Transplant International最新文献

A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-20 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13965

Nida Saleem, Wai H Lim, Jacqueline H Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Armando Teixeira-Pinto, Eleonora Dal Grande, Martin Howell, Farzaneh Boroumand, Anita van Zwieten, Chandana Guha, Nicole Scholes-Robertson, Steven J Chadban, Carmel M Hawley, Jonathan C Craig, Jeremy R Chapman, Danyal Hassan, Greg Knoll, Naoka Murakami, Germaine Wong

{"title":"A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients.","authors":"Nida Saleem, Wai H Lim, Jacqueline H Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Armando Teixeira-Pinto, Eleonora Dal Grande, Martin Howell, Farzaneh Boroumand, Anita van Zwieten, Chandana Guha, Nicole Scholes-Robertson, Steven J Chadban, Carmel M Hawley, Jonathan C Craig, Jeremy R Chapman, Danyal Hassan, Greg Knoll, Naoka Murakami, Germaine Wong","doi":"10.3389/ti.2024.13965","DOIUrl":"10.3389/ti.2024.13965","url":null,"abstract":"Cancer is a major cause of morbidity and mortality in kidney transplant recipients. Health professionals have a critical role in promoting cancer screening participation. From March 2023 to February 2024, an online survey was distributed to kidney transplant health professionals globally to assess their screening practices. We compared their reported screening practices to recommended guidelines and analyzed factors associated with these practices. We received 97 responses, and most were nephrologists (70%), and around 80% recommended breast, colorectal, and cervical cancer screening for kidney transplant candidates and recipients. About 85% recommended lung cancer screening for higher-risk individuals. Skin cancer screening recommendations varied from 69% for transplant candidates and 84% for recipients. Self-reported cervical cancer screening practices were most concordant with recommended guidelines, followed by breast and skin cancers. Barriers reported included a lack of cancer screening awareness (28%), perceived financial constraints (35%), and deficient structured cancer screening systems (51%). Professionals from high-income countries were more likely to advise screening than those from lower-middle-income countries, with odds ratios ranging from 2.9 to 12.3. Most health professionals reported recommending cancer screening for kidney transplant candidates and recipients. However, recommendations were influenced by costs and service delivery gaps within health systems.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13965"},"PeriodicalIF":2.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14091

Ekaterina Fedorova, Sofia Nehring Firmino, Dixon B Kaufman, Jon S Odorico, David Aufhauser, Carrie Thiessen, David P Al-Adra, Didier Mandelbrot, Brad C Astor, Sandesh Parajuli

{"title":"Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients.","authors":"Ekaterina Fedorova, Sofia Nehring Firmino, Dixon B Kaufman, Jon S Odorico, David Aufhauser, Carrie Thiessen, David P Al-Adra, Didier Mandelbrot, Brad C Astor, Sandesh Parajuli","doi":"10.3389/ti.2025.14091","DOIUrl":"https://doi.org/10.3389/ti.2025.14091","url":null,"abstract":"The role of pre-transplant hypoalbuminemia and its impact on post-transplant outcomes in patients undergoing simultaneous pancreas-kidney (SPK) transplantation remains unclear. We analyzed all SPK recipients at our center, who had at least 2 weeks of pancreas and kidney graft survival and had serum albumin measured within 45 days pre-transplant. Recipients were categorized based on pretransplant albumin level as normal (≥4.0 g/dL, N = 222, 42%), mild hypoalbuminemia (≥3.5-<4.0 g/dL, N = 190, 36%), and moderate hypoalbuminemia (<3.5 g/dL, N = 120, 23%). Kidney delayed graft function (DGF), length of stay (LOS) after transplant, re-hospitalization within 30 days after discharge, and need for a return to the operating room (OR) related to transplant surgical complications, acute rejection, and uncensored and death-censored graft failure, within the first years post-transplant were outcomes of interest. A total of 532 SPK recipients were included. Mild or moderate hypoalbuminemia was not associated with DGF, LOS, re-hospitalization, or return to the OR in unadjusted or adjusted analyses. Similarly, mild or moderate hypoalbuminemia was not associated with a risk of graft rejection or graft failure. Among SPK recipients, pre-transplant hypoalbuminemia was not associated with worse outcomes and should not be the determining factor in selecting patients for SPK transplant.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14091"},"PeriodicalIF":2.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Infectious Complications in Pig Xenograft Donors and Recipients.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-15 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13594

Nicolas J Mueller, Linda Scobie

{"title":"Potential Infectious Complications in Pig Xenograft Donors and Recipients.","authors":"Nicolas J Mueller, Linda Scobie","doi":"10.3389/ti.2024.13594","DOIUrl":"https://doi.org/10.3389/ti.2024.13594","url":null,"abstract":"Preclinical and clinical xenotransplantation trials have shown that successful outcomes depend on a number of factors including the prevention of xenozoonoses. Preclinical trials involving pig kidneys and hearts transplanted into various non-human primates have revealed the potential impact of pig pathogens being present in the transplanted organ/tissue, mainly viruses. The concept of \"designated pathogen-free donor animals\" was developed to ensure elimination of pathogens during the breeding of donor animals to mitigate this occurrence. This is a challenging process as confirmation of presence and absence of some pathogen, in particular for latent viruses, requires a validated armamentarium of direct and indirect tests. The importance of using the correct diagnostic regimen was highlighted during the first pig-to-man cardiac transplantation with both porcine cytomegalovirus (PCMV), also known as porcine roseolovirus (PRV), and porcine circovirus (PCV) detected in the transplanted organ and in the patient. To further improve xenotransplantation and to achieve trials in Europe it is important that we use these data to inform process for diagnostics both in donor and recipients before and after xenotransplantation to ensure safety. As part of this sensitive and specific pathogen detection systems should be validated and readily available.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13594"},"PeriodicalIF":2.7,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024: A Year in Review.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-14 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.14243

Thierry Berney, Maria Irene Bellini, Louise Benning, Oriol Bestard, Christophe Masset, Beat Moeckli, Marco Maria Pascale, Nina Pilat, Mario Sabatino, Stefan Schneeberger

引用次数: 0

The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-13 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13942

S A Sanatkar, K Kinoshita, A Maenaka, H Hara, D K C Cooper

{"title":"The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.","authors":"S A Sanatkar, K Kinoshita, A Maenaka, H Hara, D K C Cooper","doi":"10.3389/ti.2024.13942","DOIUrl":"10.3389/ti.2024.13942","url":null,"abstract":"An overview is provided of the evolution of strategies towards xenotransplantation during the past almost 40 years, focusing on advances in gene-editing of the organ-source pigs, pre-transplant treatment of the recipient, immunosuppressive protocols, and adjunctive therapy. Despite initial challenges, including hyperacute rejection resulting from natural (preformed) antibody binding and complement activation, significant progress has been made through gene editing of the organ-source pigs and refinement of immunosuppressive regimens. Major steps were the identification and deletion of expression of the three known glycan xenoantigens on pig vascular endothelial cells, the transgenic expression of human \"protective\" proteins, e.g., complement-regulatory, coagulation-regulatory, and anti-inflammatory proteins, and the administration of an immunosuppressive regimen based on blockade of the CD40/CD154 T cell co-stimulation pathway. Efforts to address systemic inflammation followed. The synergy between gene editing and judicious immunomodulation appears to largely prevent graft rejection and is associated with a relatively good safety profile. Though there remains an incidence of severe or persistent proteinuria (nephrotic syndrome) in a minority of cases. This progress offers renewed hope for patients in need of life-saving organ transplants.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13942"},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endovascular Preparation With Innovative Custom-Made Stent-Graft Before Kidney Transplantation: The Solution for Patients With Hostile Iliac Calcification.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-08 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13486

Matthieu Arsicot, Raffaele Pio Ammollo, Marine Bordet, Leila Dehina-Khenniche, Olivier Thaunat, Nellie Della Schiava, Antoine Millon, Emilien Seizilles De Mazancourt, Lionel Badet, Xavier Matillon

{"title":"Endovascular Preparation With Innovative Custom-Made Stent-Graft Before Kidney Transplantation: The Solution for Patients With Hostile Iliac Calcification.","authors":"Matthieu Arsicot, Raffaele Pio Ammollo, Marine Bordet, Leila Dehina-Khenniche, Olivier Thaunat, Nellie Della Schiava, Antoine Millon, Emilien Seizilles De Mazancourt, Lionel Badet, Xavier Matillon","doi":"10.3389/ti.2024.13486","DOIUrl":"10.3389/ti.2024.13486","url":null,"abstract":"The increasing age of patients with end-stage renal disease raises the issue of hostile arterial access for transplantation, with technical difficulties associated with clamping and suturing the iliac artery. Some of these patients - who theoretically represent those who would benefit the most from transplantation in terms of mortality - are contraindicated because of anatomical and medical issues. In this context, a specific endovascular device called EndoPreKiT (Endovascular Preparation for Kidney Transplantation) has been designed, enabling arterial access for transplantation via a mini-invasive procedure. It consists of a woven Dacron supported by self-expanding nitinol rings, ensuring anchorage and allowing arterial clamping. The middle part of the anterior face of the device is stentless, enabling the anastomosis directly onto the Dacron once the calcified artery wall has been removed. After a cadaveric study validating its technical feasibility, such device was successfully implanted in 10 patients considered unfit for transplantation due to severe wall calcification. Two of them have been successfully transplanted with excellent outcomes after 13 and 3 months of follow-up. EndoPreKiT device may be a significant breakthrough in transplant surgery, that could expand the horizon of eligibility to include even the most fragile patients with challenging arterial access.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13486"},"PeriodicalIF":2.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation. 抗胸腺细胞球蛋白预处理对小鼠同种异体肾移植模型的影响。

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-07 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13997

An He, Yiren Yang, Katja Kotsch, Arne Sattler

{"title":"Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation.","authors":"An He, Yiren Yang, Katja Kotsch, Arne Sattler","doi":"10.3389/ti.2024.13997","DOIUrl":"10.3389/ti.2024.13997","url":null,"abstract":"Kidney transplantation is the treatment of choice for end-stage organ failure. To improve transplantation outcomes, particularly of \"marginal\" organs from extended criteria donors (ECD), attempts have been made to therapeutically modulate donor or graft pre-transplantation. Anti-thymocyte globulin (ATG) has a history as lymphocyte-depleting, immunosuppressive drug for treating rejection episodes post transplantation. In this study, however, we aimed to comprehensively analyze the effects of ATG donor pre-conditioning in a mouse model of kidney transplantation. ATG pre-treatment of potential donors led to a broad depletion of T- and NK cells in peripheral blood, non-lymphoid (including kidney) and lymphoid organs within 48 h, whereas myeloid cells were spared. ATG was also effectively depleting renal innate lymphoid type 1 and 2 cells. Importantly, transplantation of kidneys from ATG pre-treated donors into fully mismatched recipients showed only mild effects on leukocyte re-composition post transplantation. In line with this, serum creatinine and urea levels were similar in animals receiving kidneys from ATG treated donors or controls, demonstrating that donor treatment had no effect on allograft function in the early post-transplantation phase. In summary, our findings are suggestive of a more cell-type-specific depletion strategy in concert with an experimental model better reflecting aspects of clinical transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13997"},"PeriodicalIF":2.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nurse-Led Self-Management Support After Organ Transplantation - A Multicenter, Stepped-Wedge Randomized Controlled Trial. 器官移植后护士主导的自我管理支持——一项多中心、楔形步进随机对照试验。

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-06 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13175

Regina van Zanten, Monique van Dijk, Joost van Rosmalen, Denise K Beck, AnneLoes van Staa, Ann Van Hecke, Emma K Massey

{"title":"Nurse-Led Self-Management Support After Organ Transplantation - A Multicenter, Stepped-Wedge Randomized Controlled Trial.","authors":"Regina van Zanten, Monique van Dijk, Joost van Rosmalen, Denise K Beck, AnneLoes van Staa, Ann Van Hecke, Emma K Massey","doi":"10.3389/ti.2024.13175","DOIUrl":"10.3389/ti.2024.13175","url":null,"abstract":"In this unblinded multi-center stepped-wedge randomized controlled trial the effectiveness of the nurse-led ZENN-intervention was tested in promoting self-management skills in comparison to standard care among heart, lung and kidney transplant recipients. This intervention is based on behaviour change theories and was conducted in four sessions over 6 months at the outpatient clinic. The experimental group received standard care, plus the ZENN-intervention, while the control group received only standard care. Both groups completed questionnaires at baseline, at 6 months and 1 year follow-up. At baseline, the experimental group (n = 69) scored significantly lower than the control group (n = 106) on the primary outcome Skills and Technique Acquisition (STA). No significant between-group differences were found on the secondary outcomes self-management, self-regulation, quality of life and medication adherence at T1 and T2. There was a significant increase on the self-management scale STA between T0 and T1 in the experimental group. Therefore, participants included in the experimental group had lower self-management skills at baseline and reported significant improvement after completing the intervention. No significant intervention effect was found in the primary analysis, however, for recipients with reduced self-management skills the intervention may be beneficial.Clinical trial registration: https://onderzoekmetmensen.nl/en/trial/24150, Netherlands Trial Register NL8469.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13175"},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Scope of Microvascular Inflammation: Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts. 扩大微血管炎症的范围：揭示其存在超越抗体介导的排斥进入t细胞介导的背景。

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-06 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13464

Hilal Varol, Anne Wagenmakers, Konrad Hoeft, Jasper Callemeyn, Roos Bodewes, Wichor Bramer, Andrew Stubbs, Rafael Kramann, Maarten Naesens, Marian C Clahsen-Van Groningen

{"title":"Expanding the Scope of Microvascular Inflammation: Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts.","authors":"Hilal Varol, Anne Wagenmakers, Konrad Hoeft, Jasper Callemeyn, Roos Bodewes, Wichor Bramer, Andrew Stubbs, Rafael Kramann, Maarten Naesens, Marian C Clahsen-Van Groningen","doi":"10.3389/ti.2024.13464","DOIUrl":"10.3389/ti.2024.13464","url":null,"abstract":"Microvascular inflammation (MVI) in kidney transplant biopsies is mainly associated with antibody-mediated rejection (AMR), sparking debate within the Banff Classification of Renal Allograft Pathology regarding its exclusivity. This study reviewed the literature on MVI in T cell-mediated rejection (TCMR) and analyzed MVI in our transplant population. We searched English publications in MEDLINE, Embase, Web of Science, Cochrane, and Google Scholar until June 2024, focusing on glomerulitis (g), peritubular capillaritis (ptc), or MVI in kidney transplant biopsies classified as TCMR. Additionally, we examined g, ptc, and MVI in 69 patients with AMR, TCMR, and no rejection. Our search yielded 541 citations, with 10 studies included, covering 810 TCMR and 156 AMR biopsies. The studies showed g, ptc, and MVI were present in TCMR but were less prevalent and severe than in AMR. In our cohort, AMR had significantly higher g, ptc, and MVI scores compared to aTCMR and ATN, however, aTCMR also displayed MVI. These findings confirm that MVI occurs in aTCMR and should not be exclusively linked to AMR. These findings highlight the need to further explore MVI's significance in TCMR and investigate the inflammatory composition. This could refine the Banff Classification, improving Classification accuracy of kidney transplant pathology assessments.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13464"},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus.

IF 2.7 3区医学

Transplant International Pub Date : 2025-01-06 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13886

Lucrezia Furian, Uwe Heemann, Mats Bengtsson, Oriol Bestard, Isabelle Binet, Georg A Böhmig, John Boletis, David Briggs, Frans H J Claas, Lionel Couzi, Emanuele Cozzi, Marta Crespo, Aiko P J De Vries, Fritz Diekmann, Magdalena Durlik, Denis Glotz, Ilkka Helantera, Annette Jackson, Stanley C Jordan, Dirk Kuypers, Carmen Lefaucheur, Christophe Legendre, Tomas Lorant, Umberto Maggiore, Nizam Mamode, Smaragdi Marinaki, Annick Massart, Thomas Müller, Rainer Oberbauer, Lutz Renders, Dave Roelen, Jean-Luc Taupin, Ondřej Viklický, Angeliki Vittoraki, Annelies E de Weerd, Maarten Naesens

{"title":"Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus.","authors":"Lucrezia Furian, Uwe Heemann, Mats Bengtsson, Oriol Bestard, Isabelle Binet, Georg A Böhmig, John Boletis, David Briggs, Frans H J Claas, Lionel Couzi, Emanuele Cozzi, Marta Crespo, Aiko P J De Vries, Fritz Diekmann, Magdalena Durlik, Denis Glotz, Ilkka Helantera, Annette Jackson, Stanley C Jordan, Dirk Kuypers, Carmen Lefaucheur, Christophe Legendre, Tomas Lorant, Umberto Maggiore, Nizam Mamode, Smaragdi Marinaki, Annick Massart, Thomas Müller, Rainer Oberbauer, Lutz Renders, Dave Roelen, Jean-Luc Taupin, Ondřej Viklický, Angeliki Vittoraki, Annelies E de Weerd, Maarten Naesens","doi":"10.3389/ti.2024.13886","DOIUrl":"10.3389/ti.2024.13886","url":null,"abstract":"Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor-recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically. Hence, this Delphi methodology was used to reach a consensus from a multi-disciplinary team (MDT) of experts from 15 countries on the management of HS patients undergoing imlifidase HLAi from a deceased donor (DD) KTx. This Delphi consensus provides clinical practice guidance on the use of imlifidase in the end-to-end management of HS patients undergoing an HLAi DD KTx and supports centers in the development of guidelines for the utilization and integration of imlifidase into clinical practice.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13886"},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0