Transplant International最新文献_第8页

Blood pressure control after solid organ transplantation: opportunities for optimizing care. 实体器官移植后血压控制：优化护理的机会。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-30 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16565

A M Posthumus, T J Knobbe, D Kremer, M F Eisenga, J S F Sanders, S P Berger, C Smit, F Klont, C T Gan, E A M Verschuuren, K Damman, M H de Borst, H Blokzijl, S J L Bakker, V E de Meijer

{"title":"Blood pressure control after solid organ transplantation: opportunities for optimizing care.","authors":"A M Posthumus, T J Knobbe, D Kremer, M F Eisenga, J S F Sanders, S P Berger, C Smit, F Klont, C T Gan, E A M Verschuuren, K Damman, M H de Borst, H Blokzijl, S J L Bakker, V E de Meijer","doi":"10.3389/ti.2026.16565","DOIUrl":"10.3389/ti.2026.16565","url":null,"abstract":"Hypertension affects 50%-90% of solid organ transplant recipients (SOTR) and is a major driver of cardiovascular disease. Nevertheless, hypertension control has received little attention in this population. We assessed blood pressure control 1 year after heart, liver, lung or kidney transplantation using cross-sectional data from 1112 SOTR (39% female, mean age 57 ± 13 years) from the TransplantLines biobank and cohort study. Suboptimal control was defined as systolic blood pressure >130 mmHg or diastolic blood pressure >80 mmHg. Overall, 997 (90%) SOTR had hypertension. Suboptimal control occurred in 721 (72%), including 146 (20%) who received no antihypertensive treatment despite elevated blood pressure. Rates of suboptimal control were consistently high across organ types (71%-84%). Older age (OR = 1.03; 95%CI1.01-1.04), diabetes (OR = 1.99; 95%CI1.18-3.36), and higher cholesterol (OR = 1.23; 95%CI1.01-1.51) were independently associated with suboptimal control. Among treated SOTR, recipients were older (OR = 1.03; 95%CI1.01-1.05), more often male (OR = 1.55; 95%CI1.03-2.34), and had more prior cardiovascular events (OR = 2.06; 95%CI1.14-3.95). In sensitivity analyses using alternative blood pressure thresholds, suboptimal control remained common, affecting 40% of hypertensive SOTR using a ≤140/90 mmHg threshold. In conclusion, nearly three out of four hypertensive SOTR have suboptimal blood pressure control at 1 year after transplantation with a ≤130/80 mmHg threshold, highlighting a substantial care gap in post-transplant management.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16565"},"PeriodicalIF":3.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13468530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing and cataloguing cognitive impairment in older potential kidney transplant patients: key recommendations from the ethical and legal issues working group of ELPAT. 评估和编目老年潜在肾移植患者的认知障碍：ELPAT伦理和法律问题工作组的关键建议。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-30 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16770

J A Holland, J S L Partridge, R L Thom, I Raburn, D M Summers, A Ruck Keene, E M Bunnik, A J Cronin

{"title":"Assessing and cataloguing cognitive impairment in older potential kidney transplant patients: key recommendations from the ethical and legal issues working group of ELPAT.","authors":"J A Holland, J S L Partridge, R L Thom, I Raburn, D M Summers, A Ruck Keene, E M Bunnik, A J Cronin","doi":"10.3389/ti.2026.16770","DOIUrl":"10.3389/ti.2026.16770","url":null,"abstract":"Cognitive impairment is common in older patients with advanced kidney disease and may influence access to and outcomes from kidney transplantation. However, its assessment and documentation within transplant evaluation remain inconsistent, with important ethical and legal implications. This position paper from the Ethical and Legal Issues Working Group of ELPAT synthesises current evidence, ethical and legal frameworks, and findings from a UK-wide national survey to propose a structured approach to the assessment and documentation of cognitive impairment in older potential kidney transplant recipients. Survey data demonstrate substantial variability in screening practices, documentation, and capacity assessment during transplant workup, contrasting with the standardised evaluation of other transplant domains. Cognitive impairment may affect decision-making capacity, perioperative risk, post-transplant self-management, and graft outcomes, raising important ethical considerations regarding autonomy, equity, and resource allocation. We recommend routine screening using validated tools, standardised documentation within clinical records and registries, use of these data to inform policy and research, prioritisation of cognitive outcomes in future studies, and targeted education and training in cognitive and capacity assessment. Embedding these measures within transplant pathways will support equitable access, informed decision-making, and improved outcomes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16770"},"PeriodicalIF":3.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13468520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prepared or at-risk? Evaluating live viral vaccine coverage and vaccine immunogenicity before pediatric solid organ transplantation. 准备好了还是处于危险之中？儿童实体器官移植前评估活病毒疫苗覆盖率和疫苗免疫原性。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.15958

Benhur Sirvan Cetin, Caitlin Brammer, William Otto, Kerrigan Perkins, Teresa Ambrosino, Hilary Miller-Handley, Mark Murphy, Grant Paulsen, Emily Cain, Kathleen Campbell, Lara Danziger-Isakov

{"title":"Prepared or at-risk? Evaluating live viral vaccine coverage and vaccine immunogenicity before pediatric solid organ transplantation.","authors":"Benhur Sirvan Cetin, Caitlin Brammer, William Otto, Kerrigan Perkins, Teresa Ambrosino, Hilary Miller-Handley, Mark Murphy, Grant Paulsen, Emily Cain, Kathleen Campbell, Lara Danziger-Isakov","doi":"10.3389/ti.2026.15958","DOIUrl":"10.3389/ti.2026.15958","url":null,"abstract":"Pediatric solid organ transplant recipients are at high risk for complications from vaccine-preventable diseases, yet pre-transplant vaccination coverage is often inconsistent. We conducted a retrospective cohort study of 421 pediatric transplant recipients between 2018 and 2024 to evaluate vaccination status and serologic immunity for varicella and measles at the time of initial evaluation, listing, and transplantation. At the time of transplant, 19.2% of patients for varicella and 21.6% for measles were under-vaccinated, with infants having the highest rates of incomplete vaccination. A portion of patients (7.1% for varicella, 8.6% for measles) transitioned from full to incomplete vaccination status during the pre-transplant period, a change associated with a shorter time from evaluation to listing. Kidney recipients had the highest completed vaccination rates (>94%), whereas rates for liver and heart recipients were substantially lower (58%-72%). Among fully vaccinated patients, seronegativity was observed for varicella (23.6%) and measles (13.0%). In conclusion, many pediatric transplant candidates, particularly infants and those awaiting liver or heart transplant, are incompletely vaccinated. A dynamic change in vaccination status from evaluation to transplant highlights an urgent need for continuous monitoring and improved strategies to protect these vulnerable children.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"15958"},"PeriodicalIF":3.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"A shared enemy to confront": the experience and needs of the partners of kidney transplant patients - a qualitative study. “共同面对的敌人”：肾移植患者伴侣的经历和需求-一项定性研究。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16491

Katerina Kyriakouli, Anna Yakinthou, Smaragdi Marinaki, Christina Papachristou

{"title":"\"A shared enemy to confront\": the experience and needs of the partners of kidney transplant patients - a qualitative study.","authors":"Katerina Kyriakouli, Anna Yakinthou, Smaragdi Marinaki, Christina Papachristou","doi":"10.3389/ti.2026.16491","DOIUrl":"10.3389/ti.2026.16491","url":null,"abstract":"Kidney disease and transplantation affect not only the patients but also their partners, requiring couples and families to adapt to and to cope with complex and ongoing psychosocial and practical demands. Despite playing a crucial role in caregiving and transplant success, partners' experiences and needs often remain overlooked. This study aimed to explore the lived experiences and needs of partners of kidney transplant recipients in the specific socio-cultural context of the study. Twelve in-depth interviews with partners of kidney transplant patients were conducted and analyzed using thematic analysis. The following themes were identified: 1) The secondary presence: Partners in the background, 2) From Illness to a New Normal, 3) The Need for Support and Clearer Communication from Healthcare Professionals, 4) Redefining the \"We\" and 5) Transplantation as a Life-Changing Lesson. Findings indicate that partners overtake emotionally complex roles supporting their spouses, yet their difficulties and needs often remain invisible. While going through significant challenges during critical phases of kidney disease, they experience transplantation relationally, through dyadic coping. The shared couple's experience necessitates a focus on partner's voices and needs as well as a holistic approach aiming at managing and adapting couples to the transplantation process.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16491"},"PeriodicalIF":3.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Establishing standards for controlled donation after circulatory determination of death in adults: the Bucharest international European Society for Organ Transplantation consensus. 修正：在成人血液循环确定死亡后建立控制捐赠标准：布加勒斯特国际欧洲器官移植学会共识。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-29 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17395

Helen Opdam, Alicia Pérez-Blanco, Dale Gardiner, Richard Hasz, Nichon Esther Jansen, Matthieu Le Dorze, Alberto Sandiumenge, Giuliano Testa, Shih-Ning Then, Marinella Zanierato, Beatriz Domínguez-Gil, Gabriel C Oniscu, Umberto Cillo, Dominique E Martin

引用次数: 0

Retraction: ABO-incompatible liver transplantation for severe hepatitis B patients. 撤回：abo血型不相容的重度乙型肝炎患者肝移植。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-27 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17398

引用次数: 0

Imputed HLA typing as a practical approach to molecular mismatch risk stratification in kidney transplantation. 输入HLA分型作为肾移植分子错配风险分层的实用方法。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-23 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16964

Alice Si Hua Ho, A Vathsala, Hersharan Kaur Sran, Matthew Ross D'Costa, Zi Yun Chang, Ada Pei Yu Ng, Amy Lim, Wee-Kun Koh, Emmett Tsz Yeung Wong

引用次数: 0

Normothermic regional perfusion (NRP) use in controlled donation after circulatory determination of death (cDCDD): results of the European Society for Organ Transplantation Bucharest consensus conference. 常温区域灌注（NRP）用于循环测定死亡（cDCDD）后的受控捐献：欧洲器官移植学会布加勒斯特共识会议的结果。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-22 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16391

Eduardo Miñambres, Marius Berman, Marta Velia Antonini, Jose Luis Campo-Cañaveral De La Cruz, Kristopher Croome, Giuseppe Feltrin, Amelia Hessheimer, Carl Jorns, Simon Messer, Anji Wall, Beatriz Domínguez-Gil, Dominique Martin, Gabriel Oniscu, Umberto Cillo

{"title":"Normothermic regional perfusion (NRP) use in controlled donation after circulatory determination of death (cDCDD): results of the European Society for Organ Transplantation Bucharest consensus conference.","authors":"Eduardo Miñambres, Marius Berman, Marta Velia Antonini, Jose Luis Campo-Cañaveral De La Cruz, Kristopher Croome, Giuseppe Feltrin, Amelia Hessheimer, Carl Jorns, Simon Messer, Anji Wall, Beatriz Domínguez-Gil, Dominique Martin, Gabriel Oniscu, Umberto Cillo","doi":"10.3389/ti.2026.16391","DOIUrl":"10.3389/ti.2026.16391","url":null,"abstract":"Normothermic Regional Perfusion (NRP) is emerging as a game-changer in enhancing outcomes for Donation after Circulatory Determination of Death (DCDD). NRP maintains physiological conditions through perfusion with oxygenated blood, outperforming conventional super-rapid recovery techniques significantly improving outcomes and organ utilization. Despite its clinical benefits, widespread adoption of NRP is impeded by heterogeneous organizational, legal, and ethical frameworks. At the ESOT Bucharest Consensus Conference, leading experts in transplantation achieved consensus on 130 relevant NRP-related open issues to facilitate its implementation and guide global practice. Key recommendations include criteria for adoption of NRP, minimal requirements, procedures to be adopted before and during NRP, donor organ evaluation criteria and sequence of organ harvesting. Consensus extends to procedural components (including the configuration of perfusion parameters and strategic team coordination), ethical integrity of NRP in the context of the dead donor rule and key unmet needs for future developments. While significant strides were made in unifying practice, unresolved issues regarding maximum warm ischemic time and variability in legal standards indicate avenues for future research. This consensus underscores the imperative for global standardization in NRP application, promising to elevate the success rates of organ transplants and establish NRP as a foundational element in the evolution of DCDD.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16391"},"PeriodicalIF":3.6,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13437514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The European Board of transplant medicine: evolution, present role and future directions toward harmonised transplant medicine training in Europe. 欧洲移植医学委员会：欧洲协调移植医学培训的演变、目前的作用和未来方向。

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-21 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16968

Nuria Montero, Miha Arnol, Susanne Beckebaum, Isabelle Binet, Vito Cicinnati, David Cucchiari, Caroline Den Hoed, Antoine Durrbach, Speranta Iacob, Smaragdi Marinaki, Anna Paola Mitterhofer, Anna Mrzljak, Adam Remport, Pablo Ruiz, Susana Sampaio, Francesca Tinti, Marios Prikis

引用次数: 0

Both perfusion pressure and flow are critical in abdominal normothermic regional perfusion! 在腹部常温区域灌注中，灌注压力和流量都是至关重要的！

IF 3.6 3区医学

Transplant International Pub Date : 2026-07-16 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16734

Raphaël Giraud, Benjamin Assouline, Franz Immer, Yvan Gasche, Karim Bendjelid

引用次数: 0