Thoracic Cancer最新文献

{"title":"Central Nervous System Activity of Lazertinib in EGFR-Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG-LU20-15 and LU21-01.","authors":"Dong Hyun Kim, Min Hee Hong, Hyun Ae Jung, Tae Min Kim, Chang Gon Kim, Hee Kyung Ahn, Youngjoo Lee, Yu Jung Kim, Miso Kim, Jeonghwan Youk, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Dong-Wan Kim, Myung-Ju Ahn, Yoon Ji Choi, Sun Min Lim, Jin Hyoung Kang, Bhumsuk Keam, Hye Ryun Kim","doi":"10.1111/1759-7714.70387","DOIUrl":"10.1111/1759-7714.70387","url":null,"abstract":"<p><strong>Background: </strong>Central nervous system (CNS) involvement remains a major cause of mortality in patients with epidermal growth factor receptor (EGFR)-mutated nonsmall cell lung cancer (NSCLC), particularly, after progression on EGFR tyrosine kinase inhibitors (TKIs). This pooled analysis evaluated the efficacy of lazertinib in patients with EGFR-mutated NSCLC and CNS involvement, using data from two Phase II trials.</p><p><strong>Patients and methods: </strong>Patients with EGFR-mutated NSCLC and CNS involvement following prior EGFR TKI therapy enrolled in the KCSG-LU20-15 and KCSG-LU21-01 were included. Overall and intracranial objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS) were assessed.</p><p><strong>Results: </strong>Seventy-two patients were included. The median age was 63 years and 45 patients (62.5%) had leptomeningeal metastases (LM). T790M status was positive in 7 patients, negative in 44, and unknown in 21. Intracranial tumor responses were evaluable in 46 patients; the intracranial ORR was 50.0%, and the intracranial DCR was 97.8%. The median intracranial PFS was 15.2 months. Among 66 patients evaluable for systemic response, the overall ORR and DCR were 22.7% and 97.0%, respectively. The median PFS and overall survival were 10.6 and 17.8 months, respectively. Patients with LM experienced inferior OS and intracranial PFS compared with those without LM. No significant differences in clinical outcomes were observed according to T790M status.</p><p><strong>Conclusion: </strong>Lazertinib demonstrated meaningful CNS activity in patients with EGFR-mutated NSCLC and CNS involvement after prior EGFR TKI exposure, including those with LM. Notably, this activity was observed in a cohort with a low prevalence of confirmed T790M positivity.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70387"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Occurrence of Lung Cancer Leptomeningeal Metastasis and Era-Associated Post-LM Survival: A 14-Year Single-Center Cohort Study.","authors":"Xiaoxing Gao, Jie Gao, Qiuyue Ye, Chen Wei, Qing Zhou, Xiaoyan Liu, Minjiang Chen, Jing Zhao, Hanping Wang, Xiaoyan Si, Wei Zhong, Yan Xu, Mengzhao Wang","doi":"10.1111/1759-7714.70386","DOIUrl":"10.1111/1759-7714.70386","url":null,"abstract":"<p><strong>Introduction: </strong>Leptomeningeal metastasis (LM) is a devastating complication of lung cancer. We investigated the clinical and molecular evolution of LM in the modern targeted-therapy era and factors associated with post-LM survival.</p><p><strong>Methods: </strong>We retrospectively analyzed 201 patients with cytologically confirmed lung cancer LM diagnosed between November 2012 and May 2026. Patients were classified by LM diagnosis date (2012-2016 vs. 2017-2026). Intervals from lung cancer and Stage IV diagnosis to LM were compared using the Mann-Whitney U test. Paired primary tumor and cerebrospinal fluid (CSF) molecular profiles were assessed in 80 patients. Overall survival (OS) was evaluated using Kaplan-Meier and prespecified multivariable cox analyses.</p><p><strong>Results: </strong>Adenocarcinoma accounted for 93.0% of cases. The intervals from lung cancer and Stage IV diagnosis to LM were longer in the later cohort (23.7 vs. 13.8 months, p < 0.001; 17.4 vs. 10.4 months, p = 0.002). Unadjusted OS from LM diagnosis did not differ significantly between eras (9.8 vs. 11.3 months, p = 0.864). Tissue-CSF driver discordance occurred in 7/80 patients (8.75%). In multivariable analysis, later diagnostic era, smoking, and ECOG PS ≥ 2 were associated with higher mortality (adjusted HR, 1.826, p = 0.014; 1.847, p = 0.014; and 1.674, p = 0.007, respectively), whereas post-LM third-generation EGFR-TKI exposure was associated with lower mortality (adjusted HR, 0.385; p < 0.001).</p><p><strong>Conclusion: </strong>The later era was associated with a longer interval to LM diagnosis but no statistically significant improvement in unadjusted post-LM OS. Adjusted associations require cautious interpretation because of residual confounding and post-baseline treatment bias. CSF profiling may provide clinically relevant information beyond primary tumor genotyping.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70386"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Low-Grade Fibromyxoid Sarcoma of the Left Upper Lobe Treated With Uniportal Video-Assisted Thoracoscopic Lobectomy.","authors":"Giovanni Tacchi, Luca Frasca, Filippo Longo, Ilaria Suriano, Antonio Sarubbi, Lorenzo Nibid, Vincenzo Canalella, Pierfilippo Crucitti","doi":"10.1111/1759-7714.70391","DOIUrl":"10.1111/1759-7714.70391","url":null,"abstract":"<p><p>Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor that usually affects young adults and arises on the proximal extremities and trunk. Primary pulmonary LGFMS is an extremely rare entity. We reported a postsurgical diagnosis of a primary lung LGFMS in a patient with single pulmonary nodule located in the left upper lobe. A uniportal thoracoscopic lobectomy with mediastinal lymph node dissection was performed. The histopathological report supposed the hypothesis of a primary lung LGFMS. The immunohistochemical investigation yielded intense and diffuse positivity of the neoplastic cells for MUC-4. Next Generation Sequencing analysis showed the presence of EWSR1-CREB3L2 gene fusion that was previously reported in literature only in a single case. Histological and molecular diagnosis for LGFMS is challenging and therefore a dedicated pathologist opinion is warranted. Surgery is the gold-standard treatment for primary lung LGFMS and this is the first report about uniportal video-assisted thoracoscopic lobectomy performed for such disease.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 18","pages":"e70391"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) to Detect Missed Lung Nodules During Robot-Assisted Thoracoscopic Surgery.","authors":"Alfonso Fiorelli, Antonio Marella, Marco Aiello, Valentina Brancato, Marco Salvatore, Daniela Comunale, Francesco Ferrigno, Gaetana Messina","doi":"10.1111/1759-7714.70377","DOIUrl":"10.1111/1759-7714.70377","url":null,"abstract":"<p><p>Herein, we reported the use of Intraoperative-Contrast Enhanced Ultrasonography (Io-CEUS) during Robotic Assisted Thoracic Surgery (RATS) for identification of malignant lung nodule that was missed during previous operation. Pre-operative CT scan with 3D reconstruction defined the prompt position of the target lesion within S8 segment of right lower lobe and the anatomic landmarks as the distance from interlobar fissure and diaphragm. The lesion was then successfully detected by Io-CEUS. The different arterial enhancement observed during wash-in (hyperenhancement) and wash-out (hypo-enhancement) phases helped to differentiate the nodule from lung parenchyma. The lesion was resected by mechanical stapler and frozen section analysis diagnosed metastasis from colon carcinoma. Post-operative course was unremarkable; patient was discharged on post-operative day 3.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70377"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: PD-L1 Expressed From Tumor Cells Promotes Tumor Growth and Invasion in Lung Cancer via Modulating TGF-β1/SMAD4 Expression.","authors":"","doi":"10.1111/1759-7714.70390","DOIUrl":"10.1111/1759-7714.70390","url":null,"abstract":"<p><strong>Retraction: </strong>M.-J. Chen, Y.-C. Wang, L. Wang, C.-J. Shen, C.-Y. Chen and H. Lee, \"PD-L1 Expressed From Tumor Cells Promotes Tumor Growth and Invasion in Lung Cancer via Modulating TGF-β1/SMAD4 Expression,\" Thoracic Cancer 13, no. 9 (2022): 1322-1332, https://doi.org/10.1111/1759-7714.14388. The above article, published online on 04 April 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Tateaki Naito; China Lung Oncology Group; and John Wiley & Sons Australia, Ltd. The retraction has been agreed upon following concerns raised by a third party. An investigation identified several duplications between images presented in Figures 1c and 1d; 1a and 1d; 3a and 3c; 3c and 3d; and 4c and 4d. The authors were contacted to comment on the concerns and provide supporting data but did not respond. The editors consider the results and conclusions to be unreliable. The authors did not respond to the retraction notice.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 18","pages":"e70390"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia of Inflammation in Solid Tumor Patients and Practical Education for Oncologists and Nurses.","authors":"Xiaoyan Si, Xiaomin Wei, Xiaoyan Liu, Mei Li, Mengzhao Wang, Li Zhang","doi":"10.1111/1759-7714.70388","DOIUrl":"10.1111/1759-7714.70388","url":null,"abstract":"<p><p>Anemia is prevalent in patients with cancer, and anemia of inflammation (AI) is a common pathophysiological type. AI is mainly characterized by functional iron deficiency. This review summarizes the current knowledge regarding the epidemiology, clinical manifestations, molecular mechanisms, diagnostic criteria, and therapeutic advancements in cancer-related AI. It focuses on the central role of interleukin-6 (IL-6) and the emerging therapeutic strategies targeting the IL-6-hepcidin-ferroportin axis. Additionally, this review integrates practical educational content designed for oncologists and nurses to enhance their clinical competence in recognizing, diagnosing, and managing AI; it is essential to alleviate the symptom burden and improve the quality of life of patients with cancer.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70388"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extent of Endobronchial Ultrasound Nodal Sampling and Risk of Pathologic N2 Upstaging in Clinical N0-N1 Non-Small Cell Lung Cancer.","authors":"Min Jee Kim, Jae Cheol Lee, Chang-Min Choi, Sei Won Lee, Jae Seung Lee, Kyung-Wook Jo, Ho Cheol Kim, Jee Hwan Ahn, Jang Ho Lee, Dong-Gon Hyun, Wonjun Ji","doi":"10.1111/1759-7714.70365","DOIUrl":"10.1111/1759-7714.70365","url":null,"abstract":"<p><strong>Background: </strong>Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is strongly recommended for mediastinal staging in resectable non-small cell lung cancer (NSCLC). However, the optimal sampling extent remains uncertain. This study aimed to evaluate whether the extent of nodal sampling during staging EBUS is associated with pathologic N2 upstaging in clinical N0-N1 NSCLC.</p><p><strong>Methods: </strong>This retrospective cohort included patients with cN0-N1 NSCLC who underwent preoperative EBUS-TBNA between January 2022 and December 2023. Patients were stratified into three groups according to the number of sampled lymph node stations at the N2/N3 levels: Group 1, ≤ 1 mediastinal station at N2 or N3; Group 2, one N2 and one N3 station; Group 3, ≥ 3 stations, including at least one N2 and one N3. The primary outcome was pathologic N2 upstaging, defined as N2 disease confirmed on surgical pathology despite preoperative stage N0-N1.</p><p><strong>Results: </strong>A total of 418 patients were included (mean age, 68.6 years; 64.1% male). Most had adenocarcinoma (75.4%) and cN0 disease (94.7%). Group distribution was 140 (33.5%) in Group 1, 92 (22.0%) in Group 2, and 186 (44.5%) in Group 3. Pathologic N2 upstaging occurred in 21/140 (15.0%) in Group 1, 8/92 (8.7%) in Group 2, and 8/186 (4.3%) in Group 3. The rate decreased with increasing sampling, with Group 3 showing a lower rate than Group 1 (p = 0.005).</p><p><strong>Conclusions: </strong>Comprehensive staging EBUS-TBNA with ≥ 3 N2/N3 stations was associated with a lower rate of occult N2 upstaging in clinical N0-N1 NSCLC, underscoring the importance of comprehensive nodal evaluation for accurate staging.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70365"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Assisted Pulmonary Nodule Diagnosis by Thoracic Surgeons: A Comparative Study on Clinical Effectiveness.","authors":"Yeong Jeong Jeon, Jonghun Jeong, Doohyun Park, Jung-Hyun Kang, Eun Kyoung Hong, Younjoon Chung, Boram Park, Seong Yong Park","doi":"10.1111/1759-7714.70354","DOIUrl":"10.1111/1759-7714.70354","url":null,"abstract":"<p><strong>Main problem: </strong>Clinician experience variability affects lung cancer detection using computed tomography. AI-based computer-aided diagnosis (CAD) systems can improve diagnostic accuracy, but their influence on thoracic surgeons with varying experience is unclear. This study aimed to evaluate the impact of CAD system on thoracic surgeons' assessment of pulmonary nodule malignancy.</p><p><strong>Methods: </strong>A multireader, crossover study included 20 thoracic surgeons (8 junior, 12 senior). Each reader interpreted 100 anonymized pulmonary nodules twice-once with CAD and once without-following a washout period. Nodules were assessed using a 10-point likelihood of malignancy (LOM) scale and a binary (benign/malignant) assessment.</p><p><strong>Results: </strong>The CAD system demonstrated high malignancy prediction (AUROC = 0.929). CAD assistance significantly improved diagnostic accuracy across all readers (AUROC: 0.770-0.804, p = 0.0014 [BINARY]; 0.833-0.879, p < 0.001 [LOM]). Junior readers showed greater improvement (BINARY: 0.780-0.848, p < 0.001; LOM: 0.838-0.904, p < 0.001) compared with senior readers (BINARY: 0.763-0.775, p = 0.344; LOM: 0.831-0.862, p = 0.026). Specificity significantly increased with CAD (p = 0.008 overall, p < 0.001 junior readers), while sensitivity remained unchanged. Reading time slightly increased with CAD for benign cases (p < 0.05), but remained stable for malignant cases.</p><p><strong>Conclusions: </strong>The CAD system improved thoracic surgeons' diagnostic performance, especially junior readers, by enhancing specificity and overall accuracy. AI-based CAD systems are beneficial for reducing diagnostic variability and supporting lung nodule malignancy assessment by inexperienced thoracic surgeons.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 18","pages":"e70354"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Contrast-Enhanced Ultrasound to Assess Lymph Node Resection and Involvement in Patients Undergoing Robotic-Assisted Thoracic Surgery Lobectomy for Management of Non-Small Cell Lung Cancer.","authors":"Messina Gaetana, Morena Fasano, Davide Gerardo Pica, Giuseppe Vicario, Martina Robustelli, Vincenzo di Filippo, Francesca Capasso, Anna D'Agostino, Rosa Mirra, Beatrice Leonardi, Riccardo Vinciguerra, Alessia Angela Guarino, Ciro Balbo, Sara Di Lorenzo, Mariellina Laudato, Giovanni Vicidomini, Fortunato Ciardiello, Antonio D'Andrilli, Alfonso Fiorelli","doi":"10.1111/1759-7714.70308","DOIUrl":"10.1111/1759-7714.70308","url":null,"abstract":"<p><strong>Background: </strong>Mediastinal staging is crucial in patients undergoing lung resection for cancer to plan further adjuvant. Current guidelines recommend resecting at least three mediastinal lymph node stations, including Group7. Herein, we evaluated the role of intraoperative Contrast-enhanced ultrasound (CEUS) to guide lymph node resection in patients undergoing RATS lobectomy for management of non-small cell lung cancer.</p><p><strong>Methods: </strong>It was a retrospective study including 24 consecutive patients underwent RATS lobectomy for management lung cancer. The hilar and mediastinal lymph node was firstly evaluated with a CEUS and then resected. A bolus of 2.4 mL SonoVue was injected into the antecubital vein and the perfusion was scanned continuously for at least 3 min. The dynamic image obtained was used to evaluate the mediastinal and hilar lymph nodal and guide the dissection. A radical lymph-adenectomy was performed in all cases independently from the CEUS results.</p><p><strong>Results: </strong>We evaluated 144 lymph nodes with a CEUS during RATS lobectomy. Histological examination of the lymph nodes showed five lymph nodes metastatic (3.5%); of which 3 (60%) metastatic N1 lymph nodes; 2 (40%) metastatic N2 lymph nodes. Intraoperative CEUS of hilar and mediastinal lymph nodes showed: sensitivity 83%; specificity 98%; PPV, 77%; PNV, 99% and accuracy 94%.</p><p><strong>Conclusion: </strong>Our preliminary results seem to confirm the value of intraoperative CEUS to assess lymph node resection during RATS lobectomy. It may help the lymph node dissection and reduce the risk of intraoperative injury. Future study should confirm our preliminary results and confirm the value of intraoperative CEUS.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 18","pages":"e70308"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Rapid On-Site Evaluation (ROSE) vs. Frozen Section in Lung Surgery: A Prospective Study on Diagnostic Speed and Accuracy.","authors":"Honghai Ma, Lei Ke, Qiuming Chen, Qiuxiang Wang, Qihan You, Shi Feng, Wang Lv, Jian Hu, Luming Wang","doi":"10.1111/1759-7714.70385","DOIUrl":"10.1111/1759-7714.70385","url":null,"abstract":"<p><strong>Introduction: </strong>Frozen section (FS) is the most widely used method to assess resected pulmonary lesions intraoperatively, although it also prolongs the operation time. We aimed to evaluate the accuracy of intraoperative rapid on-site evaluation (ROSE) and evaluate whether it can serve as a faster auxiliary judgment alongside FS.</p><p><strong>Methods: </strong>A prospective study was conducted on patients undergoing complete resection. Rapid Romanowsky (DiffQuik) staining was used for ROSE. The results of intraoperative ROSE were compared with those of frozen section and final pathological diagnosis.</p><p><strong>Results: </strong>A total of 75 patients were enrolled in the study, and 81 samples were taken for ROSE, which could assess biopsied samples within a few minutes. The time required for ROSE is significantly shorter than that for intraoperative frozen section analysis, and the mean time to diagnosis was significantly shorter for ROSE (by surgeon) than for FS (9.75 min vs. 29.70 min, p < 0.001). The diagnostic accuracy of ROSE was 90.1% for surgeons, 95.6% for experienced pathologists, and 81.5% for junior pathologists, respectively.</p><p><strong>Conclusion: </strong>ROSE can serve as an auxiliary judgment tool, enabling frozen sections to make intraoperative decisions more rapidly. It is a valuable technique for diagnosing lung tumor intraoperatively.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":"17 17","pages":"e70385"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13545268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}