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Targeting ACSLs to modulate ferroptosis and cancer immunity. 以 ACSL 为靶点，调节铁氧化酶和癌症免疫。
Trends in Endocrinology & Metabolism Pub Date : 2024-10-17 DOI: 10.1016/j.tem.2024.09.003
Junhong Lin,Yongfeng Lai,Fujia Lu,Weimin Wang
{"title":"Targeting ACSLs to modulate ferroptosis and cancer immunity.","authors":"Junhong Lin,Yongfeng Lai,Fujia Lu,Weimin Wang","doi":"10.1016/j.tem.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.09.003","url":null,"abstract":"Five acyl-CoA synthetase long-chain family members (ACSLs) are responsible for catalyzing diverse long-chain fatty acids (LCFAs) into LCFA-acyl-coenzyme A (CoA) for their subsequent metabolism, including fatty acid oxidation (FAO), lipid synthesis, and protein acylation. In this review, we focus on ACSLs and their LCFA substrates and introduce their involvement in regulation of cancer proliferation, metastasis, and therapeutic resistance. Along with the recognition of the decisive role of ACSL4 in ferroptosis - an immunogenic cell death (ICD) initiated by lipid peroxidation - we review the functions of ACSLs on regulating ferroptosis sensitivity. Last, we discuss the current understanding of ACSL on the antitumor immune response. We emphasize the necessity to explore the functions of immune cells expressing ACSLs for developing novel strategies to augment immunotherapy by targeting ACSL.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic reprogramming of macrophages in cancer therapy. 在癌症治疗中对巨噬细胞进行代谢重编程。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-19 DOI: 10.1016/j.tem.2024.08.009
Xudong Wang,Shaolong Zhang,Dixuan Xue,Dante Neculai,Jin Zhang
{"title":"Metabolic reprogramming of macrophages in cancer therapy.","authors":"Xudong Wang,Shaolong Zhang,Dixuan Xue,Dante Neculai,Jin Zhang","doi":"10.1016/j.tem.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.009","url":null,"abstract":"Cancer presents a significant global public health challenge. Within the tumor microenvironment (TME), macrophages are the most abundant immune cell population. Tumor-associated macrophages (TAMs) undergo metabolic reprogramming through influence of the TME; thus, by manipulating key metabolic pathways such as glucose, lipid, or amino acid metabolism, it may be possible to shift TAMs towards an antitumor state, enhancing the immune response against tumors. Here, we highlight the metabolic reprogramming of macrophages as a potential approach for cancer immunotherapy. We explore the major pathways involved in the metabolic reprogramming of TAMs and offer new and valuable insights on the current technologies utilized for TAM reprogramming, including genome editing, antibodies, small molecules, nanoparticles and other in situ editing strategies.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum. 孕期和产后睡眠和昼夜节律紊乱对代谢的影响。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-18 DOI: 10.1016/j.tem.2024.08.008
Erin E Kishman,Sirimon Reutrakul,Josiane L Broussard
{"title":"Metabolic consequences of sleep and circadian disruption during pregnancy and postpartum.","authors":"Erin E Kishman,Sirimon Reutrakul,Josiane L Broussard","doi":"10.1016/j.tem.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.008","url":null,"abstract":"Physiological changes during pregnancy may predict future cardiovascular and metabolic diseases; thus, identifying mechanisms driving cardiometabolic impairments, as well as potential interventions to improve health during pregnancy, is crucial. We discuss how sleep and circadian disruption during pregnancy and postpartum affect cardiometabolic risk, and identify future research directions.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss. 减肥后的皮下脂肪组织和骨骼肌线粒体
Trends in Endocrinology & Metabolism Pub Date : 2024-09-16 DOI: 10.1016/j.tem.2024.08.002
Birgitta W van der Kolk,Eija Pirinen,Rachel Nicoll,Kirsi H Pietiläinen,Sini Heinonen
{"title":"Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss.","authors":"Birgitta W van der Kolk,Eija Pirinen,Rachel Nicoll,Kirsi H Pietiläinen,Sini Heinonen","doi":"10.1016/j.tem.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.002","url":null,"abstract":"Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain these improvements over time. Adipose tissue and skeletal muscle metabolism are crucial in weight regulation, and obesity is linked to mitochondrial dysfunction in both tissues. The impact of bariatric surgery versus dieting on adipose tissue and skeletal muscle mitochondrial metabolism remains to be elucidated. Understanding the molecular pathways that modulate tissue metabolism following weight loss holds potential for identifying novel therapeutic targets in obesity management. This narrative review summarizes current knowledge on mitochondrial metabolism following bariatric surgery and diet-induced weight loss in adipose tissue and skeletal muscle, and sheds light on their respective effects.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAD+ (nicotinamide adenine dinucleotide, oxidized form). NAD+（烟酰胺腺嘌呤二核苷酸，氧化型）。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-11 DOI: 10.1016/j.tem.2024.08.007
Valentina Ferro,Sofia Moco
{"title":"NAD+ (nicotinamide adenine dinucleotide, oxidized form).","authors":"Valentina Ferro,Sofia Moco","doi":"10.1016/j.tem.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.007","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating a picture of brown fat with creatine-CEST. 用肌酸-CEST 绘制棕色脂肪图。
Trends in Endocrinology & Metabolism Pub Date : 2024-09-09 DOI: 10.1016/j.tem.2024.08.013
Mohammed K Hankir
{"title":"Creating a picture of brown fat with creatine-CEST.","authors":"Mohammed K Hankir","doi":"10.1016/j.tem.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.tem.2024.08.013","url":null,"abstract":"Accurate assessment of brown fat thermogenesis by non-invasive means remains challenging. Writing in Nature Metabolism, Cai et al. leverage the futile creatine cycling characteristic of thermogenic adipocytes to show that a type of magnetic resonance imaging (MRI) technique sensitive to endogenous creatine levels faithfully tracks brown fat thermogenesis in rodents and in humans.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adiponectin 脂联素
Trends in Endocrinology & Metabolism Pub Date : 2024-06-26 DOI: 10.1016/j.tem.2024.05.004
Yan LI, Toshiharu Onodera, Philipp E. Scherer
{"title":"Adiponectin","authors":"Yan LI, Toshiharu Onodera, Philipp E. Scherer","doi":"10.1016/j.tem.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.tem.2024.05.004","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A double-edged sword: risks and benefits of heat for human health 一把双刃剑：高温对人类健康的风险和益处
Trends in Endocrinology & Metabolism Pub Date : 2024-04-01 DOI: 10.1016/j.tem.2024.02.015
Hannah Pallubinsky, D. Blondin, Ollie Jay
{"title":"A double-edged sword: risks and benefits of heat for human health","authors":"Hannah Pallubinsky, D. Blondin, Ollie Jay","doi":"10.1016/j.tem.2024.02.015","DOIUrl":"https://doi.org/10.1016/j.tem.2024.02.015","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"761 ","pages":"277-279"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current status and future trends of the global burden of MASLD MASLD 全球负担的现状和未来趋势
Trends in Endocrinology & Metabolism Pub Date : 2024-02-29 DOI: 10.1016/j.tem.2024.02.007
Lei Miao, Giovanni Targher, Christopher D. Byrne, Ying-Ying Cao, Ming-Hua Zheng
{"title":"Current status and future trends of the global burden of MASLD","authors":"Lei Miao, Giovanni Targher, Christopher D. Byrne, Ying-Ying Cao, Ming-Hua Zheng","doi":"10.1016/j.tem.2024.02.007","DOIUrl":"https://doi.org/10.1016/j.tem.2024.02.007","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD on healthcare systems, thus further highlighting the urgent need for global efforts to tackle this common and burdensome liver condition. We emphasize the clinical relevance of early interventions and a holistic approach that includes public health strategies to reduce the global impact of MASLD.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140001339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving liver disease insights from NAFLD to MASLD 从 NAFLD 到 MASLD 不断发展的肝脏疾病见解
Trends in Endocrinology & Metabolism Pub Date : 2024-02-29 DOI: 10.1016/j.tem.2024.02.012
Xiude Fan, Yongfeng Song, Jiajun Zhao
{"title":"Evolving liver disease insights from NAFLD to MASLD","authors":"Xiude Fan, Yongfeng Song, Jiajun Zhao","doi":"10.1016/j.tem.2024.02.012","DOIUrl":"https://doi.org/10.1016/j.tem.2024.02.012","url":null,"abstract":"The recent renaming of ‘non-alcoholic fatty liver disease’ (NAFLD) to ‘metabolic dysfunction-associated steatotic liver disease’ (MASLD) emphasizes metabolic dysfunction in steatotic liver disease and advocates for tailored, comprehensive treatment strategies, driving forward the development of personalized care and innovative therapeutic approaches.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140011539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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