Transplant InternationalPub Date : 2025-01-30eCollection Date: 2025-01-01DOI: 10.3389/ti.2025.13944
Gyungah Kim, Jee Hwan Ahn, Tae Sun Shim, Pil-Je Kang, Geun Dong Lee, Sehoon Choi, Won Kim, Sung-Ho Jung, Dong Kwan Kim, Seung-Il Park, Sang-Bum Hong
{"title":"Improved Results Over Time With Bridge-to-Lung Transplantation: A 10-Year Experience of a Single High-Volume Center.","authors":"Gyungah Kim, Jee Hwan Ahn, Tae Sun Shim, Pil-Je Kang, Geun Dong Lee, Sehoon Choi, Won Kim, Sung-Ho Jung, Dong Kwan Kim, Seung-Il Park, Sang-Bum Hong","doi":"10.3389/ti.2025.13944","DOIUrl":"10.3389/ti.2025.13944","url":null,"abstract":"<p><p>When donor scarcity limits timely lung transplantation (LTx), extracorporeal membrane oxygenation (ECMO) as a bridge to transplantation (BTT) can prolong survival and delay deconditioning until the donor lungs become available. We reviewed 10-year BTT experiences of a single high-volume center, where 99 (59%) were on ECMO BTT among 169 eligible adult LTx cases. Both 28-day and 2-year survivals did not differ between BTT and non-BTT. The BTT data was then divided into two periods, delineated by the most recent 3 years. The clinical outcomes of the earlier period (\"Period 1\") and the later period (\"Period 2\") were compared, and mortality within 28 days of LTx was significantly lower in Period 2 (n = 1, 1.7%) than in Period 1 (n = 6, 14.6%, <i>p</i> < 0.01). Improved survival was observed in the subgroup with BTT duration of 14 days or more. Taken together, more experiences in BTT and improved competence may contribute to better survival after LTx, especially in patients receiving ECMO for 14 days or more.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13944"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/ti.2025.13844
Leke Wiering, Annette Aigner, Marieke van Rosmalen, Brigitta Globke, Tomasz Dziodzio, Nathanael Raschzok, Münevver Demir, Wenzel Schöning, Frank Tacke, Petra Reinke, Johann Pratschke, Robert Öllinger, Paul V Ritschl
{"title":"Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany.","authors":"Leke Wiering, Annette Aigner, Marieke van Rosmalen, Brigitta Globke, Tomasz Dziodzio, Nathanael Raschzok, Münevver Demir, Wenzel Schöning, Frank Tacke, Petra Reinke, Johann Pratschke, Robert Öllinger, Paul V Ritschl","doi":"10.3389/ti.2025.13844","DOIUrl":"10.3389/ti.2025.13844","url":null,"abstract":"<p><p>In liver allocation systems based on the Model for End-stage Liver Disease (MELD) score, sex inequities have been identified in countries with high organ donation rates. Whether similar inequities exist in regions with average to low donation rates remained unclear. We assessed the impact of sex on transplantation rates, waiting list mortality and post-transplant survival in 25,943 patients waitlisted for liver transplantation in Germany between 2003 and 2017 using competing risk analysis. Women are currently underrepresented on the waiting list (33.3%) and among transplant recipients (31.1%) compared to their proportion of severe liver disease cases (35.1%). The introduction of MELD-based allocation has worsened this disadvantage [HR before: 0.89 (0.81-0.98), after: 0.77 (0.74-0.81)]. Three key factors contribute to this disparity: Women have lower creatinine levels despite worse renal function, reducing their MELD score (median 1, 0-3). Second, exceptional MELD points are more frequently granted to men [HR 1.61 (1.54-1.69) compared to regular allocation]. Third, the small height of women has the highest impact on the probability of not being transplanted [adjusted HR 0.85 (0.81-0.9)]. Even in countries with lower organ donation rates, MELD-based allocation leads to sex inequity. Measures are needed to ensure sex-neutral liver allocation in MELD-based systems worldwide.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13844"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/ti.2025.13884
Junji Yamauchi, Amy M Cizik, Katalin Fornadi, Dominik Thomas, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Motaz Selim, Michael Zimmerman, Istvan Mucsi, Miklos Z Molnar
{"title":"Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes.","authors":"Junji Yamauchi, Amy M Cizik, Katalin Fornadi, Dominik Thomas, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Motaz Selim, Michael Zimmerman, Istvan Mucsi, Miklos Z Molnar","doi":"10.3389/ti.2025.13884","DOIUrl":"10.3389/ti.2025.13884","url":null,"abstract":"<p><p>Simple and validated physical function measures are needed for kidney transplant candidates because pretransplant low physical function is a common and potentially modifiable risk factor. This single-center retrospective study investigated the associations between pretransplant physical function assessed by the Patient-Reported Outcomes Measurement Information System<sup>®</sup> Physical Function (PROMIS-PF) computer adaptive testing and early posttransplant outcomes. We analyzed 154 adult kidney-alone transplant recipients. The median pretransplant PROMIS-PF score was 43 (interquartile range, 39-47). Patient characteristics were not significantly different across the score category (normal, score ≥45; mild, score of 40-45; and moderate/severe, score <40). The PROMIS-PF score was not associated with length of transplant hospital stay, delayed graft function, 6-month and 12-month graft function, or 12-month patient and graft survival. However, a lower PROMIS-PF score was significantly associated with a higher risk of emergency room visits [adjusted odds ratios compared to normal: mild, 1.68 (95% confidence interval, 0.76-3.83); moderate/severe, 3.23 (1.34-7.79)] and rehospitalization [adjusted odds ratios: mild, 2.61 (1.16-5.90); moderate/severe, 2.53 (1.07-6.00)] within 1 month posttransplant. Results suggest that PROMIS-PF is a practical tool for assessing physical function in kidney transplant candidates. Larger studies are needed to confirm the utility of PROMIS-PF to identify transplant candidates who would benefit from pretransplant prehabilitation.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13884"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/ti.2025.12859
Xavier Charmetant, Guillaume Rigault, Chien-Chia Chen, Hannah Kaminski, Jonathan Visentin, Benjamin Taton, Gabriel Marseres, Virginie Mathias, Alice Koenig, Thomas Barba, Pierre Merville, Stéphanie Graff-Dubois, Emmanuel Morelon, Julie Déchanet-Merville, Valérie Dubois, Jean-Paul Duong van Huyen, Lionel Couzi, Olivier Thaunat
{"title":"γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models.","authors":"Xavier Charmetant, Guillaume Rigault, Chien-Chia Chen, Hannah Kaminski, Jonathan Visentin, Benjamin Taton, Gabriel Marseres, Virginie Mathias, Alice Koenig, Thomas Barba, Pierre Merville, Stéphanie Graff-Dubois, Emmanuel Morelon, Julie Déchanet-Merville, Valérie Dubois, Jean-Paul Duong van Huyen, Lionel Couzi, Olivier Thaunat","doi":"10.3389/ti.2025.12859","DOIUrl":"10.3389/ti.2025.12859","url":null,"abstract":"<p><p>The generation of donor-specific antibodies (DSA) requires that alloreactive B cells receive help from follicular helper T (T<sub>FH</sub>) cells. Recent works have suggested that γδ T cells could contribute to T cell-dependent humoral responses, leading us to investigate their role in DSA generation. Analysis of a cohort of 331 kidney transplant recipients found no relation between the number of circulating γδ T cells and the risk to develop DSA. Coculture models demonstrated that activated γδ T cells were unable to promote the differentiation of B cells into plasma cells, ruling out that they can be \"surrogate\" T<sub>FH</sub>. In line with this, γδ T cells preferentially localized outside the B cell follicles, in the T cell area of lymph nodes, suggesting that they could instead act as \"antigen-presenting cell\" (APC) to prime αβ T<sub>FH</sub>. This hypothesis was proven wrong since γδ T cells failed to acquire APC functions <i>in vitro</i>. These findings were validated <i>in vivo</i> by the demonstration that following transplantation with an allogeneic Balb/c (H2<sup>d</sup>) heart, wild-type and TCRδKO C57BL/6 (H2<sup>b</sup>) mice developed similar DSA responses, whereas TCRαKO recipients did not develop DSA. We concluded that the generation of DSA is unfazed by the absence of γδ T cells.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"12859"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Inflammatory Profile During <i>Ex Vivo</i> Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis.","authors":"Andrea Costamagna, Eleonora Balzani, Matteo Marro, Erika Simonato, Alessandro Burello, Mauro Rinaldi, Luca Brazzi, Massimo Boffini, Vito Fanelli","doi":"10.3389/ti.2025.13794","DOIUrl":"10.3389/ti.2025.13794","url":null,"abstract":"<p><p>PGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the association between the levels of proinflammatory biomarkers during EVLP and PGD3 development within the firsts 72 h post-Ltx. Biomarkers were categorized by timing (1-hour, T0 and 4-hours, Tend from EVLPstart) and by their biological function (adhesion molecules, chemokines, cytokines, damage-associated-molecular-patterns, growth-factors, metabolites). We employed a four-level mixed-effects model with categorical predictors for biomarker groups to identify differences between patients with PGD3 and others. The single study and individual measurements were considered random intercepts. We included 8 studies (610 measurements at T0 and 884 at Tend). The pooled effect was 0.74 (<i>p</i> = 0.021) at T0, and 0.90 (<i>p</i> = 0.0015) at Tend. The four-level model indicated a large pooled correlation between developing PGD3 at 72 h post-Ltx and inflammatory biomarkers values, <i>r</i> = 0.62 (<i>p</i> = 0.009). Chemokine group showed the strongest association with the outcome (z-value = 1.26, <i>p</i> = 0.042). Pooled panels of inflammation markers, particularly chemokines, measured at T0 or at Tend, are associated with the development of PGD3 within the first 72 h after Ltx.</p><p><strong>Systematic review registration: </strong>https://osf.io/gkxzh/.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13794"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/ti.2025.14107
Leonard Knoedler, Thomas Schaschinger, Tobias Niederegger, Gabriel Hundeshagen, Adriana C Panayi, Curtis L Cetrulo, Maxime Jeljeli, Elena Hofmann, Max Heiland, Steffen Koerdt, Alexandre G Lellouch
{"title":"Multi-Center Outcome Analysis of 16 Face Transplantations - A Retrospective OPTN Study.","authors":"Leonard Knoedler, Thomas Schaschinger, Tobias Niederegger, Gabriel Hundeshagen, Adriana C Panayi, Curtis L Cetrulo, Maxime Jeljeli, Elena Hofmann, Max Heiland, Steffen Koerdt, Alexandre G Lellouch","doi":"10.3389/ti.2025.14107","DOIUrl":"10.3389/ti.2025.14107","url":null,"abstract":"<p><p>Facial Vascularized Composite Allotransplantation (fVCA) restores form and function for patients with severe facial disfigurements, yet multi-center outcome data remain scarce. We accessed the Organ Procurement and Transplantation Network (OPTN) database from 2008 to 2024 to identify all full- or partial-face fVCA recipients, excluding patients under 18 years and those with physiologically impossible BMIs. Of 25 identified patients, 16 (64%) met inclusion criteria (69% male; mean age 43 ± 14 years). Recipients experienced a median of 5 [IQR 0.0-10] acute rejection episodes, which correlated with inotrope use during donor procurement (p = 0.033). On average, patients were hospitalized 2.4 ± 1.8 times, with arginine vasopressin (AVP) administration linked to fewer hospitalizations (p = 0.035). Seven recipients (44%) experienced complications, and extended-criteria donor (ECD) status was associated with higher complication rates (p = 0.049). These findings underscore the promise of fVCA to address complex facial defects while identifying key risk factors-particularly inotrope use and ECD status, while AVP administration may mitigate hospital stays. Further studies with larger cohorts are warranted to refine perioperative strategies, improve outcomes, and expand the clinical utility of fVCA.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14107"},"PeriodicalIF":2.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discrimination of Anti-Donor Response in Allogeneic Transplantation Using an Alloreactive T-Cell Detection Assay.","authors":"Ryosuke Arata, Naoki Tanimine, Akhmet Seidakhmetov, Kentaro Ide, Yuka Tanaka, Hideki Ohdan","doi":"10.3389/ti.2025.13879","DOIUrl":"10.3389/ti.2025.13879","url":null,"abstract":"<p><p>Understanding donor-reactive T-cell behavior post-transplantation is challenging owing to the rarity and diversity of these cells. Here, we aimed to evaluate the relevance of an assay for rapidly detecting alloreactive T cells in a mouse transplantation model. After 18 h of one-way mixed lymphocyte reaction (MLR) culture with pre-activated donor-derived stimulators, CD4<sup>+</sup> and CD8<sup>+</sup> donor-reactive T cells were identified by CD154 and CD137 expression, respectively. Using full MHC mismatched mouse skin transplant models, we observed an increased donor-reactive T-cell proportion by direct presentation with elevated interferon gamma and granzyme B production 7 days post-transplantation, before graft rejection. Immunosuppression with CTLA-4 IgG and anti-CD154 antibody varied depending on donor-recipient strain combinations. On day 7, donor-reactive CD8<sup>+</sup> T-cell proportions were lower in the tolerance model (BALB/c to C3H/HeJ) than in the rejection model (BALB/c to C57BL/6); conventional proliferation readout after 4 days of MLR could not distinguish these responses. Overall, although the conventional readout for evaluating T-cell proliferation following an MLR quantifies the precursor frequency of alloreactive T cells, the assay reported herein assesses T-cell activation markers after a short-term MLR to characterize immediate immune status. These findings offer a promising tool to elucidate immune responses post-transplantation.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13879"},"PeriodicalIF":2.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Donors With Previous Malignancy: When Is It Safe to Proceed With Organ Transplantation?","authors":"Vitor Turra, Joao Manzi, Sarah Rombach, Simone Zaragoza, Raphaella Ferreira, Giselle Guerra, Kendra Conzen, Trevor Nydam, Alan Livingstone, Rodrigo Vianna, Phillipe Abreu","doi":"10.3389/ti.2025.13716","DOIUrl":"10.3389/ti.2025.13716","url":null,"abstract":"<p><p>The growing number of organ donors in the United States, from 14,011 in 2012 to 21,374 in 2022, highlights progress in addressing the critical issue of organ shortages. However, the demand remains high, with 17 patients dying daily while on the waiting list. As of August 2023, over 103,544 individuals are awaiting transplants, predominantly for kidneys (85.7%). To expand the donor pool, the inclusion of elderly donors, including those with a history of malignancies, is increasingly considered. In 2022, 7% of all donors were aged 65 and above, despite the complexities their medical histories may introduce, particularly the risk of donor-transmitted cancer (DTC). This review examines the challenges and potential benefits of using donors with known malignancy histories, balancing the risks of DTC against the urgency for transplants. A critical analysis is presented on current knowledge and the decision-making processes that consider cancer types, stages, and patient survival outcomes. The goal is to identify missed opportunities and improve strategies for safe and effective organ transplantation from this donor demographic.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13716"},"PeriodicalIF":2.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-23eCollection Date: 2024-01-01DOI: 10.3389/ti.2024.13545
Nathalie Grall, Maksud Assadi, Marina Esposito-Farese, Brice Lortat-Jacob, Sébastien Tanaka, Enora Atchade, Jonathan Messika, Vincent Bunel, Hervé Mal, Pierre Mordant, Yves Castier, Bastien Garnier, Signara Gueye, Marie Petitjean, Erick Denamur, Laurence Armand-Lefevre, Charles Burdet, Philippe Montravers, Alexy Tran-Dinh
{"title":"No Emergence of Colistin Resistance in the Respiratory Tract of Lung Transplant Patients Treated With Inhaled Colistin.","authors":"Nathalie Grall, Maksud Assadi, Marina Esposito-Farese, Brice Lortat-Jacob, Sébastien Tanaka, Enora Atchade, Jonathan Messika, Vincent Bunel, Hervé Mal, Pierre Mordant, Yves Castier, Bastien Garnier, Signara Gueye, Marie Petitjean, Erick Denamur, Laurence Armand-Lefevre, Charles Burdet, Philippe Montravers, Alexy Tran-Dinh","doi":"10.3389/ti.2024.13545","DOIUrl":"10.3389/ti.2024.13545","url":null,"abstract":"<p><p>Secondary prophylaxis using inhaled colistin (IC) was implemented to prevent recurrences of Pseudomonas aeruginosa or extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) pneumonia during the postoperative intensive care unit (ICU) stay after lung transplantation (LT). We evaluated the risk of emergence of colistin resistance in the respiratory tract during secondary IC prophylaxis. We conducted a prospective, single-centre, observational study of all adult patients who underwent LT between 1 July 2018 and 30 June 2019. IC was started and continued for at least 90 days for <i>P. aeruginosa</i> or ESBL-PE pneumonia. During the 90 days following LT, all respiratory samples were routinely tested for the presence of GNB of reduced susceptibility to colistin. Twenty-seven (38.6%) of the 70 included patients received IC. Among the 867 respiratory samples tested, IC did not promote the emergence of bacterial species with natural or acquired resistance to colistin (incidence-rate ratio of 0.21 [0.03-1.58], <i>p</i> = 0.13 and 1.68 [0.55-5.12], <i>p</i> = 0.37, respectively). Our study suggests no association between the use of IC and an increased risk of colistin resistance in the respiratory tract within 90 days of LT.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13545"},"PeriodicalIF":2.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transplant InternationalPub Date : 2025-01-20eCollection Date: 2024-01-01DOI: 10.3389/ti.2024.13965
Nida Saleem, Wai H Lim, Jacqueline H Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Armando Teixeira-Pinto, Eleonora Dal Grande, Martin Howell, Farzaneh Boroumand, Anita van Zwieten, Chandana Guha, Nicole Scholes-Robertson, Steven J Chadban, Carmel M Hawley, Jonathan C Craig, Jeremy R Chapman, Danyal Hassan, Greg Knoll, Naoka Murakami, Germaine Wong
{"title":"A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients.","authors":"Nida Saleem, Wai H Lim, Jacqueline H Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Armando Teixeira-Pinto, Eleonora Dal Grande, Martin Howell, Farzaneh Boroumand, Anita van Zwieten, Chandana Guha, Nicole Scholes-Robertson, Steven J Chadban, Carmel M Hawley, Jonathan C Craig, Jeremy R Chapman, Danyal Hassan, Greg Knoll, Naoka Murakami, Germaine Wong","doi":"10.3389/ti.2024.13965","DOIUrl":"10.3389/ti.2024.13965","url":null,"abstract":"<p><p>Cancer is a major cause of morbidity and mortality in kidney transplant recipients. Health professionals have a critical role in promoting cancer screening participation. From March 2023 to February 2024, an online survey was distributed to kidney transplant health professionals globally to assess their screening practices. We compared their reported screening practices to recommended guidelines and analyzed factors associated with these practices. We received 97 responses, and most were nephrologists (70%), and around 80% recommended breast, colorectal, and cervical cancer screening for kidney transplant candidates and recipients. About 85% recommended lung cancer screening for higher-risk individuals. Skin cancer screening recommendations varied from 69% for transplant candidates and 84% for recipients. Self-reported cervical cancer screening practices were most concordant with recommended guidelines, followed by breast and skin cancers. Barriers reported included a lack of cancer screening awareness (28%), perceived financial constraints (35%), and deficient structured cancer screening systems (51%). Professionals from high-income countries were more likely to advise screening than those from lower-middle-income countries, with odds ratios ranging from 2.9 to 12.3. Most health professionals reported recommending cancer screening for kidney transplant candidates and recipients. However, recommendations were influenced by costs and service delivery gaps within health systems.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13965"},"PeriodicalIF":2.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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