Transplant International最新文献

Growth of liver transplantation in the United Arab Emirates: lessons from the national deceased organ donation program and international collaboration. 阿拉伯联合酋长国肝移植的发展：来自国家死者器官捐赠计划和国际合作的经验教训。

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-05 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16160

Shiva Kumar, Ali Al Obaidli, Maria Gomez, Mustafa Al Mousawi, Giuseppe Iuppa, Luis Campos

引用次数: 0

Prospective evaluation of donor-derived cell-free DNA for noninvasive detection of acute rejection in an Asian heart transplant population. 亚洲心脏移植人群中供体来源的无细胞DNA无创检测急性排斥反应的前瞻性评估。

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-05 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16415

Shanshan Zheng, Sheng Liu, Zhiyuan Zhu, Jie Huang, Zhongkai Liao, Zhe Zheng, Xiaonan Fang, Lin Zhang, Hang Xu, Jiexu Ma, Yige Huyan, Xinhe Xu, Zhengbang Zou

{"title":"Prospective evaluation of donor-derived cell-free DNA for noninvasive detection of acute rejection in an Asian heart transplant population.","authors":"Shanshan Zheng, Sheng Liu, Zhiyuan Zhu, Jie Huang, Zhongkai Liao, Zhe Zheng, Xiaonan Fang, Lin Zhang, Hang Xu, Jiexu Ma, Yige Huyan, Xinhe Xu, Zhengbang Zou","doi":"10.3389/ti.2026.16415","DOIUrl":"10.3389/ti.2026.16415","url":null,"abstract":"Endomyocardial biopsy (EMB) is the gold standard for diagnosing post-heart transplant acute rejection (AR) but is invasive. Donor-derived cell-free DNA (dd-cfDNA) is a promising noninvasive biomarker, yet thresholds for Asian recipients remain undefined. This prospective study enrolled 80 patients, with 299 dd-cfDNA specimens analyzed via a novel Chinese-developed next-generation sequencing assay targeting 48 Indel sites. A reference cohort (n = 42) established post-transplant dd-cfDNA kinetics, while a biopsy cohort (n = 41, 18 acute cellular rejection [ACR], 9 antibody-mediated rejection [AMR], 14 no rejection [NR]) paired with EMB evaluated diagnostic performance. dd-cfDNA peaked at week 1, with a stable trend emerging from week 4 and stable levels reached by week 8. AR patients had significantly higher dd-cfDNA levels than NR patients (0.87% vs. 0.23%, P < 0.001). The optimal composite AR threshold was 0.33% (AUC = 0.874, sensitivity 81.0%, specificity 85.7%). dd-cfDNA decreased post-therapy (P = 0.011) and showed an inverse association with left ventricular ejection fraction (LVEF) (P = 0.004). This study provides initial evidence for an assay- and cohort-specific dd-cfDNA threshold (0.33%) for AR detection in Chinese recipients. Given the modest NPV (75.0%), this threshold is better suited for a \"rule-in\" strategy, and low values should not be used in isolation to defer biopsy. External validation in multicenter cohorts is required before routine clinical implementation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16415"},"PeriodicalIF":3.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From graft survival to lived experience: a new research agenda in transplant medicine. 从移植物存活到生活经验：移植医学的新研究议程。

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-05 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17264

Chiara Becchetti, Sofia C Zambrano

{"title":"From graft survival to lived experience: a new research agenda in transplant medicine.","authors":"Chiara Becchetti, Sofia C Zambrano","doi":"10.3389/ti.2026.17264","DOIUrl":"https://doi.org/10.3389/ti.2026.17264","url":null,"abstract":"Solid organ transplantation has achieved remarkable improvements in graft and patient survival, making traditional biomedical outcomes alone insufficient to fully define transplant success. Thus, attention is growing directed toward patient-reported outcomes, quality of life, psychological wellbeing, treatment burden, social reintegration, and the broader lived experience of transplant recipients. These dimensions are often subjective and context-dependent making them difficult to capture through quantitative methods alone. Qualitative research offers a complementary approach by exploring how patients, caregivers, donor families, and healthcare professionals perceive and give meaning to transplantation. In transplant medicine, qualitative methods may represent a relevant resource. Despite its potential, qualitative research remains underrepresented in leading transplantation journals and is often limited by misconceptions regarding rigor, lack of methodological training, and lacking editorial know-how. Integrating qualitative, quantitative, and mixed-methods approaches may help generate more comprehensive evidence. A new research agenda in transplantation should therefore move beyond graft survival to include lived experience as a central component of patient-centered care.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"17264"},"PeriodicalIF":3.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consent in the dark: Can living kidney donation proceed amid marital infidelity? 暗中同意：在婚姻不忠的情况下，活体肾脏捐赠还能继续吗？

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-02 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16580

Crystal Lim, Teck Chuan Voo, Peter Chiu-Leung Chow, Lalit Kumar Radha Krishna

{"title":"Consent in the dark: Can living kidney donation proceed amid marital infidelity?","authors":"Crystal Lim, Teck Chuan Voo, Peter Chiu-Leung Chow, Lalit Kumar Radha Krishna","doi":"10.3389/ti.2026.16580","DOIUrl":"10.3389/ti.2026.16580","url":null,"abstract":"Living kidney donation requires rigorous medical, psychosocial, and ethical evaluation to safeguard donor welfare, ensure valid informed consent, and prevent wrongful exploitation. In Singapore, the Human Organ Transplant Act mandates review by a transplant ethics committee (TEC) for all living-donor transplants. However, ethical judgment is not reducible to TEC approval or procedural compliance; transplant programs themselves carry a broader responsibility to evaluate relational dynamics that may affect voluntariness and authenticity of consent. This paper examines three cases involving concealed marital infidelity history in either kidney donor or recipient candidates or ongoing extramarital relationships in potential kidney donors and recipients that raised ethical concerns. Key issues include the materiality of information for informed consent, risks of psychosocial harm, integrity of caregiving arrangements, and potential institutional complicity in ongoing deception. While personal moral discomfort alone does not justify rejection, undisclosed relational complexities may warrant conditional deferral to protect donor welfare, program credibility, and public trust. In certain contexts, proceeding without disclosure may be ethically permissible when consent remains autonomous, donor privacy is respected, and anticipated harm is minimal. Transplant programs must balance substantial clinical benefit with ethical stewardship to preserve public confidence and the moral credibility of living donation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16580"},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The frequency and timing of leukopenia and CMV infections in kidney transplant recipients in Finland - a retrospective observational study. 芬兰肾移植受者白细胞减少和巨细胞病毒感染的频率和时间——一项回顾性观察研究

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16893

Ilkka Helanterä, Fernanda Ortiz, Essi Havula, Samuli Tuominen, Markus Hakamäki, Tapio Hellman, Satu Mäkelä, Riku Korhonen

{"title":"The frequency and timing of leukopenia and CMV infections in kidney transplant recipients in Finland - a retrospective observational study.","authors":"Ilkka Helanterä, Fernanda Ortiz, Essi Havula, Samuli Tuominen, Markus Hakamäki, Tapio Hellman, Satu Mäkelä, Riku Korhonen","doi":"10.3389/ti.2026.16893","DOIUrl":"10.3389/ti.2026.16893","url":null,"abstract":"This retrospective observational study investigated the frequency of post-transplant leukopenia and neutropenia (PTLN) and its association with cytomegalovirus (CMV) infections, clinical outcomes, and healthcare resource utilization (HCRU) in kidney transplant recipients (KTRs) in Finland. Clinical and HCRU data were collected from electronic medical records and national registries for the years 2013-2022. Clinical outcomes were assessed during the first 18 months, and cost-related outcomes were evaluated up to 4 years post-transplant. The cohort included 966 KTRs, with the following donor/recipient CMV serostatus distribution: R+ 706 (73.1%), D+/R─ 200 (20.7%), and D─/R─ 60 (6.2%). At 12 months, PTLN occurred in 224 (31.7%) R+, 103 (51.5%) D+/R─, and 6 (10.0%) D─/R─ recipients (p < 0.001). Valganciclovir prophylaxis was started in 28.0% of R+ and 95.0% of D+/R─ patients. CMV DNAemia occurred in 357 (50.6%) R+ and 106 (53.0%) D+/R─ recipients, with median time to CMV DNAemia of 66 days (IQI: 48-110) in R+ and 239 days (IQI: 175-323) in D+/R─ recipients (p < 0.001). PTLN and D+/R─ serostatus were associated with higher HCRU and increased healthcare costs. In conclusion, PTLN was more common in CMV D+/R─ KTRs and both D+/R─ serostatus and PTLN were linked to greater healthcare utilization and cost burden.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16893"},"PeriodicalIF":3.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Don't forget to safeguard the lungs during DCD multi-organ retrieval! Early in situ oxygenated preservation matters. 在DCD多器官取物过程中，不要忘记保护好肺部！早期原位氧化保存很重要。

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17507

Carlos Jordá Aragón, Alilis Fontana Bellorín

引用次数: 0

Disparities in outcomes among patients on lung transplantation waitlist in Saudi Arabia. 沙特阿拉伯肺移植等候名单患者预后差异

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17165

Amjad Albatli, Ruqayyah Fadhel, Yehia Rabea Yousef, Rana Ahmed Saleh, Haifa Aldakhil, Yasmin Altwaijri, Faisal Albaiz, Khaled Alkattan, Waleed Saleh, Moheeb Alawwami, Amer Alzahrani, Husna Thalib, Bedour Almudaiheem, Kris Marquez, Rayid Abdulqawi

引用次数: 0

Reply to Don't forget to safeguard the lungs during DCD multi-organ retrieval! Early in situ oxygenated preservation matters. 回复：DCD多器官取物时，别忘了保护好肺！早期原位氧化保存很重要。

IF 3.6 3区医学

Transplant International Pub Date : 2026-10-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17755

Eduardo Miñambres, Dale Gardiner, Helen Opdam

引用次数: 0

Guiding light: new European guidelines on CLAD prevention and treatment. 指导意见：新的欧洲预防和治疗覆胺感染指南。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-30 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17855

Kieran Halloran

引用次数: 0

Decoding AI for transplantation: many models, one patient: why there is no single "AI for transplantation" - and what to ask instead. 解读用于移植的人工智能：许多模型，一个病人：为什么没有单一的“用于移植的人工智能”——以及该问什么。