Transplant International最新文献

{"title":"Transplant Trial Watch.","authors":"Simon R Knight, John M O'Callaghan, John Fallon","doi":"10.3389/ti.2024.13360","DOIUrl":"10.3389/ti.2024.13360","url":null,"abstract":"","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13360"},"PeriodicalIF":2.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm and Lung Transplantation.","authors":"Alessandro Palleschi, Giovanni Mattioni, Antonella LoMauro, Emilia Privitera, Valeria Musso, Letizia Morlacchi, Maurizio Vergari, Daniele Velardo, Giacomo Grasselli","doi":"10.3389/ti.2024.12897","DOIUrl":"10.3389/ti.2024.12897","url":null,"abstract":"<p><p>Mutual interactions between the diaphragm and lung transplantation (LTx) are known to exist. Before LTx, many factors can exert notable impact on the diaphragmatic function, such as the underlying respiratory disease, the comorbidities, and the chronic treatments of the patient. In the post-LTx setting, even the surgical procedure itself can cause a stressful trauma to the diaphragm, potentially leading to morphological and functional alterations. Conversely, the diaphragm can significantly influence various aspects of the LTx process, ranging from graft-to-chest cavity size matching to the long-term postoperative respiratory performance of the recipient. Despite this, there are still no standard criteria for evaluating, defining, and managing diaphragmatic dysfunction in the context of LTx to date. This deficiency hampers the accurate assessment of those factors which affect the diaphragm and its reciprocal influence on LTx outcomes. The objective of this narrative review is to delve into the complex role the diaphragm plays in the different stages of LTx and into the modifications of this muscle following surgery.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12897"},"PeriodicalIF":2.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Killer Cell Presence in Antibody-Mediated Rejection.","authors":"Matthias Diebold, Evan A Farkash, Jenna Barnes, Heinz Regele, Nicolas Kozakowski, Martina Schatzl, Katharina A Mayer, Susanne Haindl, Hannes Vietzen, Luis G Hidalgo, Philip F Halloran, Farsad Eskandary, Georg A Böhmig","doi":"10.3389/ti.2024.13209","DOIUrl":"10.3389/ti.2024.13209","url":null,"abstract":"<p><p>Transcript analyses highlight an important contribution of natural killer (NK) cells to microvascular inflammation (MVI) in antibody-mediated rejection (ABMR), but only few immunohistologic studies have quantified their spatial distribution within graft tissue. This study included 86 kidney transplant recipients who underwent allograft biopsies for a positive donor-specific antibody (DSA) result. NK cells were visualized and quantified within glomeruli and peritubular capillaries (PTC), using immunohistochemistry for CD34 alongside CD16/T-bet double-staining. Staining results were analyzed in relation to histomorphology, microarray analysis utilizing the Molecular Microscope Diagnostic System, functional NK cell genetics, and clinical outcomes. The number of NK cells in glomeruli per mm² glomerular area (NK_glom) and PTC per mm² cortical area (NK_PTC) was substantially higher in biopsies with ABMR compared to those without rejection, and correlated with MVI scores (NK_glom Spearman's correlation coefficient [SCC] = 0.55, <i>p</i> < 0.001, NK_PTC 0.69, <i>p</i> < 0.001). In parallel, NK cell counts correlated with molecular classifiers reflecting ABMR activity (ABMR_prob: NK_glom 0.59, NK_PTC 0.75) and showed a trend towards higher levels in association with high functional <i>FCGR3A</i> and <i>KLRC2</i> gene variants. Only NK_PTC showed a marginally significant association with allograft function and survival. Our immunohistochemical results support the abundance of NK cells in DSA-positive ABMR.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13209"},"PeriodicalIF":2.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and Rehabilitation After Heart Transplantation: A Clinical Consensus Statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a Section of ESOT.","authors":"Maria Simonenko, Dominique Hansen, Josef Niebauer, Maurizio Volterrani, Stamatis Adamopoulos, Cristiano Amarelli, Marco Ambrosetti, Stefan D Anker, Antonio Bayes-Genis, Tuvia Ben Gal, T Scott Bowen, Francesco Cacciatore, Giuseppe Caminiti, Elena Cavarretta, Ovidiu Chioncel, Andrew J S Coats, Alain Cohen-Solal, Flavio D'Ascenzi, Carmen de Pablo Zarzosa, Andreas B Gevaert, Finn Gustafsson, Hareld Kemps, Loreena Hill, Tiny Jaarsma, Ewa Jankowska, Emer Joyce, Nicolle Krankel, Mitja Lainscak, Lars H Lund, Brenda Moura, Kari Nytrøen, Elena Osto, Massimo Piepoli, Luciano Potena, Amina Rakisheva, Giuseppe Rosano, Gianluigi Savarese, Petar M Seferovic, David R Thompson, Thomas Thum, Emeline M Van Craenenbroeck","doi":"10.3389/ti.2024.13191","DOIUrl":"10.3389/ti.2024.13191","url":null,"abstract":"<p><p>Little is known either about either physical activity patterns, or other lifestyle-related prevention measures in heart transplantation (HTx) recipients. The history of HTx started more than 50 years ago but there are still no guidelines or position papers highlighting the features of prevention and rehabilitation after HTx. The aims of this scientific statement are (i) to explain the importance of prevention and rehabilitation after HTx, and (ii) to promote the factors (modifiable/non-modifiable) that should be addressed after HTx to improve patients' physical capacity, quality of life and survival. All HTx team members have their role to play in the care of these patients and multidisciplinary prevention and rehabilitation programmes designed for transplant recipients. HTx recipients are clearly not healthy disease-free subjects yet they also significantly differ from heart failure patients or those who are supported with mechanical circulatory support. Therefore, prevention and rehabilitation after HTx both need to be specifically tailored to this patient population and be multidisciplinary in nature. Prevention and rehabilitation programmes should be initiated early after HTx and continued during the entire post-transplant journey. This clinical consensus statement focuses on the importance and the characteristics of prevention and rehabilitation designed for HTx recipients.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13191"},"PeriodicalIF":2.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Preservation of Rat Small Intestine Transplantation Graft by Introduction of Mesenchymal Stem Cell-Secreted Fractions.","authors":"Takumi Teratani, Yasuhiro Fujimoto, Yasunaru Sakuma, Naoya Kasahara, Masashi Maeda, Atsushi Miki, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama","doi":"10.3389/ti.2024.11336","DOIUrl":"10.3389/ti.2024.11336","url":null,"abstract":"<p><p>Segmental grafts from living donors have advantages over grafts from deceased donors when used for small intestine transplantation. However, storage time for small intestine grafts can be extremely short and optimal graft preservation conditions for short-term storage remain undetermined. Secreted factors from mesenchymal stem cells (MSCs) that allow direct activation of preserved small intestine grafts. Freshly excised Luc-Tg LEW rat tissues were incubated in preservation solutions containing MSC-conditioned medium (MSC-CM). Preserved Luc-Tg rat-derived grafts were then transplanted to wild-type recipients, after which survival, injury score, and tight junction protein expression were examined. Luminance for each graft was determined using <i>in vivo</i> imaging. The findings indicated that 30-100 and 3-10 kDa fractions of MSC-CM have superior activating effects for small intestine preservation. Expression of the tight-junction proteins claudin-3, and zonula occludens-1 preserved for 24 h in University of Wisconsin (UW) solution containing MSC-CM with 50-100 kDa, as shown by immunostaining, also indicated effectiveness. Reflecting the improved graft preservation, MSC-CM preloading of grafts increased survival rate from 0% to 87%. This is the first report of successful transplantation of small intestine grafts preserved for more than 24 h using a rodent model to evaluate graft preservation conditions that mimic clinical conditions.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"11336"},"PeriodicalIF":2.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing Considerations for Sleeve Gastrectomy in Kidney Transplant Patients: A Single Center Evaluation.","authors":"Mario Spaggiari, Alessandro Martinino, Giulia Bencini, Mario A Masrur, Egor Petrochenkov, Amy Lian, Joanna Olazar, Pierpaolo Di Cocco, Jorge Almario-Alvarez, Enrico Benedetti, Ivo Tzvetanov","doi":"10.3389/ti.2024.12690","DOIUrl":"10.3389/ti.2024.12690","url":null,"abstract":"<p><p>Current scientific literature is deficient in detailing the optimal timing for conducting bariatric surgery in relation to kidney transplantation. In this study, we performed a retrospective evaluation of kidney transplant recipients with BMI >35 kg/m². It aimed to provide data on those who received both sleeve gastrectomy (SG) and kidney transplantation (KT) simultaneously, as well as on patients who underwent SG and KT at different times, either before or after. In addition, the acceptance levels of the bariatric surgery among different scenarios were assessed. Our findings demonstrated that combined KT and SG led to successful weight loss, in contrast to undergoing kidney transplant alone, while maintaining comparable rates of graft and patient survival. Weight loss was similar between recipients who had a combined operation and those who underwent SG following the transplant. Additionally, over a median time frame of 1.7 years, patients who underwent SG before KT exhibited a statistically significant reduction in BMI at the time of the transplant. Notably, our study highlights that patients offered the combined procedure were significantly more likely to undergo SG compared to those for whom SG was presented at a different operative time than the transplant.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12690"},"PeriodicalIF":2.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and Management of Multi-Drug Resistant Organism Infections in Solid Organ Transplant Recipients Across the World: A Narrative Review.","authors":"Maristela Pinheiro Freire, Stephanie Pouch, Abi Manesh, Maddalena Giannella","doi":"10.3389/ti.2024.12469","DOIUrl":"10.3389/ti.2024.12469","url":null,"abstract":"<p><p>Solid organ transplant (SOT) recipients are particularly susceptible to infections caused by multidrug-resistant organisms (MDRO) and are often the first to be affected by an emerging resistant pathogen. Unfortunately, their prevalence and impact on morbidity and mortality according to the type of graft is not systematically reported from high-as well as from low and middle-income countries (HIC and LMIC). Thus, epidemiology on MDRO in SOT recipients could be subjected to reporting bias. In addition, screening practices and diagnostic resources may vary between countries, as well as the availability of new drugs. In this review, we aimed to depict the burden of main Gram-negative MDRO in SOT patients across HIC and LMIC and to provide an overview of current diagnostic and therapeutic resources.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12469"},"PeriodicalIF":2.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Heart and Kidney Transplantation: A Systematic Review and Proportional Meta-Analysis of Its Characteristics and Long-Term Variables.","authors":"Natália Zaneti Sampaio, Matheus Daniel Faleiro, Laynara Vitória da Silva Vieira, Gabriele Eckerdt Lech, Sofia Wagemaker Viana, Clara Pereira Oliveira Tavares, Adela D Mattiazzi, George W Burke","doi":"10.3389/ti.2024.12750","DOIUrl":"10.3389/ti.2024.12750","url":null,"abstract":"<p><p>Patients with end-stage heart disease who undergo a heart transplant frequently have simultaneous kidney insufficiency, therefore simultaneous heart and kidney transplantation is an option and it is necessary to understand its characteristics and long-term variables. The recipient characteristics and operative and long-term variables were assessed in a meta-analysis. A total of 781 studies were screened, and 33 were thoroughly reviewed. 15 retrospective cohort studies and 376 patients were included. The recipient's mean age was 51.1 years (95% CI 48.52-53.67) and 84% (95% CI 80-87) were male. 71% (95% CI 59-83) of the recipients were dialysis dependent. The most common indication was ischemic cardiomyopathy [47% (95% CI 41-53)] and cardiorenal syndrome [22% (95% CI 9-35)]. Also, 33% (95% CI 20-46) of the patients presented with delayed graft function. During the mean follow-up period of 67.49 months (95% CI 45.64-89.33), simultaneous rejection episodes of both organ allografts were described in 5 cases only. Overall survival was 95% (95% CI 88-100) at 30 days, 81% (95% CI 76-86) at 1 year, 79% (95% CI 71-87) at 3, and 71% (95% CI 59-83) at 5 years. Simultaneous heart and kidney transplantation is an important option for concurrent cardiac and renal dysfunction and has acceptable rejection and survival rates.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12750"},"PeriodicalIF":2.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant Trial Watch.","authors":"John M O'Callaghan, Keno Mentor","doi":"10.3389/ti.2024.13211","DOIUrl":"https://doi.org/10.3389/ti.2024.13211","url":null,"abstract":"","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13211"},"PeriodicalIF":3.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Transplant Frequencies of FoxP3⁺CD25⁺ in CD3⁺CD8⁺ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients.","authors":"Agnes A Mooslechner, Max Schuller, Verena Pfeifer, Konstantin A Klötzer, Barbara Prietl, Alexander H Kirsch, Philipp Stiegler, Robert Sucher, Harald Sourij, Alexander R Rosenkranz, Kathrin Eller","doi":"10.3389/ti.2024.12963","DOIUrl":"10.3389/ti.2024.12963","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8⁺ T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8⁺ T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2). Comparing the two timepoints, we found an increase in granulocyte, monocyte and CD3⁺CD8⁺ T cells numbers, while FoxP3⁺CD25⁺, LAG-3⁺ and PD-1⁺ frequencies were reduced at T2. CMV DNAemia occurred in 33 recipients (55.8%) during the first year. Intermediate risk patients were disproportionally affected by posttransplant CMV (<i>N</i> = 29/45, 64.4%). Intermediate risk recipients developing CMV after transplantation exhibited lower leukocyte, monocyte, and granulocyte counts and higher FoxP3⁺CD25⁺ frequencies in CD3⁺CD8⁺ T cells pre-transplantation compared to patients staying CMV negative. Pre-transplant FoxP3⁺CD25⁺ in CD3⁺CD8⁺ T cells had the best discriminatory potential for CMV infection prediction within the first year after transplantation (AUC: 0.746). The FoxP3⁺CD25⁺ CD3⁺CD8⁺ T cell subset may aid in selecting intermediate risk kidney transplant recipients for CMV prophylaxis.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12963"},"PeriodicalIF":2.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}