血管紧张素 II-1 型受体抗体在实体器官移植中的应用--是时候进行测试了吗？

IF 2.7 3区医学 Q1 SURGERY

Transplant International Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI:10.3389/ti.2024.13280

Paul James Patrick Martin, Michelle Willicombe, Candice Roufosse

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引用次数: 0

摘要

血管紧张素 II-1 型受体抗体（AT1R-Ab）被认为是急性和慢性抗体介导排斥反应（AMR）的潜在效应因子。在班夫 AMR 诊断分类系统不断发展和组织相容性检测建议不断完善的背景下，移植中致敏性风险评估（STAR）工作组对有关该主题的文献进行了仔细研究。这篇微型综述讨论了对病理生理学机制的最新理解、AT1R-Ab 致病性的临床证据以及实验室检测方法。

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Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation - Is It Time to Test?

Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving Banff AMR diagnostic classification system and refinement of recommendations for histocompatibility testing by the Sensitization in Transplantation Assessment of Risk (STAR) workgroup. This mini-review discusses the latest understanding of pathophysiological mechanisms, clinical evidence for the pathogenicity of AT1R-Ab, and methods of laboratory testing.

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来源期刊

Transplant International 医学-外科

CiteScore

4.70

自引率

6.50%

发文量

211

审稿时长

3-8 weeks

期刊介绍： The aim of the journal is to serve as a forum for the exchange of scientific information in the form of original and high quality papers in the field of transplantation. Clinical and experimental studies, as well as editorials, letters to the editors, and, occasionally, reviews on the biology, physiology, and immunology of transplantation of tissues and organs, are published. Publishing time for the latter is approximately six months, provided major revisions are not needed. The journal is published in yearly volumes, each volume containing twelve issues. Papers submitted to the journal are subject to peer review.