Transplant International最新文献_第10页

A Split-Lung Ex Vivo Perfusion Model for Time- and Cost-Effective Evaluation of Therapeutic Interventions to the Human Donor Lung. 分肺活体灌注模型，用于对人类捐献肺的治疗干预进行时间和成本效益评估。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12573

Nicholas J S Chilvers, Jenny Gilmour, Marnie L Brown, Lucy Bates, Chong Yun Pang, Henning Pauli, John Dark, Andrew J Fisher

{"title":"A Split-Lung Ex Vivo Perfusion Model for Time- and Cost-Effective Evaluation of Therapeutic Interventions to the Human Donor Lung.","authors":"Nicholas J S Chilvers, Jenny Gilmour, Marnie L Brown, Lucy Bates, Chong Yun Pang, Henning Pauli, John Dark, Andrew J Fisher","doi":"10.3389/ti.2024.12573","DOIUrl":"10.3389/ti.2024.12573","url":null,"abstract":"With the ongoing shortage of donor lungs, ex vivo lung perfusion (EVLP) offers the opportunity for objective assessment and potential therapeutic repair of marginal organs. There is a need for robust research on EVLP interventions to increase the number of transplantable organs. The use of human lungs, which have been declined for transplant, for these studies is preferable to animal organs and is indeed essential if clinical translation is to be achieved. However, experimental human EVLP is time-consuming and expensive, limiting the rate at which promising interventions can be assessed. A split-lung EVLP model, which allows stable perfusion and ventilation of two single lungs from the same donor, offers advantages scientifically, financially and in time to yield results. Identical parallel circuits allow one to receive an intervention and the other to act as a control, removing inter-donor variation between study groups. Continuous hemodynamic and airway parameters are recorded and blood gas, perfusate, and tissue sampling are facilitated. Pulmonary edema is assessed directly using ultrasound, and indirectly using the lung tissue wet:dry ratio. Evans blue dye leaks into the tissue and can quantify vascular endothelial permeability. The split-lung ex vivo perfusion model offers a cost-effective, reliable platform for testing therapeutic interventions with relatively small sample sizes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12573"},"PeriodicalIF":3.1,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study. 肝移植后癫痫发作的临床影响和风险因素：巢式病例对照研究

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12342

Minyu Kang, Hwa-Hee Koh, Deok-Gie Kim, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo

{"title":"Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study.","authors":"Minyu Kang, Hwa-Hee Koh, Deok-Gie Kim, Seung Hyuk Yim, Mun Chae Choi, Eun-Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo","doi":"10.3389/ti.2024.12342","DOIUrl":"10.3389/ti.2024.12342","url":null,"abstract":"Seizures are a frequent neurological consequence following liver transplantation (LT), however, research on their clinical impact and risk factors is lacking. Using a nested case-control design, patients diagnosed with seizures (seizure group) within 1-year post-transplantation were matched to controls who had not experienced seizures until the corresponding time points at a 1:5 ratio to perform survival and risk factor analyses. Seizures developed in 61 of 1,243 patients (4.9%) at median of 11 days after LT. Five-year graft survival was significantly lower in the seizure group than in the controls (50.6% vs. 78.2%, respectively, p < 0.001) and seizure was a significant risk factor for graft loss after adjusting for variables (HR 2.04, 95% CI 1.24-3.33). In multivariable logistic regression, body mass index <23 kg/m2, donor age ≥45 years, intraoperative continuous renal replacement therapy and delta sodium level ≥4 mmol/L emerged as independent risk factors for post-LT seizure. Delta sodium level ≥4 mmol/L was associated with seizures, regardless of the severity of preoperative hyponatremia. Identifying and controlling those risk factors are required to prevent post-LT seizures which could result in worse graft outcome.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12342"},"PeriodicalIF":3.1,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140111469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the First Year: Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation. 超越第一年：肾移植后晚期机会性感染的流行病学与管理》（Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation）。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12065

V Esnault, L Hoisnard, B Peiffer, V Fihman, S Fourati, C Angebault, C Champy, S Gallien, P Attias, A Morel, P Grimbert, G Melica, M Matignon

{"title":"Beyond the First Year: Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation.","authors":"V Esnault, L Hoisnard, B Peiffer, V Fihman, S Fourati, C Angebault, C Champy, S Gallien, P Attias, A Morel, P Grimbert, G Melica, M Matignon","doi":"10.3389/ti.2024.12065","DOIUrl":"10.3389/ti.2024.12065","url":null,"abstract":"Late opportunistic infections (OI) occurring beyond the first year after kidney transplantation (KT) are poorly described and not targeted by prophylactic strategies. We performed a ten-year retrospective monocentric cohort study describing epidemiology, risk factors and impact of late OI occurring 1 year after KT. We included clinically symptomatic OI requiring treatment besides BK virus nephropathy. Control groups included early OI occurring in the first year after KT, and KT recipients without OI since KT and alive with a functional allograft at 1 year. Among 1066 KT recipients, 185 (19.4%) presented a first episode of OI 21.0 (8.0-45.0) months after KT: 120 late OI (64.9%) and 65 early OI (35.1%). Late OI were mainly viral (N = 83, 69.2%), mostly herpes zoster (HZ) (N = 36, 43.4%). Pneumocystis represented most late fungal infections (N = 12/25, 48%). Compared to early OI, we reported more pneumocystis (p = 0.002) and less invasive aspergillosis (p = 0.01) among late OI. Patients with late OI were significatively younger at KT (54.0 ± 13.3 vs. 60.2 ± 14.3 years, p = 0.05). Patient and allograft survival rates between late OI and control groups were similar. Only age was independently associated with mortality. While late OI were not associated with higher mortality or graft loss, implementing prophylactic strategies might prevent such infections.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12065"},"PeriodicalIF":3.1,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of De Novo Post-Transplant Malignancies in Thai Adult Kidney Transplant Recipients: A Single-Center, Population-Controlled, Retrospective Cohort Study at the Highest Volume Kidney Transplant Center in Thailand. 泰国成人肾移植受者移植后新发恶性肿瘤的发生率：泰国移植量最大的肾移植中心的单中心、人群控制、回顾性队列研究。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.11614

Praopilad Srisuwarn, Napun Sutharattanapong, Sinee Disthabanchong, Surasak Kantachuvesiri, Chagriya Kitiyakara, Bunyong Phakdeekitcharoen, Atiporn Ingsathit, Vasant Sumethkul

{"title":"Incidence of De Novo Post-Transplant Malignancies in Thai Adult Kidney Transplant Recipients: A Single-Center, Population-Controlled, Retrospective Cohort Study at the Highest Volume Kidney Transplant Center in Thailand.","authors":"Praopilad Srisuwarn, Napun Sutharattanapong, Sinee Disthabanchong, Surasak Kantachuvesiri, Chagriya Kitiyakara, Bunyong Phakdeekitcharoen, Atiporn Ingsathit, Vasant Sumethkul","doi":"10.3389/ti.2024.11614","DOIUrl":"10.3389/ti.2024.11614","url":null,"abstract":"Kidney transplant recipients (KTRs) are at increased risk of developing de novo post-transplant malignancies (PTMs), with regional differences in types with excess risk compared to the general population. A single-center, population-controlled, retrospective cohort study was conducted at a tertiary care center in Thailand among all adults who underwent their first kidney transplant from 1986 to 2018. Standardized incidence ratios (SIRs) of malignancy by age, sex, and place of residence were obtained using data from the National Cancer Registry of Thailand as population control. There were 2,024 KTRs [mean age, 42.4 years (SD 11.4); female patients, 38.6%] during 16,495 person-years at risk. Of these, 125 patients (6.2%) developed 133 de novo PTMs. The SIR for all PTMs was 3.85 (95% CI 3.22, 4.56), and for pooled solid and hematologic PTMs, it was 3.32 (95% CI 2.73, 3.99). Urothelial malignancies had the largest excess risk, especially in women [female SIR 114.7 (95% CI 66.8, 183.6); male SIR 17.5 (95% CI 8.72, 31.2)]. The next two most common cancers were non-Hodgkin's lymphoma and skin cancer [SIR 20.3 (95% CI 13.6, 29.1) and 24.7 (95% CI 15.3-37.8), respectively]. Future studies are needed to identify the risk factors and assess the need for systematic screening among PTMs with excess risk in KTRs.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"11614"},"PeriodicalIF":3.1,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Predictive Value of Graft Viability and Bioenergetics Testing Towards the Outcome in Liver Transplantation. 移植物存活率和生物能检测对肝移植结果的预测价值。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12380

Andras T Meszaros, Annemarie Weissenbacher, Melanie Schartner, Tim Egelseer-Bruendl, Martin Hermann, Jasmin Unterweger, Christa Mittelberger, Beatrix A Reyer, Julia Hofmann, Bettina G Zelger, Theresa Hautz, Thomas Resch, Christian Margreiter, Manuel Maglione, Timea Komlódi, Hanno Ulmer, Benno Cardini, Jakob Troppmair, Dietmar Öfner, Erich Gnaiger, Stefan Schneeberger, Rupert Oberhuber

{"title":"The Predictive Value of Graft Viability and Bioenergetics Testing Towards the Outcome in Liver Transplantation.","authors":"Andras T Meszaros, Annemarie Weissenbacher, Melanie Schartner, Tim Egelseer-Bruendl, Martin Hermann, Jasmin Unterweger, Christa Mittelberger, Beatrix A Reyer, Julia Hofmann, Bettina G Zelger, Theresa Hautz, Thomas Resch, Christian Margreiter, Manuel Maglione, Timea Komlódi, Hanno Ulmer, Benno Cardini, Jakob Troppmair, Dietmar Öfner, Erich Gnaiger, Stefan Schneeberger, Rupert Oberhuber","doi":"10.3389/ti.2024.12380","DOIUrl":"10.3389/ti.2024.12380","url":null,"abstract":"Donor organ biomarkers with sufficient predictive value in liver transplantation (LT) are lacking. We herein evaluate liver viability and mitochondrial bioenergetics for their predictive capacity towards the outcome in LT. We enrolled 43 consecutive patients undergoing LT. Liver biopsy samples taken upon arrival after static cold storage were assessed by histology, real-time confocal imaging analysis (RTCA), and high-resolution respirometry (HRR) for mitochondrial respiration of tissue homogenates. Early allograft dysfunction (EAD) served as primary endpoint. HRR data were analysed with a focus on the efficacy of ATP production or P-L control efficiency, calculated as 1-L/P from the capacity of oxidative phosphorylation P and non-phosphorylating respiration L. Twenty-two recipients experienced EAD. Pre-transplant histology was not predictive of EAD. The mean RTCA score was significantly lower in the EAD cohort (-0.75 ± 2.27) compared to the IF cohort (0.70 ± 2.08; p = 0.01), indicating decreased cell viability. P-L control efficiency was predictive of EAD (0.76 ± 0.06 in IF vs. 0.70 ± 0.08 in EAD-livers; p = 0.02) and correlated with the RTCA score. Both RTCA and P-L control efficiency in biopsy samples taken during cold storage have predictive capacity towards the outcome in LT. Therefore, RTCA and HRR should be considered for risk stratification, viability assessment, and bioenergetic testing in liver transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12380"},"PeriodicalIF":3.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-20 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12235

Juulia Grasberger, Fernanda Ortiz, Agneta Ekstrand, Ville Sallinen, Kaisa Ahopelto, Patrik Finne, Mika Gissler, Marko Lempinen, Ilkka Helanterä

{"title":"Infection-Related Hospitalizations After Simultaneous Pancreas-Kidney Transplantation Compared to Kidney Transplantation Alone.","authors":"Juulia Grasberger, Fernanda Ortiz, Agneta Ekstrand, Ville Sallinen, Kaisa Ahopelto, Patrik Finne, Mika Gissler, Marko Lempinen, Ilkka Helanterä","doi":"10.3389/ti.2024.12235","DOIUrl":"10.3389/ti.2024.12235","url":null,"abstract":"The total burden of infections after transplantation has not been compared in detail between recipients of simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). We compared infection-related hospitalizations and bacteremias after transplantation during 1- and 5-year follow-up among 162 patients undergoing SPK. The control group consisted of 153 type 1 diabetics undergoing KTA with the inclusion criteria of donor and recipient age < 60, and BMI < 30. During the first year, SPK patients had more infection-related hospitalizations (0.54 vs. 0.31 PPY, IRR 1.76, p = <0.001) and bacteremias (0.11 vs. 0.01 PPY, IRR 17.12, p = <0.001) compared to KTA patients. The first infection-related hospitalizations and bacteremias occurred later during follow-up in KTA patients. SPK was an independent risk factor for infection-related hospitalization and bacteremia during the first year after transplantation, but not during the 5-year follow-up. Patient survival did not differ between groups, however, KTA patients had inferior kidney graft survival. SPK patients are at greater risk for infection-related hospitalizations and bacteremias during the first year after transplantation compared to KTA patients, however, at the end of the follow-up the risk of infection was similar between groups.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12235"},"PeriodicalIF":3.1,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tacrolimus Drug Exposure Level and Smoking Are Modifiable Risk Factors for Early De Novo Malignancy After Liver Transplantation for Alcohol-Related Liver Disease. 他克莫司药物暴露水平和吸烟是酒精相关肝病肝移植术后早期新恶性肿瘤的可调节风险因素

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12055

Benedict T K Vanlerberghe, Hannah van Malenstein, Mauricio Sainz-Barriga, Ina Jochmans, David Cassiman, Diethard Monbaliu, Schalk van der Merwe, Jacques Pirenne, Frederik Nevens, Jef Verbeek

{"title":"Tacrolimus Drug Exposure Level and Smoking Are Modifiable Risk Factors for Early De Novo Malignancy After Liver Transplantation for Alcohol-Related Liver Disease.","authors":"Benedict T K Vanlerberghe, Hannah van Malenstein, Mauricio Sainz-Barriga, Ina Jochmans, David Cassiman, Diethard Monbaliu, Schalk van der Merwe, Jacques Pirenne, Frederik Nevens, Jef Verbeek","doi":"10.3389/ti.2024.12055","DOIUrl":"10.3389/ti.2024.12055","url":null,"abstract":"De novo malignancy (DNM) is the primary cause of mortality after liver transplantation (LT) for alcohol-related liver disease (ALD). However, data on risk factors for DNM development after LT are limited, specifically in patients with ALD. Therefore, we retrospectively analyzed all patients transplanted for ALD at our center before October 2016. Patients with a post-LT follow-up of <12 months, DNM within 12 months after LT, patients not on tacrolimus in the 1st year post-LT, and unknown smoking habits were excluded. Tacrolimus drug exposure level (TDEL) was calculated by area under the curve of trough levels in the 1st year post-LT. 174 patients received tacrolimus of which 19 (10.9%) patients developed a DNM between 12 and 60 months post-LT. Multivariate cox regression analysis identified TDEL [HR: 1.710 (1.211-2.414); p = 0.002], age [1.158 (1.076-1.246); p < 0.001], number of pack years pre-LT [HR: 1.021 (1.004-1.038); p = 0.014] and active smoking at LT [HR: 3.056 (1.072-8.715); p = 0.037] as independent risk factors for DNM. Tacrolimus dose minimization in the 1st year after LT and smoking cessation before LT might lower DNM risk in patients transplanted for ALD.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12055"},"PeriodicalIF":3.1,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum: Real-World Treatment Patterns of Antiviral Prophylaxis for Cytomegalovirus Among Adult Kidney Transplant Recipients: A Linked USRDS-Medicare Database Study. 更正：成人肾移植受者巨细胞病毒抗病毒预防治疗的现实世界治疗模式：USRDS-Medicare 数据库关联研究》。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-14 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.11921

Amit D Raval, Michael L Ganz, Kathy Fraeman, Andrea L Lorden, Shanmugapriya Saravanan, Yuexin Tang, Carlos A Q Santos

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12711

Simon R Knight, John M O'Callaghan

引用次数: 0

New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties. 肝移植中抗耐多药革兰氏阴性菌的新抗生素：临床视角、毒性和 PK/PD 特性。

IF 3.1 3区医学

Transplant International Pub Date : 2024-02-01 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.11692

Andrea Lombardi, Laura Alagna, Emanuele Palomba, Giulia Viero, Anna Tonizzo, Davide Mangioni, Alessandra Bandera

{"title":"New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties.","authors":"Andrea Lombardi, Laura Alagna, Emanuele Palomba, Giulia Viero, Anna Tonizzo, Davide Mangioni, Alessandra Bandera","doi":"10.3389/ti.2024.11692","DOIUrl":"10.3389/ti.2024.11692","url":null,"abstract":"Antimicrobial resistance is a growing global health problem, and it is especially relevant among liver transplant recipients where infections, particularly when caused by microorganisms with a difficult-to-treat profile, are a significant cause of morbidity and mortality. We provide here a complete dissection of the antibiotics active against multidrug-resistant Gram-negative bacteria approved over the last years, focusing on their activity spectrum, toxicity profile and PK/PD properties, including therapeutic drug monitoring, in the setting of liver transplantation. Specifically, the following drugs are presented: ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam, cefiderocol, and eravacycline. Overall, studies on the safety and optimal employment of these drugs in liver transplant recipients are limited and especially needed. Nevertheless, these pharmaceuticals have undeniably enhanced therapeutic options for infected liver transplant recipients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"11692"},"PeriodicalIF":3.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0