Transplant International最新文献

筛选
英文 中文
Malignancies After Lung Transplantation. 肺移植后的恶性肿瘤
IF 2.7 3区 医学
Transplant International Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.12127
Caroline Stenman, Andreas Wallinder, Erik Holmberg, Kristjan Karason, Jesper Magnusson, Göran Dellgren
{"title":"Malignancies After Lung Transplantation.","authors":"Caroline Stenman, Andreas Wallinder, Erik Holmberg, Kristjan Karason, Jesper Magnusson, Göran Dellgren","doi":"10.3389/ti.2024.12127","DOIUrl":"10.3389/ti.2024.12127","url":null,"abstract":"<p><p>Lung transplantation (LTx) is a well-known treatment for end-stage lung disease. This study aimed to report the incidence of cancer after LTx and long-term outcome among lung transplant recipients with a pretransplant diagnosis of cancer. Patients who underwent LTx between 1990-2016 were included in the study. Detection of cancer was obtained by cross-checking the study population with the Swedish Cancer Registry and the Cause-of-Death registry. A total of 614 patients were followed for a median of 5.1 years. In all, 159 malignancies were diagnosed. The excess risk of cancer or standardized incidence ratio (SIR) following LTx was 5.6-fold compared to the general Swedish population. The most common malignancies were non-melanoma skin cancer (NMSC) (SIR 76.5 (95%CI 61.7-94.8); non-Hodgkin lymphoma (SIR 23.5, 95%CI 14.8-37.2); and lung cancer (SIR 8.89, 95%CI 5.67-13.9). There was no significant difference in overall survival between those with and without a history of cancer before LTx (p = 0.56). In total, 159 malignancies were identified after LTx, which was a 5.6-fold higher relative to the general population. A history of previous cancer yields similar survival in selected recipients, compared to those without cancer prior to LTx.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"12127"},"PeriodicalIF":2.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relative Risk of COVID-19 in Solid Organ Transplant Recipients Over Waves of the Pandemic. 大流行期间实体器官移植受者感染 COVID-19 的相对风险。
IF 2.7 3区 医学
Transplant International Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13351
Amanda J Vinson, Alfred J Anzalone, Makayla Schissel, Ran Dai, Gaurav Agarwal, Stephen B Lee, Amy Olex, Roslyn B Mannon
{"title":"The Relative Risk of COVID-19 in Solid Organ Transplant Recipients Over Waves of the Pandemic.","authors":"Amanda J Vinson, Alfred J Anzalone, Makayla Schissel, Ran Dai, Gaurav Agarwal, Stephen B Lee, Amy Olex, Roslyn B Mannon","doi":"10.3389/ti.2024.13351","DOIUrl":"10.3389/ti.2024.13351","url":null,"abstract":"<p><p>Solid organ transplant recipients (SOTR) are at increased risk from COVID-19. Over time, the absolute risk of adverse outcomes after COVID-19 has decreased in both the non-immunosuppressed/immunocompromised (non-ISC) general population, and amongst SOTR. Using the N3C, we examined the absolute risk of mortality, major adverse renal or cardiac events, and hospitalization after COVID-19 diagnosis amongst non-ISC and SOTR populations over five waves of the pandemic (Wave 1: Ancestral COVID; Wave 2: Alpha; Wave 3: Delta; Wave 4: Omicron; Wave 5: Omicron). Within each wave, we determined the relative risk of each outcome for SOTR versus the non-ISC population based on crude event rates, and then used multivariable cox proportional hazards models and logistic regression to determine the adjusted risk of each outcome based on SOT status. Throughout the pandemic, including during the Omicron wave (Wave 5), SOTR were at greater absolute risk for each outcome than non-ISC patients (<i>p</i>-values all <0.001). The adjusted risk of SOT status for each outcome was relatively stable over time (aHR 1.28-1.61 for mortality; aHR 1.31-1.47 for MACE; aHR 1.72-1.90 for MARCE; aHR 1.75-2.07 for AKI; and aOR 1.53-1.81 for hospitalization). Despite a reduction in the absolute risk of COVID-19 complications, the relative risk for SOTR versus the non-ISC population has not improved.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13351"},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ex-Vivo Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment. 体外人体器官机器灌注:关于医学影像在器官状况评估中的附加值的系统性综述。
IF 3.1 3区 医学
Transplant International Pub Date : 2024-09-04 DOI: 10.3389/ti.2024.12827
Jan L Van Der Hoek,Marleen E Krommendijk,Srirang Manohar,Jutta Arens,Erik Groot Jebbink
{"title":"Ex-Vivo Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment.","authors":"Jan L Van Der Hoek,Marleen E Krommendijk,Srirang Manohar,Jutta Arens,Erik Groot Jebbink","doi":"10.3389/ti.2024.12827","DOIUrl":"https://doi.org/10.3389/ti.2024.12827","url":null,"abstract":"Machine perfused ex-vivo organs offer an excellent experimental platform, e.g., for studying organ physiology and for conducting pre-clinical trials for drug delivery. One main challenge in machine perfusion is the accurate assessment of organ condition. Assessment is often performed using viability markers, i.e., lactate concentrations and blood gas analysis. Nonetheless, existing markers for condition assessment can be inconclusive, and novel assessment methods remain of interest. Over the last decades, several imaging modalities have given unique insights into the assessment of organ condition. A systematic review was conducted according to accepted guidelines to evaluate these medical imaging methods, focussed on literature that use machine perfused human-sized organs, that determine organ condition with medical imaging. A total of 18 out of 1,465 studies were included that reported organ condition results in perfused hearts, kidneys, and livers, using both conventional viability markers and medical imaging. Laser speckle imaging, ultrasound, computed tomography, and magnetic resonance imaging were used to identify local ischemic regions and quantify intra-organ perfusion. A detailed investigation of metabolic activity was achieved using 31P magnetic resonance imaging and near-infrared spectroscopy. The current review shows that medical imaging is a powerful tool to assess organ condition.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"11 5 1","pages":"12827"},"PeriodicalIF":3.1,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Kidney Graft Function and Survival in an Emulated Trial With Living Donors and Brain-Dead Donors. 活体捐献者与脑死亡捐献者肾移植功能和存活率的模拟试验比较
IF 3.1 3区 医学
Transplant International Pub Date : 2024-08-29 DOI: 10.3389/ti.2024.13208
Emilie Savoye,Gaëlle Santin,Camille Legeai,François Kerbaul,François Gaillard,Myriam Pastural
{"title":"Comparison of Kidney Graft Function and Survival in an Emulated Trial With Living Donors and Brain-Dead Donors.","authors":"Emilie Savoye,Gaëlle Santin,Camille Legeai,François Kerbaul,François Gaillard,Myriam Pastural","doi":"10.3389/ti.2024.13208","DOIUrl":"https://doi.org/10.3389/ti.2024.13208","url":null,"abstract":"Living donation (LD) transplantation is the preferred treatment for kidney failure as compared to donation after brain death (DBD), but age may play a role. We compared the 1-year estimated glomerular filtration rate (eGFR) after kidney transplantation for recipients of LD and DBD stratified by recipient and donor age between 2015 and 2018 in a matched cohort. The strength of the association between donation type and 1-year eGFR differed by recipient age (P interaction < 0.0001). For LD recipients aged 40-54 years versus same-aged DBD recipients, the adjusted odds ratio (aOR) for eGFR ≥60 mL/min/1.73 m2 was 1.48 (95% CI: 1.16-1.90). For DBD recipients aged ≥ 60 years, the aOR was 0.18 (95% CI: 0.12-0.29) versus DBD recipients aged 40-54 years but was 0.91 (95% CI: 0.67-1.24) versus LD recipients aged ≥60 years. In the matched cohort, 4-year graft and patient survival differed by donor age and type. As compared with DBD grafts, LD grafts increased the proportion of recipients with 1-year eGFR ≥60 mL/min/1.73 m2. Recipients aged ≥60 years benefited most from LD transplantation, even if the donor was aged ≥60 years. For younger recipients, large age differences between donor and recipient could also be addressed with a paired exchange program.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"102 1","pages":"13208"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up. 肝移植中抗体介导的排斥反应:免疫病理特征与长期随访
IF 3.1 3区 医学
Transplant International Pub Date : 2024-08-29 DOI: 10.3389/ti.2024.13232
Luca Cicalese,Zachary C Walton,Xiaotang Du,Rupak Kulkarni,Suimin Qiu,Mohamed El Hag,Heather L Stevenson
{"title":"Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up.","authors":"Luca Cicalese,Zachary C Walton,Xiaotang Du,Rupak Kulkarni,Suimin Qiu,Mohamed El Hag,Heather L Stevenson","doi":"10.3389/ti.2024.13232","DOIUrl":"https://doi.org/10.3389/ti.2024.13232","url":null,"abstract":"The diagnosis of liver antibody-mediated rejection (AMR) is challenging and likely under-recognized. The association of AMR with donor-specific antibodies (DSA), and its clinical course in relation to pathologic findings and treatment are ill defined. We identified cases of liver AMR by following the criteria outlined by the 2016 Banff Working Group. Patient demographics, native liver disease, histopathologic findings, treatment type, clinical outcome, and transaminase levels during AMR diagnosis, treatment, and resolution were determined. Patients (n = 8) with AMR average age was 55.2 years (range: 19-68). Seven of eight cases met the Banff criteria for AMR. Personalized treatment regimens consisted of optimization of immunosuppression, intravenous pulse steroids, plasmapheresis, IVIG, rituximab, and bortezomib. Five patients experienced complete resolution of AMR, return of transaminases to baseline, and decreased DSA at long-term follow-up. One patient developed chronic AMR and two patients required re-transplantation. Follow-up after AMR diagnosis ranged from one to 11 years. Because AMR can present at any time, crossmatch, early biopsy, and routine monitoring of DSA levels should be implemented following transaminase elevation to recognize AMR. Furthermore, treatment should be immediately implemented to reverse AMR and prevent graft failure, chronic damage, re-transplantation, and possibly mortality.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"13 1","pages":"13232"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Variability of Barriers to Adherence to Immunosuppressive Medication in Adult Heart Transplant Recipients. A Secondary Data Analysis of the BRIGHT Study. 成人心脏移植受者坚持使用免疫抑制药物的障碍的国际差异。BRIGHT研究的二次数据分析。
IF 3.1 3区 医学
Transplant International Pub Date : 2024-08-29 DOI: 10.3389/ti.2024.12874
Kris Denhaerynck,Gabriele Berger Wermuth,Fabienne Dobbels,Lut Berben,Cynthia L Russell,Sabina De Geest
{"title":"International Variability of Barriers to Adherence to Immunosuppressive Medication in Adult Heart Transplant Recipients. A Secondary Data Analysis of the BRIGHT Study.","authors":"Kris Denhaerynck,Gabriele Berger Wermuth,Fabienne Dobbels,Lut Berben,Cynthia L Russell,Sabina De Geest","doi":"10.3389/ti.2024.12874","DOIUrl":"https://doi.org/10.3389/ti.2024.12874","url":null,"abstract":"Non-adherence to immunosuppressive medication among transplant patients is associated with poor clinical outcomes and higher economic costs. Barriers to immunosuppressives are a proximal determinant of non-adherence. So far, international variability of barriers to adherence in transplantation has not been studied. As part of the cross-sectional multi-country and multi-center BRIGHT study, barriers to adherence were measured in 1,382 adult heart transplant recipients of 11 countries using the 28-item self-report questionnaire \"Identifying Medication Adherence Barriers\" (IMAB). Barriers were ranked by their frequency of occurrence for the total sample and by country. Countries were also ranked the by recipients' total number of barriers. Intra-class correlations were calculated at country and center level. The five most frequently mentioned barriers were sleepiness (27.1%), being away from home (25.2%), forgetfulness (24.5%), interruptions to daily routine (23.6%) and being busy (22.8%), fairly consistently across countries. The participants reported on average three barriers, ranging from zero up to 22 barriers. The majority of the variability among reported barriers frequency was situated at the recipient level (94.8%). We found limited international variability in primarily person-level barriers in our study. Understanding of barriers in variable contexts guides intervention development to support adherence to the immunosuppressive regimen in real-world settings.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"188 1","pages":"12874"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Perfusion and Bioengineering Strategies in Transplantation-Beyond the Emerging Concepts. 移植手术中的机器灌注和生物工程策略--超越新兴概念。
IF 3.1 3区 医学
Transplant International Pub Date : 2024-08-29 DOI: 10.3389/ti.2024.13215
Anna Niroomand,George Emilian Nita,Sandra Lindstedt
{"title":"Machine Perfusion and Bioengineering Strategies in Transplantation-Beyond the Emerging Concepts.","authors":"Anna Niroomand,George Emilian Nita,Sandra Lindstedt","doi":"10.3389/ti.2024.13215","DOIUrl":"https://doi.org/10.3389/ti.2024.13215","url":null,"abstract":"Solid organ transplantation has progressed rapidly over the decades from the first experimental procedures to its role in the modern era as an established treatment for end-stage organ disease. Solid organ transplantation including liver, kidney, pancreas, heart, and lung transplantation, is the definitive option for many patients, but despite the advances that have been made, there are still significant challenges in meeting the demand for viable donor grafts. Furthermore, post-operatively, the recipient faces several hurdles, including poor early outcomes like primary graft dysfunction and acute and chronic forms of graft rejection. In an effort to address these issues, innovations in organ engineering and treatment have been developed. This review covers efforts made to expand the donor pool including bioengineering techniques and the use of ex vivo graft perfusion. It also covers modifications and treatments that have been trialed, in addition to research efforts in both abdominal organs and thoracic organs. Overall, this article discusses recent innovations in machine perfusion and organ bioengineering with the aim of improving and increasing the quality of donor organs.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"214 1","pages":"13215"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Trajectories of Estimated Glomerular Filtration Rate in a European Population of Living Kidney Donors. 欧洲活体肾脏捐献者估计肾小球滤过率的纵向轨迹。
IF 3.1 3区 医学
Transplant International Pub Date : 2024-08-26 DOI: 10.3389/ti.2024.13356
Manuela Almeida,Pedro Reis Pereira,José Silvano,Catarina Ribeiro,Sofia Pedroso,Sandra Tafulo,La Salete Martins,Miguel Silva Ramos,Jorge Malheiro
{"title":"Longitudinal Trajectories of Estimated Glomerular Filtration Rate in a European Population of Living Kidney Donors.","authors":"Manuela Almeida,Pedro Reis Pereira,José Silvano,Catarina Ribeiro,Sofia Pedroso,Sandra Tafulo,La Salete Martins,Miguel Silva Ramos,Jorge Malheiro","doi":"10.3389/ti.2024.13356","DOIUrl":"https://doi.org/10.3389/ti.2024.13356","url":null,"abstract":"A living donor (LD) kidney transplant is the best treatment for kidney failure, but LDs safety is paramount. We sought to evaluate our LDs cohort's longitudinal changes in estimated glomerular filtration rate (eGFR). We retrospectively studied 320 LDs submitted to nephrectomy between 1998 and 2020. The primary outcome was the eGFR change until 15 years (y) post-donation. Subgroup analysis considered distinct donor characteristics and kidney function reduction rate (%KFRR) post-donation [-(eGFR6 months(M)-eGFRpre-donation)/eGFRpre-donation*100]. Donors had a mean age of 47.3 ± 10.5 years, 71% female. Overall, LDs presented an average eGFR change 6 M onward of +0.35 mL/min/1.73 m2/year. The period with the highest increase was 6 M-2 Y, with a mean eGFR change of +0.85L/min/1.73 m2/year. Recovery plateaued at 10 years. Normal weight donors presented significantly better recovery of eGFR +0.59 mL/min/1.73 m2/year, compared to obese donors -0.18L/min/1.73 m2/year (p = 0.020). Noteworthy, these results only hold for the first 5 years. The subgroup with a lower KFRR (<26.2%) had a significantly higher decrease in eGFR overall of -0.21 mL/min/1.73 m2/year compared to the groups with higher KFRR (p < 0.001). These differences only hold for 6 M-2 Y. Moreover, an eGFR<50 mL/min/1.73 m2 was a rare event, with ≤5% prevalence in the 2-15 Y span, correlating with eGFR pre-donation. Our data show that eGFR recovery is significant and may last until 10 years post-donation. However, some subgroups presented more ominous kidney function trajectories.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"9 1","pages":"13356"},"PeriodicalIF":3.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplant Trial Watch. 移植试验观察。
IF 2.7 3区 医学
Transplant International Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13593
Simon R Knight, John Fallon, Reshma Rana Magar
{"title":"Transplant Trial Watch.","authors":"Simon R Knight, John Fallon, Reshma Rana Magar","doi":"10.3389/ti.2024.13593","DOIUrl":"https://doi.org/10.3389/ti.2024.13593","url":null,"abstract":"","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13593"},"PeriodicalIF":2.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normothermic Regional Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Systematic Review and Meta-Analysis. 常温区域灌注在循环死亡肝移植后控制性捐献中的应用:系统回顾与元分析》。
IF 2.7 3区 医学
Transplant International Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI: 10.3389/ti.2024.13263
Carly Mastrovangelis, Charles Frost, Amy Hort, Jerome Laurence, Tony Pang, Henry Pleass
{"title":"Normothermic Regional Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Systematic Review and Meta-Analysis.","authors":"Carly Mastrovangelis, Charles Frost, Amy Hort, Jerome Laurence, Tony Pang, Henry Pleass","doi":"10.3389/ti.2024.13263","DOIUrl":"10.3389/ti.2024.13263","url":null,"abstract":"<p><p>Liver grafts from controlled donation after circulatory death (cDCD) donors have lower utilization rates due to inferior graft and patient survival rates, largely attributable to the increased incidence of ischemic cholangiopathy, when compared with grafts from brain dead donors (DBD). Normothermic regional perfusion (NRP) may improve the quality of cDCD livers to allow for expansion of the donor pool, helping to alleviate the shortage of transplantable grafts. A systematic review and metanalysis was conducted comparing NRP cDCD livers with both non-NRP cDCD livers and DBD livers. In comparison to non-NRP cDCD outcomes, NRP cDCD grafts had lower rates of ischemic cholangiopathy [RR = 0.23, 95% CI (0.11, 0.49), p = 0.0002], primary non-function [RR = 0.51, 95% CI (0.27, 0.97), p = 0.04], and recipient death [HR = 0.5, 95% CI (0.36, 0.69), p < 0.0001]. There was no difference in outcomes between NRP cDCD donation compared to DBD liver donation. In conclusion, NRP improved the quality of cDCD livers compared to their non-NRP counterparts. NRP cDCD livers had similar outcomes to DBD grafts. This provides further evidence supporting the continued use of NRP in cDCD liver transplantation and offers weight to proposals for its more widespread adoption.</p>","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"37 ","pages":"13263"},"PeriodicalIF":2.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信