Transplant International最新文献_第4页

The Impact of Patient Age on Causes of Graft Loss After Renal Transplantation. 患者年龄对肾移植术后移植物丢失原因的影响。

IF 2.7 3区医学

Transplant International Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14544

Susanne Winkler, Min-Jeong Kim, Andrea Fisler, Stefan Farese, Felix Burkhalter, Seraina von Moos, Christian Forster, Caroline Wehmeier, Michael Dickenmann, Stefan Schaub

{"title":"The Impact of Patient Age on Causes of Graft Loss After Renal Transplantation.","authors":"Susanne Winkler, Min-Jeong Kim, Andrea Fisler, Stefan Farese, Felix Burkhalter, Seraina von Moos, Christian Forster, Caroline Wehmeier, Michael Dickenmann, Stefan Schaub","doi":"10.3389/ti.2025.14544","DOIUrl":"10.3389/ti.2025.14544","url":null,"abstract":"The interplay of recipient age and graft loss causes is underexplored, despite its relevance for patient management and endpoint definition in clinical trials. This study aimed to investigate the impact of recipient age on graft loss causes. In this retrospective single-center cohort study with 1743 kidney transplantations between 1995 and 2022, graft losses were assigned to either death with graft function (DwGF) or graft failure (GF). Additionally, causes of death and GF were determined by reviewing all available clinical/histological information. Data were analyzed across recipient age groups (≤40, 41-60 and >60 years) and across three time periods (1995-2004, 2005-2014, 2015-2022). Among 816 graft losses, 56% were attributed to DwGF and 44% to GF. The proportion of DwGF increased stepwise with age (21% in young vs. 52% in middle-aged vs. 76% in elderly patients; p < 0.0001), with similar proportions across the three time periods. Rejection alone or in combination with other events caused GF in 76% of young, 51% of middle-aged, and 34% of elderly patients (p < 0.0001). Main death-causes were cardiovascular events (23%), infections (23%) and malignancies (23%). Graft loss causes are strongly age-related. This might have significant implications for clinical study design and patient management.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14544"},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraparenchymal Enzyme Injections in Islet Isolations With Incomplete Ductal Perfusion of Enzymes. 肝实质内酶注射在胰岛导管酶灌注不完全分离中的应用。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.13507

Maarten C Tol, Dirk-Jan Cornelissen, Yun Suk Chae, Ezra J van der Wel, Jeroen C Sijtsma, Jason B Doppenberg, Corine J Vermeulen, Maaike A J Hanegraaf, Evelien H van Rossenberg, J Sven D Mieog, Bert A Bonsing, Volkert A L Huurman, Eelco J P de Koning, Marten A Engelse

引用次数: 0

Tremors and Health-Related Quality of Life in Liver Transplant Recipients: Post-hoc Analysis of a Multicenter, Randomized, Controlled Trial Comparing a Life Cycle Pharma-Tacrolimus Regimen and Extended-Release Tacrolimus Regimen. 肝移植受者的震颤和健康相关生活质量：一项多中心、随机、对照试验的事后分析，比较生命周期药物-他克莫司方案和缓释他克莫司方案。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14189

M B Mulder, J J Busschbach, B van Hoek, W G Polak, I P J Alwayn, B C M de Winter, S Darwish Murad, E Verhey-Hart, L Elshove, N S Erler, D A Hesselink, C M den Hoed, H J Metselaar

{"title":"Tremors and Health-Related Quality of Life in Liver Transplant Recipients: Post-hoc Analysis of a Multicenter, Randomized, Controlled Trial Comparing a Life Cycle Pharma-Tacrolimus Regimen and Extended-Release Tacrolimus Regimen.","authors":"M B Mulder, J J Busschbach, B van Hoek, W G Polak, I P J Alwayn, B C M de Winter, S Darwish Murad, E Verhey-Hart, L Elshove, N S Erler, D A Hesselink, C M den Hoed, H J Metselaar","doi":"10.3389/ti.2025.14189","DOIUrl":"https://doi.org/10.3389/ti.2025.14189","url":null,"abstract":"We investigated whether life cycle pharma (LCP)-tacrolimus compared to extended-release (ER)-tacrolimus results in a difference in severity of tremors and HRQoL. In this multi-center, open-label, randomized, controlled trial, 108 patients were randomized in a 1:1 ratio to either LCP-tacrolimus regimen or ER-tacrolimus regimen after transplantation. HRQoL was assessed with the EQ-5D-5L and SF-36 questionnaire (two generic HRQoL instruments) and the quality of life in essential tremor (QUEST) questionnaire (domain specific HRQoL instrument). The EQ-5D-5L scores were translated to the societal values. We examined the HRQoL over the course of the study by fitting generalized mixed effect models. In total, 105 patients were included, 53 to the LCP- and 52 to the ER-tacrolimus regimen. Baseline questionnaires were available for every LT recipient. At 12 months 25% [10/40], 95% confidence interval (CI) 14.2%-40.2% of the LT recipients in the LCP-tacrolimus regimen group experienced tremors compared to 30.4% [14/46], 95%-CI 19.1%-44.8% of the LT recipients in the ER-tacrolimus regimen group; risk difference: 0.054; 95%-CI -0.151-0.249; p = 0.63. No statistically significant differences in HRQoL were seen between the two regimens. We could not demonstrate differences in the HRQoL or occurrence of tremors between LCP-tacrolimus and ER-tacrolimus regimens.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14189"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lapdoctor: Multicentre Validation of a Scoring System for Preoperative Evaluation of Difficulty of Laparoscopic Donor Nephrectomy. 腹腔镜供肾切除术难度评估评分系统的多中心验证。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14100

Jacopo Romagnoli, Gionata Spagnoletti, Francesco Emilio Rossini, Roberto Iezzi, Alessandro Posa, Maria Paola Salerno, Patrizia Silvestri, Aldo Eugenio Rossini, Cristina Silvestre, Barbara Franchin, Alessandro Giacomoni, Leonardo Centonze, Marco Spada, Maurizio Iaria, Carmelo Puliatti, Lucrezia Furian

{"title":"Lapdoctor: Multicentre Validation of a Scoring System for Preoperative Evaluation of Difficulty of Laparoscopic Donor Nephrectomy.","authors":"Jacopo Romagnoli, Gionata Spagnoletti, Francesco Emilio Rossini, Roberto Iezzi, Alessandro Posa, Maria Paola Salerno, Patrizia Silvestri, Aldo Eugenio Rossini, Cristina Silvestre, Barbara Franchin, Alessandro Giacomoni, Leonardo Centonze, Marco Spada, Maurizio Iaria, Carmelo Puliatti, Lucrezia Furian","doi":"10.3389/ti.2025.14100","DOIUrl":"10.3389/ti.2025.14100","url":null,"abstract":"We previously developed and validated LAPDOCTOR (LAParoscopic-Donor-nephreCTomy-scORe), a novel scoring system for the preoperative assessment of the difficulty of living donor nephrectomy (LDN). To prove its significance, we extended our investigation to a prospective, multicenter, national study. Difficulty was assessed by the operating surgeon using a scale from 1 to 3 (1-standard, 2-moderately difficult, 3-very difficult) based on eight parameters: availability of laparoscopic space, mobilization of the colon, kidney, gonadal, adrenal and renal vein, renal artery, and ureter. Donor CT-scans were blindly reviewed by a radiologist, and the LAPDOCTOR scores were compared with the difficulty levels assigned by the surgeon to investigate the match rates. One hundred eighty-five donors were enrolled, with a mean age of 54 years (range 24-77), BMI 25 kg/m2 (range 17-35), and male/female 59/126. LDN was blindly scored as standard in 45% of the cases, moderately-difficult in 52%, and very-difficult in 3%. The agreement between the LAPDOCTOR and expert donor surgeons' rate in categorizing LDN into risk groups had a QWK of 0.711 (95% CI 0.577-0.844) with p < 0.001. The LAPDOCTOR enables precise preoperative determination of the difficulty of LDN, particularly in very difficult cases, and assessment of surgical risk in living kidney donors.Clinical trial notation: https://ClinicalTrials.gov, Identifier NCT05769686.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14100"},"PeriodicalIF":2.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Path Forward: A Review on Enhanced Recovery After Cardiothoracic Transplantation. 前进的道路：心肺移植后增强康复的综述。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14163

Irene Bello, Laurens J Ceulemans, Cristiano Amarelli

引用次数: 0

Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs. 大鼠脑死亡增加供体器官中性粒细胞胞外陷阱形成。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14223

Maryna Van Zyl, Roberto Armstrong Junior, Petra Ottens, Harry Van Goor, Mia-Jeanne Van Rooy, Ton Lisman, Henri G D Leuvenink, Jan-Luuk Hillebrands

{"title":"Brain-Death in Rats Increases Neutrophil Extracellular Trap Formation in Donor Organs.","authors":"Maryna Van Zyl, Roberto Armstrong Junior, Petra Ottens, Harry Van Goor, Mia-Jeanne Van Rooy, Ton Lisman, Henri G D Leuvenink, Jan-Luuk Hillebrands","doi":"10.3389/ti.2025.14223","DOIUrl":"https://doi.org/10.3389/ti.2025.14223","url":null,"abstract":"During brain-death, increased numbers of neutrophils are recruited to organs as part of the inflammatory response. In the organ microenvironment, the recruited neutrophils may release neutrophil extracellular traps (NETs) through interaction with various pro-inflammatory stimuli, contributing to brain-death-induced endothelial activation, microthrombus formation and ultimately a decline in organ quality. To investigate whether NETs form in organs from brain-dead donors; kidneys, hearts, livers, and plasma samples were collected from brain-dead or sham-operated rats. The presence of NET-specific components, neutrophils and macrophages were analyzed through immunofluorescent microscopy. Endothelial activation and platelet infiltration were analyzed through immunohistochemistry and qRT-PCR analysis. Plasma free thiol levels were used to evaluate systemic oxidative stress. Increased neutrophils, NETs and NET/neutrophil ratios were observed in kidneys, hearts and livers of brain-dead rats compared to sham-operated rats. Numbers of NETs positively correlated with the extent of endothelial cell activation. Brain-dead animals also had increased kidney and liver macrophages, increased infiltrated platelets in the liver, and elevated systemic oxidative stress, compared to sham-operated animals. Our findings established the presence of NETs in organs from a brain-dead donor model and suggest that NETs, alongside increased inflammation and a redox imbalance, might prime organs for microvascular endothelial dysfunction and increased injury during brain-death.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14223"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contributions of Europeans to Xenotransplantation Research: 2. Pig Islet and Cell Xenotransplantation. 欧洲人对异种器官移植研究的贡献：猪胰岛与细胞异种移植。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14143

Rita Bottino, Krish Vasudev, Zuzanna Iwanczyk, Emanuele Cozzi, David K C Cooper

{"title":"Contributions of Europeans to Xenotransplantation Research: 2. Pig Islet and Cell Xenotransplantation.","authors":"Rita Bottino, Krish Vasudev, Zuzanna Iwanczyk, Emanuele Cozzi, David K C Cooper","doi":"10.3389/ti.2025.14143","DOIUrl":"https://doi.org/10.3389/ti.2025.14143","url":null,"abstract":"Pig islet xenotransplantation in nonhuman primates (NHPs) has made considerable progress during the past 30 years, and European scientists in both Europe and the USA have contributed to this progress. At times, there have been, or are, active research programs in Sweden, Germany, Belgium, and the USA. The first clinical experiments of wild-type (i.e., genetically-unmodified) pig islet xenotransplantation were carried out by Groth and his colleagues in Stockholm in 1994, but without significant success. Hering's group in Minneapolis was the first to report prolonged survival of wild-type pig islets in NHPs in 2006, and the first report of insulin-independence for >12 months was by a \"European\" research team at the University of Pittsburgh in 2009. Recent progress has been slow, in part through a lack of funding, but recent advances in pig organ xenotransplantation suggest that pig islet xenotransplantation is poised for clinical experiments in the near future. In addition, there have been encouraging experimental studies of pig neural cell injections into the brains of monkeys with a pharmacologically-induced Parkinson's disease.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14143"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal Rejection Assessment: New Strategies for Early Detection. 热排斥评估：早期检测的新策略。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14108

Irina Filz von Reiterdank, Rohil Jain, Eloi de Clermont-Tonnerre, Alexandra Tchir, Curtis L Cetrulo, Alexandre G Lellouch, J Henk Coert, Aebele B Mink van der Molen, Shannon N Tessier, Korkut Uygun

{"title":"Thermal Rejection Assessment: New Strategies for Early Detection.","authors":"Irina Filz von Reiterdank, Rohil Jain, Eloi de Clermont-Tonnerre, Alexandra Tchir, Curtis L Cetrulo, Alexandre G Lellouch, J Henk Coert, Aebele B Mink van der Molen, Shannon N Tessier, Korkut Uygun","doi":"10.3389/ti.2025.14108","DOIUrl":"https://doi.org/10.3389/ti.2025.14108","url":null,"abstract":"Skin pigmentation can pose challenges for physicians to diagnose pathologies. In Vascularized Composite Allotransplantation (VCA), this increases the difficulty of diagnosing rejection by clinical observation, which could be improved by noninvasive monitoring, thereby completely avoiding or aiding in guiding location for invasive diagnostics. In this study, pigmented and non-pigmented allogeneic and non-pigmented syngeneic control transplant recipients underwent daily thermal assessment using infrared (IR) gun and forward-looking IR (FLIR) imaging of VCAs using a rodent partial hindlimb transplant model. Daily clinical assessment was performed, and biopsies were taken on postoperative day (POD) 1, 3, and 7. Clinical and histological assessments indicated signs of rejection on POD 3. In contrast, thermal assessment using the IR gun detected significant differences as early as POD 1, notably a decrease in temperature, when comp ared to syngeneic control transplants. This demonstrates the capability of thermal assessments to identify early signs of rejection before clinical symptoms become apparent. The findings suggest that thermal assessments can serve as a non-contact, objective adjunct tool for early detection of graft rejection, with consideration of skin pigmentation. This approach may reduce the need for invasive biopsies, thereby improving patient comfort and reducing potential complications associated with current diagnostic methods.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14108"},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14654

Simon R Knight, John Fallon

引用次数: 0

The Feasibility of a Beating-Heart Transplant From Brain-Dead Donors. 从脑死亡捐赠者身上移植跳动心脏的可行性。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.13921

Igor Vendramin, Sandro Sponga, Alessandro Di Lorenzo, Sandro Nalon, Uberto Bortolotti, Ugolino Livi, Andrea Lechiancole

引用次数: 0