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The postpartum recovery window as a determinant of maternal aging
Trends in Endocrinology & Metabolism Pub Date : 2026-10-22 DOI: 10.1016/j.tem.2026.09.002
Stephen M. Albright,Jesse R. Poganik
{"title":"The postpartum recovery window as a determinant of maternal aging","authors":"Stephen M. Albright,Jesse R. Poganik","doi":"10.1016/j.tem.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.002","url":null,"abstract":"Higher parity predicts an elevated mortality risk in many cohorts, yet the association is inconsistent across populations and poorly explained by existing mechanistic accounts. Accumulating evidence indicates that pregnancy transiently accelerates biological age and that the postpartum period represents a recovery window during which this acceleration partially reverses. When a subsequent pregnancy begins before recovery is complete, this normalization is truncated and the aging burden may compound across successive pregnancies. We propose that the interpregnancy interval, as the determinant of how much recovery occurs between pregnancies, is the missing variable linking reproductive history to the long-term maternal aging trajectory. We develop falsifiable predictions, identify the study designs needed to test them, and argue that reproductive spacing may be a modifiable determinant of the lifelong aging trajectory.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149230038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyocholic acid: a primary bile acid regulating lifespan immunometabolism 胆酸：一种调节终身免疫代谢的初级胆汁酸
Trends in Endocrinology & Metabolism Pub Date : 2026-10-14 DOI: 10.1016/j.tem.2026.09.016
Wei Jia,Xiaojiao Zheng
{"title":"Hyocholic acid: a primary bile acid regulating lifespan immunometabolism","authors":"Wei Jia,Xiaojiao Zheng","doi":"10.1016/j.tem.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.016","url":null,"abstract":"Hyocholic acid (HCA), a newly identified human primary bile acid, regulates glucose and lipid metabolism and maintains immunometabolic homeostasis. This forum article highlights HCA and its derivatives as key mediators of inter-organ crosstalk across the lifespan, underscoring their potential to advance diagnostics and therapeutics for immunometabolic disorders.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isobutyrylcarnitine Isobutyrylcarnitine
Trends in Endocrinology & Metabolism Pub Date : 2026-10-13 DOI: 10.1016/j.tem.2026.09.018
Xiaoqiang Tang,Peng Gao,Hou-Zao Chen
{"title":"Isobutyrylcarnitine","authors":"Xiaoqiang Tang,Peng Gao,Hou-Zao Chen","doi":"10.1016/j.tem.2026.09.018","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.018","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain energy allocation is consistent with adaptive thermogenesis 大脑能量分配与适应性产热是一致的
Trends in Endocrinology & Metabolism Pub Date : 2026-10-13 DOI: 10.1016/j.tem.2026.09.013
Manfred J. Müller,Anja Bosy-Westphal
{"title":"Brain energy allocation is consistent with adaptive thermogenesis","authors":"Manfred J. Müller,Anja Bosy-Westphal","doi":"10.1016/j.tem.2026.09.013","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.013","url":null,"abstract":"Caloric restriction and weight loss reduce resting metabolic rate (RMR) beyond what is explained by the loss of fat-free mass, a phenomenon known as adaptive thermogenesis (ATRMR). Here, we frame ATRMR conceptually as the result of shifts in energy budgets within the body. Given the brain’s central role as both a key regulator of energy intake and a major energy consumer within the body, we hypothesize that ATRMR represents one component of the weight-loss-associated reduction in energy expenditure and may reflect a redistribution of energy from the body to the brain, consistent with the hypothesis that adequate cerebral energy supply is preferentially maintained.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ATP 三磷酸腺苷
Trends in Endocrinology & Metabolism Pub Date : 2026-10-12 DOI: 10.1016/j.tem.2026.09.017
Annamaria Lia,Paola Pizzo
{"title":"ATP","authors":"Annamaria Lia,Paola Pizzo","doi":"10.1016/j.tem.2026.09.017","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.017","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the mechanistic mystery of SGLT2 inhibitors in heart failure 揭示SGLT2抑制剂在心力衰竭中的机制奥秘
Trends in Endocrinology & Metabolism Pub Date : 2026-10-11 DOI: 10.1016/j.tem.2026.09.015
Tan Nguyen,Brian N. Finck,Justin H. Berger
{"title":"Unraveling the mechanistic mystery of SGLT2 inhibitors in heart failure","authors":"Tan Nguyen,Brian N. Finck,Justin H. Berger","doi":"10.1016/j.tem.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.015","url":null,"abstract":"Heart failure (HF) is a leading cause of hospitalizations and deaths worldwide. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been shown to improve HF outcomes despite no evidence of cardiac SGLT2 expression. This forum highlights some proposed mechanisms of SGLT2i efficacy, limitations of these studies, and potential future directions.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Running on ROS: redefining metabolic adaptation and healthy aging 在ROS上跑步：重新定义代谢适应和健康衰老
Trends in Endocrinology & Metabolism Pub Date : 2026-10-08 DOI: 10.1016/j.tem.2026.09.012
Jaydeep Sharma,Mahima Kumari,Sam J. Mathew
{"title":"Running on ROS: redefining metabolic adaptation and healthy aging","authors":"Jaydeep Sharma,Mahima Kumari,Sam J. Mathew","doi":"10.1016/j.tem.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.012","url":null,"abstract":"Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of antioxidant signaling. Xirouchaki et al. show that NRF2 activation in skeletal muscle regulates metabolic homeostasis and healthy aging. Complementary evolutionary adaptations enhancing NRF2 signaling in horses underscore its role in muscle function and metabolism.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149124067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoform usage dynamics in metabolic adaptation 代谢适应中的异构体使用动态
Trends in Endocrinology & Metabolism Pub Date : 2026-10-01 DOI: 10.1016/j.tem.2026.09.008
Yadanar T. Naing,Xianli Ju,Jia Li,Lei Sun
{"title":"Isoform usage dynamics in metabolic adaptation","authors":"Yadanar T. Naing,Xianli Ju,Jia Li,Lei Sun","doi":"10.1016/j.tem.2026.09.008","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.008","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferro-aging: iron–lipid axis in systemic decline 铁老化：铁脂轴全体性下降
Trends in Endocrinology & Metabolism Pub Date : 2026-10-01 DOI: 10.1016/j.tem.2026.09.009
Lixiao Liu,Jing Qu,Guang-Hui Liu,Weiqi Zhang
{"title":"Ferro-aging: iron–lipid axis in systemic decline","authors":"Lixiao Liu,Jing Qu,Guang-Hui Liu,Weiqi Zhang","doi":"10.1016/j.tem.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.009","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
European Society of Endocrinology 2026 awards 获得2026年欧洲内分泌学会奖
Trends in Endocrinology & Metabolism Pub Date : 2026-09-30 DOI: 10.1016/j.tem.2026.09.007
Anna L. Gloyn, Ido Goldstein, Maria-Christina Zennaro
{"title":"European Society of Endocrinology 2026 awards","authors":"Anna L. Gloyn, Ido Goldstein, Maria-Christina Zennaro","doi":"10.1016/j.tem.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.tem.2026.09.007","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149085104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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