Transplant International最新文献_第5页

T₁ Relaxation Time for the Prediction of Renal Transplant Dysfunction. T1松弛时间对肾移植功能障碍的预测。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14301

Haris Omić, Farsad Eskandary, Dietrich Beitzke, Marcos Wolf, Nicolas Kozakowski, Georg Böhmig, Andrea Beck-Tölly, Michael Eder

{"title":"T1 Relaxation Time for the Prediction of Renal Transplant Dysfunction.","authors":"Haris Omić, Farsad Eskandary, Dietrich Beitzke, Marcos Wolf, Nicolas Kozakowski, Georg Böhmig, Andrea Beck-Tölly, Michael Eder","doi":"10.3389/ti.2025.14301","DOIUrl":"https://doi.org/10.3389/ti.2025.14301","url":null,"abstract":"Quantitative magnetic resonance imaging (MRI) is emerging as a non-invasive tool to measure tissue scarring in renal allografts. However, whether prolonged T1 relaxation time results in lower transplant survival rates is unknown. This retrospective cohort study analyzed the capability to predict renal allograft dysfunction based on median T1 time. Forty-six transplant recipients with non-contrast 1.5T MRI and allograft biopsy were included. The primary endpoint was the eGFR slope over 24 months. T1 relaxation time correlated significantly with eGFR levels at all follow-up stages. Patients with T1 relaxation time above the median (T1 high) had a consistent decline in kidney function as compared to the patient group below the median (T1 low): overall eGFR slope: 11.3 vs. 1.4 mL/min/1.73 m2 over 24 months, p = 0.016. Graft survival rates at 24 months were 52% in the T1 high vs. 87% in the T1 low group, p = 0.0015. ROC analysis discovered a positive predictive value of 52% and a negative predictive value of 91% for graft loss. T1 mapping identified patients with a persistent decline of allograft function and an increased risk of allograft loss. MRI could significantly influence monitoring strategies in transplant surveillance, offering a safe, non-invasive alternative to traditional diagnostic methods.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14301"},"PeriodicalIF":2.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor-Recipient Mismatch in Lung Transplantation: The Role of Graft Sizing in Clinical Outcomes. 肺移植供体-受体不匹配：移植物大小在临床结果中的作用。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14387

Chiara Catelli, Miriana D'Alessandro, Andrea Lloret Madrid, Antonella Fossi, Federico Franchi, David Bennett, Piero Paladini, Elena Bargagli, Luca Luzzi

{"title":"Donor-Recipient Mismatch in Lung Transplantation: The Role of Graft Sizing in Clinical Outcomes.","authors":"Chiara Catelli, Miriana D'Alessandro, Andrea Lloret Madrid, Antonella Fossi, Federico Franchi, David Bennett, Piero Paladini, Elena Bargagli, Luca Luzzi","doi":"10.3389/ti.2025.14387","DOIUrl":"https://doi.org/10.3389/ti.2025.14387","url":null,"abstract":"Lung transplantation is a life-saving procedure for end-stage lung diseases. Size matching is critical in the donor-recipient selection process. This retrospective study analyzed 146 patients who underwent lung transplantation between 2013 and 2023. Patients who required graft resizing were assigned to the sizing group (S), non-resizing cases to the non-sizing group (NS). The primary goal was to identify predictive factors for graft resizing. Secondary endpoints included ischemia time, ventilation time, primary graft dysfunction (PGD) and hospital stay. The S group was further stratified on baseline parameters to assess differences in outcomes. Recipient height and single transplants were higher in the NS group. Donor-recipient height ratio was the only predictor for resizing (p = 0.02). Postoperative outcomes and overall survival were similar between the groups. In Group S, male patients showed higher rates of acute kidney injury (AKI) and chronic rejection, the former being associated also with anatomical resections; patients older than 50 experienced higher rates of PGD. Graft resizing is a feasible strategy for addressing size mismatch, but it is associated with increased risks of PGD and AKI, particularly in older male recipients and those undergoing anatomical resections. These findings highlight the importance of careful preoperative donor-recipient size matching.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14387"},"PeriodicalIF":2.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Radiological Fusion: A New Frontier in Predicting Post-Transplant Diabetes Mellitus. 临床和放射学融合：预测移植后糖尿病的新前沿。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14377

Pooja Budhiraja, Byron H Smith, Aleksandra Kukla, Timothy L Kline, Panagiotis Korfiatis, Mark D Stegall, Caroline C Jadlowiec, Wisit Cheungpasitporn, Hani M Wadei, Yogish C Kudva, Salah Alajous, Suman S Misra, Hay Me Me, Ian P Rios, Harini A Chakkera

{"title":"Clinical and Radiological Fusion: A New Frontier in Predicting Post-Transplant Diabetes Mellitus.","authors":"Pooja Budhiraja, Byron H Smith, Aleksandra Kukla, Timothy L Kline, Panagiotis Korfiatis, Mark D Stegall, Caroline C Jadlowiec, Wisit Cheungpasitporn, Hani M Wadei, Yogish C Kudva, Salah Alajous, Suman S Misra, Hay Me Me, Ian P Rios, Harini A Chakkera","doi":"10.3389/ti.2025.14377","DOIUrl":"https://doi.org/10.3389/ti.2025.14377","url":null,"abstract":"This study developed a predictive model for Post-Transplant Diabetes Mellitus (PTDM) by integrating clinical and radiological data to identify at-risk kidney transplant recipients. In a retrospective analysis across three Mayo Clinic sites, clinical metrics were combined with deep learning analysis of pre-transplant CT images, focusing on body composition parameters like adipose tissue and muscle mass instead of BMI or other biomarkers. Among 2,005 nondiabetic kidney recipients, 335 (16.7%) developed PTDM within the first year. PTDM patients were older, had higher BMIs, elevated triglycerides, and were more likely to be male and non-White. They exhibited lower skeletal muscle area, greater visceral adipose tissue (VAT), more intermuscular fat, and higher subcutaneous fat (all p < 0.001). Multivariable analysis identified age (OR: 1.05, 95% CI: 1.03-1.08, p < 0.0001), family diabetes history (OR: 1.55, CI: 1.14-2.09, p = 0.0061), White race (OR: 0.43, CI: 0.28-0.66, p < 0.0001), and VAT area (OR: 1.37, CI: 1.14-1.64, p = 0.0009) as predictors. The combined model achieved C-statistic of 0.724 (CI: 0.692-0.757), outperforming the clinical-only model (C-statistic 0.68). Patients with PTDM in the first year had higher mortality than those without PTDM. This model improves predictive precision, enabling accurate identification and intervention for at risk patients.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14377"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival? 肾移植后饮食指南：这是恢复和移植存活的缺失环节吗？

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14288

Suzanne Schneider, Deborah Biggerstaff, Thomas M Barber

{"title":"Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival?","authors":"Suzanne Schneider, Deborah Biggerstaff, Thomas M Barber","doi":"10.3389/ti.2025.14288","DOIUrl":"https://doi.org/10.3389/ti.2025.14288","url":null,"abstract":"The physiology of a transplanted kidney is affected from the moment it is separated from the donor. The risk of complications arising from surgery are highly associated with ischemic-reperfusion injury (IRI) due to the effects of hypoxia and oxidative stress during the procurement, preservation and reperfusion procedures. Hypoxia promotes the formation of reactive oxygen species (ROS) and it seems apparent that finding ways of optimising the metabolic milieu for the transplanted kidney would improve recovery and graft survival. Studies have demonstrated the benefits of nutrition and antioxidant compounds in mitigating the disturbance of energy supply to cells post-transplant and at improving long-term graft survival. Particularly in patients who may be nutritionally deficient following long-term dialysis. Despite the high incidence of allograft failure, a search of the literature and grey literature reveals no medical nutriti on therapy guidelines on beneficial nutrient intake to aid transplant recovery and survival. This narrative review aims to summarise current knowledge of specific macro and micronutrients and their effect on allograft recovery and survival in the perioperative period, up to 1-year post transplant, to optimise the metabolic environment and mitigate risk to graft injury.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14288"},"PeriodicalIF":2.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion. 非原位恒温机器灌注时对比增强超声评估肾脏质量。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14268

Samuel J Tingle, Chloe Connelly, Emily K Glover, Ben Stenberg, Andrew McNeill, Georgios Kourounis, Beth G Gibson, Balaji Mahendran, Lucy Bates, Madison N Cooper, Rhys R Pook, Samantha Lee, Marnie L Brown, Rodrigo Figueiredo, Kevin J Marchbank, Simi Ali, Neil S Sheerin, Colin H Wilson, Emily R Thompson

{"title":"Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion.","authors":"Samuel J Tingle, Chloe Connelly, Emily K Glover, Ben Stenberg, Andrew McNeill, Georgios Kourounis, Beth G Gibson, Balaji Mahendran, Lucy Bates, Madison N Cooper, Rhys R Pook, Samantha Lee, Marnie L Brown, Rodrigo Figueiredo, Kevin J Marchbank, Simi Ali, Neil S Sheerin, Colin H Wilson, Emily R Thompson","doi":"10.3389/ti.2025.14268","DOIUrl":"https://doi.org/10.3389/ti.2025.14268","url":null,"abstract":"Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate total blood flow, is a key pathophysiology in ischaemia-mediated acute kidney injury. Contrast-enhanced ultrasound (CEUS) could allow objective assessment of microvascular perfusion during renal NMP. Blood-based NMP was performed on porcine kidneys (circulatory death model) and human kidneys declined for transplant (preclinical). CEUS was performed with a contrast bolus into the NMP circuit arterial limb. Microvascular perfusion quality was quantified and z-score normalisation allowed combination of metrics and regions into an overall \"CEUS-score.\" In porcine kidneys, inferior microvascular perfusion of cortex and medulla correlated with increased urinary NGAL (Neutrophil gelatinase-associated lipocalin) and histological DNA-fragmentation (a hallmark of apoptosis). In human kidneys, CEUS-score at 2 h was correlated with histological DNA-fragmentation (r = -0.937; P = 0.019) and predicted urinary NGAL at 24 h of NMP (r = -0.925; P = 0.024). Total renal flow was not correlated with these outcomes. An open-source web application (stingle.shinyapps.io/Time_intensity_analysis) and R package (\"tican\") were developed for quantitative time-intensity curve analysis. CEUS allows objective point-of-care microvascular perfusion assessment during NMP. As 2-hour CEUS-score predicts NGAL at 24 h, CEUS warrants future clinical investigation as a potential tool to assess kidney quality in assessment and reconditioning centres.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14268"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Neurogenin 3 Induction on Endocrine Differentiation and Delamination in Adult Human Pancreatic Ductal Organoids. 神经原素3诱导对成人胰腺导管类器官内分泌分化和分层的影响。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.13422

Juri Juksar, Rachel Mijdam, Sabine Bosman, Alexander van Oudenaarden, Françoise Carlotti, Eelco J P de Koning

{"title":"Effects of Neurogenin 3 Induction on Endocrine Differentiation and Delamination in Adult Human Pancreatic Ductal Organoids.","authors":"Juri Juksar, Rachel Mijdam, Sabine Bosman, Alexander van Oudenaarden, Françoise Carlotti, Eelco J P de Koning","doi":"10.3389/ti.2025.13422","DOIUrl":"https://doi.org/10.3389/ti.2025.13422","url":null,"abstract":"Diabetes mellitus is characterized by the loss of pancreatic insulin-secreting β-cells in the Islets of Langerhans. Understanding the regenerative potential of human islet cells is relevant in the context of putative restoration of islet function after damage and novel islet cell replacement therapies. Adult human pancreatic tissue can be cultured as three-dimensional organoids with the capacity for long-term expansion and the promise of endocrine cell formation. Here, we characterize the endocrine differentiation potential of human adult pancreatic organoids. Because exocrine-to-endocrine differentiation is dependent on the expression of Neurogenin 3 (NEUROG3), we first generated NEUROG3-inducible organoid lines. We show that doxycycline-induced NEUROG3 expression in the organoids leads to the formation of chromogranin A positive (CHGA+) endocrine progenitor cells. The efficiency of this differentiation was improved with the addition of thyroid hormone T3 and the AXL inhibitor R428. Further, compound screening demonstrated that modifying the pivotal embryonic endocrine pancreas signalling pathways driven by Notch, YAP, and EGFR led to increased NEUROG3 expression in organoids. In a similar fashion to embryonic development, adult ductal cells delaminated from the organoids after NEUROG3 induction. Thus, mechanisms in islet (re)generation including the initiation of endocrine differentiation and delamination can be achieved by NEUROG3 induction.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"13422"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic Islet Transplantation: Chronicle of a Death Foretold? 异体胰岛移植：死亡预言的编年史？

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14598

Thierry Berney, Olivier Thaunat, Ekaterine Berishvili

{"title":"Allogeneic Islet Transplantation: Chronicle of a Death Foretold?","authors":"Thierry Berney, Olivier Thaunat, Ekaterine Berishvili","doi":"10.3389/ti.2025.14598","DOIUrl":"https://doi.org/10.3389/ti.2025.14598","url":null,"abstract":"Innovative solutions have entered the routine management of patients with type 1 diabetes or are making the headlines and this is shaking the world of beta cell replacement therapies. Above all, allogeneic islet transplantation is enthusiastically doomed to extinction by the aficionados of \"closed loop\" artificial insulin delivery systems or those convinced of the imminent large scale availability of stem-cell derived insulin-producing tissues. This opinion paper will propose that neither will be a universal solution in the very near future and will argue that xenogeneic islet transplantation may be a serious outsider in the race for new therapies. In the meantime, the odds are in favor of allogeneic islet (and pancreas) transplantation remaining first line options in the treatment of complicated type 1 diabetes. There is no question that \"closed loop\" systems have already greatly improved the management of type 1 diabetes, but, while \"unlimited\" sources of insulin-producing cells are jockeying for approval as standard-of-care, these improvements are more likely to drive a shift of indications -from islet transplant alone to simultaneous islet-kidney transplantation- than to herald the demise of islet transplantation.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14598"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up. 1型糖尿病β细胞替代疗法的最后一英里：是时候长大了。

IF 2.7 3区医学

Transplant International Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14565

Lorenzo Piemonti

{"title":"The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up.","authors":"Lorenzo Piemonti","doi":"10.3389/ti.2025.14565","DOIUrl":"https://doi.org/10.3389/ti.2025.14565","url":null,"abstract":"Beta cell replacement therapy for type 1 diabetes (T1D) is undergoing a transformative shift, driven by advances in stem cell biology, gene editing, and tissue engineering. While islet transplantation has demonstrated proof-of-concept success in restoring endogenous insulin production, its clinical impact remains limited by donor scarcity, immune rejection, and procedural complexities. The emergence of stem cell-derived beta-like cells represents a paradigm shift, with initial clinical trials showing promising insulin secretion in vivo. However, translating these breakthroughs into scalable, widely accessible treatments poses significant challenges. Drawing parallels to space exploration, this paper argues that while scientific feasibility has been demonstrated, true accessibility remains elusive. Without a strategic shift, beta cell therapy risks becoming an elite intervention, restricted by cost and infrastructure. Lessons from gene and cell therapies for rare diseases highlight the dangers of unsustainable pricing and limited market viability. To bridge the \"last mile\" a Quality by Design approach is proposed, emphasizing scalability, ease of use, and economic feasibility from the outset. By emphasizing practical implementation over academic achievements, corporate interests, market economics, or patent constraints, beta cell therapy can progress from proof-of-concept to a viable, widely accessible treatment.","PeriodicalId":23343,"journal":{"name":"Transplant International","volume":"38 ","pages":"14565"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Transplant for Acute Cholestatic Crisis in Sickle Cell Disease. 肝移植治疗镰状细胞病急性胆汁淤积危重症。

IF 2.7 3区医学

Transplant International Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14086

Sabrina Welland, Jan Christopher Kamp, Björn Hartleben, Richard Taubert, René Abu Isneineh

引用次数: 0

Transplant Trial Watch. 移植试验观察。

IF 2.7 3区医学

Transplant International Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.3389/ti.2025.14603

John O'Callaghan, John Fallon

引用次数: 0