American Journal of Pharmacy And Health Research最新文献

Theoretical Models For Photocatalysis Process 光催化过程的理论模型

American Journal of Pharmacy And Health Research Pub Date : 2021-12-20 DOI: 10.46624/ajphr.2021.v9.i12.001

T. Marsagishvili, M. Machavariani, G. Tatishvili, E. Tskhakaia, R. Agladze

引用次数: 2

Non-Steroidal Anti-Inflammatory Drugs Current Challenges and Future Perceptions 非甾体抗炎药当前的挑战和未来的看法

American Journal of Pharmacy And Health Research Pub Date : 2021-12-20 DOI: 10.46624/ajphr.2021.v9.i12.003

K. Malleswari⃰, D. R. Reddy, K. C. Sri, D. B. Vali, G. Suresh

引用次数: 0

The Therapeutic Action of Queen of Herb (Ocimum Tenuiflorum) 中药皇后茴香的治疗作用

American Journal of Pharmacy And Health Research Pub Date : 2021-12-20 DOI: 10.46624/ajphr.2021.v9.i12.002

Sagar B. Marathe, Mali Naitik, Azam Z. Shaikh

引用次数: 0

In-vitro Anti Arthritic Activity potentials of Erythroxylum monogynum leaves Hydro-alcoholic Extract 红草叶水醇提取物体外抗关节炎活性的研究

American Journal of Pharmacy And Health Research Pub Date : 2021-11-20 DOI: 10.46624/ajphr.2021.v9.i11.001

Sudharshana Raju Ambati, B. Reddy, Manibangaru Jyothi Priya, D., Sunil, M. B. Sri, M. Anjali

{"title":"In-vitro Anti Arthritic Activity potentials of Erythroxylum monogynum leaves Hydro-alcoholic Extract","authors":"Sudharshana Raju Ambati, B. Reddy, Manibangaru Jyothi Priya, D., Sunil, M. B. Sri, M. Anjali","doi":"10.46624/ajphr.2021.v9.i11.001","DOIUrl":"https://doi.org/10.46624/ajphr.2021.v9.i11.001","url":null,"abstract":"Rheumatoid arthritis (RA) is an evolving, enduring, and a crippling disorder categorized by puffiness, agony, and synovial joints arduousness. The exact reason of this devastating illness is mysterious. However, it is strongly linked to self-protection reaction triggered by various genetic and external factors. The current research work was designed to explore the anti-arthritic probable of the plant Erythroxylum monogynum. The plant leaves was collected, shade dried, blended and extracted (continuous hot percolation) with Hydro-alcoholic solvent. Preliminary phytochemical evaluation were carried out. Entirely the in-vitro models i.e. inhibition of protein denaturation, membrane stabilization and proteinase inhibition were carried out by using standard reference drug diclofenac sodium. In the present study there was significant (p<0.05) inhibition of protein denaturation in both standard and extract treated group and % inhibition of protein denaturation produced by extract at concentrations 100 and 300?g/ml exhibited improved activity than standard (Diclofenac sodium). From the results of the present study it can be stated that Erythroxylum monogynum may control the production of auto-antigens by preventing in-vivo denaturation of proteins in rheumatic diseases. Dose based and significant (p<0.05)of anti arthritic activity in in-vitro designs were found. The results disclose hopeful anti arthritic probables of the herb. However further pharmacological investigation using isolated active ingredients can be carried out to confirm its usefulness and effectiveness.","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131932203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Nanocarriers Third Generation As Targeted Delivery Systems for Cancer Therapy 第三代纳米载体作为肿瘤靶向递送系统的研究进展

American Journal of Pharmacy And Health Research Pub Date : 2021-10-25 DOI: 10.46624/ajphr.2021.v9.i10.001

M. Chandira

引用次数: 0

A Review on Chemistry of Anti-malarials 抗疟疾药物化学研究进展

American Journal of Pharmacy And Health Research Pub Date : 2021-10-25 DOI: 10.46624/ajphr.2021.v9.i10.002

P. M. Chandira, CH. Nvs Mastanrao, B. Venkateswarlu

引用次数: 0

Peroxisome Proliferator-Activated Receptors: A New Ray Of Hope For Parkinson’s Disease 过氧化物酶体增殖物激活受体:帕金森病的新希望

American Journal of Pharmacy And Health Research Pub Date : 2021-09-25 DOI: 10.46624/ajphr.2021.v9.i9.003

R. Bhatt, S. Parmar

{"title":"Peroxisome Proliferator-Activated Receptors: A New Ray Of Hope For Parkinson’s Disease","authors":"R. Bhatt, S. Parmar","doi":"10.46624/ajphr.2021.v9.i9.003","DOIUrl":"https://doi.org/10.46624/ajphr.2021.v9.i9.003","url":null,"abstract":"PD (PD) is a debilitating progressive age-related neurodegenerative disorder that negatively \u0000impacts bodily movement. It is the second most common type of neurodegenerative disease after \u0000Alzheimer's disease. Although the etiology and pathogenesis of PD remain unknown, a vast body \u0000of evidence indicates that oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, \u0000and proteasomal dysfunction all play a role in the disease's pathogenesis. Because of the \u0000multifactorial nature of the disease, current drug treatment can only offer symptomatic relief and \u0000cannot stop or delay the disease progression. The Peroxisome proliferator-activated receptors \u0000(PPARs) are the member of the receptor’s superfamily called, nuclear receptors, regulates the \u0000growth, differentiation of the tissues, inflammation, mitochondrial function, wound healing, lipid \u0000metabolism, and glucose metabolism. Several PPAR agonists have recently been shown to \u0000protect neurons from oxidative damage, inflammation, and apoptosis in Alzheimer's disease, PD, \u0000Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. We review the \u0000research on the neuroprotective effects of PPAR agonists in in-vitro and in-vivo models of PD in \u0000this paper. Similarly, the pharmacological mechanism of PPAR agonists' neuroprotective effects \u0000is examined. Finally, PPAR agonists exert neuroprotective effects by controlling the expression \u0000of a set of genes involved in cell survival processes, suggesting that they may be a potential \u0000therapeutic target in crippling neurodegenerative diseases like PD. \u0000Keywords: Parkinson’s disease, neuroprotective, neuro inflammatory, oxidative stress, PPAR \u0000agonist","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116277622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Sustained Release Floating Pellets of Amlodipine Besylate 苯磺酸氨氯地平缓释漂浮微丸的研制与评价

American Journal of Pharmacy And Health Research Pub Date : 2021-09-25 DOI: 10.46624/ajphr.2021.v9.i9.002

K. Manjunath, S. V. Kulkarni

{"title":"Formulation and Evaluation of Sustained Release Floating Pellets of Amlodipine Besylate","authors":"K. Manjunath, S. V. Kulkarni","doi":"10.46624/ajphr.2021.v9.i9.002","DOIUrl":"https://doi.org/10.46624/ajphr.2021.v9.i9.002","url":null,"abstract":"The aim of the present study is to design and develop sustained release pellets formulations for \u0000Amlodipine besylate. Amlodipine is an oral antihypertensive agent, commonly used as calcium \u0000channel blocker for treating high blood pressure. It is frequently used to treat heart diseases like \u0000angina pectoris. The dose of Amlodipine in case of hypertension or angina initially 5 mg daily \u0000later adjusted to 10 mg daily by oral route. Amlodipine has a maximum solubility in acidic pH. \u0000Amlodipine has a high bioavailability ranging from 60 to 80 % and slow rate of elimination. \u0000Amlodipine besylate at different drug to polymer ratios were prepared by extrusion and \u0000spheronization technique. The influence of the proportion of the polymer on the release rate of \u0000the drug from the pellets was studied. The in-vitro release studies of pellets were carried out in \u00000.1N HCl for 12 hours. The studies indicated that the drug release can be modulated by varying \u0000the concentration of the polymer. Pellets were prepared and evaluated for loose bulk density, \u0000tapped bulk density, compressibility index and angle of repose, shows satisfactory results. \u0000Formulation was optimized on the basis of acceptable pellet properties and in-vitro drug release. \u0000The resulting formulation produced robust pellets with acceptable drug content and low \u0000friability. The release data was fitted to various mathematical models such as, Higuchi, \u0000Korsmeyer- Peppas, First-order and Zero-order to evaluate the kinetics and mechanism of the \u0000drug release. \u0000Keywords: Sustained release, Ethyl cellulose, HPMC, Pellets, Amlodipine besylate","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"286 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116856506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prospective Study on Evaluation of Efficacy of Combination Therapy of Tamsulosin and Deflazacort In Ureteric Stone Expulsion 坦索罗辛与地沙可联合治疗输尿管结石排出的前瞻性研究

American Journal of Pharmacy And Health Research Pub Date : 2021-09-25 DOI: 10.46624/ajphr.2021.v9.i9.001

S. Kumar, E. J. Kumar, Marylynn Samson, Catherine Samantha

{"title":"A Prospective Study on Evaluation of Efficacy of Combination Therapy of Tamsulosin and Deflazacort In Ureteric Stone Expulsion","authors":"S. Kumar, E. J. Kumar, Marylynn Samson, Catherine Samantha","doi":"10.46624/ajphr.2021.v9.i9.001","DOIUrl":"https://doi.org/10.46624/ajphr.2021.v9.i9.001","url":null,"abstract":"The patients with ureteric stone are increasing day by day all over the world. A ureteric stone is a \u0000mineral mass in the ureter which may or may not originated in the kidney and travelled down to \u0000the ureter. The presence of stone in ureter causes inflammation and edema. There are mainly four \u0000types of ureteric stone such as Calcium stones, Uric acid stones, Struvite stone, Cystine stone. \u0000About 23-53% of spontaneous stone expulsion occurs where the size of stone is 5-10mm \u0000diameter. Tamsulosin is an alpha 1 adrenergic blocker which has a spasmolytic action and thus \u0000hasten stone expulsion. Deflazacort is a corticosteroid prodrug which acts on the glucocorticoid \u0000receptor to show an anti-inflammatory effect. Deflazacort decreases the edema and when \u0000prescribed along with alpha 1 adrenergic receptor blocker it facilitate the expulsion of calculi. \u0000This study was conducted in 20 patients diagnosed with ureteric calculi. The study was \u0000conducted by using suitable proforma for collecting various data’s like site of stones, presence of \u0000hydronephrosis, signs and symptoms. Health related quality of life of the patients with ureteric \u0000calculi under the treatment of Tamsulosin and Deflazacort combination were assessed by using \u0000Wisconsin Stone-QOL questionnaire. As counselling aid patients information leaflet was \u0000provided. The patients were asked to review after 10 days of taking the medication. At the end of \u0000the study all the parameters and scores were compared with baseline to the end of the study. In \u0000our study we analyzed that the data collected from 20 patients diagnosed with ureteric calculi \u0000accessed the improvement of quality of life of patients under the treatment of Tamsulosin and \u0000Deflazacort combination by using Wisconsin Stone-QOL questionnaire. The observed difference \u0000before and after the treatment with Tamsulosin and Deflazacort w","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131384193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Antibiotic use in Pregnant Women in a Tertiary care Teaching Hospital – A Cross Sectional Observational Study 三级护理教学医院孕妇抗生素使用评估——一项横断面观察研究

American Journal of Pharmacy And Health Research Pub Date : 2021-08-25 DOI: 10.46624/ajphr.2021.v9.i8.005

Rahul Sabbu, Anienye Prince, Doddaya Hiremath

{"title":"Assessment of Antibiotic use in Pregnant Women in a Tertiary care Teaching Hospital – A Cross Sectional Observational Study","authors":"Rahul Sabbu, Anienye Prince, Doddaya Hiremath","doi":"10.46624/ajphr.2021.v9.i8.005","DOIUrl":"https://doi.org/10.46624/ajphr.2021.v9.i8.005","url":null,"abstract":"During pregnancy, most women are at risk for respiratory tract infections (RTIs), urinary tract \u0000infections (UTIs), and ear, nose, and throat infections. Antimicrobials are the most commonly \u0000given medications to treat acquired illnesses during this time. This study aimed to assess \u0000antibiotic use in pregnant women in a tertiary care teaching hospital. The present study was a \u0000cross- sectional prospective observational study and was conducted for three months in a tertiary \u0000care health centre in North Karnataka with 57 participants.All case records of pregnant women \u0000who use antibiotics admitted to Obstetrics and Gynecology department and pregnant women \u0000with more than 18 years of age were included in the study. Out of 57 participants, 40.3% of them \u0000were belonging to the age category of 19-23 years of age, followed by 33.3% in 24-28 years. \u0000Most prevalent infections which required antimicrobials prescription were UTIs (36.82%), \u0000followed by Gastroenteritis (17.54%) and Pyrexia (14.03%). Majority of the antimicrobials \u0000prescribed were from Betalactams (40.34%), followed by Nitrofuranes (29.82%). To assist in \u0000making prescribing decisions for pregnant women, health care professionals should examine the \u0000teratogenic and toxic risk profiles of antibiotics. These could be especially significant if anti-\u0000infective countermeasures are needed to safeguard the health, safety, and survival of people who \u0000have been exposed to pathogenic bacteriologic agents as a result of bioterrorism. \u0000Keywords: Antimicrobials, pregnancy, teratogenic effect, urinary tract infections","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123924006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0