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Harmful Effects of Alcohol On Essential Physiological Organs 酒精对重要生理器官的有害影响
American Journal of Pharmacy And Health Research Pub Date : 2018-07-20 DOI: 10.46624/ajphr.2018.v6.i7.005
Shahnawaz Ahmad Teli, Y. Joshi
{"title":"Harmful Effects of Alcohol On Essential Physiological Organs","authors":"Shahnawaz Ahmad Teli, Y. Joshi","doi":"10.46624/ajphr.2018.v6.i7.005","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i7.005","url":null,"abstract":"Alcohol abuse is one of major and increasingly attributable risk factor for mortality and morbidity worldwide. The underlying purpose of this review is to promote awareness and significance in relation to the effects of alcohol on various body systems especially on cardiovascular system, liver, adipose tissue, skeletal muscle, brain, water and electrolyte metabolism and endocrine system. Alcohol when used above the normal range can results in harmful consequences on different biological organs. Average volumes consumed and patterns and frequency of drinking are three dimensions of alcohol consumption that need to be considered in efforts to reduce the burden of alcohol-related harmful effects. To reduce such harmful effects, national policies need to be developed to keep track of alcohol consumption and its consequences, and to raise awareness amongst the public. It is up to both public and concerned governments to encourage debate and formulate effective public health oriented policies and measures in order to minimize the harm caused by alcohol.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128230643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological account of Hibiscus Sabdariffa Linn. 芙蓉的药理作用。
American Journal of Pharmacy And Health Research Pub Date : 2018-07-20 DOI: 10.46624/ajphr.2018.v6.i7.006
S. Mulay
{"title":"Pharmacological account of Hibiscus Sabdariffa Linn.","authors":"S. Mulay","doi":"10.46624/ajphr.2018.v6.i7.006","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i7.006","url":null,"abstract":"Hibiscus sabdariffa Linn. is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine. The plant is reported to contain proteins, fats, carbohydrates, flavonoids, acids, minerals and vitamins. The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer and antioxidant properties. The present paper is an overview on its pharmacological properties reported in the literature. Keyword: Hibiscus sadariffa, Antihypertensive, Anticancer, Antioxidant, Flavonoids etc. Mulay et al., Am. J. Pharm Health Res 2018;6(06) ISSN: 2321-3647 www.ajphr.com 70 *Corresponding Author Email: sudhir_mulay@rediffmail.com Received 10 September 2018, Accepted October 2018","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"12 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113955832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy 用于偏头痛治疗的可生物降解负载苹果酸阿莫曲坦壳聚糖纳米颗粒的设计和表征
American Journal of Pharmacy And Health Research Pub Date : 2018-07-20 DOI: 10.46624/ajphr.2018.v6.i7.001
Akila Rm, Sneha Saju
{"title":"Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy","authors":"Akila Rm, Sneha Saju","doi":"10.46624/ajphr.2018.v6.i7.001","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i7.001","url":null,"abstract":"Nanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124025233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Formulation and Optimization of In-Situ Buffered Formulation Containing Indomethacin In Combination With Pantoprazole 吲哚美辛与泮托拉唑原位缓冲配方的制备及优化
American Journal of Pharmacy And Health Research Pub Date : 2018-07-20 DOI: 10.46624/ajphr.2018.v6.i7.002
Preeti Khulbe, Birendra Srivastava Pankaj sharma
{"title":"Formulation and Optimization of In-Situ Buffered Formulation Containing Indomethacin In Combination With Pantoprazole","authors":"Preeti Khulbe, Birendra Srivastava Pankaj sharma","doi":"10.46624/ajphr.2018.v6.i7.002","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i7.002","url":null,"abstract":"In-Situ buffer formulation contain agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. Here this approach is used for making combination capsule formulation to reduce the side effects of Nonsteroidal antiinflammatory drugs. Pantoprazole is an acid labile drug which is very useful for the prevention and treatment of NSAID related gastric ulcer, so to reduce its side effects this approach was used. In this Indomethacin is used as Nonsteroidal anti-inflammatory drugs. For this purpose, macroenvironment buffering method was used. Based on their acid neutralizing capacity the best buffering combination was selected. In this method immediate release excipients or superdisintegarnts (SSG & CCS) whereas rate retarding polymers (Guar gum, Xanthan gum & ethyl cellulose) were added in the formula. Ex vivo permeation study was performed by using Non-everted intestinal sac method in selected optimized batch. For optimization full factorial 2 design was used along with mathematical models. Prepared optimized formulation was compared with marketed formulation. Final pH from optimized formulation was found to be 5 to 6. The prepared optimized capsule is having 98.86% immediate release of pantoprazole sodium sesquihydrate upto 30 min and 99.84% sustain release of indomethacin upto 12 hrs. The prepared formulation showed immediate release of stable pantoprazole sodium sesquihydrate (due to the presence of in-situ buffering agents inside the capsule) along with the sustained release Indomethacin with very less adverse effects.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130521003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report on Thiazide-type Diuretic Induced Fixed Drug Eruption 噻嗪类利尿剂致固定药疹1例
American Journal of Pharmacy And Health Research Pub Date : 2018-07-20 DOI: 10.46624/ajphr.2018.v6.i7.004
R. Rawat, Y. Joshi, Ankita Sharma
{"title":"A Case Report on Thiazide-type Diuretic Induced Fixed Drug Eruption","authors":"R. Rawat, Y. Joshi, Ankita Sharma","doi":"10.46624/ajphr.2018.v6.i7.004","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i7.004","url":null,"abstract":"Fixed drug eruption (FDE) is one of the most common cutaneous adverse drug reactions in Indian patients. Chlorthalidone (CTD), a thiazide-type diuretic that inhibits distal convoluted tubule sodium and chloride resorption, is a commonly used oral antihypertensive. We are presenting a case of chlorthalidone induced FDE where a 75 year old hypertensive male admitted in hospital with complains of rashes associated with burning sensation on trunk, back and left arm after the administration of tablet chlorthalidone. FDE is believed to be a lymphocyte CD8-mediated reaction, wherein the offending drug may induce local reactivation of memory T cell lymphocytes localized in epidermal and dermal tissues and targeted initially by the viral infection. The initial treatment of FDE is discontinuation of the causative agent.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116690746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RP-HPLC Method Development and Validation for Simultaneous Estimation of Hydrocortisone and Acyclovir in Pharmaceutical dosage forms. 药品剂型中氢化可的松和阿昔洛韦同时测定的反相高效液相色谱方法的建立与验证。
American Journal of Pharmacy And Health Research Pub Date : 2018-06-20 DOI: 10.46624/ajphr.2018.v6.i6.002
R. M. Naik, Syed Ahmed, G. Naveen kumar Reddy
{"title":"RP-HPLC Method Development and Validation for Simultaneous Estimation of Hydrocortisone and Acyclovir in Pharmaceutical dosage forms.","authors":"R. M. Naik, Syed Ahmed, G. Naveen kumar Reddy","doi":"10.46624/ajphr.2018.v6.i6.002","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i6.002","url":null,"abstract":"The Chromatographic condition were successfully developed for the separation of Acyclovir and Hydrocortisone by using Agilent C8 column (25 cm x 4.6 mm i.d., 5 μ). A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Hydrocortisone and Acyclovir from pharmaceutical formulation. The method was carried out on a C8 (25 cm x 4.6 mm i.d., 5 μ) column with a mobile phase consisting of Methanol: water (adjusted to pH 3.0 using ophosphoric acid) in the ratio of 80:20 v/v. The retention time of Hydricortusone and Acyclovir was 3.50 min and 6.00 min respectively with the flow rate of 1mL/ min. Eluents were detected at 254 nm. The linear regression analysis data for the linearity plot showed good linear relationship with correlation coefficient value for Hydrocortisone and Acyclovir were R=0.9995 and R=0.9996 in the concentration range of 10-40μg. mL , 20-80 μg. mL respectively. The relative standard deviation for intra-day precision was lower than 2.0 %. The method was validated according to the ICH guidelines. The method was also found to be robust. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131633041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
In-Vitro Anticoagulant and Clot-Lysis Potential of Aqueous Extract of Datura Metel L. 曼陀罗水提物的体外抗凝血和凝块溶解电位。
American Journal of Pharmacy And Health Research Pub Date : 2018-06-20 DOI: 10.46624/ajphr.2018.v6.i6.003
A. Muchandi, Nitin S. Thorat, Suhas R. Mahanwar
{"title":"In-Vitro Anticoagulant and Clot-Lysis Potential of Aqueous Extract of Datura Metel L.","authors":"A. Muchandi, Nitin S. Thorat, Suhas R. Mahanwar","doi":"10.46624/ajphr.2018.v6.i6.003","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i6.003","url":null,"abstract":"Thromboembolic disorders affecting millions of people worldwide. Presently available anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation but having limited use due serious side effects. A medicinal herb Datura metel belongs to family Solanaceae, has been widely used in traditional medicine. In the present study, different concentrations (20-100 μg/ml) of aqueous extract of leaves of Datura metel was evaluated for in-vitro anticoagulant and clot lysis activity. The results showed that, there was concentration dependent increase in anticoagulant activity as a measure of increased prothrombin time activity. Similarly, there was concentration dependent increase in percentage clot lysis activity. A maximum 23.81% clot lysis activity was reported at concentration 100 μg/ml of extract. Thus, it was concluded that, aqueous extract of leaves of Datura metel has potential in-vitro anticoagulant and clot lysis activity and may be beneficial in the treatment of cardiovascular diseases.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132032159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Raoultella Ornithinolytica Urinary Tract Infections are on the Rise: A Case Report 尿路感染Raoultella ornithintica正在上升:一个病例报告
American Journal of Pharmacy And Health Research Pub Date : 2018-06-20 DOI: 10.46624/ajphr.2018.v6.i6.001
Atif Katib, Bassem A. Dakkak, H. Katib, S. Alem
{"title":"Raoultella Ornithinolytica Urinary Tract Infections are on the Rise: A Case Report","authors":"Atif Katib, Bassem A. Dakkak, H. Katib, S. Alem","doi":"10.46624/ajphr.2018.v6.i6.001","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i6.001","url":null,"abstract":"Community-acquire urinary tract infection (UTI) with Raoultella ornithinolytica is rare, with only 36 cases have been reported in the literature. The case in hand reports a 29 yrs. old lady with pelvic inflammatory disease who suffered from bothering irritative lower urinary tract symptoms (LUTS) ten days after removing an intrauterine contraceptive device. Urine culture recovered the rare bacterium of Raoultella ornithinolytica. Based on the sensitivity result, the patient has been treated with levofloxacin antibiotic and has responded favorably.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"59 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123630282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Evaluation of Antimicrobial Activity of Topical Niosomal Gel of ErythromycinFormulation and Evaluation of Antimicrobial Activity of Topical Niosomal Gel of Erythromycin 红霉素乳质体凝胶配方及抗菌活性评价。红霉素乳质体凝胶配方及抗菌活性评价
American Journal of Pharmacy And Health Research Pub Date : 2018-06-20 DOI: 10.46624/ajphr.2018.v6.i6.004
Nettem Lalithajyotsna, Mohammad Sarfaraz Ali Ahmed, Mahendar choudary, D. Bakshi
{"title":"Formulation and Evaluation of Antimicrobial Activity of Topical Niosomal Gel of ErythromycinFormulation and Evaluation of Antimicrobial Activity of Topical Niosomal Gel of Erythromycin","authors":"Nettem Lalithajyotsna, Mohammad Sarfaraz Ali Ahmed, Mahendar choudary, D. Bakshi","doi":"10.46624/ajphr.2018.v6.i6.004","DOIUrl":"https://doi.org/10.46624/ajphr.2018.v6.i6.004","url":null,"abstract":"Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. The drugs in the form of topical gels avoid gastro-intestinal irritation, to overcome first pass effect and to maximize the drug concentration at the site of action. The main objective of the study is to formulate and evaluate the antimicrobial activity of erythromycin formulation for effective topical delivery of the drug. The antimicrobial activity of the erythromycin loaded gel is carried by cup-plate method and the zone of inhibition was noted. The current analysis demonstrates persistence release of drug, an increase in amount of drug maintenance into skin and enhanced permeation across the skin after entrapment of Erythromycin into niosomal topical gel.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129498026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Formulation and Characterization of Solid Lipid Microparticles 固体脂质微颗粒的制备与表征
American Journal of Pharmacy And Health Research Pub Date : 1900-01-01 DOI: 10.46624/ajphr.2019.v7.i4.002
Adnya D. Bahurupi, Prashant J. Burange, M. Tawar, Shital R. Ingole
{"title":"Formulation and Characterization of Solid Lipid Microparticles","authors":"Adnya D. Bahurupi, Prashant J. Burange, M. Tawar, Shital R. Ingole","doi":"10.46624/ajphr.2019.v7.i4.002","DOIUrl":"https://doi.org/10.46624/ajphr.2019.v7.i4.002","url":null,"abstract":"The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based microparticles (SLMs) has advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid microparticles.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130440582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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