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RNA modifications: disease biomarkers and signaling molecules RNA修饰：疾病生物标志物和信号分子
Trends in Endocrinology & Metabolism Pub Date : 2026-03-17 DOI: 10.1016/j.tem.2026.01.004
Shijia Pan, Liwen Zhang, Yunfang Zhang, Junchao Shi, Ying Zhang
{"title":"RNA modifications: disease biomarkers and signaling molecules","authors":"Shijia Pan, Liwen Zhang, Yunfang Zhang, Junchao Shi, Ying Zhang","doi":"10.1016/j.tem.2026.01.004","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.004","url":null,"abstract":"RNA modifications constitute a dynamic regulatory code governing RNA structure, fate, and translation. Modified nucleosides, long dismissed as metabolic waste, are now recognized as stable biomarkers and active signaling messengers involved in metabolic and reproductive regulation. Advances in methods for detecting modified nucleosides could accelerate translation toward clinical diagnostics and monitoring.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do metabolic fluxes change with age? 代谢通量随年龄变化吗？
Trends in Endocrinology & Metabolism Pub Date : 2026-03-17 DOI: 10.1016/j.tem.2026.01.013
Sebastian J. Hofer, Anna Katharina Simon, Frank Madeo
{"title":"Do metabolic fluxes change with age?","authors":"Sebastian J. Hofer, Anna Katharina Simon, Frank Madeo","doi":"10.1016/j.tem.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.013","url":null,"abstract":"Metabolomes change with age. Yet, fluxomics points to a contradiction: <ce:inter-ref xlink:href=\"https://doi.org/10.1016/j.cmet.2025.09.009\" xlink:type=\"simple\">Jankowski <ce:italic>et al</ce:italic>.</ce:inter-ref> in <ce:italic>Cell Metabolism</ce:italic> report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders. 三甲胺- n -氧化物：免疫介导疾病的微生物线索。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-11 DOI: 10.1016/j.tem.2026.02.008
Gauri Mirji,Sajad Ahmad Bhat,Rahul S Shinde
{"title":"Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders.","authors":"Gauri Mirji,Sajad Ahmad Bhat,Rahul S Shinde","doi":"10.1016/j.tem.2026.02.008","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.008","url":null,"abstract":"Trimethylamine-N-oxide (TMAO), a gut microbial metabolite derived from dietary choline and carnitine, has emerged as a pivotal link between diet, microbial metabolism, and host immunity. Beyond its historical role as a marine osmolyte, TMAO engages core immune pathways-driving oxidative stress, inflammasome activation, and type I interferon signaling-to shape macrophage polarization, T cell responses, and systemic immune tone. These actions place TMAO at the intersection of chronic diseases, exacerbating cardiovascular, metabolic, renal, and neurodegenerative pathology while paradoxically enhancing antitumor immunity in pancreatic and breast cancers. Such duality underscores its significance as both a biomarker and a therapeutic target. We discuss current advances in TMAO biology, immune mechanisms, and strategies to modulate its activity through diet, microbiome interventions, and enzymatic inhibition.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucocorticoids mediate fasting efficacy in breast cancer. 糖皮质激素介导乳腺癌的空腹疗效。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-11 DOI: 10.1016/j.tem.2026.02.001
Anlei Li,Hao Huang,Rong Xiang
{"title":"Glucocorticoids mediate fasting efficacy in breast cancer.","authors":"Anlei Li,Hao Huang,Rong Xiang","doi":"10.1016/j.tem.2026.02.001","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.001","url":null,"abstract":"Addressing endocrine resistance in hormone receptor-positive breast cancer, Padrão et al. identify the glucocorticoid receptor (GR) as the key transducer of fasting benefits. They demonstrate that pharmacological GR activation recapitulates antitumor efficacy, offering a targeted therapeutic avenue that avoids the challenges of rigorous dieting.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Communication breakdown: senescent cells in interorgan communication of aging. 通讯中断：衰老细胞在器官间通讯的老化。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-10 DOI: 10.1016/j.tem.2026.02.002
Rituparna Ghosh,Shweta S Dipali,Gabriela Desdín-Míco,Matthew J Yousefzadeh
{"title":"Communication breakdown: senescent cells in interorgan communication of aging.","authors":"Rituparna Ghosh,Shweta S Dipali,Gabriela Desdín-Míco,Matthew J Yousefzadeh","doi":"10.1016/j.tem.2026.02.002","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.002","url":null,"abstract":"Cellular senescence is a complex cell fate characterized by stable cell cycle arrest and other heterogeneous changes. Senescent cells play a causal role in aging, although the underlying mechanisms remain under active investigation. In this opinion article, we propose that senescent cells can act as key mediators of interorgan communication of aging. Recent work defines multifaceted mechanisms, including the production of senescence-associated secretory phenotype factors that act to propagate senescence signals to nearby and distant cells, as well as age-related alterations in immune function that drive chronic inflammation, known as 'inflammaging'. Further investigation of these mechanisms could yield improved strategies to target senescent cells and mitigate their effects on systemic aging via interorgan communication of aging.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heme as a metabolic cell-fate switch. 血红素作为一种代谢细胞命运开关。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-10 DOI: 10.1016/j.tem.2026.01.017
Jia Liu,Rui Kang,Daolin Tang
{"title":"Heme as a metabolic cell-fate switch.","authors":"Jia Liu,Rui Kang,Daolin Tang","doi":"10.1016/j.tem.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.017","url":null,"abstract":"Heme availability shapes mitochondrial function, redox balance, and innate immune signaling. Recent studies reveal threshold-dependent heme states that predispose cells to cuproptosis, ferroptosis, apoptosis, pyroptosis, or PANoptosis. Viewing heme as a metabolic rheostat provides a unifying framework for interpreting regulated cell death across cancer, infection, and metabolic disease.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to redefine success in continuous glucose monitoring. 是时候重新定义连续血糖监测的成功了。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-10 DOI: 10.1016/j.tem.2026.02.007
Lara Albert,Ismael Capel,Mercedes Rigla
{"title":"Time to redefine success in continuous glucose monitoring.","authors":"Lara Albert,Ismael Capel,Mercedes Rigla","doi":"10.1016/j.tem.2026.02.007","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.007","url":null,"abstract":"Continuous glucose monitoring (CGM) has become standard care in type 1 diabetes, yet the key measures used to interpret CGM data, such as time spent within, below, or above the target glucose range, and glycemic variability, remain based on outdated thresholds. We discuss why updating these targets is essential for modern diabetes care.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut dysbiosis-mediated platelet activation as MASLD and cardiovascular disease link. 肠道失调介导的血小板活化与MASLD和心血管疾病的关系。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-09 DOI: 10.1016/j.tem.2026.02.003
Francesco Violi,Pasquale Pignatelli,Roberto Carnevale,Simona Bartimoccia
{"title":"Gut dysbiosis-mediated platelet activation as MASLD and cardiovascular disease link.","authors":"Francesco Violi,Pasquale Pignatelli,Roberto Carnevale,Simona Bartimoccia","doi":"10.1016/j.tem.2026.02.003","DOIUrl":"https://doi.org/10.1016/j.tem.2026.02.003","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by liver disease progression and cardiovascular disease (CVD). The mechanism linking MASLD with CVD is not fully understood. Here, we report experimental and clinical studies suggesting that platelet activation may be implicated in the pathogenesis of MASLD and CVD.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ-ovary crosstalk as a vital determinant of women's health. 器官卵巢相声是女性健康的重要决定因素。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-07 DOI: 10.1016/j.tem.2026.01.019
Seow Neng Chan,Jun Wei Pek
{"title":"Organ-ovary crosstalk as a vital determinant of women's health.","authors":"Seow Neng Chan,Jun Wei Pek","doi":"10.1016/j.tem.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.019","url":null,"abstract":"The ovary is more than just a reproductive organ. Recent evidence in mammalian and invertebrate models consistently highlights novel mechanistic insights into organ-ovary crosstalk via classical hormones and emerging secretomes, such as extracellular vesicles. Thus, the ovary functions as an integral organ to maintain organismal health through crosstalk with various organs.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting mitochondrial metabolism with combined metabolic activators. 联合代谢激活剂靶向线粒体代谢。
Trends in Endocrinology & Metabolism Pub Date : 2026-03-07 DOI: 10.1016/j.tem.2026.01.018
Hong Yang,Xiangtai Kong,Xinmeng Liao,Hasan Turkez,Jan Boren,Mathias Uhlen,Ozlem Altay,Adil Mardinoglu
{"title":"Targeting mitochondrial metabolism with combined metabolic activators.","authors":"Hong Yang,Xiangtai Kong,Xinmeng Liao,Hasan Turkez,Jan Boren,Mathias Uhlen,Ozlem Altay,Adil Mardinoglu","doi":"10.1016/j.tem.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.tem.2026.01.018","url":null,"abstract":"Mitochondria play a central role in energy metabolism, redox balance, and cellular homeostasis, and their dysfunction has been implicated in the pathogenesis of complex human diseases. Advances in systems biology and omics technologies have elucidated the mechanisms underlying these conditions, including metabolic dysfunction, mitochondrial impairment, inflammation, and redox imbalance. Preclinical and early clinical studies of combined metabolic activators (CMA), a formulation of bioactive metabolites, have demonstrated improvements in mitochondrial function and systemic metabolic profiles across multiple diseases. In this review, we provide a comprehensive overview of the mechanistic rationale for CMA, summarize evidence from preclinical models and clinical studies investigating CMA and its components, and evaluate its translational potential and challenges as a mitochondrial-targeted therapeutic strategy for complex human diseases.","PeriodicalId":23301,"journal":{"name":"Trends in Endocrinology & Metabolism","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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