A Prospective Study on Evaluation of Efficacy of Combination Therapy of Tamsulosin and Deflazacort In Ureteric Stone Expulsion

S. Kumar, E. J. Kumar, Marylynn Samson, Catherine Samantha
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Abstract

The patients with ureteric stone are increasing day by day all over the world. A ureteric stone is a mineral mass in the ureter which may or may not originated in the kidney and travelled down to the ureter. The presence of stone in ureter causes inflammation and edema. There are mainly four types of ureteric stone such as Calcium stones, Uric acid stones, Struvite stone, Cystine stone. About 23-53% of spontaneous stone expulsion occurs where the size of stone is 5-10mm diameter. Tamsulosin is an alpha 1 adrenergic blocker which has a spasmolytic action and thus hasten stone expulsion. Deflazacort is a corticosteroid prodrug which acts on the glucocorticoid receptor to show an anti-inflammatory effect. Deflazacort decreases the edema and when prescribed along with alpha 1 adrenergic receptor blocker it facilitate the expulsion of calculi. This study was conducted in 20 patients diagnosed with ureteric calculi. The study was conducted by using suitable proforma for collecting various data’s like site of stones, presence of hydronephrosis, signs and symptoms. Health related quality of life of the patients with ureteric calculi under the treatment of Tamsulosin and Deflazacort combination were assessed by using Wisconsin Stone-QOL questionnaire. As counselling aid patients information leaflet was provided. The patients were asked to review after 10 days of taking the medication. At the end of the study all the parameters and scores were compared with baseline to the end of the study. In our study we analyzed that the data collected from 20 patients diagnosed with ureteric calculi accessed the improvement of quality of life of patients under the treatment of Tamsulosin and Deflazacort combination by using Wisconsin Stone-QOL questionnaire. The observed difference before and after the treatment with Tamsulosin and Deflazacort w
坦索罗辛与地沙可联合治疗输尿管结石排出的前瞻性研究
输尿管结石患者在世界范围内日益增多。输尿管结石是输尿管内的一种矿物块,可能起源于肾脏,也可能不是,并向下移动到输尿管。输尿管结石会引起炎症和水肿。输尿管结石主要有四种类型:钙结石、尿酸结石、鸟粪石结石、胱氨酸结石。约23-53%的自发排石发生在结石直径为5-10mm的地方。坦索罗辛是一种α - 1肾上腺素能阻滞剂,具有解痉作用,从而加速结石排出。地拉法柯是一种皮质类固醇前药,作用于糖皮质激素受体,具有抗炎作用。地拉法柯可减少水肿,当与α - 1肾上腺素受体阻滞剂一起使用时,可促进结石的排出。本研究对20例诊断为输尿管结石的患者进行了研究。该研究采用合适的形式收集各种数据,如结石的位置,肾积水的存在,体征和症状。采用威斯康辛石-生活质量问卷评估坦索罗新与地拉法柯联合治疗输尿管结石患者的健康相关生活质量。作为咨询援助,向病人提供了资料单张。患者被要求在服药10天后进行复查。在研究结束时,将所有参数和分数与研究结束时的基线进行比较。本研究收集了20例输尿管结石患者的资料,采用Wisconsin Stone-QOL问卷分析坦索罗新与地拉法柯联合治疗对患者生活质量的改善情况。观察坦索罗辛与地扎克特治疗前后的差异
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