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Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism. 超越脂肪储存：神经元脂滴调节全身代谢。
Trends in Endocrinology & Metabolism Pub Date : 2026-07-02 DOI: 10.1016/j.tem.2026.06.004
Diana U Rodrigues,Julie Jacquemyn,Maria S Ioannou
{"title":"Beyond fat storage: neuronal lipid droplets regulate whole-body metabolism.","authors":"Diana U Rodrigues,Julie Jacquemyn,Maria S Ioannou","doi":"10.1016/j.tem.2026.06.004","DOIUrl":"https://doi.org/10.1016/j.tem.2026.06.004","url":null,"abstract":"Lipid droplets are dynamic organelles long thought to form in neurons only during disease. However, a study by Manceau et al. discovered that lipid droplets are not only present in healthy neurons but also regulate whole-body metabolism when formed in hunger-responsive neurons in the brain.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148372397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
Trends in Endocrinology & Metabolism Pub Date : 2026-07-01 DOI: 10.1016/s1043-2760(26)00157-8
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(26)00157-8","DOIUrl":"https://doi.org/10.1016/s1043-2760(26)00157-8","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
Trends in Endocrinology & Metabolism Pub Date : 2026-07-01 DOI: 10.1016/s1043-2760(26)00154-2
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1043-2760(26)00154-2","DOIUrl":"https://doi.org/10.1016/s1043-2760(26)00154-2","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol-LXR axis in metabolic regulation of liver fibrosis and hepatocarcinogenesis. 胆固醇- lxr轴在肝纤维化和肝癌发生中的代谢调节。
Trends in Endocrinology & Metabolism Pub Date : 2026-04-22 DOI: 10.1016/j.tem.2026.03.011
Elena Piccinin,Gaetano Villani,Antonio Moschetta
{"title":"Cholesterol-LXR axis in metabolic regulation of liver fibrosis and hepatocarcinogenesis.","authors":"Elena Piccinin,Gaetano Villani,Antonio Moschetta","doi":"10.1016/j.tem.2026.03.011","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.011","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease is increasing worldwide, and its progression to metabolic dysfunction-associated steatohepatitis (MASH) and ultimately hepatocellular carcinoma (HCC) remains a major clinical challenge. In this review, we discuss the role of liver X receptors (LXRs), transcriptional regulators of fatty acid synthesis, and cholesterol balance, which play an apparently paradoxical metabolic role: while their activation increases lipogenesis, driving steatosis, their inhibition leads to harmful cholesterol buildup and inflammation, central to the pathogenesis of MASH and HCC. In HCC, disrupted LXR signalling prevents cholesterol efflux, fuelling tumour growth. Therapeutic strategies targeting LXRs must therefore be stage-specific and cell type-specific to avoid worsening liver injury.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147735168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
H19 long noncoding RNA in maternal obesity-driven metabolic programming. H19长链非编码RNA在母体肥胖驱动的代谢编程中的作用。
Trends in Endocrinology & Metabolism Pub Date : 2026-04-20 DOI: 10.1016/j.tem.2026.04.001
Sharmeen Islam,Min Du
{"title":"H19 long noncoding RNA in maternal obesity-driven metabolic programming.","authors":"Sharmeen Islam,Min Du","doi":"10.1016/j.tem.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.tem.2026.04.001","url":null,"abstract":"Maternal obesity alters H19 expression, disrupting epigenetic modifications during embryonic development, impairing muscle development, promoting fibrogenesis, and perturbing metabolic homeostasis, thereby predisposing offspring to fibrosis and metabolic dysfunction. Metformin in early pregnancy may mitigate these alterations by modulating placental H19 through AMP-activated protein kinase (AMPK) and epigenetic regulation, improving offspring metabolic health.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fuel partitioning perspective on appetite suppression by GLP-1 receptor agonists. GLP-1受体激动剂对食欲抑制的能量分配观点。
Trends in Endocrinology & Metabolism Pub Date : 2026-04-15 DOI: 10.1016/j.tem.2026.03.013
Mark I Friedman,Jens Lund
{"title":"A fuel partitioning perspective on appetite suppression by GLP-1 receptor agonists.","authors":"Mark I Friedman,Jens Lund","doi":"10.1016/j.tem.2026.03.013","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.013","url":null,"abstract":"Appetite suppression by glucagon-like peptide-1 receptor agonists (GLP-1RAs) is thought to result from direct actions on neural circuits controlling food intake. In this article, we (1) propose that a shift in fuel partitioning toward fat oxidation caused by GLP-1RAs contributes to appetite suppression and (2) explore potential lines of research to test this hypothesis.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding hypoparathyroidism as a disease of broad functional deficiency. 了解甲状旁腺功能低下是一种广泛功能缺陷的疾病。
Trends in Endocrinology & Metabolism Pub Date : 2026-04-10 DOI: 10.1016/j.tem.2026.03.009
Maria Luisa Brandi,Jean-Philippe Bertocchio,Istvan Takacs,Ellen K Colman,Ying Kong,Lars Rejnmark,Aliya A Khan
{"title":"Understanding hypoparathyroidism as a disease of broad functional deficiency.","authors":"Maria Luisa Brandi,Jean-Philippe Bertocchio,Istvan Takacs,Ellen K Colman,Ying Kong,Lars Rejnmark,Aliya A Khan","doi":"10.1016/j.tem.2026.03.009","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.009","url":null,"abstract":"Hypoparathyroidism (HypoPT) is a rare disease defined by undetectable, low, or inappropriately normal parathyroid hormone (PTH) concentrations in the presence of hypocalcemia. Calcium and active vitamin D are often used for the treatment of HypoPT but do not address the underlying lack of physiological PTH activity. In this review, we discuss how the chronic inadequacy of PTH leads to broad functional consequences. This functional deficiency results in a wide spectrum of symptoms, impaired functioning and quality of life, and significant economic and healthcare costs. We consider how kidney complications could develop in patients with HypoPT and highlight recent developments in understanding the heterogeneity of bone health in HypoPT, including certain patient populations.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LIFe of the sugar-free party in cancer metabolism. 无糖一方在癌症代谢中的生活。
Trends in Endocrinology & Metabolism Pub Date : 2026-04-09 DOI: 10.1016/j.tem.2026.03.010
Khaled Tighanimine,Brendan D Manning
{"title":"LIFe of the sugar-free party in cancer metabolism.","authors":"Khaled Tighanimine,Brendan D Manning","doi":"10.1016/j.tem.2026.03.010","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.010","url":null,"abstract":"Tumor cells can thrive in nutrient-scarce environments. Glucose deprivation can trigger adaptive responses that coordinate cell-cell communication within the tumor microenvironment (TME). Recently, Luciano-Mateo et al. demonstrated that glucose withdrawal promotes cancer cell secretion of the cytokine leukemia inhibitory factor (LIF), which exerts protumorigenic effects on the TME.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycine (aminoacetic acid) 甘氨酸（氨基乙酸）
Trends in Endocrinology & Metabolism Pub Date : 2026-04-06 DOI: 10.1016/j.tem.2026.03.001
Jinwang Hou, Xugang Luo, Chuanlong Wang
{"title":"Glycine (aminoacetic acid)","authors":"Jinwang Hou, Xugang Luo, Chuanlong Wang","doi":"10.1016/j.tem.2026.03.001","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.001","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estradiol 雌二醇
Trends in Endocrinology & Metabolism Pub Date : 2026-04-06 DOI: 10.1016/j.tem.2026.03.008
Sara Della Torre
{"title":"Estradiol","authors":"Sara Della Torre","doi":"10.1016/j.tem.2026.03.008","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.008","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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