Lorenzo, Sandro Nalon, Uberto Bortolotti, Ugolino Livi, Andrea Lechiancole

引用次数: 0

T₁ Relaxation Time for the Prediction of Renal Transplant Dysfunction. T1松弛时间对肾移植功能障碍的预测。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14301

Haris Omić, Farsad Eskandary, Dietrich Beitzke, Marcos Wolf, Nicolas Kozakowski, Georg Böhmig, Andrea Beck-Tölly, Michael Eder

{"title":"T1 Relaxation Time for the Prediction of Renal Transplant Dysfunction.","authors":"Haris Omić, Farsad Eskandary, Dietrich Beitzke, Marcos Wolf, Nicolas Kozakowski, Georg Böhmig, Andrea Beck-Tölly, Michael Eder","doi":"10.3389/ti.2025.14301","DOIUrl":"https://doi.org/10.3389/ti.2025.14301","url":null,"abstract":"Quantitative magnetic resonance imaging (MRI) is emerging as a non-invasive tool to measure tissue scarring in renal allografts. However, whether prolonged T1 relaxation time results in lower transplant survival rates is unknown. This retrospective cohort study analyzed the capability to predict renal allograft dysfunction based on median T1 time. Forty-six transplant recipients with non-contrast 1.5T MRI and allograft biopsy were included. The primary endpoint was the eGFR slope over 24 months. T1 relaxation time correlated significantly with eGFR levels at all follow-up stages. Patients with T1 relaxation time above the median (T1 high) had a consistent decline in kidney function as compared to the patient group below the median (T1 low): overall eGFR slope: 11.3 vs. 1.4 mL/min/1.73 m2 over 24 months, p = 0.016. Graft survival rates at 24 months were 52% in the T1 high vs. 87% in the T1 low group, p = 0.0015. ROC analysis discovered a positive predictive value of 52% and a negative predictive value of 91% for graft loss. T1 mapping identified patients with a persistent decline of allograft function and an increased risk of allograft loss. MRI could significantly influence monitoring strategies in transplant surveillance, offering a safe, non-invasive alternative to traditional diagnostic methods.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14301"},"PeriodicalIF":2.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-Recipient Mismatch in Lung Transplantation: The Role of Graft Sizing in Clinical Outcomes. 肺移植供体-受体不匹配：移植物大小在临床结果中的作用。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14387

Chiara Catelli, Miriana D'Alessandro, Andrea Lloret Madrid, Antonella Fossi, Federico Franchi, David Bennett, Piero Paladini, Elena Bargagli, Luca Luzzi

{"title":"Donor-Recipient Mismatch in Lung Transplantation: The Role of Graft Sizing in Clinical Outcomes.","authors":"Chiara Catelli, Miriana D'Alessandro, Andrea Lloret Madrid, Antonella Fossi, Federico Franchi, David Bennett, Piero Paladini, Elena Bargagli, Luca Luzzi","doi":"10.3389/ti.2025.14387","DOIUrl":"https://doi.org/10.3389/ti.2025.14387","url":null,"abstract":"Lung transplantation is a life-saving procedure for end-stage lung diseases. Size matching is critical in the donor-recipient selection process. This retrospective study analyzed 146 patients who underwent lung transplantation between 2013 and 2023. Patients who required graft resizing were assigned to the sizing group (S), non-resizing cases to the non-sizing group (NS). The primary goal was to identify predictive factors for graft resizing. Secondary endpoints included ischemia time, ventilation time, primary graft dysfunction (PGD) and hospital stay. The S group was further stratified on baseline parameters to assess differences in outcomes. Recipient height and single transplants were higher in the NS group. Donor-recipient height ratio was the only predictor for resizing (p = 0.02). Postoperative outcomes and overall survival were similar between the groups. In Group S, male patients showed higher rates of acute kidney injury (AKI) and chronic rejection, the former being associated also with anatomical resections; patients older than 50 experienced higher rates of PGD. Graft resizing is a feasible strategy for addressing size mismatch, but it is associated with increased risks of PGD and AKI, particularly in older male recipients and those undergoing anatomical resections. These findings highlight the importance of careful preoperative donor-recipient size matching.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14387"},"PeriodicalIF":2.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Radiological Fusion: A New Frontier in Predicting Post-Transplant Diabetes Mellitus. 临床和放射学融合：预测移植后糖尿病的新前沿。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14377

Pooja Budhiraja, Byron H Smith, Aleksandra Kukla, Timothy L Kline, Panagiotis Korfiatis, Mark D Stegall, Caroline C Jadlowiec, Wisit Cheungpasitporn, Hani M Wadei, Yogish C Kudva, Salah Alajous, Suman S Misra, Hay Me Me, Ian P Rios, Harini A Chakkera

{"title":"Clinical and Radiological Fusion: A New Frontier in Predicting Post-Transplant Diabetes Mellitus.","authors":"Pooja Budhiraja, Byron H Smith, Aleksandra Kukla, Timothy L Kline, Panagiotis Korfiatis, Mark D Stegall, Caroline C Jadlowiec, Wisit Cheungpasitporn, Hani M Wadei, Yogish C Kudva, Salah Alajous, Suman S Misra, Hay Me Me, Ian P Rios, Harini A Chakkera","doi":"10.3389/ti.2025.14377","DOIUrl":"https://doi.org/10.3389/ti.2025.14377","url":null,"abstract":"This study developed a predictive model for Post-Transplant Diabetes Mellitus (PTDM) by integrating clinical and radiological data to identify at-risk kidney transplant recipients. In a retrospective analysis across three Mayo Clinic sites, clinical metrics were combined with deep learning analysis of pre-transplant CT images, focusing on body composition parameters like adipose tissue and muscle mass instead of BMI or other biomarkers. Among 2,005 nondiabetic kidney recipients, 335 (16.7%) developed PTDM within the first year. PTDM patients were older, had higher BMIs, elevated triglycerides, and were more likely to be male and non-White. They exhibited lower skeletal muscle area, greater visceral adipose tissue (VAT), more intermuscular fat, and higher subcutaneous fat (all p < 0.001). Multivariable analysis identified age (OR: 1.05, 95% CI: 1.03-1.08, p < 0.0001), family diabetes history (OR: 1.55, CI: 1.14-2.09, p = 0.0061), White race (OR: 0.43, CI: 0.28-0.66, p < 0.0001), and VAT area (OR: 1.37, CI: 1.14-1.64, p = 0.0009) as predictors. The combined model achieved C-statistic of 0.724 (CI: 0.692-0.757), outperforming the clinical-only model (C-statistic 0.68). Patients with PTDM in the first year had higher mortality than those without PTDM. This model improves predictive precision, enabling accurate identification and intervention for at risk patients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14377"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0