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Estradiol 雌二醇
Trends in Endocrinology & Metabolism Pub Date : 2026-04-06 DOI: 10.1016/j.tem.2026.03.008
Sara Della Torre
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引用次数: 0
Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis 肝脏新生脂肪形成中的底物供应、区隔和利用
Trends in Endocrinology & Metabolism Pub Date : 2026-04-02 DOI: 10.1016/j.tem.2026.01.001
Daniel J. Pape, Eric B. Taylor
{"title":"Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis","authors":"Daniel J. Pape, Eric B. Taylor","doi":"10.1016/j.tem.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.001","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives 胰腺癌进展中的脂质信号网络及其治疗前景
Trends in Endocrinology & Metabolism Pub Date : 2026-04-02 DOI: 10.1016/j.tem.2026.03.004
Andrea Costamagna, Giulia Milan, Maria Chiara De Santis, Alessandro Carrer, Miriam Martini
{"title":"Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives","authors":"Andrea Costamagna, Giulia Milan, Maria Chiara De Santis, Alessandro Carrer, Miriam Martini","doi":"10.1016/j.tem.2026.03.004","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.004","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation 打开燃料，加热就开始了！肉毒碱合成作为燃料适应的生理介质
Trends in Endocrinology & Metabolism Pub Date : 2026-04-02 DOI: 10.1016/j.tem.2026.03.007
Nicolai R. Hathiramani, Alexandra E. Jerrett, Jessica B. Spinelli
{"title":"Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation","authors":"Nicolai R. Hathiramani, Alexandra E. Jerrett, Jessica B. Spinelli","doi":"10.1016/j.tem.2026.03.007","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.007","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immunoregulatory role of progesterone during embryo implantation and pregnancy 黄体酮在胚胎着床和妊娠中的免疫调节作用
Trends in Endocrinology & Metabolism Pub Date : 2026-04-01 DOI: 10.1016/j.tem.2026.02.009
Alessandra Colamatteo, Fortunata Carbone, Clorinda Fusco, Claudia Russo, Teresa Micillo, Debora Carluccio, Claudia La Rocca, Wenjing Zheng, Salvatore Longobardi, Giuseppe Matarese
{"title":"The immunoregulatory role of progesterone during embryo implantation and pregnancy","authors":"Alessandra Colamatteo, Fortunata Carbone, Clorinda Fusco, Claudia Russo, Teresa Micillo, Debora Carluccio, Claudia La Rocca, Wenjing Zheng, Salvatore Longobardi, Giuseppe Matarese","doi":"10.1016/j.tem.2026.02.009","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.009","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker 肠道微生物组在糖尿病药物治疗中的3M作用：介质、调节剂和标记物
Trends in Endocrinology & Metabolism Pub Date : 2026-04-01 DOI: 10.1016/j.tem.2025.12.006
Jeong In Seo, Ara Koh, Soo Lim, Hye Hyun Yoo
{"title":"The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker","authors":"Jeong In Seo, Ara Koh, Soo Lim, Hye Hyun Yoo","doi":"10.1016/j.tem.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.tem.2025.12.006","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new era in childhood obesity 儿童肥胖的新时代
Trends in Endocrinology & Metabolism Pub Date : 2026-04-01 DOI: 10.1016/j.tem.2026.03.006
Gabriel Á. Martos-Moreno, Blanca Guijo, Manuel Tena-Sempere, Julie A. Chowen, Jesús Argente
{"title":"A new era in childhood obesity","authors":"Gabriel Á. Martos-Moreno, Blanca Guijo, Manuel Tena-Sempere, Julie A. Chowen, Jesús Argente","doi":"10.1016/j.tem.2026.03.006","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.006","url":null,"abstract":"","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reprogramming the mitochondrial-circadian energy code with incretins. 用肠促胰岛素重新编程线粒体-昼夜节律能量代码。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-31 DOI: 10.1016/j.tem.2026.02.011
Enzo Nisoli,Maurizio Ragni,Chiara Ruocco,Alessandra Valerio
{"title":"Reprogramming the mitochondrial-circadian energy code with incretins.","authors":"Enzo Nisoli,Maurizio Ragni,Chiara Ruocco,Alessandra Valerio","doi":"10.1016/j.tem.2026.02.011","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.011","url":null,"abstract":"Mitochondrial dysfunction, circadian disruption, and the accumulation of senescent cells converge to impair metabolic flexibility, a unifying phenotype of obesity and aging. We frame obesity as a nutrient-driven and aging as a time-driven expression of a disrupted mitochondrial-circadian energy code, with shared outputs: impaired substrate switching and flattened energy rhythms. This opinion argues that restoring code integrity, indexed clinically by gains in metabolic flexibility, should guide therapy. Beyond appetite and glycemia, GLP-1 (glucagon-like peptide-1) and dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide) agonists may enhance mitochondrial efficiency, support circadian alignment, and temper prosenescent signaling across target tissues (muscle, liver, adipose, islets, and brain). We outline how node-specific and combination strategies (senolytics/senomorphics, mitophagy/NAD+ support, and chrono-entrainment) could reprogram systemic energy coordination, improve durability of response, and delay age-related metabolic decline.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"242 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Citrate-mediated control of chromatin and mitosis. 柠檬酸盐介导的染色质和有丝分裂的控制。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-31 DOI: 10.1016/j.tem.2026.03.005
Philippe Icard,Laurent Plard,Stéphane Allouche,Luca Simula
{"title":"Citrate-mediated control of chromatin and mitosis.","authors":"Philippe Icard,Laurent Plard,Stéphane Allouche,Luca Simula","doi":"10.1016/j.tem.2026.03.005","DOIUrl":"https://doi.org/10.1016/j.tem.2026.03.005","url":null,"abstract":"Citrate metabolism remains poorly understood during mitosis, raising unresolved questions about citrate dynamics, compartmentalization, and targeting in cancer. Here, we propose a comprehensive model to explain how ATP-citrate lyase degradation at mitotic onset induces a transient citrate peak, promoting histone H3 phosphorylation and mitotic progression, while mitotic exit relies on acetate-driven lipogenesis.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting ferroptosis to halt MASLD and MASH. 靶向铁下垂阻止MASLD和MASH。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-31 DOI: 10.1016/j.tem.2026.01.007
Fudi Wang
{"title":"Targeting ferroptosis to halt MASLD and MASH.","authors":"Fudi Wang","doi":"10.1016/j.tem.2026.01.007","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.007","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic, with its inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), driving cirrhosis and hepatocellular carcinoma. Ferroptosis, an iron-dependent form of programmed cell death, is a central pathogenic mechanism in MASLD and MASH. The core drivers of ferroptosis include dysregulated iron metabolism, an increase in peroxidation-susceptible phospholipids, and impaired antioxidant defenses. These changes promote hepatocyte death via a so-called 'ferroptotic explosion' triggered by an increase in FerroLipid, thus driving the transition from a profibrotic state to overt fibrosis. Notably, targeting ferroptosis with iron chelators and ferroptosis inhibitors shows promise as a therapeutic strategy by restoring redox and lipid homeostasis. Furthermore, systemic crosstalk between the liver, adipose tissue, and gut microbiota modulates ferroptotic susceptibility, revealing new avenues for developing precision-targeted therapies.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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