Transplant International最新文献_第2页

Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion. 常温灌注时肾小管的靶向性和分布增强。

IF 3 3区医学

Transplant International Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14747

Enrique Montagud-Marrahi, Adriana Rodriguez-Gonzalo, Rubén López-Aladid, Yosu Luque, Ruben Rabadán-Ros, Elena Cuadrado-Payan, Elisenda Bañón-Maneus, Jordi Rovira, Marta Lazo-Rodríguez, Oriol Aguilà, Carolt Arana, Ainhoa García-Busquets, Natalia Hierro, Thomas Prudhomme, Mireia Musquera, Yun Xia, Fritz Diekmann, Josep M Campistol, Maria José Ramírez-Bajo

{"title":"Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion.","authors":"Enrique Montagud-Marrahi, Adriana Rodriguez-Gonzalo, Rubén López-Aladid, Yosu Luque, Ruben Rabadán-Ros, Elena Cuadrado-Payan, Elisenda Bañón-Maneus, Jordi Rovira, Marta Lazo-Rodríguez, Oriol Aguilà, Carolt Arana, Ainhoa García-Busquets, Natalia Hierro, Thomas Prudhomme, Mireia Musquera, Yun Xia, Fritz Diekmann, Josep M Campistol, Maria José Ramírez-Bajo","doi":"10.3389/ti.2025.14747","DOIUrl":"10.3389/ti.2025.14747","url":null,"abstract":"Tubuloids have become a promising tool for modeling and regenerating kidney disease, although their ability for integration and regeneration in vivo is not well documented. Here, we established, characterized, and compared human tubuloids using two optimized protocols: one involving prior isolation of tubular cells (Crude tubuloids) and the other involving prior isolation of proximal tubular cells (F4 tubuloids). Next, healthy rat-derived tubuloids were established using this protocol. Finally, we compared two strategies for delivering GFP tubuloids to a kidney host: 1) subcapsular/intracortical injection and 2) tubuloid infusion during normothermic preservation in a rat transplantation model and a discarded human kidney. F4 tubuloids achieved a higher level of differentiation state compared to Crude tubuloids. When analyzing tubuloid delivery to the kidney, normothermic perfusion was found to be more efficient than in vivo injection. Moreover, fully developed tubules were observed in the host parenchyma at 1 week and 1 month after infusion during normothermic perfusion represent a potential strategy to enhance the translatability of kidney regenerative therapies into clinical practice to condition kidney grafts and to treat kidney diseases.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14747"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Performance in Patients With Alcohol-Associated Liver Disease Undergoing Liver Transplantation. 肝移植术后酒精相关性肝病患者的认知表现

IF 3 3区医学

Transplant International Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.12869

Magdalena Grusiecka-Stańczyk, Maciej K Janik, Piotr Olejnik, Aleksandra Golenia, Jolanta MaƗyszko, Joanna Raszeja-Wyszomirska

{"title":"Cognitive Performance in Patients With Alcohol-Associated Liver Disease Undergoing Liver Transplantation.","authors":"Magdalena Grusiecka-Stańczyk, Maciej K Janik, Piotr Olejnik, Aleksandra Golenia, Jolanta MaƗyszko, Joanna Raszeja-Wyszomirska","doi":"10.3389/ti.2025.12869","DOIUrl":"10.3389/ti.2025.12869","url":null,"abstract":"Cognitive impairment (CI) in alcohol-related liver cirrhosis (ALD) is often underestimated, primarily attributed to hepatic encephalopathy (HE), despite evidence suggesting that deficits may persist after liver transplantation (LT). This study assessed CI both before and after LT through a structured psychiatric evaluation. A total of 101 ALD patients listed for LT were assessed; 61 underwent transplantation. Three patients died pre-LT, and six post-LT, leaving 55 for longitudinal cognitive evaluation. The Addenbrooke's Cognitive Examination III (ACE III) was administered at LT listing and 7.1 months post-LT. Pre-LT CI was prevalent, with 86% scoring below the ACE III threshold. Mild cognitive impairment (MCI) was observed in 33%, and 52% had a high probability of dementia. Post-LT, ACE III scores improved (Δ +7.07 ± 8.47, P < 0.01), with the greatest gains in memory (+1.46, P = 0.01) and verbal fluency (+1.43, P = 0.02), while attention remained largely unchanged. Despite overall cognitive recovery, persistent deficits were observed, particularly in executive function and fluency. LT improves cognition, but persistent deficits suggest CI in ALD is not entirely reversible. These findings underscore the need for targeted cognitive interventions before and after LT.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"12869"},"PeriodicalIF":3.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State of Art of Dose Individualization to Support tacrolimus drug monitoring: What's Next? 支持他克莫司药物监测的个体化剂量技术现状：下一步是什么？

IF 3 3区医学

Transplant International Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14201

N Lloberas, B Fernández-Alarcón, A Vidal-Alabró, H Colom

{"title":"State of Art of Dose Individualization to Support tacrolimus drug monitoring: What's Next?","authors":"N Lloberas, B Fernández-Alarcón, A Vidal-Alabró, H Colom","doi":"10.3389/ti.2025.14201","DOIUrl":"10.3389/ti.2025.14201","url":null,"abstract":"Tacrolimus is an immunosuppressant with a narrow therapeutic index and a high intra- and inter-patient variability showing significant challenges in optimal dosing and monitoring. Historically, pre-dose concentration monitoring and simplified area under the curve measurements have been the standard approach. However, recent advances in pharmacokinetic modeling have improved individualized dosing strategies, moving beyond empirical methods. This review explores the evolving landscape of Tacrolimus therapeutic drug monitoring, focusing on advanced modeling techniques that support personalized dosing. Key methodological approaches include Population Pharmacokinetic (PopPK) modeling, Bayesian prediction, Physiologically-Based Pharmacokinetic (PBPK) modeling, and emerging machine learning and artificial intelligence technologies. While no single method provides a perfect solution, these approaches are complementary and offer increasingly sophisticated tools for dose individualization. The review critically examines the potential and limitations of current modeling strategies, highlighting the complexity of translating advanced statistical and mathematical techniques into clinically accessible tools. A significant challenge remains the gap between sophisticated modeling techniques and the practical usability for healthcare professionals. The need for user-friendly platforms is emphasized, with recognition of existing commercial solutions while also noting their inherent limitations. Future directions point towards more integrated, intelligent systems that can bridge the current technological and practical gaps in personalized immunosuppressant therapy.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14201"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outscoring "Fire and Forget"? Current Practice of Lipid Management in Kidney Transplant Recipients. 得分超过了“开火即弃”？肾移植受者血脂管理的现状。

IF 3 3区医学

Transplant International Pub Date : 2025-08-29 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14600

Eric Amelunxen, Roland Schmitt, Laura Katharina Sievers

引用次数: 0

Kidney Transplantation From Uncontrolled Donation After Circulatory Death Maintained by Normothermic Regional Perfusion: An 8-Year Portuguese Single-Centre Experience. 常温区域灌注维持循环死亡后无控制捐献肾移植：葡萄牙8年单中心经验。

IF 3 3区医学

Transplant International Pub Date : 2025-08-26 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14651

Ana Pinho, Susana Sampaio, Inês Alencastre, Maria João Polidoro, Margarida Rios, Roberto Roncon-Albuquerque, João Silva, Carlos Silva, Manuel Pestana

{"title":"Kidney Transplantation From Uncontrolled Donation After Circulatory Death Maintained by Normothermic Regional Perfusion: An 8-Year Portuguese Single-Centre Experience.","authors":"Ana Pinho, Susana Sampaio, Inês Alencastre, Maria João Polidoro, Margarida Rios, Roberto Roncon-Albuquerque, João Silva, Carlos Silva, Manuel Pestana","doi":"10.3389/ti.2025.14651","DOIUrl":"10.3389/ti.2025.14651","url":null,"abstract":"In January 2016, our hospital started a program of uncontrolled donation after circulatory death (uDCD) to increase organ availability for kidney transplantation. We analysed the results of 523 consecutive kidney transplants (KT) performed from January 2016 to December 2023 in our center and compared the outcomes of 142 KT from uDCD maintained by abdominal normothermic regional perfusion (A-NRP) with those from 194 KT from standard-criteria brain-death donors (SCD) and 187 KT from expanded-criteria brain-death donors (ECD). Primary non-function (PNF) was similar in uDCD (16.9%) and ECD (13.4%, p = 0.460) and more common than in SCD (4.6%; p < 0.001). In addition, delayed graft function (DGF) differed among the groups, being higher in the uDCD (69.7%), followed by ECD (43.9%) and SCD (37.6%; p ≤ 0.05). However, the estimated glomerular filtration rate (eGFR) at 7 years was similar in uDCD and SCD (62.27 ± 18.38 mL/min/1.73 m2 vs. 65.48 ± 19.24 mL/min/1.73 m2, p = 1) and higher than in ECD (47.67 ± 23.05 mL/min/1.73 m2, p < 0.001). When excluding PNF, the 7-year death-censored graft survival was similar among the three groups (SCD, 91.4%; uDCD, 96.2%; ECD, 82.7%). Despite the increased risk of PNF and DGF, functional and survival outcomes of uDCD KT at 7 years were comparable to those of SCD, thus supporting the use of uDCD kidneys maintained under A-NRP as a successful resource to address organ scarcity.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14651"},"PeriodicalIF":3.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Living Well After Organ Transplantation. 社论：器官移植后的良好生活。

IF 3 3区医学

Transplant International Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15345

Coby Annema, Kevin Fowler, Allison Jaure, Fabienne Dobbels, Sabina De Geest

引用次数: 0

Advancements in Cytomegalovirus Management Among Solid Organ Transplant Recipients: Insights From the ESOT CMV Workshop 2023. 实体器官移植受者巨细胞病毒治疗的进展：来自ESOT CMV研讨会2023的见解

IF 3 3区医学

Transplant International Pub Date : 2025-08-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14195

Luca Toti, Nassim Kamar, Sophie Alain, Oriol Manuel, Nikolina Basic-Jukic, Paolo Antonio Grossi, Hannah Kaminski, Paolo Solidoro, Luciano Potena

{"title":"Advancements in Cytomegalovirus Management Among Solid Organ Transplant Recipients: Insights From the ESOT CMV Workshop 2023.","authors":"Luca Toti, Nassim Kamar, Sophie Alain, Oriol Manuel, Nikolina Basic-Jukic, Paolo Antonio Grossi, Hannah Kaminski, Paolo Solidoro, Luciano Potena","doi":"10.3389/ti.2025.14195","DOIUrl":"10.3389/ti.2025.14195","url":null,"abstract":"Cytomegalovirus (CMV) infection poses significant challenges in solid organ transplant (SOT) recipients, impacting graft outcomes, morbidity, and in some cases survival. The ESOT CMV Workshop 2023 convened European experts to discuss current practices and advances in the management of CMV with the aim of improving the quality of life of transplant recipients. Discussions covered crucial areas such as preventive strategies, diagnostic challenges, therapeutic approaches, and the role of cell-mediated immunity (CMI) monitoring. Despite advances, ambiguity persists in optimal CMV management across European transplant centers. Preventive strategies, including universal prophylaxis and pre-emptive therapy, are effective but consensus is lacking with respect to the preferred approach. Diagnostic challenges such as standardization of viral load thresholds and detection of end-organ disease complicate timely intervention. While newer therapies like maribavir hold promise for treating complicated CMV infections, sustaining viral clearance remains a challenge. Integrating CMI monitoring into CMV management could personalize treatment decisions but has limitations in in terms of predictive value and accessibility. Further research is needed to fill these gaps and optimize CMV management. The collaborative efforts, led by the European Society for Organ Transplantation (ESOT), aim to standardize and improve CMV care, ensuring better outcomes for SOT recipients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14195"},"PeriodicalIF":3.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Safety and Efficacy of Daprodustat for Recipients in Peritransplant Period: a Single-Center Retrospective Study on Post-Transplant Anemia Management in Kidney Transplantation. 达生产司他对移植围期受者的安全性和有效性：肾移植术后贫血管理的单中心回顾性研究。

IF 3 3区医学

Transplant International Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.15237

Yu Sato, Hiroshi Noguchi, Shinsuke Kubo, Yu Hisadome, Keizo Kaku, Soichiro Tajima, Yasuhiro Okabe, Masafumi Nakamura

引用次数: 0

Positive Impact of ERAS Programme on Living and Deceased Donor Renal Transplant Recipients During COVID-19 Pandemic. COVID-19大流行期间ERAS计划对活体和已故供体肾移植受者的积极影响

IF 3 3区医学

Transplant International Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14238

Rachel A B Thomas, Hannah K Chalmers, Helen M E Usher, Olivia Pestrin, Emily J Simpson-Dent, Maia I Webb, Hilary M Guthrie, Sonia J Wakelin, Gabriel C Oniscu

引用次数: 0

The Progress and Challenges of Implementing HLA Molecular Matching in Clinical Practice. HLA分子配型在临床应用中的进展与挑战。

IF 3 3区医学

Transplant International Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14716

Suzanne Bezstarosti, Sebastiaan Heidt

{"title":"The Progress and Challenges of Implementing HLA Molecular Matching in Clinical Practice.","authors":"Suzanne Bezstarosti, Sebastiaan Heidt","doi":"10.3389/ti.2025.14716","DOIUrl":"https://doi.org/10.3389/ti.2025.14716","url":null,"abstract":"HLA molecular matching in solid organ transplantation in the form of eplets, solvent-accessible amino acids or PIRCHE-II has been proposed as a more granular method than HLA matching on the antigen level. While many studies have shown the association between molecular mismatches and de novo donor-specific antibody formation, rejection and graft loss, evidence for prospective molecular matching in allocation is currently lacking, and the actual practical implementation and feasibility of molecular matching remains unclear. In this review the various potential applications of molecular matching in transplantation are discussed, including 1) organ allocation in deceased donor programs, 2) living donor selection, 3) increasing the transplantability of highly sensitized patients and 4) risk stratification to facilitate personalized immunosuppressive management, along with the challenges and gaps in current knowledge regarding these approaches. While clinical application of molecular mismatch analysis in solid organ transplantation holds promise, the fundamentals of HLA-specific antibody biology and epitope-paratope interactions should be further elucidated. This will aid in unraveling the factors that affect the relative immunogenicity of HLA molecular mismatches in order to start using molecular matching in clinical transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14716"},"PeriodicalIF":3.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0