A Case Report on Thiazide-type Diuretic Induced Fixed Drug Eruption

Abstract

Fixed drug eruption (FDE) is one of the most common cutaneous adverse drug reactions in Indian patients. Chlorthalidone (CTD), a thiazide-type diuretic that inhibits distal convoluted tubule sodium and chloride resorption, is a commonly used oral antihypertensive. We are presenting a case of chlorthalidone induced FDE where a 75 year old hypertensive male admitted in hospital with complains of rashes associated with burning sensation on trunk, back and left arm after the administration of tablet chlorthalidone. FDE is believed to be a lymphocyte CD8-mediated reaction, wherein the offending drug may induce local reactivation of memory T cell lymphocytes localized in epidermal and dermal tissues and targeted initially by the viral infection. The initial treatment of FDE is discontinuation of the causative agent.