肝脏异种移植：一条通往临床现实的道路。

IF 2.7 3区医学 Q1 SURGERY

Transplant International Pub Date : 2025-01-03 eCollection Date: 2024-01-01 DOI:10.3389/ti.2024.14040

Serkan Sucu, Yucel Yankol, Luis A Fernandez, Burcin Ekser

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引用次数: 0

摘要

由于基因工程和免疫抑制疗法的最新发展，肝脏异种移植已成为解决已故人类供体器官短缺的潜在解决方案，现在正成为现实。使用非人类灵长类动物和转基因猪的早期努力面临着重大挑战，如血小板减少症和移植物排斥反应。了解这些挑战背后的机制和使用新型基因工程猪使研究人员能够克服一些障碍，但还需要更多的研究。然而，新的进展可能使猪肝异种移植在不久的将来有可能成为肝异体移植的桥梁或允许天然肝脏再生。

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Liver Xenotransplantation: A Path to Clinical Reality.

Liver xenotransplantation has emerged as a potential solution to the shortage of deceased human donor organs and is now becoming a reality due to recent developments in genetic engineering and immunosuppressive therapy. Early efforts using non-human primates and genetically modified pigs faced significant challenges such as thrombocytopenia and graft rejection. Understanding the mechanism behind those challenges and using novel genetically engineered pigs enabled researchers to overcome some of the hurdles, but more research is needed. However, new advances might allow pig liver xenotransplantation to potentially serve as a bridge to liver allotransplantation or allow native liver regeneration in the near future.

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来源期刊

Transplant International 医学-外科

CiteScore

4.70

自引率

6.50%

发文量

211

审稿时长

3-8 weeks

期刊介绍： The aim of the journal is to serve as a forum for the exchange of scientific information in the form of original and high quality papers in the field of transplantation. Clinical and experimental studies, as well as editorials, letters to the editors, and, occasionally, reviews on the biology, physiology, and immunology of transplantation of tissues and organs, are published. Publishing time for the latter is approximately six months, provided major revisions are not needed. The journal is published in yearly volumes, each volume containing twelve issues. Papers submitted to the journal are subject to peer review.