Transplant International最新文献_第4页

Locus-specific HLA matching and induction therapy in simultaneous pancreas-kidney transplantation: a national UK cohort study. 同时胰肾移植的基因座特异性HLA匹配和诱导治疗：一项英国国家队列研究。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-09 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16427

Abdullah K Malik, Jenni Banks, Claire Counter, Lewis Simmonds, Samuel J Tingle, Sanjay Sinha, Anand Muthasamy, Andrew Sutherland, John Casey, Martin Drage, David van Dellen, Chris J Callaghan, Doruk Elker, Derek M Manas, Gavin J Pettigrew, Neil Russell, Neil S Sheerin, Colin H Wilson, Steven A White

{"title":"Locus-specific HLA matching and induction therapy in simultaneous pancreas-kidney transplantation: a national UK cohort study.","authors":"Abdullah K Malik, Jenni Banks, Claire Counter, Lewis Simmonds, Samuel J Tingle, Sanjay Sinha, Anand Muthasamy, Andrew Sutherland, John Casey, Martin Drage, David van Dellen, Chris J Callaghan, Doruk Elker, Derek M Manas, Gavin J Pettigrew, Neil Russell, Neil S Sheerin, Colin H Wilson, Steven A White","doi":"10.3389/ti.2026.16427","DOIUrl":"10.3389/ti.2026.16427","url":null,"abstract":"The impact of HLA mismatch and induction therapy in simultaneous pancreas-kidney transplantation on outcomes remains incompletely defined. We conducted a retrospective cohort study of 1705 SPK recipients transplanted in the UK between 2007 and 2019. Using national transplant registry data, we analysed the impact of locus-specific HLA mismatch and induction therapy (Alemtuzumab vs. Basiliximab) on pancreas graft survival primarily. Kidney graft and patient survival were also analysed as secondary outcomes. Multivariable Cox proportional hazards models were adjusted for donor, recipient, and transplant variables. Pancreas graft survival at 1- and 10-year post-transplant was estimated to be 88.6% and 72.7%, respectively. Kidney graft and patient survival at 10 years were 76.7% and 75.3%. In adjusted analyses, donor age, cold ischaemic time, and HLA-DQ mismatch were significantly associated with pancreas graft loss. No significant survival difference was seen between Alemtuzumab and Basiliximab induction therapy. Induction therapy and HLA-mismatch status were not associated with pancreas graft outcome in this large registry study.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16427"},"PeriodicalIF":3.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the cost-effectiveness of introducing donation after controlled circulatory death for heart transplantation in France. 模拟在法国心脏移植中引入受控循环死亡后捐献的成本效益。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-09 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17149

Jamal Atfeh, Pascale Guerre, Julien Guihaire, Laurent Sebbag, Matteo Pozzi, Laure Huot

{"title":"Modeling the cost-effectiveness of introducing donation after controlled circulatory death for heart transplantation in France.","authors":"Jamal Atfeh, Pascale Guerre, Julien Guihaire, Laurent Sebbag, Matteo Pozzi, Laure Huot","doi":"10.3389/ti.2026.17149","DOIUrl":"10.3389/ti.2026.17149","url":null,"abstract":"Heart transplantation following donation after controlled circulatory death (DCD) could alleviate the global shortage of organs. We assessed the cost-effectiveness of this strategy and outlined the factors enabling an efficient DCD heart program. Two strategies were compared: donation after brain death (DBD) using static cold storage vs. DBD + DCD transplantation, where DCD hearts are preserved with a normothermic ex situ perfusion system. Costs (€; 2024 value) and outcomes (quality-adjusted life years (QALYs)) were modelled through a 15-year time horizon. Our main assumption was that DCD would increase transplant access without affecting waitlist mortality, with equivalent post-transplant outcomes. With a 20% annual increase in transplant activity, the DBD + DCD strategy resulted in a mean incremental gain of 0.14 QALYs at an additional cost of €20,618 compared with DBD alone. The incremental cost-effectiveness ratio was €146,373 per QALY gained. An 8% relative reduction in waitlist mortality (i.e., four additional lives saved annually among 500 new waitlisted patients) would make the DCD heart program cost-effective at €100,000 per QALY. Lower consumable costs would further improve cost-effectiveness. Decision-makers should consider these findings in light of the disease severity and the persistent shortage of heart donors that could be alleviated with DCD.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"17149"},"PeriodicalIF":3.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-transplant acute pancreatitis after pancreas transplantation: application of the International Study Group for Pancreatic Surgery definition and clinical impact in a multicenter cohort study. 胰腺移植后急性胰腺炎：国际胰腺外科研究小组定义的应用和多中心队列研究的临床影响

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16849

Stefano Partelli, Valentina Andreasi, Matteo Santangelo, Oriana Ciacio, Rossana Caldara, Arianna Bertuol, Valentina Tomajer, Davide Catarinella, Alessandra Ida, Caterina Di Bella, Gabriella Pittau, Chady Salloum, Gioia Sgrinzato, Paolo Rigotti, Lorenzo Piemonti, Antonio Sa Cunha, Lucrezia Furian, Massimo Falconi

{"title":"Post-transplant acute pancreatitis after pancreas transplantation: application of the International Study Group for Pancreatic Surgery definition and clinical impact in a multicenter cohort study.","authors":"Stefano Partelli, Valentina Andreasi, Matteo Santangelo, Oriana Ciacio, Rossana Caldara, Arianna Bertuol, Valentina Tomajer, Davide Catarinella, Alessandra Ida, Caterina Di Bella, Gabriella Pittau, Chady Salloum, Gioia Sgrinzato, Paolo Rigotti, Lorenzo Piemonti, Antonio Sa Cunha, Lucrezia Furian, Massimo Falconi","doi":"10.3389/ti.2026.16849","DOIUrl":"10.3389/ti.2026.16849","url":null,"abstract":"Graft pancreatitis is a clinically relevant but poorly standardized complication after pancreas transplantation (PT). In contrast, post-pancreatectomy acute pancreatitis has been formally defined and validated by the International Study Group for Pancreatic Surgery (ISGPS). This study assessed the clinical applicability of an adapted ISGPS-based framework to define post-transplant acute pancreatitis (PTAP) after PT and its association with clinically relevant outcomes. Consecutive patients undergoing PT at three European centers between 2010 and 2024 were included. PTAP was defined by sustained postoperative hyperamylasemia (POH) for ≥48 h combined with CT findings consistent with pancreatitis within 30 days after transplantation. Imaging was performed in 89% of patients based on clinical indication and center-specific protocols. Among 432 patients, the adapted definition was applicable in 416. Sustained POH occurred in 196 patients (47%), and PTAP was diagnosed in 86 (21%). PTAP was the only independent predictor of severe postoperative complications (OR, 2.482; P = 0.001), was independently associated with prolonged hospital stay (OR, 3.817; P < 0.001), and with worse death-censored graft survival (P < 0.001). Cold ischemia time was the only independent determinant of PTAP (P < 0.001). PTAP was a frequent and clinically meaningful complication after PT, occurring in approximately one in five patients and associated with worse short- and long-term outcomes.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16849"},"PeriodicalIF":3.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The perfused liver utilisation study (PLUS): challenges and innovation in the evaluation of an emerging technology. 灌注肝利用研究（PLUS）：新兴技术评估中的挑战和创新。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16653

Simon Robert Knight, Helen L Thomas, Rosemary Brown, Charlie Brown, Kerrie Brusby, Emily Arbon, Laura Silsby, Alice Newton, Jennifer Mehew, Aleema Iqbal, Katie Keen, Syeda Bahar, Christopher Watson, Brian Davidson, David Nasralla, Carlo Ceresa, Barbara Fiore, Ahmed E Sherif, Colin Wilson, Balaji Mahendran, Joerg-Matthias Pollok, Rebeca S Mateos, Wayel Jassem, Rohit Gaurav, Gabriel C Oniscu, Craig Marshall, Angus Hann, Reena Ravikumar, Constantin Coussios, Peter J Friend

{"title":"The perfused liver utilisation study (PLUS): challenges and innovation in the evaluation of an emerging technology.","authors":"Simon Robert Knight, Helen L Thomas, Rosemary Brown, Charlie Brown, Kerrie Brusby, Emily Arbon, Laura Silsby, Alice Newton, Jennifer Mehew, Aleema Iqbal, Katie Keen, Syeda Bahar, Christopher Watson, Brian Davidson, David Nasralla, Carlo Ceresa, Barbara Fiore, Ahmed E Sherif, Colin Wilson, Balaji Mahendran, Joerg-Matthias Pollok, Rebeca S Mateos, Wayel Jassem, Rohit Gaurav, Gabriel C Oniscu, Craig Marshall, Angus Hann, Reena Ravikumar, Constantin Coussios, Peter J Friend","doi":"10.3389/ti.2026.16653","DOIUrl":"10.3389/ti.2026.16653","url":null,"abstract":"Previous studies suggest that donor liver normothermic machine perfusion (NMP) reduces injury and enables functional assessment, resulting in an increase in utilisation. The PLUS study was designed to assess the impact of NMP availability on utilisation of livers at high risk of non-use. Using a threshold-crossing design, functional utilisation was assessed in a real-world retrospective registry-based control cohort. A predetermined efficacy threshold was set, and a prospective cohort was recruited in all UK liver transplant centres with NMP made available for all livers at high risk of non-utilisation. Availability of NMP resulted in a significant increase in functional utilisation (OR: 1.26, 95% CI: 1.04-1.53), but this did not exceed the pre-determined efficacy threshold. The threshold was exceeded in the subgroup of donation after circulatory death (DCD) livers, although this increase was reduced with adjustment for the use of normothermic regional perfusion. NMP was used in only 31% of retrieved livers, with variation between centres. The benefit of having NMP available was less than anticipated, likely due to low use in some centres associated with staff availability. Provision of NMP as a service, or centralisation of NMP use in assessment and recovery centres, may improve uptake.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16653"},"PeriodicalIF":3.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved access to kidney transplantation with favorable graft survival in highly sensitized candidates under the French acceptable mismatch program. 在法国可接受的错配方案下，在高度敏感的候选人中改善了获得良好移植物存活的肾移植的途径。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16762

Corinne Antoine, Emilie Savoye, Benoit Audry, Camille Legeai, Myriam Pastural, Anne Cesbron, Valerie Dubois, Jean-Luc Taupin

{"title":"Improved access to kidney transplantation with favorable graft survival in highly sensitized candidates under the French acceptable mismatch program.","authors":"Corinne Antoine, Emilie Savoye, Benoit Audry, Camille Legeai, Myriam Pastural, Anne Cesbron, Valerie Dubois, Jean-Luc Taupin","doi":"10.3389/ti.2026.16762","DOIUrl":"10.3389/ti.2026.16762","url":null,"abstract":"The scarcity of the human leukocyte antigen (HLA)-compatible donor pool, which leads to a long waiting time for transplantation, often requires specific national or supranational strategies to improve kidney graft access for highly sensitized (HS) patients. Acceptable national mismatch priority is a way to increase the number of potential matched donors without increasing the immunologic graft failure risk. In 2005, the French Acceptable Mismatch program (AMP) was successfully introduced as a strategy to improve kidney allocation for HS patients. The AMP was enhanced in 2015, authorizing up to four HLA-A, -B, -DR, and -DQβ mismatches, provided that each mismatch was an acceptable antigen. Our study compared graft survival between AMP allocation and other kidney allocation modalities among HS recipients between 2016 and 2022 (N = 2,985). After adjustment for donor and recipient characteristics using Cox regression, we found that the risk of graft failure was higher for HS non-AMP transplantations (hazard ratio 1.19 [95% CI 1.04-1.36]; 1.31 [95% CI 1.08-1.59] with death censored). The French AMP improves access to kidney transplantation for HS patients. Post-transplant survival is comparable to other kidney allocation modalities, possibly because of the absence of preformed donor-specific antibodies in recipients' historical and recent serum, which is associated with reduced risk of rejection.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16762"},"PeriodicalIF":3.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential dual-organ living donation: selection, operative approach, and early donor outcomes at a Canadian center. 序贯双器官活体捐献：选择、手术方式和加拿大中心的早期供体结果。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-07 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16970

Su Kah Goh, Nazia Selzner, Sunita K Singh, Ian D McGilvray, Chaya Shwaartz, Trevor W Reichman, Nicolas Goldaracena, Jason Y Lee, Markus Selzner, Gonzalo Sapisochin, Blayne Amir Sayed, Mark S Cattral, Anand Ghanekar

{"title":"Sequential dual-organ living donation: selection, operative approach, and early donor outcomes at a Canadian center.","authors":"Su Kah Goh, Nazia Selzner, Sunita K Singh, Ian D McGilvray, Chaya Shwaartz, Trevor W Reichman, Nicolas Goldaracena, Jason Y Lee, Markus Selzner, Gonzalo Sapisochin, Blayne Amir Sayed, Mark S Cattral, Anand Ghanekar","doi":"10.3389/ti.2026.16970","DOIUrl":"10.3389/ti.2026.16970","url":null,"abstract":"Sequential dual-organ living donation, defined as donation of a kidney and a partial liver graft by the same individual in separate operations, represents a rare extension of living donor transplantation. A donor-focused analysis was performed to characterize the donor population, the operative considerations posed by a second donor operation, and early donor outcomes at a single high-volume center. A retrospective review of all dual-organ living donors at our institute was performed. Twenty-four donors were identified (n = 10 liver-first and n = 14 kidney-first). The median interval between donations was 2 years (IQR 1.1-4.2). Twelve donors donated both organs anonymously, nine donated one organ anonymously and directed the other, and three directed both donations. Anonymous donation is a strong motivator in this unique population. Ten donors (42%) participated in kidney paired donation. Liver donations (left lateral segment (42%), left lobe (25%), and right lobe (33%)) were performed by an open approach. Laparoscopic nephrectomy was performed in all cases except two prior liver donors. Liver-after-kidney donors (n = 14) did not develop renal dysfunction after donation. Prior organ donation does not usually require modification of surgical technique for the second procedure. Dual-organ living donation is rare but can be safely performed independent of sequence.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16970"},"PeriodicalIF":3.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond generic principles: a framework for the ethical analysis of artificial intelligence in organ transplantation. 超越一般原则：器官移植中人工智能的伦理分析框架。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-04 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16525

Nadia Primc

{"title":"Beyond generic principles: a framework for the ethical analysis of artificial intelligence in organ transplantation.","authors":"Nadia Primc","doi":"10.3389/ti.2026.16525","DOIUrl":"10.3389/ti.2026.16525","url":null,"abstract":"Artificial intelligence (AI) is increasingly entering clinical medicine, and organ transplantation is no exception. While a growing body of literature addresses the ethical challenges of AI in healthcare, systematic analysis of the specific ethical dimensions of AI use in organ transplantation is missing. This gap reflects a genuine analytical challenge: the transplantation process is ethically complex in ways that general AI ethics frameworks do not adequately capture. Transplantation medicine simultaneously bears ethical obligations to deceased donors, living donors, donor families, organ recipients, and the public at large. These obligations shift substantially across the stages of the transplantation process, from the patient-centred ethics of donor identification and listing decisions, through the distributive justice logic governing organ allocation, to the professional responsibility questions of the peri- and post-transplant phases. A rigorous ethical analysis of AI in organ transplantation therefore requires, first, a systematic mapping of AI use cases and models onto the transplantation process; second, an identification of the stakeholder-specific ethical obligations pertinent at each stage; and third, an in-depth analysis of how those obligations are specifically affected by the properties of the AI system in question. This paper proposes this framework and illustrates it using the example of AI-assisted organ allocation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16525"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menopause influences lung inflammatory response and miRNA expression in brain death donors. 绝经影响脑死亡供者肺部炎症反应和miRNA表达。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-04 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16846

Elizabeth Cristina Miola, Nicholas Pietro Agulha Toneto, Fernanda Yamamoto Ricardo-da-Silva, Pedro Luis Zonta de Freitas, Marina Vidal-Dos-Santos, Luciana Coelho Marques, Henri Gerrit Derk Leuvenink, Luiz Felipe Pinho Moreira, Cristiano Jesus Correia, Ana Cristina Breithaupt-Faloppa

{"title":"Menopause influences lung inflammatory response and miRNA expression in brain death donors.","authors":"Elizabeth Cristina Miola, Nicholas Pietro Agulha Toneto, Fernanda Yamamoto Ricardo-da-Silva, Pedro Luis Zonta de Freitas, Marina Vidal-Dos-Santos, Luciana Coelho Marques, Henri Gerrit Derk Leuvenink, Luiz Felipe Pinho Moreira, Cristiano Jesus Correia, Ana Cristina Breithaupt-Faloppa","doi":"10.3389/ti.2026.16846","DOIUrl":"10.3389/ti.2026.16846","url":null,"abstract":"Lungs are highly affected by brain death, with females showing a higher inflammatory response, linked sex hormones acute reduction. With the aging of world population, the number of older donors is increasing. So, the study of menopause associated changes gain importance. Here we investigated menopause's effects in female brain death rats, previously subjected to transitional follicular depletion and aging. Female Wistar rats were divided in young and menopause groups. After follicular depletion, rats aged for 10 weeks. The animals were submitted to brain death and Sham operated rats served as controls. White blood cell counts, bronchoalveolar lavage were analyzed and inflammatory mediators were quantified. Lung tissue was evaluated for myeloperoxidase, intercellular adhesion molecules, miRNA expression, and protein and gene expression of estradiol receptors. In menopause group, there was increase in systemic and tissue leukocyte infiltration, myeloperoxidase expression, inducible nitric oxide synthase, intercellular adhesion molecule-1, lung edema, and loss of IL-10 regulation. Additionally, we found alterations in estradiol receptors along with changes in the expression of miRNAs associated to inflammation, vascular function and senescence. Menopause increases lung inflammation after brain death, by higher leukocyte infiltration and reduction of IL-10 and may impact the outcome of lung transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16846"},"PeriodicalIF":3.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public perception of xenotransplantation and its implication for policy and regulation: lessons learnt from a qualitative study of the Swedish public. 公众对异种移植的看法及其对政策和法规的影响：从瑞典公众的定性研究中吸取的教训。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-03 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16483

Rui Liu, Markus Idvall, Susanne Lundin

{"title":"Public perception of xenotransplantation and its implication for policy and regulation: lessons learnt from a qualitative study of the Swedish public.","authors":"Rui Liu, Markus Idvall, Susanne Lundin","doi":"10.3389/ti.2026.16483","DOIUrl":"10.3389/ti.2026.16483","url":null,"abstract":"The field of xenotransplantation is advances rapidly. Its cross-species nature creates regulatory challenges different from those in allotransplantation. Public opinion is promoted as an essential element in developing responsible governance for this technology. This study takes a qualitative thematic approach to analyze data collected through a questionnaire (n = 136) to the Swedish public. The aim is, first, to analyze how respondents articulate concerns, hopes, and moral evaluations regarding XT, and second, to reflect on what these responses reveal about the methodological conditions required for meaningful public engagement in the development of regulatory frameworks for emerging biomedical technologies. The findings demonstrate that public views are not directly associated with the technical assessment of risk and benefit but are anchored in shifting sociocultural perceptions regarding human survival, animal welfare, and vulnerability as individuals move between different scenarios. We conclude that developing policy and regulations for XT require continuous engagement with the underlying public opinions. We learned that meaningful public engagement with emerging biomedical technologies involves sustained processes of familiarization, communication, and dialogue between science, society, and policy.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16483"},"PeriodicalIF":3.6,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the gift: unveiling the impact of donor-recipient relationship on donors' quality of life and mental health - results of a european bi-center study. 超越礼物：揭示捐赠者-接受者关系对捐赠者生活质量和心理健康的影响——欧洲双中心研究的结果。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-02 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16536

Christina Papachristou, Natalia Papoulaki, Entela Kondi, Klemens Budde, Xavier Torres, Nina Babel, Ignacio Revuelta

{"title":"Beyond the gift: unveiling the impact of donor-recipient relationship on donors' quality of life and mental health - results of a european bi-center study.","authors":"Christina Papachristou, Natalia Papoulaki, Entela Kondi, Klemens Budde, Xavier Torres, Nina Babel, Ignacio Revuelta","doi":"10.3389/ti.2026.16536","DOIUrl":"10.3389/ti.2026.16536","url":null,"abstract":"While living kidney donation is considered safe and beneficial, long-term psychosocial donor outcomes remain under-explored, particularly regarding donor-recipient relationships and caregiving dimensions. This study examined quality of life (QoL) and psychological outcomes among 713 living kidney donors from two major European transplant centers, assessing QoL, anxiety, depression and somatization alongside donor-recipient relationship types, caregiver role, caregiving burden and perceived responsibility for the recipient's health. After adjusting for gender, age, center and time since donation, relationship type was not associated with physical wellbeing, but was linked to lower mental wellbeing in spouse donors compared to child-to parent and other genetically related donors. Caregiver role was linked to lower mental wellbeing and increased anxiety, caregiving burden with higher somatization, and perceived responsibility for recipient's health with higher depression. Identified differences in mental health between centers likely reflect cultural and organisational characteristics, while differences in wellbeing linked to older age and time since donation are eventually understood within ageing processes. Conclusively, caregiving burden and perceived responsibility for the recipient's health emerged as key predictors of psychological distress, while the effect of relationship type on wellbeing remains inconclusive. While most donors demonstrate good psychosocial outcomes, at-risk subgroups warrant appropriate attention prior and after donation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16536"},"PeriodicalIF":3.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0