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Parathyroid hormone–PTH1R signaling in cardiovascular disease and homeostasis 心血管疾病和稳态中的甲状旁腺激素-PTH1R 信号转导
Trends in Endocrinology & Metabolism Pub Date : 2024-02-29 DOI: 10.1016/j.tem.2024.02.005
Dwight A. Towler
{"title":"Parathyroid hormone–PTH1R signaling in cardiovascular disease and homeostasis","authors":"Dwight A. Towler","doi":"10.1016/j.tem.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.tem.2024.02.005","url":null,"abstract":"Primary hyperparathyroidism (pHPT) afflicts our aging population with an incidence approaching 50 per 100 000 patient-years at a female:male ratio of ~3:1. Decisions surrounding surgical management are currently driven by age, hypercalcemia severity, presence of osteoporosis, renal insufficiency, or hypercalciuria with or without nephrolithiasis. Cardiovascular (CV) disease (CVD) is not systematically considered. This is notable since the parathyroid hormone (PTH) 1 receptor (PTH1R) is biologically active in the vasculature, and adjusted CV mortality risk is increased almost threefold in individuals with pHPT who do not meet contemporary recommendations for surgical cure. We provide an overview of epidemiology, pharmacology, and physiology that highlights the need to: (i) identify biomarkers that establish a healthy ‘set point’ for CV PTH1R signaling tone; (ii) better understand the pharmacokinetic–pharmacodynamic (PK-PD) relationships of PTH1R ligands in CV homeostasis; and (iii) incorporate CVD risk assessment into the management of hyperparathyroidism.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140011615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin K-dependent carboxylation in β-cells and diabetes β细胞中依赖维生素 K 的羧化作用与糖尿病
Trends in Endocrinology & Metabolism Pub Date : 2024-02-29 DOI: 10.1016/j.tem.2024.02.006
Julie Lacombe, Mathieu Ferron
{"title":"Vitamin K-dependent carboxylation in β-cells and diabetes","authors":"Julie Lacombe, Mathieu Ferron","doi":"10.1016/j.tem.2024.02.006","DOIUrl":"https://doi.org/10.1016/j.tem.2024.02.006","url":null,"abstract":"Vitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins in β-cells, including endoplasmic reticulum Gla protein (ERGP), implicated in the control of intracellular Ca levels. In this review we discuss these recent advances linking vitamin K and glucose metabolism, and argue that identification of γ-carboxylated proteins in β-cells is pivotal to better understand how vitamin K protects from T2D and to design targeted therapies for this disease.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"258 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140011660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysine lactylation in the regulation of tumor biology 调控肿瘤生物学的赖氨酸乳化作用
Trends in Endocrinology & Metabolism Pub Date : 2024-02-22 DOI: 10.1016/j.tem.2024.01.011
Zijian Yang, Yingqi Zheng, Qiang Gao
{"title":"Lysine lactylation in the regulation of tumor biology","authors":"Zijian Yang, Yingqi Zheng, Qiang Gao","doi":"10.1016/j.tem.2024.01.011","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.011","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary methionine restriction in cancer development and antitumor immunity 膳食蛋氨酸限制在癌症发展和抗肿瘤免疫中的作用
Trends in Endocrinology & Metabolism Pub Date : 2024-02-20 DOI: 10.1016/j.tem.2024.01.009
Ming Ji, Qing Xu, Xiaoling Li
{"title":"Dietary methionine restriction in cancer development and antitumor immunity","authors":"Ming Ji, Qing Xu, Xiaoling Li","doi":"10.1016/j.tem.2024.01.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.009","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139917098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
Trends in Endocrinology & Metabolism Pub Date : 2024-02-12 DOI: 10.1016/s1043-2760(24)00005-5
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1043-2760(24)00005-5","DOIUrl":"https://doi.org/10.1016/s1043-2760(24)00005-5","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139917025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
Trends in Endocrinology & Metabolism Pub Date : 2024-02-12 DOI: 10.1016/s1043-2760(24)00008-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(24)00008-0","DOIUrl":"https://doi.org/10.1016/s1043-2760(24)00008-0","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139917122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise is also medicine for iron homeostasis 运动也是促进铁平衡的良药
Trends in Endocrinology & Metabolism Pub Date : 2024-02-02 DOI: 10.1016/j.tem.2024.01.010
Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces
{"title":"Exercise is also medicine for iron homeostasis","authors":"Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces","doi":"10.1016/j.tem.2024.01.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.010","url":null,"abstract":"<p>High-intensity interval training (HIIT) is gaining popularity as an effective exercise modality to improve cardiometabolic health. Combining high-throughput/sensitivity proteome analyses in subcutaneous adipose tissue with biochemical blood measures, Larsen <em>et al.</em> recently provided mechanistic insights into a potential beneficial role of this exercise modality on iron homeostasis at the whole-body level.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing evidence for immune surveillance of β-cell senescence 建立免疫监视β细胞衰老的证据
Trends in Endocrinology & Metabolism Pub Date : 2024-02-02 DOI: 10.1016/j.tem.2024.01.003
Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson
{"title":"Establishing evidence for immune surveillance of β-cell senescence","authors":"Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson","doi":"10.1016/j.tem.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.003","url":null,"abstract":"<p>Cellular senescence is a programmed state of cell cycle arrest that involves a complex immunogenic secretome, eliciting immune surveillance and senescent cell clearance. Recent work has shown that a subpopulation of pancreatic β-cells becomes senescent in the context of diabetes; however, it is not known whether these cells are normally subject to immune surveillance. In this opinion article, we advance the hypothesis that immune surveillance of β-cells undergoing a senescence stress response normally limits their accumulation during aging and that the breakdown of these mechanisms is a driver of senescent β-cell accumulation in diabetes. Elucidation and therapeutic activation of immune surveillance mechanisms in the pancreas holds promise for the improvement of approaches to target stressed senescent β-cells in the treatment of diabetes.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders 针对代谢、昼夜节律和睡眠障碍的体外下丘脑病理生理学建模
Trends in Endocrinology & Metabolism Pub Date : 2024-02-01 DOI: 10.1016/j.tem.2024.01.001
Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas
{"title":"Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders","authors":"Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas","doi":"10.1016/j.tem.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.001","url":null,"abstract":"<p>The hypothalamus, a small and intricate brain structure, orchestrates numerous neuroendocrine functions through specialized neurons and nuclei. Disruption of this complex circuitry can result in various diseases, including metabolic, circadian, and sleep disorders. Advances in <em>in vitro</em> models and their integration with new technologies have significantly benefited research on hypothalamic function and pathophysiology. We explore existing <em>in vitro</em> hypothalamic models and address their challenges and limitations as well as translational findings. We also highlight how collaborative efforts among multidisciplinary teams are essential to develop relevant and translational experimental models capable of replicating intricate neural circuits and neuroendocrine pathways, thereby advancing our understanding of therapeutic targets and drug discovery in hypothalamus-related disorders.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology of human mitochondrial tRNA metabolism 人类线粒体 tRNA 代谢的病理生理学
Trends in Endocrinology & Metabolism Pub Date : 2024-02-01 DOI: 10.1016/j.tem.2024.01.002
Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou
{"title":"Pathophysiology of human mitochondrial tRNA metabolism","authors":"Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou","doi":"10.1016/j.tem.2024.01.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.002","url":null,"abstract":"<p><span>Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various </span>mitochondrial diseases<span> caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes.</span></p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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