Trends in Endocrinology & Metabolism最新文献

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Advisory Board and Contents 咨询委员会和内容
Trends in Endocrinology & Metabolism Pub Date : 2024-02-12 DOI: 10.1016/s1043-2760(24)00005-5
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引用次数: 0
Subscription and Copyright Information 订阅和版权信息
Trends in Endocrinology & Metabolism Pub Date : 2024-02-12 DOI: 10.1016/s1043-2760(24)00008-0
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(24)00008-0","DOIUrl":"https://doi.org/10.1016/s1043-2760(24)00008-0","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139917122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise is also medicine for iron homeostasis 运动也是促进铁平衡的良药
Trends in Endocrinology & Metabolism Pub Date : 2024-02-02 DOI: 10.1016/j.tem.2024.01.010
Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces
{"title":"Exercise is also medicine for iron homeostasis","authors":"Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces","doi":"10.1016/j.tem.2024.01.010","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.010","url":null,"abstract":"<p>High-intensity interval training (HIIT) is gaining popularity as an effective exercise modality to improve cardiometabolic health. Combining high-throughput/sensitivity proteome analyses in subcutaneous adipose tissue with biochemical blood measures, Larsen <em>et al.</em> recently provided mechanistic insights into a potential beneficial role of this exercise modality on iron homeostasis at the whole-body level.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing evidence for immune surveillance of β-cell senescence 建立免疫监视β细胞衰老的证据
Trends in Endocrinology & Metabolism Pub Date : 2024-02-02 DOI: 10.1016/j.tem.2024.01.003
Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson
{"title":"Establishing evidence for immune surveillance of β-cell senescence","authors":"Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson","doi":"10.1016/j.tem.2024.01.003","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.003","url":null,"abstract":"<p>Cellular senescence is a programmed state of cell cycle arrest that involves a complex immunogenic secretome, eliciting immune surveillance and senescent cell clearance. Recent work has shown that a subpopulation of pancreatic β-cells becomes senescent in the context of diabetes; however, it is not known whether these cells are normally subject to immune surveillance. In this opinion article, we advance the hypothesis that immune surveillance of β-cells undergoing a senescence stress response normally limits their accumulation during aging and that the breakdown of these mechanisms is a driver of senescent β-cell accumulation in diabetes. Elucidation and therapeutic activation of immune surveillance mechanisms in the pancreas holds promise for the improvement of approaches to target stressed senescent β-cells in the treatment of diabetes.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139660131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders 针对代谢、昼夜节律和睡眠障碍的体外下丘脑病理生理学建模
Trends in Endocrinology & Metabolism Pub Date : 2024-02-01 DOI: 10.1016/j.tem.2024.01.001
Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas
{"title":"Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders","authors":"Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas","doi":"10.1016/j.tem.2024.01.001","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.001","url":null,"abstract":"<p>The hypothalamus, a small and intricate brain structure, orchestrates numerous neuroendocrine functions through specialized neurons and nuclei. Disruption of this complex circuitry can result in various diseases, including metabolic, circadian, and sleep disorders. Advances in <em>in vitro</em> models and their integration with new technologies have significantly benefited research on hypothalamic function and pathophysiology. We explore existing <em>in vitro</em> hypothalamic models and address their challenges and limitations as well as translational findings. We also highlight how collaborative efforts among multidisciplinary teams are essential to develop relevant and translational experimental models capable of replicating intricate neural circuits and neuroendocrine pathways, thereby advancing our understanding of therapeutic targets and drug discovery in hypothalamus-related disorders.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathophysiology of human mitochondrial tRNA metabolism 人类线粒体 tRNA 代谢的病理生理学
Trends in Endocrinology & Metabolism Pub Date : 2024-02-01 DOI: 10.1016/j.tem.2024.01.002
Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou
{"title":"Pathophysiology of human mitochondrial tRNA metabolism","authors":"Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou","doi":"10.1016/j.tem.2024.01.002","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.002","url":null,"abstract":"<p><span>Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various </span>mitochondrial diseases<span> caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes.</span></p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics unravels protein–metabolite relationships 遗传学揭示蛋白质与代谢物的关系
Trends in Endocrinology & Metabolism Pub Date : 2024-01-31 DOI: 10.1016/j.tem.2024.01.008
James R. Hilser, Aldons J. Lusis, Hooman Allayee
{"title":"Genetics unravels protein–metabolite relationships","authors":"James R. Hilser, Aldons J. Lusis, Hooman Allayee","doi":"10.1016/j.tem.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.008","url":null,"abstract":"<p><span><span>Integrating molecular traits into genetic studies enhances our understanding of how </span>DNA variation influences complex clinical and physiological phenotypes. In a recent article, </span><span>Benson and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg><span> apply this systems genetics approach with proteomics<span> and metabolomics data in plasma from humans to identify and validate several previously unrecognized causal protein–metabolite associations.</span></span></p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketogenesis favors oxidative phosphorylation to promote disease tolerance 酮体生成有利于氧化磷酸化,从而促进疾病耐受性
Trends in Endocrinology & Metabolism Pub Date : 2024-01-31 DOI: 10.1016/j.tem.2024.01.006
Kátia Jesus, Luís F. Moita
{"title":"Ketogenesis favors oxidative phosphorylation to promote disease tolerance","authors":"Kátia Jesus, Luís F. Moita","doi":"10.1016/j.tem.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.tem.2024.01.006","url":null,"abstract":"<p><span><em>Pseudomonas aeruginosa</em></span><span> is an opportunistic pathogen of great medical relevance, although the mechanisms involved in chronic </span><em>P. aeruginosa</em> infection are unclear. <span>Tomlinson <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg><span> have now shown that systemic and local pathogen-induced ketone bodies<span> (KBs) select strains that preserve respiratory integrity by failing to substantially increase glycolysis, which drives immunopathology resulting from resistance mechanisms.</span></span></p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The redox requirement and regulation during cell proliferation 细胞增殖过程中的氧化还原要求和调节
Trends in Endocrinology & Metabolism Pub Date : 2024-01-22 DOI: 10.1016/j.tem.2023.12.010
Zhuoran Zhen, Jiankun Ren, Jiajun Zhu
{"title":"The redox requirement and regulation during cell proliferation","authors":"Zhuoran Zhen, Jiankun Ren, Jiajun Zhu","doi":"10.1016/j.tem.2023.12.010","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.010","url":null,"abstract":"<p>The intracellular metabolic network comprises a variety of reduction–oxidation (redox) reactions that occur in a temporally and spatially distinct manner. In order to coordinate these redox processes, mammalian cells utilize a collection of electron-carrying molecules common to many redox reactions, including NAD, NADP, coenzyme Q (CoQ), and glutathione (GSH). This review considers the metabolic basis of redox regulation in the context of cell proliferation by analyzing how cells acquire and utilize electron carriers to maintain directional carbon flux, sustain reductive biosynthesis, and support antioxidant defense. Elucidating the redox requirement during cell proliferation can advance the understanding of human diseases such as cancer, and reveal effective therapeutic opportunities in the clinic.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"256 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy homeostasis in the bone 骨骼中的能量平衡
Trends in Endocrinology & Metabolism Pub Date : 2024-01-18 DOI: 10.1016/j.tem.2023.12.009
Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo
{"title":"Energy homeostasis in the bone","authors":"Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo","doi":"10.1016/j.tem.2023.12.009","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.009","url":null,"abstract":"<p>The bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases. Here, we review the main sources of energy in bone cells and their regulation, as well as the endocrine role of the bone in systemic energy homeostasis. Moreover, we discuss metabolic changes that occur as a result of osteoporosis. Exploration in this area will contribute to an enhanced comprehension of bone energy metabolism, presenting novel possibilities to address metabolic diseases.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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