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Adipose tissue-targeting nanomedicines for obesity pharmacotherapy. 脂肪组织靶向纳米药物用于肥胖药物治疗。
Trends in Endocrinology & Metabolism Pub Date : 2025-04-14 DOI: 10.1016/j.tem.2025.03.010
Lingling Wang,Qingyi Jia,Jinhan He,Yanping Li
{"title":"Adipose tissue-targeting nanomedicines for obesity pharmacotherapy.","authors":"Lingling Wang,Qingyi Jia,Jinhan He,Yanping Li","doi":"10.1016/j.tem.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.010","url":null,"abstract":"The increasing global prevalence of obesity presents a substantial challenge to public health. Current nutrient-stimulated hormone (NuSH)-based therapeutics are hindered by receptor desensitization, muscle loss, and weight regain. The adipose tissue, the primary organ responsible for energy storage and metabolic management, is a promising target for obesity treatment. Nanomedicine holds promise to precisely deliver medication to the adipose tissue to maximize therapeutic efficacy and minimize off-target effects; indeed, various adipose tissue-targeting nanomedicines have shown impressive anti-obesity effects by optimizing drug pharmacokinetic profiles and reducing nonspecific distribution in preclinical studies. Here we examine the current state of the art of adipose tissue-targeting nanomedicines, offering insights into recent advances, future possibilities, and the remaining challenges associated with their application in obesity treatment.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting PKLR in liver diseases 靶向PKLR治疗肝脏疾病
Trends in Endocrinology & Metabolism Pub Date : 2025-04-11 DOI: 10.1016/j.tem.2025.03.009
Meng Yuan, Mengnan Shi, Hong Yang, Sajda Ashraf, Shazia Iqbal, Hasan Turkez, Jan Boren, Cheng Zhang, Mathias Uhlén, Ozlem Altay, Adil Mardinoglu
{"title":"Targeting PKLR in liver diseases","authors":"Meng Yuan, Mengnan Shi, Hong Yang, Sajda Ashraf, Shazia Iqbal, Hasan Turkez, Jan Boren, Cheng Zhang, Mathias Uhlén, Ozlem Altay, Adil Mardinoglu","doi":"10.1016/j.tem.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.009","url":null,"abstract":"Pyruvate kinase is a key regulator in hepatic glucose metabolism, encoded by the gene pyruvate kinase liver/red blood cells (<ce:italic>PKLR</ce:italic>). Systems biology-based approaches, including metabolic and gene co-expression networks analyses, as well as genome-wide association studies (GWAS), have led to the identification of <ce:italic>PKLR</ce:italic> as a pivotal gene influencing liver metabolism in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). Here, we review the critical role of <ce:italic>PKLR</ce:italic> in MASLD and HCC progression and examine the effects of <ce:italic>PKLR</ce:italic> modulation both <ce:italic>in vitro</ce:italic> and <ce:italic>in vivo</ce:italic>. We also discuss the development of therapeutic strategies for patients with MASLD and HCC by modulating <ce:italic>PKLR</ce:italic>, highlighting its promising future in a broader range of liver diseases.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease. 推进代谢功能障碍相关脂肪变性肝病的精准医学研究。
Trends in Endocrinology & Metabolism Pub Date : 2025-04-10 DOI: 10.1016/j.tem.2025.03.006
Bryan A Priego-Parra,Rocío Gallego-Durán,Berenice M Román-Calleja,José Antonio Velarde-Ruiz Velasco,Manuel Romero-Gómez,Jordi Gracia-Sancho
{"title":"Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease.","authors":"Bryan A Priego-Parra,Rocío Gallego-Durán,Berenice M Román-Calleja,José Antonio Velarde-Ruiz Velasco,Manuel Romero-Gómez,Jordi Gracia-Sancho","doi":"10.1016/j.tem.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.tem.2025.03.006","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a pressing global health concern. The complexity of MASLD and the lack of universally effective treatments expose the limitations of current interventions, which focus mainly on lifestyle modifications. Here, we explore the multilayered nature of MASLD, emphasizing its pathophysiology in shaping future medical and lifestyle interventions from a personalized medicine perspective, based on individual molecular profiles. Additionally, we address the limitations of current animal models in reflecting human metabolic syndrome and sex-specific differences. We argue that a holistic approach, integrating social determinants of health, patient preferences, and adherence patterns, is essential for advancing MASLD management effectively.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
Trends in Endocrinology & Metabolism Pub Date : 2025-03-03 DOI: 10.1016/s1043-2760(25)00031-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(25)00031-1","DOIUrl":"https://doi.org/10.1016/s1043-2760(25)00031-1","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
Trends in Endocrinology & Metabolism Pub Date : 2025-03-03 DOI: 10.1016/s1043-2760(25)00028-1
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1043-2760(25)00028-1","DOIUrl":"https://doi.org/10.1016/s1043-2760(25)00028-1","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lineage tracing of pancreatic cells for mechanistic and therapeutic insights. 胰腺细胞谱系追踪的机制和治疗见解。
Trends in Endocrinology & Metabolism Pub Date : 2025-01-18 DOI: 10.1016/j.tem.2024.12.008
Huan Zhao,Bin Zhou
{"title":"Lineage tracing of pancreatic cells for mechanistic and therapeutic insights.","authors":"Huan Zhao,Bin Zhou","doi":"10.1016/j.tem.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.12.008","url":null,"abstract":"Recent advances in lineage-tracing technologies have significantly improved our understanding of pancreatic cell biology, particularly in elucidating the ontogeny and regenerative capacity of pancreatic cells. A deeper appreciation of the mechanisms underlying pancreatic cell identity and plasticity holds the potential to inform the development of new therapeutic modalities for conditions such as diabetes and pancreatitis. With this goal in mind, here we summarize advances, challenges, and future directions in tracing pancreatic cell origins and fates using lineage-tracing technologies. Given their essential role for blood glucose regulation, we pay particular attention on the insights gained from endocrine cells, especially β-cells.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting ACSLs to modulate ferroptosis and cancer immunity. 以 ACSL 为靶点，调节铁氧化酶和癌症免疫。
Trends in Endocrinology & Metabolism Pub Date : 2024-10-17 DOI: 10.1016/j.tem.2024.09.003
Junhong Lin,Yongfeng Lai,Fujia Lu,Weimin Wang
{"title":"Targeting ACSLs to modulate ferroptosis and cancer immunity.","authors":"Junhong Lin,Yongfeng Lai,Fujia Lu,Weimin Wang","doi":"10.1016/j.tem.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.09.003","url":null,"abstract":"Five acyl-CoA synthetase long-chain family members (ACSLs) are responsible for catalyzing diverse long-chain fatty acids (LCFAs) into LCFA-acyl-coenzyme A (CoA) for their subsequent metabolism, including fatty acid oxidation (FAO), lipid synthesis, and protein acylation. In this review, we focus on ACSLs and their LCFA substrates and introduce their involvement in regulation of cancer proliferation, metastasis, and therapeutic resistance. Along with the recognition of the decisive role of ACSL4 in ferroptosis - an immunogenic cell death (ICD) initiated by lipid peroxidation - we review the functions of ACSLs on regulating ferroptosis sensitivity. Last, we discuss the current understanding of ACSL on the antitumor immune response. We emphasize the necessity to explore the functions of immune cells expressing ACSLs for developing novel strategies to augment immunotherapy by targeting ACSL.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic reprogramming of macrophages in cancer therapy. 在癌症治疗中对巨噬细胞进行代谢重编程。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-19 DOI: 10.1016/j.tem.2024.08.009
Xudong Wang,Shaolong Zhang,Dixuan Xue,Dante Neculai,Jin Zhang
{"title":"Metabolic reprogramming of macrophages in cancer therapy.","authors":"Xudong Wang,Shaolong Zhang,Dixuan Xue,Dante Neculai,Jin Zhang","doi":"10.1016/j.tem.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.009","url":null,"abstract":"Cancer presents a significant global public health challenge. Within the tumor microenvironment (TME), macrophages are the most abundant immune cell population. Tumor-associated macrophages (TAMs) undergo metabolic reprogramming through influence of the TME; thus, by manipulating key metabolic pathways such as glucose, lipid, or amino acid metabolism, it may be possible to shift TAMs towards an antitumor state, enhancing the immune response against tumors. Here, we highlight the metabolic reprogramming of macrophages as a potential approach for cancer immunotherapy. We explore the major pathways involved in the metabolic reprogramming of TAMs and offer new and valuable insights on the current technologies utilized for TAM reprogramming, including genome editing, antibodies, small molecules, nanoparticles and other in situ editing strategies.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum. 孕期和产后睡眠和昼夜节律紊乱对代谢的影响。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-18 DOI: 10.1016/j.tem.2024.08.008
Erin E Kishman,Sirimon Reutrakul,Josiane L Broussard
{"title":"Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum.","authors":"Erin E Kishman,Sirimon Reutrakul,Josiane L Broussard","doi":"10.1016/j.tem.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.008","url":null,"abstract":"Physiological changes during pregnancy may predict future cardiovascular and metabolic diseases; thus, identifying mechanisms driving cardiometabolic impairments, as well as potential interventions to improve health during pregnancy, is crucial. We discuss how sleep and circadian disruption during pregnancy and postpartum affect cardiometabolic risk, and identify future research directions.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss. 减肥后的皮下脂肪组织和骨骼肌线粒体
Trends in Endocrinology & Metabolism Pub Date : 2024-09-16 DOI: 10.1016/j.tem.2024.08.002
Birgitta W van der Kolk,Eija Pirinen,Rachel Nicoll,Kirsi H Pietiläinen,Sini Heinonen
{"title":"Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss.","authors":"Birgitta W van der Kolk,Eija Pirinen,Rachel Nicoll,Kirsi H Pietiläinen,Sini Heinonen","doi":"10.1016/j.tem.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.002","url":null,"abstract":"Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain these improvements over time. Adipose tissue and skeletal muscle metabolism are crucial in weight regulation, and obesity is linked to mitochondrial dysfunction in both tissues. The impact of bariatric surgery versus dieting on adipose tissue and skeletal muscle mitochondrial metabolism remains to be elucidated. Understanding the molecular pathways that modulate tissue metabolism following weight loss holds potential for identifying novel therapeutic targets in obesity management. This narrative review summarizes current knowledge on mitochondrial metabolism following bariatric surgery and diet-induced weight loss in adipose tissue and skeletal muscle, and sheds light on their respective effects.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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