Transplant International最新文献_第5页

The SystemCHANGE™ intervention improves immunosuppressive medication-taking habit: a secondary analysis of the MAGIC studies. SystemCHANGE™干预改善免疫抑制药物服用习惯：MAGIC研究的二次分析。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16252

Cynthia L Russell Lippincott, Antoine Pironet, Yaprak Sarigol Ordin, Rebecca Bartlett Ellis, Buket Celik, Eda Ayten Kankaya, Mary Beth Stephens, Serkan Yildiz, Preethi Yerram, Wuraola Awopetu, Mark Wakefield, Elizabeth Henderson

{"title":"The SystemCHANGE™ intervention improves immunosuppressive medication-taking habit: a secondary analysis of the MAGIC studies.","authors":"Cynthia L Russell Lippincott, Antoine Pironet, Yaprak Sarigol Ordin, Rebecca Bartlett Ellis, Buket Celik, Eda Ayten Kankaya, Mary Beth Stephens, Serkan Yildiz, Preethi Yerram, Wuraola Awopetu, Mark Wakefield, Elizabeth Henderson","doi":"10.3389/ti.2026.16252","DOIUrl":"10.3389/ti.2026.16252","url":null,"abstract":"Habit impacts healthy behaviors. The SystemCHANGE™ intervention supports associating medication taking with existing habits or creating new habits to improve medication adherence. This secondary analysis of United States and Türkiye MAGIC study data examines differences in habit between SystemCHANGE™ and attention control groups, differences in habit between countries, and habit as a relationship mediator between the SystemCHANGE™ intervention and immunosuppressive medication adherence in adult kidney transplant recipients. The Medication Event Monitoring System measured medication adherence. Objective habit index was computed during screening, intervention, and maintenance. During the SystemCHANGE™ intervention, habit strength was higher than during the screening and maintenance periods in both groups (mean difference 0.042, 95% confidence interval (CI): 0.004 to 0.080, p = 0.030). Habit index was lower for US participants compared to Turkish participants (mean difference -0.195, 95% CI: -0.300 to -0.089, p < 0.001). Habit was a mediator of the SystemCHANGE™ intervention on medication adherence (indirect effect was 0.094, 95% CI: 0.080 to 0.114, p < 0.001). The SystemCHANGE™ intervention exerted an impact on habit in two different populations which then had a positive impact on medication adherence.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16252"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-clamp technique facilitating end-to-side suture anastomosis in murine cervical heart transplantation. 双钳技术促进小鼠颈心移植端侧缝合吻合。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17404

Xia Huang, Xuechun Zhao, Zipei Wang

引用次数: 0

Foundations for consensus on establishing a unified definition of death: results of the European Society for Organ Transplantation Bucharest International Consensus Conference. 建立统一死亡定义的共识基础：欧洲器官移植学会布加勒斯特国际共识会议的结果。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16498

Francesco Procaccio, Alexandra Glazier, Beatriz Domínguez-Gil, Corinne Antoine, James Bernat, Helen Opdam, Mario Royo-Villanova, Gabriel C Oniscu, Umberto Cillo, Dominique E Martin

{"title":"Foundations for consensus on establishing a unified definition of death: results of the European Society for Organ Transplantation Bucharest International Consensus Conference.","authors":"Francesco Procaccio, Alexandra Glazier, Beatriz Domínguez-Gil, Corinne Antoine, James Bernat, Helen Opdam, Mario Royo-Villanova, Gabriel C Oniscu, Umberto Cillo, Dominique E Martin","doi":"10.3389/ti.2026.16498","DOIUrl":"10.3389/ti.2026.16498","url":null,"abstract":"As part of the ESOT International Consensus on Controlled Donation After Circulatory Determination of Death (cDCDD) Project, a dedicated working group addressed considerations relating to the determination of death in the context of cDCDD. Delphi methodology was used to explore international perspectives on the definition of death, and clinical and ethical standards for the determination of death in the setting of cDCDD. The results indicated consensus that establishing a \"single unified definition of death worldwide\" and specifically the \"unifying brain-based concept of death\" would be beneficial. There was consensus on the proposed definition of this concept and several principles relating to the determination of death in the context of cDCDD, such as the \"dead donor rule.\" However, limited agreement was reached on the more practical aspects of death determination. The results nevertheless provide a foundation for current policy and practice and should guide further efforts to establish minimum clinical standards for the determination of death in the context of cDCDD.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16498"},"PeriodicalIF":3.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Blood pressure control after solid organ transplantation: opportunities for optimizing care. 修正：实体器官移植后血压控制：优化护理的机会。

IF 3.6 3区医学

Transplant International Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17659

引用次数: 0

Correction: The European Board of transplant medicine: evolution, present role and future directions toward harmonised transplant medicine training in Europe. 更正：欧洲移植医学委员会：欧洲协调移植医学培训的演变、目前的作用和未来方向。

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-28 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17461

Nuria Montero, Miha Arnol, Susanne Beckebaum, Isabelle Binet, Vito Cicinnati, David Cucchiari, Caroline Den Hoed, Antoine Durrbach, Speranta Iacob, Smaragdi Marinaki, Anna Paola Mitterhofer, Anna Mrzljak, Adam Remport, Pablo Ruiz, Susana Sampaio, Francesca Tinti, Marios Prikis

引用次数: 0

Pre-transplant whole blood transcriptomic profiling identifies mRNAs linked to cirrhosis-associated immune dysfunction as candidate predictors of clinical outcomes after liver transplantation: an exploratory study. 移植前全血转录组分析鉴定与肝硬化相关免疫功能障碍相关的mrna作为肝移植后临床结果的候选预测因子：一项探索性研究。

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-28 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16292

Marie-Charlotte Delignette, Estelle Peronnet, Arnaud Riff, Teresa Antonini, Maxime Bodinier, Elisabeth Cerrato, Solène Pantel, Elsa Coz, Xavier Muller, Guillaume Rossignol, Jean-Yves Mabrut, Jérôme Dumortier, Céline Guichon, Alice Blet, Frederic Aubrun, Guillaume Monneret, Fanny Lebossé

{"title":"Pre-transplant whole blood transcriptomic profiling identifies mRNAs linked to cirrhosis-associated immune dysfunction as candidate predictors of clinical outcomes after liver transplantation: an exploratory study.","authors":"Marie-Charlotte Delignette, Estelle Peronnet, Arnaud Riff, Teresa Antonini, Maxime Bodinier, Elisabeth Cerrato, Solène Pantel, Elsa Coz, Xavier Muller, Guillaume Rossignol, Jean-Yves Mabrut, Jérôme Dumortier, Céline Guichon, Alice Blet, Frederic Aubrun, Guillaume Monneret, Fanny Lebossé","doi":"10.3389/ti.2026.16292","DOIUrl":"10.3389/ti.2026.16292","url":null,"abstract":"Cirrhosis-associated immune dysfunction (CAID) contributes to poor outcomes after liver transplantation (LT), but pre-transplant immune predictors remain insufficiently defined. We investigated whether pre-transplant whole blood transcriptomic profiling was associated with post-LT outcomes in this exploratory ancillary study of the prospective EDMONHG cohort. Transcriptomic analysis of 26 immune-related genes was performed on 97 LT recipients. PCA and volcano plots identified candidate biomarkers; associations with outcomes were assessed using ROC analyses and Kaplan-Meier estimates with cohort medians as thresholds. PC1 (43.5% of variance) decreased progressively from cACLD to ALF (p < 0.001) and was lower in post-LT infected patients (p = 0.044). Within the first month, 34 patients (35%) developed infections; 7 (7.2%) died within 1 year. Three genes met predefined exploratory criteria (q < 0.10, AUC > 0.65) for infections: GNLY and IL7R were downregulated and IL10 upregulated. Low GNLY or high IL10 expression was associated with reduced 30-day infection-free survival (p = 0.019 and p = 0.013). CIITA, IL10, CD177 and S100A9 showed associations with one-year survival, though results should be treated as exploratory given the limited number of events. Pre-transplant transcriptomics captures CAID severity and identifies candidate gene signatures associated with post-LT outcomes. These hypothesis-generating findings warrant validation in larger multicenter cohorts.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16292"},"PeriodicalIF":3.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Nurturing a sustainable transplantation journey: the best of ESOT congress 2025. 更正：培育可持续的移植之旅：2025年ESOT大会最佳会议。

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-28 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17532

引用次数: 0

The bucharest international (ESOT) consensus on controlled donation after circulatory determination of death. 布加勒斯特国际（ESOT）关于血液循环确定死亡后控制捐赠的共识。

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-28 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.17566

Umberto Cillo, Gabriel C Oniscu

引用次数: 0

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-27 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16769

Inês Mega, Eloisa Franchi, Giacomo Germani, Hermien Hartog, Speranta Iacob, Phillipe Mathurin, Silvio Nadalin, Stephen Potts, Giuliano Testa, Luca Saverio Belli

{"title":"Alcohol-related liver disease and access to liver transplantation: where we stand and where we should go.","authors":"Inês Mega, Eloisa Franchi, Giacomo Germani, Hermien Hartog, Speranta Iacob, Phillipe Mathurin, Silvio Nadalin, Stephen Potts, Giuliano Testa, Luca Saverio Belli","doi":"10.3389/ti.2026.16769","DOIUrl":"10.3389/ti.2026.16769","url":null,"abstract":"Alcohol-related liver disease (ArLD) is now a leading indication for liver transplantation worldwide, yet access to this life-saving therapy remains inequitable. Late diagnosis, persistent stigma, rigid abstinence requirements, and fragmented care pathways continue to disadvantage patients with ArLD relative to those with other liver diseases. Landmark studies have shown that early liver transplantation for severe alcohol-associated hepatitis confers a clear survival benefit when performed within rigorous selection protocols, with rates of return to drinking comparable to those achieved under the long-standing six-month abstinence rule, thereby challenging its clinical rationale. Concurrently, growing evidence supports the integration of addiction medicine and mental health expertise into transplant programs, recognizing alcohol use disorder as a chronic relapsing disease requiring sustained, multidisciplinary management. Despite this progress, substantial variability persists across centers in candidate evaluation, psychosocial assessment, and post-transplant addiction care. This Point of View examines the current landscape across six interconnected domains, epidemiology, timing of diagnosis, the dual nature of ArLD as a disease of mind and liver, stigma, access to transplantation, and multidisciplinary models of care, and proposes directions for harmonized, evidence-based, and equitable practice.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16769"},"PeriodicalIF":3.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney-alone transplantation in prior SLK candidates: a national registry analysis. 先前SLK候选人的单肾移植：一项国家登记分析。

IF 3.6 3区医学

Transplant International Pub Date : 2026-08-27 eCollection Date: 2026-01-01 DOI: 10.3389/ti.2026.16834

Beat Moeckli, Kevin B Harris, Byron Smith, David Pereyra, Xiomara Benavides, Jody Olson, Alexander R Cortez, Timucin Taner, Julie K Heimbach, Douglas A Simonetto, Samy M Riad

{"title":"Kidney-alone transplantation in prior SLK candidates: a national registry analysis.","authors":"Beat Moeckli, Kevin B Harris, Byron Smith, David Pereyra, Xiomara Benavides, Jody Olson, Alexander R Cortez, Timucin Taner, Julie K Heimbach, Douglas A Simonetto, Samy M Riad","doi":"10.3389/ti.2026.16834","DOIUrl":"10.3389/ti.2026.16834","url":null,"abstract":"Outcomes of kidney-alone transplantation (KAT) in former simultaneous liver-kidney (SLK) transplant candidates after liver waitlist delisting are not well defined. Using Scientific Registry of Transplant Recipients (SRTR) data, we identified adult recipients who underwent KAT between 2005 and 2025 after prior SLK listing (RLD-KAT), which was matched 1:5 to primary KAT recipients without liver disease by age, transplant year, and diabetes status. Patient and graft survival were evaluated using the Kaplan-Meier method and multivariable Cox proportional hazards models. We identified 163 RLD-KAT recipients matched to 815 controls. Unadjusted Kaplan-Meier analyses demonstrated lower patient survival in RLD-KAT (p = 0.020), whereas death-censored and overall graft survival were similar (p > 0.05). In multivariable models, death-censored graft survival (HR 0.89; 95% CI 0.51-1.53), overall graft survival (HR 1.00; 95% CI 0.73-1.36), and patient survival (HR 1.07; 95% CI 0.76-1.5) did not differ significantly. Six RLD-KAT recipients (3.7%) subsequently underwent liver transplantation. Kidney-alone transplantation in prior SLK candidates was associated with acceptable patient and graft outcomes and a low incidence of subsequent liver transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"39 ","pages":"16834"},"PeriodicalIF":3.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0