S. Kumar, E. J. Kumar, Marylynn Samson, Catherine Samantha
{"title":"A Prospective Study on Evaluation of Efficacy of Combination Therapy of Tamsulosin and Deflazacort In Ureteric Stone Expulsion","authors":"S. Kumar, E. J. Kumar, Marylynn Samson, Catherine Samantha","doi":"10.46624/ajphr.2021.v9.i9.001","DOIUrl":null,"url":null,"abstract":"The patients with ureteric stone are increasing day by day all over the world. A ureteric stone is a \nmineral mass in the ureter which may or may not originated in the kidney and travelled down to \nthe ureter. The presence of stone in ureter causes inflammation and edema. There are mainly four \ntypes of ureteric stone such as Calcium stones, Uric acid stones, Struvite stone, Cystine stone. \nAbout 23-53% of spontaneous stone expulsion occurs where the size of stone is 5-10mm \ndiameter. Tamsulosin is an alpha 1 adrenergic blocker which has a spasmolytic action and thus \nhasten stone expulsion. Deflazacort is a corticosteroid prodrug which acts on the glucocorticoid \nreceptor to show an anti-inflammatory effect. Deflazacort decreases the edema and when \nprescribed along with alpha 1 adrenergic receptor blocker it facilitate the expulsion of calculi. \nThis study was conducted in 20 patients diagnosed with ureteric calculi. The study was \nconducted by using suitable proforma for collecting various data’s like site of stones, presence of \nhydronephrosis, signs and symptoms. Health related quality of life of the patients with ureteric \ncalculi under the treatment of Tamsulosin and Deflazacort combination were assessed by using \nWisconsin Stone-QOL questionnaire. As counselling aid patients information leaflet was \nprovided. The patients were asked to review after 10 days of taking the medication. At the end of \nthe study all the parameters and scores were compared with baseline to the end of the study. In \nour study we analyzed that the data collected from 20 patients diagnosed with ureteric calculi \naccessed the improvement of quality of life of patients under the treatment of Tamsulosin and \nDeflazacort combination by using Wisconsin Stone-QOL questionnaire. The observed difference \nbefore and after the treatment with Tamsulosin and Deflazacort w","PeriodicalId":233230,"journal":{"name":"American Journal of Pharmacy And Health Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pharmacy And Health Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46624/ajphr.2021.v9.i9.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The patients with ureteric stone are increasing day by day all over the world. A ureteric stone is a
mineral mass in the ureter which may or may not originated in the kidney and travelled down to
the ureter. The presence of stone in ureter causes inflammation and edema. There are mainly four
types of ureteric stone such as Calcium stones, Uric acid stones, Struvite stone, Cystine stone.
About 23-53% of spontaneous stone expulsion occurs where the size of stone is 5-10mm
diameter. Tamsulosin is an alpha 1 adrenergic blocker which has a spasmolytic action and thus
hasten stone expulsion. Deflazacort is a corticosteroid prodrug which acts on the glucocorticoid
receptor to show an anti-inflammatory effect. Deflazacort decreases the edema and when
prescribed along with alpha 1 adrenergic receptor blocker it facilitate the expulsion of calculi.
This study was conducted in 20 patients diagnosed with ureteric calculi. The study was
conducted by using suitable proforma for collecting various data’s like site of stones, presence of
hydronephrosis, signs and symptoms. Health related quality of life of the patients with ureteric
calculi under the treatment of Tamsulosin and Deflazacort combination were assessed by using
Wisconsin Stone-QOL questionnaire. As counselling aid patients information leaflet was
provided. The patients were asked to review after 10 days of taking the medication. At the end of
the study all the parameters and scores were compared with baseline to the end of the study. In
our study we analyzed that the data collected from 20 patients diagnosed with ureteric calculi
accessed the improvement of quality of life of patients under the treatment of Tamsulosin and
Deflazacort combination by using Wisconsin Stone-QOL questionnaire. The observed difference
before and after the treatment with Tamsulosin and Deflazacort w