在确定的生命早期窗口中播种微生物以对抗糖尿病。

Trends in Endocrinology & Metabolism Pub Date : 2025-05-01 DOI:10.1016/j.tem.2025.04.005

Shuqin Zeng,Shaopu Wang,Dezhi Mu

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摘要

早期肠道微生物群的建立与宿主发育相一致，如果被破坏，就容易出现长期疾病风险。最近，Hill等人精确地描述了人类和小鼠生命早期的一个关键窗口期，在此期间，特定的真菌和细菌在β细胞发育中起着不可或缺的作用，从而调节终身代谢稳态。

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Seeding microbes in defined early-life windows to fight diabetes.

Establishment of the early-life gut microbiome, coinciding with the host development, predisposes to long-term disease risk if disrupted. Recently, Hill et al. precisely delineated a critical early-life window in humans and mice during which specific fungi and bacteria play indispensable roles in β-cell development, thereby regulating lifelong metabolic homeostasis.

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Trends in Endocrinology & Metabolism

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