Transplant International最新文献

The Impact of Ischaemic Type Biliary Lesions on Healthcare Costs After Liver Transplantation With Grafts From Donors After Circulatory Death.

IF 3 3区医学

Transplant International Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14719

James M Halle-Smith, Marta Burak, George Clarke, Angus Hann, Arul Suthananthan, Keith J Roberts

引用次数: 0

Long Term Outcomes of Lung Transplantation in Sensitized Patients Following Eculizumab Use With the Desensitization Protocol.

IF 3 3区医学

Transplant International Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15040

Yudai Miyashita, Taisuke Kaiho, David F Pinelli, Anthony Joudi, Mihir John, Austin Chang, Benjamin Louis Thomae, Amanda Kamar, Carl Atkinson, Ankit Bharat, G R Scott Budinger, Ambalavanan Arunachalam, Chitaru Kurihara

{"title":"Long Term Outcomes of Lung Transplantation in Sensitized Patients Following Eculizumab Use With the Desensitization Protocol.","authors":"Yudai Miyashita, Taisuke Kaiho, David F Pinelli, Anthony Joudi, Mihir John, Austin Chang, Benjamin Louis Thomae, Amanda Kamar, Carl Atkinson, Ankit Bharat, G R Scott Budinger, Ambalavanan Arunachalam, Chitaru Kurihara","doi":"10.3389/ti.2025.15040","DOIUrl":"https://doi.org/10.3389/ti.2025.15040","url":null,"abstract":"Lung transplantation remains a life-saving option for end-stage pulmonary diseases, but sensitized patients with anti HLA antibodies carry high risk; recent desensitization advances, such as eculizumab, may permit outcomes comparable to non-sensitized recipients with tailored perioperative care. In this prospective cohort study of 399 adult lung transplant recipients, 36 sensitized patients underwent a protocol combining preoperative plasmapheresis, a defined eculizumab regimen, anti-thymocyte globulin, and IVIG. In comparison, 363 non-sensitized recipients received standard immunosuppression. We compared recipient/donor characteristics, intraoperative parameters, and postoperative outcomes, including primary graft dysfunction, infection, rejection, and overall survival. Desensitized patients were older, predominantly female, and had significantly higher panel reactive antibody levels and preformed donor-specific antibodies; intraoperatively, they required more blood transfusions and VA-ECMO support. Postoperatively, they exhibited higher rates of de novo donor-specific antibodies, antibody-mediated rejection, longer ICU stays, increased dialysis requirement, and more frequent CMV infections. Despite these differences, rates of acute cellular rejection, chronic lung allograft dysfunction, and one-year and overall survival were similar between groups. Our findings suggest that lung transplantation in sensitized patients managed with a desensitization protocol, including eculizumab, is feasible and safe, achieving outcomes comparable to those of non-sensitized recipients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"15040"},"PeriodicalIF":3.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rejection after BKPyV DNAemia-Are We Treating Too Cautiously? BKPyV贫血后的排斥反应——我们是否过于谨慎？

IF 3 3区医学

Transplant International Pub Date : 2025-09-18 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15122

Wouter T Moest, Aiko P J de Vries, Aline L van Rijn, Danny van der Helm, Jesper Kers, Mariet C W Feltkamp, Joris I Rotmans

引用次数: 0

Corrigendum: Number of Pretransplant Therapeutic Plasma Exchange Sessions Increase the Recurrence Risk of Hepatocellular Carcinoma in ABO-Incompatible Living Donor Liver Transplantation. 更正：移植前治疗性血浆交换次数增加abo血型不相容的活体供肝移植中肝细胞癌复发风险。

IF 3 3区医学

Transplant International Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15498

Young Jin Yoo, Deok-Gie Kim, Eun-Ki Min, Seung Hyuk Yim, Mun Chae Choi, Hwa-Hee Koh, Minyu Kang, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo

引用次数: 0

Dermatology Scheduling Triage of Transplant Patients and Transplant Candidates to Improve Early Diagnosis and Prevention of Skin Cancer: International Immunosuppression and Transplant Skin Cancer Collaborative Expert Consensus Recommendations. 移植患者和移植候选者的皮肤病学计划分类以提高皮肤癌的早期诊断和预防：国际免疫抑制和移植皮肤癌合作专家共识建议。

IF 3 3区医学

Transplant International Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14711

Kelsey E Hirotsu, Lauren Crowe, Basia Michalski-McNeely, Sarah T Arron, Kristin Bibee, Matthew J Bottomley, David R Carr, Joi B Carter, Sean R Christensen, Christina Chung, Anokhi Jambusaria, Kimberly M Ken, Manisha J Loss, Gyorgy Paragh, Elsemieke I Plasmeijer, Charlotte Proby, Melissa Pugliano-Mauro, Kathryn T Shahwan, Melodi Javid Whitley, Bryan T Carroll

{"title":"Dermatology Scheduling Triage of Transplant Patients and Transplant Candidates to Improve Early Diagnosis and Prevention of Skin Cancer: International Immunosuppression and Transplant Skin Cancer Collaborative Expert Consensus Recommendations.","authors":"Kelsey E Hirotsu, Lauren Crowe, Basia Michalski-McNeely, Sarah T Arron, Kristin Bibee, Matthew J Bottomley, David R Carr, Joi B Carter, Sean R Christensen, Christina Chung, Anokhi Jambusaria, Kimberly M Ken, Manisha J Loss, Gyorgy Paragh, Elsemieke I Plasmeijer, Charlotte Proby, Melissa Pugliano-Mauro, Kathryn T Shahwan, Melodi Javid Whitley, Bryan T Carroll","doi":"10.3389/ti.2025.14711","DOIUrl":"10.3389/ti.2025.14711","url":null,"abstract":"Solid organ transplant recipients (SOTRs) have a high risk of developing aggressive skin cancers. However, there are no standardized triage guidelines to assist dermatology clinics with scheduling new patients pre- or post-transplant. Dermatologic care of SOTRs requires multidisciplinary coordination, extensive assessment, tailored counseling, and longitudinal care. Specialized high-risk transplant clinics are designed to address this clinical need but are a limited resource. This triage algorithm aims to provide a practical framework for tertiary care centers or community practice clinics receiving pre- or post-transplant referrals for active concerning growths or routine skin cancer screening exams. In summary, our expert panel recommends SOTRs are seen within 1-2 weeks for evaluation of an active growth and triaged according to their risk factors for the initial post-transplant screening visit (6 months-2+ years post-transplant). Transplant candidates should be seen for pre-transplant evaluation within 1 month of the referral for a skin cancer screening exam, depending on the transplant team's timeline and dermatologist availability. Overall, dermatologists face numerous challenges in caring for transplant patients, and scheduling these patients in a timely manner according to the acuity of their needs will facilitate prevention and early diagnosis of skin cancer, thus improving transplant patient outcomes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14711"},"PeriodicalIF":3.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Antibodies in Post-Transplant FSGS: New Answers or Recurrent Questions? 除抗体外，移植后FSGS：新答案还是老问题？

IF 3 3区医学

Transplant International Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15032

João Venda, Andreia Henriques, Pedro Fragoso, Clara Pardinhas, Maria Marques, Luís Rodrigues, Rita Leal, Lídia Santos, Catarina Romãozinho, Rui Alves, Arnaldo Figueiredo

引用次数: 0

Promoting and Supporting Positive Conversations and Knowledge Mobilisation About Organ Donation in NHS Staff: a Hashtag "#" Series of Projects. 促进和支持NHS员工关于器官捐赠的积极对话和知识动员：一个标签“#”系列项目。

IF 3 3区医学

Transplant International Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15131

Natalie L Clark, Dorothy Coe, Hannah Gillespie, Marcus Diamond, Michael O'Malley, David Reaich, Caroline Wroe

{"title":"Promoting and Supporting Positive Conversations and Knowledge Mobilisation About Organ Donation in NHS Staff: a Hashtag \"#\" Series of Projects.","authors":"Natalie L Clark, Dorothy Coe, Hannah Gillespie, Marcus Diamond, Michael O'Malley, David Reaich, Caroline Wroe","doi":"10.3389/ti.2025.15131","DOIUrl":"10.3389/ti.2025.15131","url":null,"abstract":"Implementation of the \"soft\" opt-out legislation in England has not had the desired impact in increasing the number of deceased donations and consent. The need for organs continues to be greater than the number of organs available, consent rates have fallen and organ donor registrations have stagnated. Introducing the legislation during the pandemic has had a profound effect with public awareness campaigns withheld, leaving a significant proportion of the population unaware of the change. Strategies to increase the public's awareness and understanding of organ donation and the opt-out legislation are needed, as well as to encourage decision-making and sharing this with their families. We outline several \"#\" projects (#conversations, #options, #speak) with NHS staff to demonstrate how we can successfully utilise this specific population as trusted individuals and advocates to promote positive communications about organ donation and the opt-out legislation. NHS England is one of the biggest employers and most ethnically diverse across Europe. We know that NHS staff are more supportive, more aware and are more likely to have made an organ donation decision and had conversations with their families than the public. This places them in a unique and valuable position to lead positive conversations about organ donation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"15131"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Individual Impact of Machine Perfusion on Liver and Kidney on Donor Expansion in Simultaneous Liver and Kidney Transplantation. 肝脏和肾脏机器灌注对肝脏和肾脏同时移植供体扩张的个体影响。

IF 3 3区医学

Transplant International Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14807

Rikako Oki, Ingrid Rocha, Saleh Al-Juburi, Luckshi Rajendran, Emily Kerby, Adhnan Mohamed, Abbas Al-Kurd, Ahmed Nassar, Dean Y Kim, Atsushi Yoshida, Marwan Abouljoud, Shunji Nagai

{"title":"The Individual Impact of Machine Perfusion on Liver and Kidney on Donor Expansion in Simultaneous Liver and Kidney Transplantation.","authors":"Rikako Oki, Ingrid Rocha, Saleh Al-Juburi, Luckshi Rajendran, Emily Kerby, Adhnan Mohamed, Abbas Al-Kurd, Ahmed Nassar, Dean Y Kim, Atsushi Yoshida, Marwan Abouljoud, Shunji Nagai","doi":"10.3389/ti.2025.14807","DOIUrl":"10.3389/ti.2025.14807","url":null,"abstract":"Machine perfusion (MP) use for both organs can increase organ usage in simultaneous liver and kidney transplantation (SLKT). We analyzed 6,956 SLKT performed between 2015 and 2024 using the United Network for Organ Sharing database. The primary outcomes were the 1-year graft survival for kidney and liver. Donor types and MP use for liver and/or kidney were captured and associations with outcomes were evaluated. SLKT from Donation after circulatory death donors (DCD) increased from 4.5% in 2015 to 16% in 2023. The median Kidney Donor Profile Index (KDPI) has increased from 23% in 2015 to 28% in 2023. MP use for kidney and liver also increased from 21% to 51% and 0%-17%, respectively. KDPI >85% was an independent risk factor of 1-year kidney graft failure in the no kidney MP group [HR 2.03, 95% CI 1.20-3.44, p = 0.009], but not in the kidney MP group. DCD was found to be an independent risk factor of 1-year liver graft failure in the no liver MP group [HR 1.56, 95% CI 1.19-2.03, p = 0.001], but not in the liver MP group. MP for both organs may contribute to expanding the donor pool for SLKT without compromising post-transplant outcomes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14807"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion. 常温灌注时肾小管的靶向性和分布增强。

IF 3 3区医学

Transplant International Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14747

Enrique Montagud-Marrahi, Adriana Rodriguez-Gonzalo, Rubén López-Aladid, Yosu Luque, Ruben Rabadán-Ros, Elena Cuadrado-Payan, Elisenda Bañón-Maneus, Jordi Rovira, Marta Lazo-Rodríguez, Oriol Aguilà, Carolt Arana, Ainhoa García-Busquets, Natalia Hierro, Thomas Prudhomme, Mireia Musquera, Yun Xia, Fritz Diekmann, Josep M Campistol, Maria José Ramírez-Bajo

{"title":"Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion.","authors":"Enrique Montagud-Marrahi, Adriana Rodriguez-Gonzalo, Rubén López-Aladid, Yosu Luque, Ruben Rabadán-Ros, Elena Cuadrado-Payan, Elisenda Bañón-Maneus, Jordi Rovira, Marta Lazo-Rodríguez, Oriol Aguilà, Carolt Arana, Ainhoa García-Busquets, Natalia Hierro, Thomas Prudhomme, Mireia Musquera, Yun Xia, Fritz Diekmann, Josep M Campistol, Maria José Ramírez-Bajo","doi":"10.3389/ti.2025.14747","DOIUrl":"10.3389/ti.2025.14747","url":null,"abstract":"Tubuloids have become a promising tool for modeling and regenerating kidney disease, although their ability for integration and regeneration in vivo is not well documented. Here, we established, characterized, and compared human tubuloids using two optimized protocols: one involving prior isolation of tubular cells (Crude tubuloids) and the other involving prior isolation of proximal tubular cells (F4 tubuloids). Next, healthy rat-derived tubuloids were established using this protocol. Finally, we compared two strategies for delivering GFP tubuloids to a kidney host: 1) subcapsular/intracortical injection and 2) tubuloid infusion during normothermic preservation in a rat transplantation model and a discarded human kidney. F4 tubuloids achieved a higher level of differentiation state compared to Crude tubuloids. When analyzing tubuloid delivery to the kidney, normothermic perfusion was found to be more efficient than in vivo injection. Moreover, fully developed tubules were observed in the host parenchyma at 1 week and 1 month after infusion during normothermic perfusion represent a potential strategy to enhance the translatability of kidney regenerative therapies into clinical practice to condition kidney grafts and to treat kidney diseases.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14747"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Performance in Patients With Alcohol-Associated Liver Disease Undergoing Liver Transplantation. 肝移植术后酒精相关性肝病患者的认知表现

IF 3 3区医学

Transplant International Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.12869

Magdalena Grusiecka-Stańczyk, Maciej K Janik, Piotr Olejnik, Aleksandra Golenia, Jolanta MaƗyszko, Joanna Raszeja-Wyszomirska

{"title":"Cognitive Performance in Patients With Alcohol-Associated Liver Disease Undergoing Liver Transplantation.","authors":"Magdalena Grusiecka-Stańczyk, Maciej K Janik, Piotr Olejnik, Aleksandra Golenia, Jolanta MaƗyszko, Joanna Raszeja-Wyszomirska","doi":"10.3389/ti.2025.12869","DOIUrl":"10.3389/ti.2025.12869","url":null,"abstract":"Cognitive impairment (CI) in alcohol-related liver cirrhosis (ALD) is often underestimated, primarily attributed to hepatic encephalopathy (HE), despite evidence suggesting that deficits may persist after liver transplantation (LT). This study assessed CI both before and after LT through a structured psychiatric evaluation. A total of 101 ALD patients listed for LT were assessed; 61 underwent transplantation. Three patients died pre-LT, and six post-LT, leaving 55 for longitudinal cognitive evaluation. The Addenbrooke's Cognitive Examination III (ACE III) was administered at LT listing and 7.1 months post-LT. Pre-LT CI was prevalent, with 86% scoring below the ACE III threshold. Mild cognitive impairment (MCI) was observed in 33%, and 52% had a high probability of dementia. Post-LT, ACE III scores improved (Δ +7.07 ± 8.47, P < 0.01), with the greatest gains in memory (+1.46, P = 0.01) and verbal fluency (+1.43, P = 0.02), while attention remained largely unchanged. Despite overall cognitive recovery, persistent deficits were observed, particularly in executive function and fluency. LT improves cognition, but persistent deficits suggest CI in ALD is not entirely reversible. These findings underscore the need for targeted cognitive interventions before and after LT.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"12869"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0