{"title":"用于偏头痛治疗的可生物降解负载苹果酸阿莫曲坦壳聚糖纳米颗粒的设计和表征","authors":"Akila Rm, Sneha Saju","doi":"10.46624/ajphr.2018.v6.i7.001","DOIUrl":null,"url":null,"abstract":"Nanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy\",\"authors\":\"Akila Rm, Sneha Saju\",\"doi\":\"10.46624/ajphr.2018.v6.i7.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics.\",\"PeriodicalId\":233230,\"journal\":{\"name\":\"American Journal of Pharmacy And Health Research\",\"volume\":\"26 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Pharmacy And Health Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46624/ajphr.2018.v6.i7.001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pharmacy And Health Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46624/ajphr.2018.v6.i7.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy
Nanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics.
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