Transplant International最新文献_第9页

Meeting the Shortage of Human Cells and Tissues: The Andalusian Quality Assurance Programme for Tissue Donation. 解决人类细胞和组织短缺问题：安达卢西亚组织捐赠质量保证计划》。

IF 3.1 3区医学

Transplant International Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12627

Antonia José Alvarez-Marquez, Jesus Huet, José Miguel Pérez-Villares, Domingo Daga-Ruiz, Concepción Diaz-Aunión, Pablo Castro de la Nuez, Natividad Cuende

{"title":"Meeting the Shortage of Human Cells and Tissues: The Andalusian Quality Assurance Programme for Tissue Donation.","authors":"Antonia José Alvarez-Marquez, Jesus Huet, José Miguel Pérez-Villares, Domingo Daga-Ruiz, Concepción Diaz-Aunión, Pablo Castro de la Nuez, Natividad Cuende","doi":"10.3389/ti.2024.12627","DOIUrl":"10.3389/ti.2024.12627","url":null,"abstract":"Background A quality assurance programme for the tissue donation process was launched in Andalusia in 2020 to facilitate the integration of tissue donation into end-of-life care, and to respond to the growing need for human tissue for therapeutic purposes. The results of this programme are presented here. Methods After identifying the hospital departments in which to intensify the detection of tissue donors, expanding training activities and designing a specific data collection system for possible tissue donors who do not donate their tissues, the results of the donation activity were quantified and the causes of non-donation were analysed by applying the critical pathway for deceased tissue donation methodology. Results After an initial drop in activity, which coincided with the coronavirus pandemic, the number of tissue donors increased by 48.4% in 2022 compared to 2019. From the eligible donors, 83% were actual tissue donors and 71% were utilised donors. The modifiable causes of tissue donation loss, in order of frequency, were family refusal, followed by organisational or logistical issues, failure to notify or failure to identify possible donors, and failure to complete donor evaluation. Conclusion As a result of the collaboration of the various professionals involved in the programme, tissue donation activity has increased remarkably, the potential and effectiveness of the donation process have been evaluated, and areas for improvement have been identified, which we hope will lead to continuous improvement of the process.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12627"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid Organ Transplant Litigation at One of Europe's Largest University Hospitals. 欧洲最大大学医院之一的实体器官移植诉讼。

IF 3.1 3区医学

Transplant International Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12439

Jacques Belghiti, François Cauchy, Corinne Antoine, Gérard Cheron, Marie Matignon

{"title":"Solid Organ Transplant Litigation at One of Europe's Largest University Hospitals.","authors":"Jacques Belghiti, François Cauchy, Corinne Antoine, Gérard Cheron, Marie Matignon","doi":"10.3389/ti.2024.12439","DOIUrl":"10.3389/ti.2024.12439","url":null,"abstract":"Due to its intrinsic complexity and the principle of collective solidarity that governs it, solid organ transplantation (SOT) seems to have been spared from the increase in litigation related to medical activity. Litigation relating to solid organ transplantation that took place in the 29 units of the Assistance Publique-Hôpitaux de Paris and was the subject of a judicial decision between 2015 and 2022 was studied. A total of 52 cases of SOT were recorded, all in adults, representing 1.1% of all cases and increasing from 0.71% to 1.5% over 7 years. The organs transplanted were 25 kidneys (48%), 19 livers (37%), 5 hearts (9%) and 3 lungs (6%). For kidney transplants, 11 complaints (44%) were related to living donor procedures and 6 to donors. The main causes of complaints were early post-operative complications in 31 cases (60%) and late complications in 13 cases (25%). The verdicts were in favour of the institution in 41 cases (79%). Solid organ transplants are increasingly the subject of litigation. Although the medical institution was not held liable in almost 80% of cases, this study makes a strong case for patients, living donors and their relatives to be better informed about SOT.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12439"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung Transplantation in Controlled Donation after Circulatory-Determination-of-Death Using Normothermic Abdominal Perfusion. 使用常温腹腔灌注进行循环死亡确定后控制性捐献的肺移植。

IF 3.1 3区医学

Transplant International Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12659

Paula Moreno, Javier González-García, Eloísa Ruíz-López, Antonio Alvarez

{"title":"Lung Transplantation in Controlled Donation after Circulatory-Determination-of-Death Using Normothermic Abdominal Perfusion.","authors":"Paula Moreno, Javier González-García, Eloísa Ruíz-López, Antonio Alvarez","doi":"10.3389/ti.2024.12659","DOIUrl":"10.3389/ti.2024.12659","url":null,"abstract":"The main limitation to increased rates of lung transplantation (LT) continues to be the availability of suitable donors. At present, the largest source of lung allografts is still donation after the neurologic determination of death (brain-death donors, DBD). However, only 20% of these donors provide acceptable lung allografts for transplantation. One of the proposed strategies to increase the lung donor pool is the use of donors after circulatory-determination-of-death (DCD), which has the potential to significantly alleviate the shortage of transplantable lungs. According to the Maastricht classification, there are five types of DCD donors. The first two categories are uncontrolled DCD donors (uDCD); the other three are controlled DCD donors (cDCD). Clinical experience with uncontrolled DCD donors is scarce and remains limited to small case series. Controlled DCD donation, meanwhile, is the most accepted type of DCD donation for lungs. Although the DCD donor pool has significantly increased, it is still underutilized worldwide. To achieve a high retrieval rate, experience with DCD donation, adequate management of the potential DCD donor at the intensive care unit (ICU), and expertise in combined organ procurement are critical. This review presents a concise update of lung donation after circulatory-determination-of-death and includes a step-by-step protocol of lung procurement using abdominal normothermic regional perfusion.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12659"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Transplant Calcimimetic Use and Dose Information Improves the Accuracy of Prediction of Tertiary Hyperparathyroidism after Kidney Transplantation: A Retrospective Cohort Study. 移植前使用降钙剂和剂量信息可提高肾移植后三级甲状旁腺功能亢进症预测的准确性：一项回顾性队列研究

IF 3.1 3区医学

Transplant International Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12704

Manabu Okada, Tetsuhiko Sato, Tomoki Himeno, Yuki Hasegawa, Kenta Futamura, Takahisa Hiramitsu, Toshihiro Ichimori, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai

{"title":"Pre-Transplant Calcimimetic Use and Dose Information Improves the Accuracy of Prediction of Tertiary Hyperparathyroidism after Kidney Transplantation: A Retrospective Cohort Study.","authors":"Manabu Okada, Tetsuhiko Sato, Tomoki Himeno, Yuki Hasegawa, Kenta Futamura, Takahisa Hiramitsu, Toshihiro Ichimori, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai","doi":"10.3389/ti.2024.12704","DOIUrl":"10.3389/ti.2024.12704","url":null,"abstract":"Tertiary hyperparathyroidism (THPT) is characterized by elevated parathyroid hormone and serum calcium levels after kidney transplantation (KTx). To ascertain whether pre-transplant calcimimetic use and dose information would improve THPT prediction accuracy, this retrospective cohort study evaluated patients who underwent KTx between 2010 and 2022. The primary outcome was the development of clinically relevant THPT. Logistic regression analysis was used to evaluate pre-transplant calcimimetic use as a determinant of THPT development. Participants were categorized into four groups according to calcimimetic dose, developing two THPT prediction models (with or without calcimimetic information). Continuous net reclassification improvement (CNRI) and integrated discrimination improvement (IDI) were calculated to assess ability to reclassify the degree of THPT risk by adding pre-transplant calcimimetic information. Of the 554 patients, 87 (15.7%) developed THPT, whereas 139 (25.1%) received pre-transplant calcimimetic treatment. Multivariate logistic regression analysis revealed that pre-transplant calcimimetic use was significantly associated with THPT development. Pre-transplant calcimimetic information significantly improved the predicted probability accuracy of THPT (CNRI and IDI were 0.91 [p < 0.001], and 0.09 [p < 0.001], respectively). The THPT prediction model including pre-transplant calcimimetic information as a predictive factor can contribute to the prevention and early treatment of THPT in the era of calcimimetics.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12704"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 3.1 3区医学

Transplant International Pub Date : 2024-04-26 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13111

Simon R Knight, John M O'Callaghan

引用次数: 0

Impact of Asian and Black Donor and Recipient Ethnicity on the Outcomes After Deceased Donor Kidney Transplantation in the United Kingdom. 英国亚裔和黑人捐献者及受者种族对已故捐献者肾移植术后结果的影响。

IF 2.7 3区医学

Transplant International Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12605

Abdul Rahman Hakeem, Sonal Asthana, Rachel Johnson, Chloe Brown, Niaz Ahmad

{"title":"Impact of Asian and Black Donor and Recipient Ethnicity on the Outcomes After Deceased Donor Kidney Transplantation in the United Kingdom.","authors":"Abdul Rahman Hakeem, Sonal Asthana, Rachel Johnson, Chloe Brown, Niaz Ahmad","doi":"10.3389/ti.2024.12605","DOIUrl":"10.3389/ti.2024.12605","url":null,"abstract":"Patients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates outcomes of renal allografts from Asian and black donors. The UK Transplant Registry was analysed for adult deceased donor kidney only transplants performed between 2001 and 2015. Asian and black ethnicity patients constituted 12.4% and 6.7% of all deceased donor recipients but only 1.6% and 1.2% of all deceased donors, respectively. Unadjusted survival analysis demonstrated significantly inferior long-term allograft outcomes associated with Asian and black donors, compared to white donors. On Cox-regression analysis, Asian donor and black recipient ethnicities were associated with poorer outcomes than white counterparts, and on ethnicity matching, compared with the white donor-white recipient baseline group and adjusting for other donor and recipient factors, 5-year graft outcomes were significantly poorer for black donor-black recipient, Asian donor-white recipient, and white donor-black recipient combinations in decreasing order of worse unadjusted 5-year graft survival. Increased deceased donation among ethnic minorities could benefit the recipient pool by increasing available organs. However, it may require a refined approach to enhance outcomes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12605"},"PeriodicalIF":2.7,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11070942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public Opinions on Removing Disincentives and Introducing Incentives for Organ Donation: Proposing a European Research Agenda. 关于消除器官捐献抑制因素和引入器官捐献激励机制的公众意见：提出欧洲研究议程。

IF 3.1 3区医学

Transplant International Pub Date : 2024-04-03 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12483

Frederike Ambagtsheer, Eline Bunnik, Liset H M Pengel, Marlies Ej Reinders, Julio J Elias, Nicola Lacetera, Mario Macis

{"title":"Public Opinions on Removing Disincentives and Introducing Incentives for Organ Donation: Proposing a European Research Agenda.","authors":"Frederike Ambagtsheer, Eline Bunnik, Liset H M Pengel, Marlies Ej Reinders, Julio J Elias, Nicola Lacetera, Mario Macis","doi":"10.3389/ti.2024.12483","DOIUrl":"https://doi.org/10.3389/ti.2024.12483","url":null,"abstract":"The shortage of organs for transplantations is increasing in Europe as well as globally. Many initiatives to the organ shortage, such as opt-out systems for deceased donation and expanding living donation, have been insufficient to meet the rising demand for organs. In recurrent discussions on how to reduce organ shortage, financial incentives and removal of disincentives, have been proposed to stimulate living organ donation and increase the pool of available donor organs. It is important to understand not only the ethical acceptability of (dis)incentives for organ donation, but also its societal acceptance. In this review, we propose a research agenda to help guide future empirical studies on public preferences in Europe towards the removal of disincentives and introduction of incentives for organ donation. We first present a systematic literature review on public opinions concerning (financial) (dis)incentives for organ donation in European countries. Next, we describe the results of a randomized survey experiment conducted in the United States. This experiment is crucial because it suggests that societal support for incentivizing organ donation depends on the specific features and institutional design of the proposed incentive scheme. We conclude by proposing this experiment's framework as a blueprint for European research on this topic.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12483"},"PeriodicalIF":3.1,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 3.1 3区医学

Transplant International Pub Date : 2024-03-13 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12853

John M O'Callaghan, John Fallon

引用次数: 0

Metabolic Syndrome and Heart Transplantation: An Underestimated Risk Factor? 代谢综合征与心脏移植：被低估的风险因素？

IF 3.1 3区医学

Transplant International Pub Date : 2024-03-08 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.11075

Sandro Sponga, Igor Vendramin, Veronica Ferrara, Michela Marinoni, Giulia Valdi, Concetta Di Nora, Chiara Nalli, Giovanni Benedetti, Daniela Piani, Andrea Lechiancole, Maria Parpinel, Uberto Bortolotti, Ugolino Livi

{"title":"Metabolic Syndrome and Heart Transplantation: An Underestimated Risk Factor?","authors":"Sandro Sponga, Igor Vendramin, Veronica Ferrara, Michela Marinoni, Giulia Valdi, Concetta Di Nora, Chiara Nalli, Giovanni Benedetti, Daniela Piani, Andrea Lechiancole, Maria Parpinel, Uberto Bortolotti, Ugolino Livi","doi":"10.3389/ti.2024.11075","DOIUrl":"10.3389/ti.2024.11075","url":null,"abstract":"Metabolic Syndrome (MetS), a multifactorial condition that increases the risk of cardio-vascular events, is frequent in Heart-transplant (HTx) candidates and worsens with immunosuppressive therapy. The aim of the study was to analyze the impact of MetS on long-term outcome of HTx patients. Since 2007, 349 HTx patients were enrolled. MetS was diagnosed if patients met revised NCEP-ATP III criteria before HTx, at 1, 5 and 10 years of follow-up. MetS was present in 35% of patients pre-HTx and 47% at 1 year follow-up. Five-year survival in patients with both pre-HTx (65% vs. 78%, p < 0.01) and 1 year follow-up MetS (78% vs 89%, p < 0.01) was worst. At the univariate analysis, risk factors for mortality were pre-HTx MetS (HR 1.86, p < 0.01), hypertension (HR 2.46, p < 0.01), hypertriglyceridemia (HR 1.50, p=0.03), chronic renal failure (HR 2.95, p < 0.01), MetS and diabetes at 1 year follow-up (HR 2.00, p < 0.01; HR 2.02, p < 0.01, respectively). MetS at 1 year follow-up determined a higher risk to develop Coronary allograft vasculopathy at 5 and 10 year follow-up (25% vs 14% and 44% vs 25%, p < 0.01). MetS is an important risk factor for both mortality and morbidity post-HTx, suggesting the need for a strict monitoring of metabolic disorders with a careful nutritional follow-up in HTx patients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"11075"},"PeriodicalIF":3.1,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Mesenchymal Stromal Cells for Tissue-Engineered Tissue and Organ Replacements. 撤回：用于组织工程组织和器官替代的间充质基质细胞。

IF 2.7 3区医学

Transplant International Pub Date : 2024-03-05 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12843

引用次数: 0