Trends in Endocrinology & Metabolism最新文献

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The redox requirement and regulation during cell proliferation 细胞增殖过程中的氧化还原要求和调节
Trends in Endocrinology & Metabolism Pub Date : 2024-01-22 DOI: 10.1016/j.tem.2023.12.010
Zhuoran Zhen, Jiankun Ren, Jiajun Zhu
{"title":"The redox requirement and regulation during cell proliferation","authors":"Zhuoran Zhen, Jiankun Ren, Jiajun Zhu","doi":"10.1016/j.tem.2023.12.010","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.010","url":null,"abstract":"<p>The intracellular metabolic network comprises a variety of reduction–oxidation (redox) reactions that occur in a temporally and spatially distinct manner. In order to coordinate these redox processes, mammalian cells utilize a collection of electron-carrying molecules common to many redox reactions, including NAD, NADP, coenzyme Q (CoQ), and glutathione (GSH). This review considers the metabolic basis of redox regulation in the context of cell proliferation by analyzing how cells acquire and utilize electron carriers to maintain directional carbon flux, sustain reductive biosynthesis, and support antioxidant defense. Elucidating the redox requirement during cell proliferation can advance the understanding of human diseases such as cancer, and reveal effective therapeutic opportunities in the clinic.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"256 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy homeostasis in the bone 骨骼中的能量平衡
Trends in Endocrinology & Metabolism Pub Date : 2024-01-18 DOI: 10.1016/j.tem.2023.12.009
Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo
{"title":"Energy homeostasis in the bone","authors":"Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo","doi":"10.1016/j.tem.2023.12.009","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.009","url":null,"abstract":"<p>The bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases. Here, we review the main sources of energy in bone cells and their regulation, as well as the endocrine role of the bone in systemic energy homeostasis. Moreover, we discuss metabolic changes that occur as a result of osteoporosis. Exploration in this area will contribute to an enhanced comprehension of bone energy metabolism, presenting novel possibilities to address metabolic diseases.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139494715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of epitranscriptomic modifications on liver disease 表观转录组修饰对肝病的影响
Trends in Endocrinology & Metabolism Pub Date : 2024-01-11 DOI: 10.1016/j.tem.2023.12.007
Keith A. Berggren, Robert E. Schwartz, Ralph E. Kleiner, Alexander Ploss
{"title":"The impact of epitranscriptomic modifications on liver disease","authors":"Keith A. Berggren, Robert E. Schwartz, Ralph E. Kleiner, Alexander Ploss","doi":"10.1016/j.tem.2023.12.007","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.007","url":null,"abstract":"<p>RNA modifications have emerged as important mechanisms of gene regulation. Developmental, metabolic, and cell cycle regulatory processes are all affected by epitranscriptomic modifications, which control gene expression in a dynamic manner. The hepatic tissue is highly metabolically active and has an impressive ability to regenerate after injury. Cell proliferation, differentiation, and metabolism, which are all essential to the liver response to injury and regeneration, are regulated via RNA modification. Two such modifications, <em>N</em><sup>6</sup>-methyladenosine (m<sup>6</sup>A)and 5-methylcytosine (m<sup>5</sup>C), have been identified as prognostic disease markers and potential therapeutic targets for liver diseases. Here, we describe progress in understanding the role of RNA modifications in liver biology and disease and discuss specific areas where unexpected results could lead to improved future understanding.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139420036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recreating metabolic interactions of the tumour microenvironment 再现肿瘤微环境的代谢相互作用
Trends in Endocrinology & Metabolism Pub Date : 2024-01-10 DOI: 10.1016/j.tem.2023.12.005
Rodrigo Curvello, Nikolaus Berndt, Sandra Hauser, Daniela Loessner
{"title":"Recreating metabolic interactions of the tumour microenvironment","authors":"Rodrigo Curvello, Nikolaus Berndt, Sandra Hauser, Daniela Loessner","doi":"10.1016/j.tem.2023.12.005","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.005","url":null,"abstract":"<p>Tumours are heterogeneous tissues containing diverse populations of cells and an abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to adapt their metabolism to survive and grow. Besides epigenetic factors, the metabolism of cancer cells is shaped by crosstalk with stromal cells and extracellular components. To date, most experimental models neglect the complexity of the tumour microenvironment and its relevance in regulating the dynamics of the metabolism in cancer. We discuss emerging strategies to model cellular and extracellular aspects of cancer metabolism. We highlight cancer models based on bioengineering, animal, and mathematical approaches to recreate cell–cell and cell–matrix interactions and patient-specific metabolism. Combining these approaches will improve our understanding of cancer metabolism and support the development of metabolism-targeting therapies.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139407876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
Trends in Endocrinology & Metabolism Pub Date : 2024-01-08 DOI: 10.1016/s1043-2760(23)00260-6
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1043-2760(23)00260-6","DOIUrl":"https://doi.org/10.1016/s1043-2760(23)00260-6","url":null,"abstract":"Abstract not available","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139379572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
Trends in Endocrinology & Metabolism Pub Date : 2024-01-08 DOI: 10.1016/s1043-2760(23)00263-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1043-2760(23)00263-1","DOIUrl":"https://doi.org/10.1016/s1043-2760(23)00263-1","url":null,"abstract":"Abstract not available","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139379549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the relationship between hyperlactatemia and anemia 探索高乳酸血症与贫血之间的关系
Trends in Endocrinology & Metabolism Pub Date : 2024-01-06 DOI: 10.1016/j.tem.2023.12.006
Shuping Zhang, Wei Liu, Tomas Ganz, Sijin Liu
{"title":"Exploring the relationship between hyperlactatemia and anemia","authors":"Shuping Zhang, Wei Liu, Tomas Ganz, Sijin Liu","doi":"10.1016/j.tem.2023.12.006","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.006","url":null,"abstract":"<p>Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a reconsideration of the multifaceted roles of lactate and lactylation in anemia and emphasizes the need to fill knowledge gaps, including the dose dependence of lactate’s effects, its sources, and its subcellular localization.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139110466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNAkines are secreted messengers shaping health and disease RNAkines 是影响健康和疾病的分泌信使
Trends in Endocrinology & Metabolism Pub Date : 2023-12-29 DOI: 10.1016/j.tem.2023.12.004
Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang
{"title":"RNAkines are secreted messengers shaping health and disease","authors":"Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang","doi":"10.1016/j.tem.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.004","url":null,"abstract":"<p>Extracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the pathogenesis of various diseases. Given the unique aspects of extracellular ncRNAs, here we propose the term ‘RNAkine’ to describe these recently identified secreted factors. We explore their roles as intercellular modulators, particularly in their ability to regulate metabolism and influence tumorigenesis, highlighting their definition and importance as a distinct class of secreted factors.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139059892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical perspective on ectopic Cushing’s syndrome 从临床角度看异位库欣综合征
Trends in Endocrinology & Metabolism Pub Date : 2023-12-23 DOI: 10.1016/j.tem.2023.12.003
Oskar Ragnarsson, C. Christofer Juhlin, David J. Torpy, Henrik Falhammar
{"title":"A clinical perspective on ectopic Cushing’s syndrome","authors":"Oskar Ragnarsson, C. Christofer Juhlin, David J. Torpy, Henrik Falhammar","doi":"10.1016/j.tem.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.003","url":null,"abstract":"<p>Cushing’s syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10–20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic NEN, medullary thyroid cancer (MTC), and pheochromocytoma are the most common. Patients with ECS frequently present with severe hypercortisolism. The risk of life-threatening complications is high in severe cases, unless the hypercortisolism is effectively treated. A good outcome in ECS requires a methodical approach, incorporating prompt diagnosis, tumour localization, control of cortisol excess, and resection of the primary tumour when possible.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138943488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large metabolic swings: when feeding exceeds its goals 新陈代谢波动大:当喂食量超过目标时
Trends in Endocrinology & Metabolism Pub Date : 2023-12-21 DOI: 10.1016/j.tem.2023.12.001
Francisco J.G. Muriana
{"title":"Large metabolic swings: when feeding exceeds its goals","authors":"Francisco J.G. Muriana","doi":"10.1016/j.tem.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.tem.2023.12.001","url":null,"abstract":"<p>Exaggerated blood excursions of nutrients and endogenous molecules in response to food intake may have health consequences if they repeatedly exceed the capacity of homeostatic mechanisms. Here, I discuss the significance of abnormally high postprandial metabolic fluctuations, the role of some influencing factors, and suggest ways to avoid them.</p>","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138840442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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